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1. 发明申请

WO2016016653A1 METHOD AND APPARATUS FOR PROTON COMPUTERISED TOMOGRAPHY 审中-公开
标题翻译：用于计算机计算机图像的方法和装置
公开(公告)号：WO2016016653A1
公开(公告)日：2016-02-04
申请号：PCT/GB2015/052208
申请日：2015-07-30
申请人： UNIVERSITY OF LINCOLN
发明人： ALLINSON, Nigel , EVANS, Phil , POLUDNIOWSKI, Gavin
IPC分类号： A61B6/03 , A61N5/10 , G01N23/04 , A61N1/16
CPC分类号： G06T11/003 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N1/16 , A61N2005/1087 , G01N23/046 , G01N2223/107 , G01N2223/419 , G06T7/0012 , G06T11/00 , G06T2207/10081
摘要： A method of reconstructing a3-dimensionalimage in a proton transmission computerised tomography (CT) apparatus is disclosed. The method comprises the creation of a reconstruction matrix. The matrix is created by directing a plurality of particles to traverse the object; and for each particle, measuring the trajectory and energy of each particle before and after it has traversed the object; for each particle, calculating the water-equivalent path length within the object; and for each particle, calculating the positions at which it entered and exited the object; and adding the water-equivalent path length, entry and exit positions to the reconstruction matrix. This procedure is repeated from a plurality of angular positions surrounding an object to be imaged. Then, a spatially varying 2- dimensional filter function is applied to the reconstruction matrix. Subsequently, a correction factor is applied to the filtered reconstruction matrix to at least partially correct for the finite extent of the matrix.
摘要翻译：公开了一种在质子传播计算机断层摄影（CT）装置中重建三维图像的方法。该方法包括创建重建矩阵。矩阵是通过引导多个粒子来遍历对象而产生的; 并且对于每个粒子，测量每个粒子在其穿过物体之前和之后的轨迹和能量; 对于每个粒子，计算物体内的水当量路径长度; 并且对于每个粒子，计算它进入和退出物体的位置; 并将等效路径长度，入口和出口位置添加到重建矩阵中。从围绕待成像对象的多个角位置重复该过程。然后，将空间变化的二维滤波函数应用于重建矩阵。随后，将校正因子应用于经滤波的重建矩阵，以至少部分地校正矩阵的有限范围。

2. 发明申请

WO2017194920A1 METHODS AND APPARATUS FOR PROTON COMPUTED TOMOGRAPHY 审中-公开
标题翻译：质子计算机断层摄影术的方法和设备
公开(公告)号：WO2017194920A1
公开(公告)日：2017-11-16
申请号：PCT/GB2017/051275
申请日：2017-05-09
申请人： UNIVERSITY OF LINCOLN
发明人： ALLINSON, Nigel , POLUDNIOWSKI, Gavin , EVANS, Philip
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , G06T2211/421 , G06T2211/436
摘要： Methods for reconstructing a 3-dimensional image in a proton computerised tomography (CT) apparatus are disclosed. The methods direct a plurality of particles at a target object, such as a human patient, from a plurality of incident angles. For each proton, a combination of parameters are recorded at each projection, from which an image can be reconstructed using either singly or in combination the various properties of the interactions of the protons with a patient: namely its stopping-power, scattering-power, attenuating-power, and straggling-power.
摘要翻译：公开了在质子计算机断层扫描（CT）设备中重建三维图像的方法。该方法从多个入射角度将多个粒子引导到诸如人类患者的目标物体处。对于每个质子，在每个投影处记录参数的组合，从中可以单独或组合质子与患者的相互作用的各种性质来重建图像，即其停止功率，散射功率，衰减力量和散步力量。

