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1. 发明申请

WO2022155188A1 METHODS AND PLATFORMS FOR PROMOTING ANTIGEN-SPECIFIC TOLERANCE IN THE TREATMENT OF TYPE 1 DIABETES AND GRAFT REJECTION AND COMPOSITIONS RELATING THERETO 审中-公开
公开(公告)号：WO2022155188A1
公开(公告)日：2022-07-21
申请号：PCT/US2022/012100
申请日：2022-01-12
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK , UNIVERSITY OF MARYLAND, BALTIMORE OFFICE OF RESEARCH AND DEVELOPMENT
发明人： JEWELL, Christopher, M. , GAMMON, Joshua, M. , TOSTANOSKI, Lisa, H. , BROMBERG, Jonathan
IPC分类号： A61P37/06 , A61K31/436 , A61P37/02 , A61K39/00
摘要： The present disclosure is directed to systems, compositions and methods for promoting immune tolerance to an antigen in a subject. Systems and methods provide for introducing directly into at least one lymph node(s) of the subject a therapeutically effective amount of a composition comprising an antigen associated with an autoimmune disease or disorder, in combination with a carrier comprising an immune modulatory agent such that an immune response to said antigen is inhibited or suppressed in the subject. The present disclosure is also directed to systems, compositions and methods for the treatment and/or prevention of autoimmune diseases and conditions, and in particular type 1 diabetes and graft rejection.

2. 发明公开

EP3258957A1 POLYELECTROLYTE MULTILAYERS ASSEMBLED FROM IMMUNE SIGNAL COMPOUNDS 审中-公开
标题翻译：由免疫信号化合物组装的聚电解质多层膜
公开(公告)号：EP3258957A1
公开(公告)日：2017-12-27
申请号：EP16752877.7
申请日：2016-02-16
申请人： University of Maryland, College Park
发明人： JEWELL, Christopher, M. , TOSTANOSKI, Lisa, H. , CHIU, Yu-Chieh
IPC分类号： A61K39/00 , A61K39/39
CPC分类号： A61K39/39 , A61K9/1611 , A61K9/1676 , A61K39/00 , A61K39/0008 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/577
摘要： Immune-polyelectrolyte multilayers (iPEMs) that can be made entirely from immune signal compounds are provided. iPEMs are formed from first layer of a first immune signal compound, and a second layer of the first immune signal compound or a second immune signal compound disposed on the first layer of the first immune signal compound. The immune signal compounds are peptides, polypeptides, nucleic acids, charged derivatives thereof. Combinations of the immune signal compounds may be in adjacent layers. The first immune signal compound and the second immune signal compound have oppositely charged domains. iPEMs can be formed on or include a substrate, such as a sacrificial substrate, which allows for the formation of a three-dimensional void which can hold various other compounds for use in modulating immune responses. The iPEMs are for use in either stimulating an immune response to one or more antigens, or inducing tolerance to one or more antigens. Methods of stimulating immune responses, or inducing tolerance using the iPEMs, are also provided.

3. 发明申请

WO2018170205A1 MICRONEEDLE-MEDIATED DELIVERY OF TOLEROGENIC IMMUNOTHERAPEUTICS 审中-公开
公开(公告)号：WO2018170205A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022549
申请日：2018-03-15
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK
发明人： JEWELL, Christopher, M. , TOSTANOSKI, Lisa, H. , GOSSELIN, Emily
IPC分类号： A61K38/16 , A61M37/00 , A61M5/32
CPC分类号： A61M37/00 , A61K9/0021 , A61K38/02 , A61M2037/0046 , A61M2037/0053
摘要： Methods, compositions and kits are provided that include microneedles coated with or formed of antigens to which immune tolerance is desired. Use of the microneedles is demonstrated using glatiramer acetate and animal models of multiple sclerosis. Dose sparing and beneficial polarization of immune responses are demonstrated.

4. 发明申请

WO2016133862A1 POLYELECTROLYTE MULTILAYERS ASSEMBLED FROM IMMUNE SIGNAL COMPOUNDS 审中-公开
标题翻译：由免疫信号化合物组装的聚电解质多层
公开(公告)号：WO2016133862A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018002
申请日：2016-02-16
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK
发明人： JEWELL, Christopher, M. , TOSTANOSKI, Lisa, H. , CHIU, Yu-Chieh
IPC分类号： A61K39/00 , A61K39/39
CPC分类号： A61K39/39 , A61K9/1611 , A61K9/1676 , A61K39/00 , A61K39/0008 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/577
摘要： Immune-polyelectrolyte multilayers (iPEMs) that can be made entirely from immune signal compounds are provided. The iPEMs are formed from first layer of a first immune signal compound, and a second layer of the first immune signal compound or a second immune signal compound disposed on the first layer of the first immune signal compound. The immune signal compounds are peptides, polypeptides, nucleic acids, charged derivatives thereof. Combinations of the immune signal compounds may be in adjacent layers. The first immune signal compound and the second immune signal compound have oppositely charged domains. iPEMs can be formed on or include a substrate, such as a sacrificial substrate, which allows for the formation of a three-dimensional void which can hold various other compounds for use in modulating immune responses. The iPEMs are for use in either stimulating an immune response to one or more antigens, or inducing tolerance to one or more antigens. Methods of stimulating immune responses, or inducing tolerance using the iPEMs, are also provided.
摘要翻译：提供可以完全由免疫信号化合物制成的免疫聚电解质多层（iPEM）。 iPEM由第一免疫信号化合物的第一层和第一免疫信号化合物的第二层或设置在第一免疫信号化合物的第一层上的第二免疫信号化合物形成。免疫信号化合物是肽，多肽，核酸，其带电衍生物。免疫信号化合物的组合可以在相邻的层中。第一免疫信号化合物和第二免疫信号化合物具有相反电荷的结构域。 iPEM可以形成在或包括诸如牺牲基底的基底，其允许形成可以容纳用于调节免疫应答的各种其它化合物的三维空隙。 iPEM用于刺激对一种或多种抗原的免疫应答，或诱导对一种或多种抗原的耐受性。还提供了使用iPEMs刺激免疫应答或诱导耐受性的方法。

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