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1. 发明申请

US20210121659A1 SELF-EXPANDING CANNULA 有权
公开(公告)号：US20210121659A1
公开(公告)日：2021-04-29
申请号：US17142375
申请日：2021-01-06
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： Zhongjun WU , Bartley P. GRIFFITH , Jun DING
IPC分类号： A61M25/00 , A61M1/36
摘要： Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (“SLC”) configurations and double lumen cannula (“DLC”) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patient's body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patient's blood vessel or a portion of the system inserted into the patient's blood vessel) from collapsing as fluid is drained from the patient.

2. 发明申请

US20210346581A1 BLOOD OXYGENATOR 有权
公开(公告)号：US20210346581A1
公开(公告)日：2021-11-11
申请号：US17380319
申请日：2021-07-20
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： Zhongjun WU , Bartley P. GRIFFITH
IPC分类号： A61M1/16 , A61M60/113 , A61M60/205
摘要： A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.

3. 发明申请

US20170252505A1 ARTIFICIAL LUNG SYSTEM AND ITS METHODS OF USE 审中-公开
公开(公告)号：US20170252505A1
公开(公告)日：2017-09-07
申请号：US15598947
申请日：2017-05-18
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , BREETHE, INC.
发明人： Zhongjun WU , Bartley GRIFFITH , David N. WELLS
IPC分类号： A61M1/36
CPC分类号： A61M1/3667 , A61M1/1698 , A61M1/3666 , A61M2202/0208 , A61M2205/8206 , A61M2209/08 , A61M2209/088
摘要： An oxygen supply unit for use with a blood oxygenator comprises an oxygen concentrator and a carbon dioxide scrubber. In an on-line operational mode, oxygen-rich gas from the oxygen concentrator is predominantly supplied to the blood oxygenator with a reduced flow of recycled gas from the concentrator. In an off-line operational mode where the oxygen supply unit is being powered by battery only, a larger flow of recycled gas from the blood oxygenator is passed through the carbon dioxide scrubber and combined with a lesser amount of oxygen-rich gas from the oxygen concentrator. The oxygen supply unit may be used in combination with a blood pump and oxygenator to provide ambulatory blood oxygenation to patients with compromised lung function.

4. 发明申请

US20170303958A1 SELF-SEALING CANNULA 审中-公开
公开(公告)号：US20170303958A1
公开(公告)日：2017-10-26
申请号：US15526107
申请日：2015-11-11
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： Zhongjun WU , Bartley P. GRIFFITH , Keshava RAJAGOPAL
IPC分类号： A61B17/34
摘要： The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. The disclosed cannula can be implemented as a single lumen cannula or a double lumen cannula, which can be used with ventricular assist devices for heart support or pump-oxygenators for ECMO and respiratory support. Through a self-sealing mechanism fixed on the ventricular wall or atrial wall, a cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula. In the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location. The present invention achieves minimally invasive insertion without surgical sutures to the heart, and allows for optimal drainage of the blood from the heart. With use of the double lumen cannula, it prevents need for multiple cannulation sites, and greatly reduces the blood recirculation. Removal of the cannula is simplified without need for suturing or insertion of a plugging member.

5. 发明公开

US20240050637A1 ARTIFICIAL LUNG SYSTEM AND ITS METHODS OF USE 审中-公开
公开(公告)号：US20240050637A1
公开(公告)日：2024-02-15
申请号：US18310846
申请日：2023-05-02
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , BREETHE, INC
发明人： Zhongjun WU , Bartley GRIFFITH , David N. WELLS
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： A61M1/3667 , A61M1/1698 , A61M1/3666 , A61M2209/088 , A61M2209/08 , A61M2202/0208 , A61M2205/8206
摘要： An oxygen supply unit for use with a blood oxygenator comprises an oxygen concentrator and a carbon dioxide scrubber. In an on-line operational mode, oxygen-rich gas from the oxygen concentrator is predominantly supplied to the blood oxygenator with a reduced flow of recycled gas from the concentrator. In an off-line operational mode where the oxygen supply unit is being powered by battery only, a larger flow of recycled gas from the blood oxygenator is passed through the carbon dioxide scrubber and combined with a lesser amount of oxygen-rich gas from the oxygen concentrator. The oxygen supply unit may be used in combination with a blood pump and oxygenator to provide ambulatory blood oxygenation to patients with compromised lung function.

