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1. 发明申请

WO2023278696A1 TARGETED PROTEIN DELIVERY TO MAMMALIAN EMBRYOS AND THERAPEUTIC APPLICATIONS USING EXOSOMES 审中-公开
公开(公告)号：WO2023278696A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/035715
申请日：2022-06-30
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , YANG, Peixin , REECE, E. Albert
发明人： YANG, Peixin , REECE, E. Albert
IPC分类号： A61K9/00 , A61K35/12 , A61K35/00 , A61K9/50 , C12N5/071 , C12N5/06
摘要： Methods for preventing neural tube defects in embryos of diabetic females via administration of Survivin-containing exosomes derived from Flk-1+ mesoderm progenitor cells are reported.

2. 发明申请

WO2018017842A9 SILICONE HYDROGEL BASED FLUORESCENT ASSAY AND CONTACT LENS 审中-公开
公开(公告)号：WO2018017842A9
公开(公告)日：2018-01-25
申请号：PCT/US2017/043087
申请日：2017-07-20
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , LAKOWICZ, Joseph R. , BADUGU, Ramachandram , REECE, E. Albert
发明人： LAKOWICZ, Joseph R. , BADUGU, Ramachandram , REECE, E. Albert
IPC分类号： A61B5/1455
摘要： A material, article, system and method include a probe composition that includes a hydrophobic portion, a hydrophilic portion, an analyte-binding portion and a fluorophore portion. The analyte-binding portion is configured to bind to an analyte in an aqueous solution. The fluorophore portion is configured to change an optical property of fluorescent light emitted in response to incident excitation light when the probe composition changes between a first state in which the analyte is not bound to the analyte-binding portion and a second state in which the analyte binds to the analyte-binding portion. A material includes the probe composition and a silicone hydrogel substrate having a hydrogel network that allows flow of aqueous solution through the solution and a silicone network that occupies interstices of the hydrogel network. A contact lens having the material enables remote detection of glucose concentration in tear fluid of a subject.

3. 发明申请

WO2018017842A1 SILICONE HYDROGEL BASED FLUORESCENT ASSAY AND CONTACT LENS 审中-公开
标题翻译：硅基水凝胶荧光分析和接触透镜
公开(公告)号：WO2018017842A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/043087
申请日：2017-07-20
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , LAKOWICZ, Joseph R. , BADUGU, Ramachandram , REECE, E. Albert
发明人： LAKOWICZ, Joseph R. , BADUGU, Ramachandram , REECE, E. Albert
IPC分类号： A61B5/1455
摘要： A material, article, system and method include a probe composition that includes a hydrophobic portion, a hydrophilic portion, an analyte-binding portion and a fluorophore portion. The analyte-binding portion is configured to bind to an analyte in an aqueous solution. The fluorophore portion is configured to change an optical property of fluorescent light emitted in response to incident excitation light when the probe composition changes between a first state in which the analyte is not bound to the analyte-binding portion and a second state in which the analyte binds to the analyte-binding portion. A material includes the probe composition and a silicone hydrogel substrate having a hydrogel network that allows flow of aqueous solution through the solution and a silicone network that occupies interstices of the hydrogel network. A contact lens having the material enables remote detection of glucose concentration in tear fluid of a subject.
摘要翻译：材料，制品，系统和方法包括包含疏水部分，亲水部分，分析物结合部分和荧光部分的探针组合物。分析物结合部分被配置成结合水溶液中的分析物。所述荧光部分构造成当所述探针组分在其中所述分析物未结合至所述分析物结合部分的第一状态和所述分析物结合部分结合的第二状态之间变化时，改变响应于入射的激发光而发射的荧光的光学性质结合到分析物结合部分。材料包括探针组合物和具有水凝胶网络的硅酮水凝胶基底，该水凝胶网络允许水溶液流过溶液和占据水凝胶网络间隙的硅酮网络。具有该材料的隐形眼镜能够远程检测受试者的泪液中的葡萄糖浓度。

4. 发明公开

EP3487406A1 SILICONE HYDROGEL BASED FLUORESCENT ASSAY AND CONTACT LENS 无效
公开(公告)号：EP3487406A1
公开(公告)日：2019-05-29
申请号：EP17831876.2
申请日：2017-07-20
申请人： University of Maryland, Baltimore
发明人： LAKOWICZ, Joseph R. , BADUGU, Ramachandram , REECE, E. Albert
IPC分类号： A61B5/1455

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