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1. 发明申请

WO2008134265A2 IMINOSUGAR TREATMENT OF TUMORS 审中-公开
标题翻译：肿瘤的治疗
公开(公告)号：WO2008134265A2
公开(公告)日：2008-11-06
申请号：PCT/US2008/060822
申请日：2008-04-18
申请人： UNIVERSITY OF OXFORD , DWEK, Raymond , BUZGARIU, Wanda , HIRTOPEANU, Anca , MORIARTY, Robert , NEGROIU, Gabriela , NICHITA, Norica , ZDRENTU, Livia , ZITZMANN, Nicole
发明人： DWEK, Raymond , BUZGARIU, Wanda , HIRTOPEANU, Anca , MORIARTY, Robert , NEGROIU, Gabriela , NICHITA, Norica , ZDRENTU, Livia , ZITZMANN, Nicole
IPC分类号： A61K31/40 , A61K31/7004 , A61P35/00 , A61P35/04
CPC分类号： A61K31/40 , A61K31/7004
摘要： A proliferation of cells can be reduced by contacting the cells with a compound having formula (I). where R and R are each alkyl groups, R" is hydrogen or an alkyl group and X 3 , X 4 and X 5 are each independently selected from the group consisting of hydrogen, benzyl, t -butyldimethylsiloxy radical and triphenylmethyl. Accordingly, compounds of formula (I) can be used for treatment of tumors including melanoma. Also a secretion of a matrix metalloproteinase (MMP) enzyme by cells can be reduced by contacting the cells with the compound having formula (I). Accordingly, compounds of formula (I) can be used for treatment physiological conditions associated with an elevated MMP level, such as tumors.
摘要翻译：通过使细胞与具有式（I）的化合物接触可以减少细胞的增殖。其中R和R各自为烷基，R“为氢或烷基，X 3，X 4和X 5各自独立地为选自氢，苄基，叔丁基二甲基甲硅烷氧基和三苯基甲基，因此式（I）化合物可用于治疗包括黑素瘤在内的肿瘤，细胞也可分泌基质金属蛋白酶（MMP）通过使细胞与具有式（I）的化合物接触而减少，因此式（I）化合物可用于治疗与升高的MMP水平如肿瘤相关的生理条件。

2. 发明公开

EP2146709A2 IMINOSUGAR FOR TREATMENT OF TUMORS 审中-公开
标题翻译：亚氨基糖类用于肿瘤的治疗
公开(公告)号：EP2146709A2
公开(公告)日：2010-01-27
申请号：EP08746271.9
申请日：2008-04-18
申请人： University of Oxford
发明人： DWEK, Raymond , BUZGARIU, Wanda , HIRTOPEANU, Anca , MORIARTY, Robert , NEGROIU, Gabriela , NICHITA, Norica , ZDRENTU, Livia , ZITZMANN, Nicole
IPC分类号： A61K31/40 , A61K31/7004 , A61P35/00 , A61P35/04
CPC分类号： A61K31/40 , A61K31/7004
摘要： A proliferation of cells can be reduced by contacting the cells with a compound having formula (I). where R and R are each alkyl groups, R' is hydrogen or an alkyl group and X3, X4 and X5 are each independently selected from the group consisting of hydrogen, benzyl, t-butyldimethylsiloxy radical and triphenylmethyl. Accordingly, compounds of formula (I) can be used for treatment of tumors including melanoma. Also a secretion of a matrix metalloproteinase (MMP) enzyme by cells can be reduced by contacting the cells with the compound having formula (I). Accordingly, compounds of formula (I) can be used for treatment physiological conditions associated with an elevated MMP level, such as tumors.

3. 发明申请

WO2012122487A1 PROTOCOL-BASED INSPECTION SYSTEM 审中-公开
标题翻译：基于协议的检查系统
公开(公告)号：WO2012122487A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028509
申请日：2012-03-09
申请人： ROLLS-ROYCE CORPORATION , SHIRKHODAIE, Amir , MORIARTY, Robert , MA, Kong
发明人： SHIRKHODAIE, Amir , MORIARTY, Robert , MA, Kong
IPC分类号： G06K9/00
CPC分类号： G01N21/8901 , G06T7/0004 , G06T2200/24 , G06T2207/20081
摘要： One form of the present application provides a system comprising an illumination source capable of providing an electromagnetic illumination of an engine component, an imaging system structured to capture illumination of the engine component, a component manipulation system structured to position the engine component in a variety of orientations relative to one of the illumination source and the imaging system, a computer based user interface capable of identifying an inspection protocol defined to acquire an image of the engine component at the variety of positions using the illumination system, the imaging system and the component manipulation system, and a processor configured to process the inspection protocol for the purposes of analyzing the acquired image in response to the inspection protocol.
摘要翻译：本申请的一种形式提供了一种系统，其包括能够提供发动机部件的电磁照明的照明源，构造成捕获发动机部件的照明的成像系统，构造成将发动机部件定位在各种相对于照明源和成像系统中的一个的方向，基于计算机的用户界面，其能够识别使用照明系统，成像系统和部件操纵来定义为在各种位置处获取发动机部件的图像的检查协议系统和被配置为处理检查协议以便响应于检查协议分析所获取的图像的处理器。