6. 发明申请

US20220347362A1 DUAL CHAMBER GAS EXCHANGER AND METHOD OF USE FOR RESPIRATORY SUPPORT 有权
公开(公告)号：US20220347362A1
公开(公告)日：2022-11-03
申请号：US17859144
申请日：2022-07-07
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , BREETHE, INC.
发明人： Zhongjun WU , Bartley P. GRIFFITH , Jiafeng ZHANG , Steven J. ORWIG
IPC分类号： A61M1/16 , A61M1/36 , A61M60/113
摘要： The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.

7. 发明申请

US20210000479A1 TRANS-ESOPHAGEAL AORTIC FLOW RATE CONTROL 有权
公开(公告)号：US20210000479A1
公开(公告)日：2021-01-07
申请号：US16978280
申请日：2019-03-05
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： Joseph RABIN , Zhongjun WU
IPC分类号： A61B17/128 , A61B17/29 , A61B17/12
摘要： A device and method is provided herein for esophageal impingement of a patients aorta. The device may be inserted into a patients esophagus and positioned at the location where the esophagus passes over the patients aorta. In this position, an actuation device is used to apply pressure to the patients aorta through their esophagus to impinge or occlude the aorta to stop or significantly reduce hemorrhaging. A manually operable actuator handle enables a physician to manipulate a head assembly of the device through three distinct degrees of freedom of movement so as to control placement and direction of force against the patients esophagus and, in turn, their aorta.

8. 发明申请

US20200206404A1 DUAL CHAMBER GAS EXCHANGER AND METHOD OF USE FOR RESPIRATORY SUPPORT 审中-公开
公开(公告)号：US20200206404A1
公开(公告)日：2020-07-02
申请号：US16791117
申请日：2020-02-14
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , BREETHE, INC
发明人： Zhongjun WU , Bartley P. GRIFFITH , Jiafeng ZHANG , Steven J. ORWIG
IPC分类号： A61M1/16 , A61M1/36 , A61M1/10
摘要： The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.

9. 发明申请

US20160296685A1 BLOOD OXYGENATOR 审中-公开
标题翻译：血液氧化剂
公开(公告)号：US20160296685A1
公开(公告)日：2016-10-13
申请号：US15100871
申请日：2014-12-23
申请人： UNIVERSITY OF MARYLAND, BALTIMORE
发明人： Zhongjun WU , Bartley P. GRIFFITH
IPC分类号： A61M1/16 , A61M1/10
CPC分类号： A61M1/1698 , A61M1/10 , A61M1/1006 , A61M1/1086 , A61M2202/0208 , A61M2205/3334 , A61M2205/3368 , A61M2205/366 , A61M2206/10 , A61M2206/16 , A61M2209/088
摘要： A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.
摘要翻译：公开了一种血液充氧器，其包括壳体，血液入口，血液出口，螺旋形蜗壳，气体入口，氧合器纤维束和气体出口。外壳包围纤维束，并提供血流路径和连接器的结构。纤维束包括气体交换膜，当血液流过膜时，氧气转移到血液中并去除二氧化碳。螺旋蜗壳引导血液流过纤维束。气流室接收含有氧气的吹扫气体并将吹扫气体分配到纤维膜中，然后将这些气体与被氧化的血液交换。

10. 发明公开

US20240325617A1 SELF-SEALING CANNULA 审中-公开
公开(公告)号：US20240325617A1
公开(公告)日：2024-10-03
申请号：US18739456
申请日：2024-06-11
申请人： University of Maryland, Baltimore
发明人： Zhongjun WU , Bartley P. GRIFFITH , Keshava RAJAGOPAL
IPC分类号： A61M1/36 , A61B17/00 , A61B17/34 , A61M60/148 , A61M60/178 , A61M60/38 , A61M60/857 , A61M60/861
CPC分类号： A61M1/3659 , A61B17/3417 , A61B17/3421 , A61B17/3439 , A61M60/178 , A61M60/38 , A61M60/857 , A61M60/861 , A61B2017/00247 , A61B2017/3419 , A61B2017/3425 , A61M60/148
摘要： The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. The disclosed cannula can be implemented as a single lumen cannula or a double lumen cannula, which can be used with ventricular assist devices for heart support or pump-oxygenators for ECMO and respiratory support. Through a self-sealing mechanism fixed on the ventricular wall or atrial wall, a cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula. In the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location. The present invention achieves minimally invasive insertion without surgical sutures to the heart, and allows for optimal drainage of the blood from the heart. With use of the double lumen cannula, it prevents need for multiple cannulation sites, and greatly reduces the blood recirculation. Removal of the cannula is simplified without need for suturing or insertion of a plugging member.

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