3. 发明申请

WO2015189601A1 ASSEMBLY, APPARATUS, SYSTEM AND METHOD 审中-公开
标题翻译：装配，装置，系统和方法
公开(公告)号：WO2015189601A1
公开(公告)日：2015-12-17
申请号：PCT/GB2015/051690
申请日：2015-06-09
申请人： UNIVERSITY OF LINCOLN
发明人： ALLINSON, Nigel , RILEY, Grainne , WALTHAM, Chris , ESPOSITO, Michela , PRICE, Tony , ALLPORT, Phil , TAYLOR, Jon , CASSE, Gianluigi , EVANS, Phil , POLUDNIOWSKI, Gavin , GREEN, Stuart , MANOLOPOULOS, Spyros , NIETO-CAMERO, Jaime , VERHOEVEN, Marcus
IPC分类号： A61N5/10 , G01T1/00
CPC分类号： A61N5/1071 , A61B6/032 , A61B6/4064 , A61B6/4241 , A61B6/4258 , A61B6/4266 , A61N5/1077 , A61N2005/1054 , A61N2005/1085 , A61N2005/1087 , G01T1/02 , G01T1/2928 , G01T1/2985
摘要： Some embodiments of the present invention provide a 2D position-sensitive detector assembly comprising at least three substantially planar detector portions arranged in overlapping relationship as viewed normal to a plane of the detector portions, each detector portion comprising an array of substantially parallel, linear detector elements, the detector elements of respective detector portions being mutually non-parallel, the detector elements each being configured to generate one or more electrical signals in response to interaction of a particle of radiation therewith.
摘要翻译：本发明的一些实施例提供一种2D位置敏感检测器组件，其包括至少三个基本上平面的检测器部分，其以与检测器部分的平面垂直的重叠关系布置，每个检测器部分包括基本上平行的线性检测器元件阵列各个检测器部分的检测器元件是相互不平行的，每个检测器元件被配置成响应于辐射粒子的相互作用而产生一个或多个电信号。

4. 发明申请

WO2015189603A1 ASSEMBLY, APPARATUS, SYSTEM AND METHOD 审中-公开
标题翻译：装配，装置，系统和方法
公开(公告)号：WO2015189603A1
公开(公告)日：2015-12-17
申请号：PCT/GB2015/051692
申请日：2015-06-09
申请人： UNIVERSITY OF LINCOLN
发明人： ALLINSON, Nigel , RILEY, Grainne , WALTHAM, Chris , ESPOSITO, Michela , PRICE, Tony , ALLPORT, Phil , TAYLOR, Jon , CASSE, Gianluigi , EVANS, Phil , POLUDNIOWSKI, Gavin , GREEN, Stuart , MANOLOPOULOS, Spyros , NIETO-CAMERO, Jaime , VERHOEVEN, Marcus
IPC分类号： A61N5/10
CPC分类号： A61N5/1071 , A61B6/032 , A61B6/4064 , A61B6/4241 , A61B6/4258 , A61B6/4266 , A61N5/1077 , A61N2005/1054 , A61N2005/1085 , A61N2005/1087 , G01T1/02 , G01T1/2928 , G01T1/2985
摘要： Some embodiments of the present invention provide apparatus having a particle beamline for passage of charged particles of radiation therealong, comprising: a first beam tracker structure comprising at least one position sensitive detector (PSD) for determining a location with respect to a cross-sectional area of the beam line at which particles pass through the PSD; energy discrimination apparatus for determining an energy of particles that have passed through the first beam tracker structure; and support means for supporting a subject in a path of a particle along the beamline between the first beam tracker structure and the energy discrimination apparatus, the apparatus being configured to be operated in a selected one of a first mode and a second mode, the apparatus being configured, in the first mode of operation, to control an energy of the beam of charged particles passing through the first beam tracker structure such that a Bragg peak of charged particle absorption is located within the subject, and in the second mode of operation, to control an energy of the beam of charged particles passing through the first beam tracker structure such that a Bragg peak of charged particle absorption is located within the energy discrimination apparatus.
摘要翻译：本发明的一些实施例提供具有粒子束线的装置，该粒子束线用于沿其上的带电粒子的通过，包括：第一光束跟踪器结构，包括至少一个位置敏感检测器（PSD），用于确定相对于横截面积的位置的粒子通过PSD的束线; 用于确定通过第一光束跟踪器结构的颗粒的能量的能量鉴别装置; 以及支撑装置，用于支撑沿着第一光束跟踪器结构和能量判别装置之间的束线的粒子路径中的对象，该装置被配置为以第一模式和第二模式中的选定的一个操作，该装置在第一操作模式中，控制通过第一光束跟踪器结构的带电粒子束的能量，使得带电粒子吸收的布拉格峰位于被摄体内，而在第二操作模式中，以控制通过第一光束跟踪器结构的带电粒子束的能量，使得带电粒子吸收的布拉格峰位于能量鉴别装置内。