4. 发明申请

WO2012122481A1 INTELLIGENT AIRFOIL COMPONENT GRAIN DEFECT INSPECTION 审中-公开
标题翻译：智能航空组件颗粒缺陷检查
公开(公告)号：WO2012122481A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028493
申请日：2012-03-09
申请人： ROLLS-ROYCE CORPORATION , KUSH, Matt , MA, Kong , MORIARTY, Robert
发明人： KUSH, Matt , MA, Kong , MORIARTY, Robert
IPC分类号： G06T7/00
CPC分类号： G01N21/8851 , G01N23/00 , G01N2021/8887
摘要： A system including a positioning system with a component manipulator structured to position a component in response to a positioning algorithm; a scanning system capable of producing a set of light waves directed at a surface of the component, detecting a set of reflected light waves from the surface of the component, and producing a reflectivity data set in response to the set of reflected light waves; and a microprocessor structured to apply a fuzzy logic algorithm to the reflectivity signal to determine a solution set and produce a grain structure characterization in response to the solution set.
摘要翻译：一种系统，包括具有构造成响应于定位算法定位组件的组件操纵器的定位系统; 扫描系统，其能够产生指向所述部件的表面的一组光波，从所述部件的表面检测一组反射光波，并且响应于所述一组反射光波产生反射率数据集; 以及微处理器，其被构造成将模糊逻辑算法应用于反射率信号以确定解集并且响应于解集而产生晶粒结构表征。

5. 发明申请

WO2012122467A1 INTELLIGENT AIRFOIL COMPONENT SURFACE IMAGING INSPECTION 审中-公开
标题翻译：智能气动元件表面成像检测
公开(公告)号：WO2012122467A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028462
申请日：2012-03-09
申请人： ROLLS-ROYCE CORPORATION , SHIRKHODAIE, Amir , MA, Kong , MORIARTY, Robert
发明人： SHIRKHODAIE, Amir , MA, Kong , MORIARTY, Robert
IPC分类号： G06K9/00
CPC分类号： G06T7/001 , G06T2207/20044 , G06T2207/30164
摘要： A method for inspecting surfaces including acquiring a surface image from a surface of a component; providing an image registration for the surface image; inspecting the component in response to the image registration to produce an input data set; creating an output data set in response to the input data set utilizing a fuzzy logic algorithm; and identifying a surface feature in response to the surface image and the output data set where acquiring the surface image further includes generating a radiation media; directing the radiation media at the component; detecting a responding radiation media in response to the directed radiation media and the component; creating the surface image in response to detecting the responding radiation media; and adjusting the generation of the radiation media in response to the surface image and a standard image.
摘要翻译：一种用于检查表面的方法，包括从部件的表面获取表面图像; 为表面图像提供图像配准; 响应于图像配准检查该组件以产生输入数据集; 使用模糊逻辑算法响应于所述输入数据集创建输出数据集; 以及响应于所述表面图像识别表面特征，并且在获取所述表面图像时所述输出数据集进一步包括产生辐射介质; 将辐射介质引导到部件上; 响应于所述定向辐射介质和所述部件检测响应的辐射介质; 响应于检测到响应的辐射介质而产生表面图像; 以及响应于所述表面图像和标准图像来调整所述辐射介质的产生。

