专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1983000017A1 ANAPLASMA ANTIGEN 审中-公开
公开(公告)号：WO1983000017A1
公开(公告)日：1983-01-06
申请号：PCT/US1982000816
申请日：1982-06-17
申请人： UNIVERSITY OF ILLINOIS FOUNDATION
发明人： UNIVERSITY OF ILLINOIS FOUNDATION , RISTIC, Miodrag , LEVY, Michael, G.
IPC分类号： A61K39/00
CPC分类号： A61K39/0233 , Y02A50/403
摘要： Water soluble antigens specific for Anaplasma sp. are produced and isolated in vitro. For example, a non-living, stable, soluble Anaplasma marginale antigen (designated "Anablock") is characterized, interalia, as a glycoprotein having a molecular weight of about 53,000 and an isoelectric point of about 6. Vaccine compositions providing immunologically effective quantities of soluble specific antigen and a suitable adjuvant are capable of provoking protective immune response to challenge with virulent Anaplasma, e.g., blocking the development of virulent A. marginale infection. The protective immune response in vaccinates is serologically characterized by positive results in latex agglutination (LAT) and fluorescent antibody (IFA) test, but negative results in complement fixation (CF) and capillary tube agglutination (CA) test.
摘要翻译： Anaplasma sp。特异性的水溶性抗原在体外产生和分离。例如，非活性，稳定的可溶性阿片平滑肌抗原（称为“Anablock”）的特征在于，作为分子量约为53,000的糖蛋白，等电点为约6的糖蛋白。提供免疫有效量的疫苗组合物可溶性特异性抗原和合适的佐剂能够引发保护性的免疫反应以用有毒的Anaplasma进行攻击，例如阻断毒性的边缘感染的发展。免疫接种中的保护性免疫应答的血清学特征是乳胶凝集（LAT）和荧光抗体（IFA）检测阳性结果，但是补体固定（CF）和毛细血管凝集（CA）检验阴性。

IPRDB

热门服务

关于我们

友情链接

联系方式