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1. 发明申请

WO2015120453A1 HORMONE TREATMENT FOR AGE-RELATED HEARING LOSS-PRESBYCUSIS 审中-公开
标题翻译：用于与年龄相关的听力损失预测的霍尔姆曼治疗
公开(公告)号：WO2015120453A1
公开(公告)日：2015-08-13
申请号：PCT/US2015/015216
申请日：2015-02-10
申请人： UNIVERSITY OF SOUTH FLORIDA , FRISINA, Robert Dana , WALTON, Joseph Paul , DING, Bo , ZHU, Xiaoxia
发明人： FRISINA, Robert Dana , WALTON, Joseph Paul , DING, Bo , ZHU, Xiaoxia
IPC分类号： A61K31/56 , A61K31/58 , A61K31/44
CPC分类号： A61K31/573 , A61K31/192 , A61K31/616 , A61K33/02 , A61K45/06 , A61K2300/00
摘要： Permanent hearing loss or deafness affects about 15% of people worldwide, about 40 million in the US alone, with no available treatment options. Age-related hearing loss (ARHL) is one of the most common forms of permanent hearing loss and deafness. ARHL is the most prevalent neurodegenerative and communication disorder, and a top 3 chronic medical conditions of our aged population. The incidence of ARHL is increasing, and cumulative effects of lifetime noise exposure, and widespread use of ototoxic chemotherapeutic and antibiotic drugs, have ototoxic side effects. A new drug is disclosed to prevent or slow the progression of ARHL, based upon natural, existing compounds. When given in the proper dosage the compounds have few, if any side effects, with in vitro experiments, and in vivo studies of aging mice, indicating is usefulness in preventing/treating one of the most pervasive forms of permanent hearing loss.
摘要翻译：永久性听力损失或耳聋影响全球约15％的人，仅在美国约4000万，没有可用的治疗方案。年龄相关性听力损失（ARHL）是永久性听力损失和耳聋的最常见形式之一。 ARHL是最常见的神经退行性疾病和沟通障碍，是我们老年人口的三大慢性疾病。 ARHL的发病率正在上升，一生噪声暴露的累积效应和耳毒性化疗药物和抗生素药物的广泛使用具有耳毒性副作用。根据天然的现有化合物，公开了一种新药来预防或减缓ARHL的发展。当以适当的剂量给予时，化合物在体外实验和老化小鼠的体内研究中几乎没有任何副作用，表明在预防/治疗永久性听力损失中最普遍形式之一是有用的。

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