6. 发明申请

WO2012122498A1 ILLUMINATION SYSTEM WITH ILLUMINATION SHIELD 审中-公开
标题翻译：具有照明屏蔽的照明系统
公开(公告)号：WO2012122498A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028543
申请日：2012-03-09
申请人： ROLLS-ROYCE CORPORATION , SHIRKHODAIE, Amir , MORIARTY, Robert , MA, Kong
发明人： SHIRKHODAIE, Amir , MORIARTY, Robert , MA, Kong
IPC分类号： F21V5/00
CPC分类号： G01N21/8806 , G01N2021/8812
摘要： An apparatus for an illumination system including a concentric light source providing a quantity of light; a diffusion shield to diffuse the light and produce a diffused illumination where the diffused illumination is provided to a component positioned in an interior portion of the diffusion shield; a support structure where the diffusion shield is mechanically coupled with the support structure at a first base portion of the diffusion shield and where the concentric light sources are mechanically coupled with the support structure and positioned radially outward from the first base portion of the diffusion shield; and a harvesting shield where the harvesting shield is mechanically coupled with the support structure and positioned radially outward from the concentric light sources and where the harvesting shield redirects at least a portion of the quantity of light from the concentric light sources towards the diffusion shield.
摘要翻译：一种照明系统的装置，包括提供一定量的光的同心光源; 扩散屏蔽，用于漫射光并产生扩散照明，其中扩散照明被提供给位于扩散屏蔽的内部中的部件; 支撑结构，其中所述扩散屏蔽在所述扩散屏蔽的第一基部处与所述支撑结构机械耦合，并且所述同心光源与所述支撑结构机械耦合并且从所述扩散屏蔽的所述第一基部径向向外定位; 收割罩与采收屏蔽机构与支撑结构机械耦合并且从同心光源径向向外定位，并且收集屏蔽将至少一部分来自同心光源的光重新定向到扩散屏蔽。

7. 发明申请

WO2012122489A2 AUTOMATED OBJECT MANIPULATION SYSTEM 审中-公开
标题翻译：自动化对象操纵系统
公开(公告)号：WO2012122489A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/028523
申请日：2012-03-09
申请人： ROLLS-ROYCE CORPORATION , SHIRKHODAIE, Amir , MORIARTY, Robert , MA, Kong
发明人： SHIRKHODAIE, Amir , MORIARTY, Robert , MA, Kong
IPC分类号： C12P13/04
CPC分类号： F16M11/123 , B65G47/904 , F16M11/18 , G01N21/95
摘要： An apparatus of an automated object manipulation system includes a support base; a finger assembly mechanically coupled to the support base; a first drive unit operable to rotate the finger assembly about a first axis; a second drive unit operable to rotate the finger assembly about a second axis; a third drive unit operable to rotate the finger assembly about a third axis, and a processor capable of conducting a profile assessment; determining a manipulation program in response to the profile assessment; and controlling the finger assembly in response to the manipulation program where the finger assembly has a support bracket with a set of parallel jaws and the support bracket is mechanically coupled to the first drive unit, a linking bracket mechanically coupled to the second drive unit and a circular frame mechanically coupled to the finger assembly and the third drive unit.
摘要翻译：一种自动化物体操纵系统的装置，包括支撑基座; 手指组件，其机械地联接到所述支撑基座; 第一驱动单元，其可操作以围绕第一轴线旋转所述手指组件; 第二驱动单元，其可操作以使指组件围绕第二轴线旋转; 第三驱动单元，其可操作以围绕第三轴线旋转所述手指组件;以及处理器，其能够执行轮廓评估; 响应于轮廓评估确定操纵程序; 以及响应于所述操纵程序来控制所述手指组件，其中所述手指组件具有支撑托架和一组平行爪，并且所述支撑支架机械地联接到所述第一驱动单元，机械地联接到所述第二驱动单元的联接支架和机械地联接到手指组件和第三驱动单元的圆形框架。

8. 发明申请

WO2012122473A1 INTELLIGENT AIRFOIL COMPONENT SURFACE INSPECTION 审中-公开
标题翻译：智能航空组件表面检查
公开(公告)号：WO2012122473A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028477
申请日：2012-03-09
申请人： ROLLS-ROYCE CORPORATION , KUSH, Matt , MA, Kong , MORIARTY, Robert
发明人： KUSH, Matt , MA, Kong , MORIARTY, Robert
IPC分类号： G01B5/28
CPC分类号： G01N21/91
摘要： A unique automated surface inspection process. Other embodiments include apparatuses, systems, devices, hardware, methods, and combinations for an automated surface inspection process including fuzzy logic analysis. The positioning system operates with a part presentation technique based on an algorithm for manipulating part in an efficient manner with minimum hunting for part surfaces and anomalies. Embodiments of positioning system can include a robotic part manipulator with a discussion of further details to follow. The positioning system utilizes illumination and imaging components to identify the type of part being inspected. Illumination can be, for example, supplied for reflection detection or shadow detection. An imaging component can be, for example, a camera capable of reproducing the image, a photo sensor capable of detecting illumination.
摘要翻译：独特的自动化表面检测流程。其他实施例包括用于包括模糊逻辑分析的自动化表面检查过程的装置，系统，装置，硬件，方法和组合。定位系统采用基于用于以部分表面和异常的最小搜索以有效方式操纵部件的算法的部件呈现技术来操作。定位系统的实施例可以包括机器人部件操纵器，其中将讨论进一步的细节。定位系统利用照明和成像组件来识别被检查部件的类型。照明可以例如被提供用于反射检测或阴影检测。成像组件可以是例如能够再现图像的照相机，能够检测照明的光传感器。

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