5. 发明申请

WO2015189602A1 ASSEMBLY, APPARATUS, SYSTEM AND METHOD 审中-公开
标题翻译：装配，装置，系统和方法
公开(公告)号：WO2015189602A1
公开(公告)日：2015-12-17
申请号：PCT/GB2015/051691
申请日：2015-06-09
申请人： UNIVERSITY OF LINCOLN
发明人： ALLINSON, Nigel , RILEY, Grainne , WALTHAM, Chris , ESPOSITO, Michela , PRICE, Tony , ALLPORT, Phil , TAYLOR, Jon , CASSE, Gianluigi , EVANS, Phil , POLUDNIOWSKI, Gavin , GREEN, Stuart , MANOLOPOULOS, Spyros , NIETO-CAMERO, Jaime , VERHOEVEN, Marcus
IPC分类号： A61N5/10 , G01T1/00 , A61B6/00
CPC分类号： A61N5/1071 , A61B6/032 , A61B6/4064 , A61B6/4241 , A61B6/4258 , A61B6/4266 , A61N5/1077 , A61N2005/1054 , A61N2005/1085 , A61N2005/1087 , G01T1/02 , G01T1/2928 , G01T1/2985
摘要： Some embodiments of the present invention provide apparatus for detecting particles of radiation comprising: a plurality of solid state semiconductor detector devices provided at spaced apart locations along a beam axis, the detector devices each being configured to generate an electrical signal indicative of passage of a particle through or absorption of a particle by the device; and at least one absorber portion configured to absorb at least a portion of an energy of a particle, wherein one said at least one absorber portion is provided in a particle path between at least one pair of adjacent detector devices, the apparatus being configured to provide an output signal indicative of the energy of a particle, the output signal provided being dependent on the electrical signals indicative of passage of a particle through or absorption of a particle by the devices.
摘要翻译：本发明的一些实施例提供了用于检测辐射颗粒的装置，包括：多个固态半导体检测器装置，沿着光束轴线设置在间隔开的位置处，每个检测器装置被配置成产生指示颗粒通过的电信号通过装置通过或吸收颗粒; 以及至少一个吸收器部分，其构造成吸收颗粒的能量的至少一部分，其中一个所述至少一个吸收体部分设置在至少一对相邻检测器装置之间的颗粒路径中，所述装置被配置为提供指示颗粒的能量的输出信号，所提供的输出信号取决于指示颗粒通过装置通过或吸收颗粒的电信号。

6. 发明公开

EP3151916A1 ASSEMBLY, APPARATUS, SYSTEM AND METHOD 有权
标题翻译： ANORDNUNG，VORRICHTUNG，SYSTEM UND VERFAHREN
公开(公告)号：EP3151916A1
公开(公告)日：2017-04-12
申请号：EP15732877.4
申请日：2015-06-09
申请人： University of Lincoln
发明人： ALLINSON, Nigel , RILEY, Grainne , WALTHAM, Chris , ESPOSITO, Michela , PRICE, Tony , ALLPORT, Phil , TAYLOR, Jon , CASSE, Gianluigi , EVANS, Phil , POLUDNIOWSKI, Gavin , GREEN, Stuart , MANOLOPOULOS, Spyros , NIETO-CAMERO, Jaime , VERHOEVEN, Marcus
IPC分类号： A61N5/10 , G01T1/00
CPC分类号： A61B6/4266 , A61B6/032 , A61B6/4064 , A61B6/4241 , A61B6/4258 , A61N5/1071 , A61N5/1077 , A61N2005/1054 , A61N2005/1085 , A61N2005/1087 , G01T1/02 , G01T1/2928 , G01T1/2985
摘要： Some embodiments of the present invention provide apparatus for detecting particles of radiation comprising: a plurality of solid state semiconductor detector devices provided at spaced apart locations along a beam axis, the detector devices each being configured to generate an electrical signal indicative of passage of a particle through or absorption of a particle by the device; and at least one absorber portion configured to absorb at least a portion of an energy of a particle, wherein one said at least one absorber portion is provided in a particle path between at least one pair of adjacent detector devices, the apparatus being configured to provide an output signal indicative of the energy of a particle, the output signal provided being dependent on the electrical signals indicative of passage of a particle through or absorption of a particle by the devices.
摘要翻译：本发明的一些实施例提供用于检测辐射粒子的装置，包括：多个固态半导体检测器装置，沿着光束轴线设置在间隔开的位置处，每个检测器装置被配置为产生指示粒子通过的电信号通过装置通过或吸收颗粒; 以及至少一个吸收器部分，其构造成吸收颗粒的能量的至少一部分，其中一个所述至少一个吸收体部分设置在至少一对相邻检测器装置之间的颗粒路径中，所述装置被配置为提供指示颗粒的能量的输出信号，提供的输出信号取决于指示颗粒通过或通过装置吸收颗粒的电信号。

7. 发明授权

EP3151918B1 COMPUTED TOMOGRAPHY APPARATUS 有权
公开(公告)号：EP3151918B1
公开(公告)日：2018-08-15
申请号：EP15732879.0
申请日：2015-06-09
申请人： The University of Lincoln
发明人： ALLINSON, Nigel , RILEY, Grainne , WALTHAM, Chris , ESPOSITO, Michela , PRICE, Tony , ALLPORT, Phil , TAYLOR, Jon , CASSE, Gianluigi , EVANS, Phil , POLUDNIOWSKI, Gavin , GREEN, Stuart , MANOLOPOULOS, Spyros , NIETO-CAMERO, Jaime , VERHOEVEN, Marcus
IPC分类号： A61N5/10
CPC分类号： A61B6/4266 , A61B6/032 , A61B6/4064 , A61B6/4241 , A61B6/4258 , A61N5/1071 , A61N5/1077 , A61N2005/1054 , A61N2005/1085 , A61N2005/1087 , G01T1/02 , G01T1/2928 , G01T1/2985
摘要： Some embodiments of the present invention provide apparatus for detecting particles of radiation comprising: a plurality of solid state semiconductor detector devices provided at spaced apart locations along a beam axis, the detector devices each being configured to generate an electrical signal indicative of passage of a particle through or absorption of a particle by the device; and at least one absorber portion configured to absorb at least a portion of an energy of a particle, wherein one said at least one absorber portion is provided in a particle path between at least one pair of adjacent detector devices, the apparatus being configured to provide an output signal indicative of the energy of a particle, the output signal provided being dependent on the electrical signals indicative of passage of a particle through or absorption of a particle by the devices.

8. 发明授权

EP3151917B1 COMPUTERIZED TOMOGRAPHY SYSTEM 有权
公开(公告)号：EP3151917B1
公开(公告)日：2020-08-05
申请号：EP15732878.2
申请日：2015-06-09
申请人： The University of Lincoln
发明人： ALLINSON, Nigel , RILEY, Grainne , WALTHAM, Chris , ESPOSITO, Michela , PRICE, Tony , ALLPORT, Phil , TAYLOR, Jon , CASSE, Gianluigi , EVANS, Phil , POLUDNIOWSKI, Gavin , GREEN, Stuart , MANOLOPOULOS, Spyros , NIETO-CAMERO, Jaime , VERHOEVEN, Marcus
IPC分类号： A61N5/10 , G01T1/00 , A61B6/00

9. 发明公开

EP3151918A1 ASSEMBLY, APPARATUS, SYSTEM AND METHOD 有权
标题翻译：安排，设备，系统及方法
公开(公告)号：EP3151918A1
公开(公告)日：2017-04-12
申请号：EP15732879.0
申请日：2015-06-09
申请人： The University of Lincoln
发明人： ALLINSON, Nigel , RILEY, Grainne , WALTHAM, Chris , ESPOSITO, Michela , PRICE, Tony , ALLPORT, Phil , TAYLOR, Jon , CASSE, Gianluigi , EVANS, Phil , POLUDNIOWSKI, Gavin , GREEN, Stuart , MANOLOPOULOS, Spyros , NIETO-CAMERO, Jaime , VERHOEVEN, Marcus
IPC分类号： A61N5/10
CPC分类号： A61B6/4266 , A61B6/032 , A61B6/4064 , A61B6/4241 , A61B6/4258 , A61N5/1071 , A61N5/1077 , A61N2005/1054 , A61N2005/1085 , A61N2005/1087 , G01T1/02 , G01T1/2928 , G01T1/2985
摘要： Some embodiments of the present invention provide apparatus for detecting particles of radiation comprising: a plurality of solid state semiconductor detector devices provided at spaced apart locations along a beam axis, the detector devices each being configured to generate an electrical signal indicative of passage of a particle through or absorption of a particle by the device; and at least one absorber portion configured to absorb at least a portion of an energy of a particle, wherein one said at least one absorber portion is provided in a particle path between at least one pair of adjacent detector devices, the apparatus being configured to provide an output signal indicative of the energy of a particle, the output signal provided being dependent on the electrical signals indicative of passage of a particle through or absorption of a particle by the devices.

10. 发明授权

EP3151916B1 COMPUTERIZED TOMOGRAPHY SYSTEM 有权
公开(公告)号：EP3151916B1
公开(公告)日：2019-02-20
申请号：EP15732877.4
申请日：2015-06-09
申请人： University of Lincoln
发明人： ALLINSON, Nigel , RILEY, Grainne , WALTHAM, Chris , ESPOSITO, Michela , PRICE, Tony , ALLPORT, Phil , TAYLOR, Jon , CASSE, Gianluigi , EVANS, Phil , POLUDNIOWSKI, Gavin , GREEN, Stuart , MANOLOPOULOS, Spyros , NIETO-CAMERO, Jaime , VERHOEVEN, Marcus
IPC分类号： A61N5/10 , G01T1/00

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