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1. 发明申请

WO1998009988A1 PROCESS TO PREPARE PHARMACEUTICAL COMPOUNDS 审中-公开
标题翻译：制备药物化合物的方法
公开(公告)号：WO1998009988A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015626
申请日：1997-09-05
申请人： ELI LILLY AND COMPANY , UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY , MARTINELLI, Michael, J. , MOHER, Eric, D.
发明人： ELI LILLY AND COMPANY , UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY
IPC分类号： C07K05/12
CPC分类号： C07D273/00
摘要： This invention provides a process for preparing diastereomerically pure cryptophycin compounds.
摘要翻译：本发明提供了制备非对映体纯的辛霉素化合物的方法。

2. 发明申请

WO1998009955A1 PROCESS AND NOVEL INTERMEDIATES 审中-公开
标题翻译：过程和新颖的中介
公开(公告)号：WO1998009955A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015703
申请日：1997-09-05
申请人： ELI LILLY AND COMPANY , UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY , HUTCHISON, Darrell, R. , JANISSE, Samantha, K. , MARTINELLI, Michael, J. , MOHER, Eric, D. , SULLIVAN, Kevin, A. , VARIE, David, L. , HOARD, David, W. , TOTH, John, E.
发明人： ELI LILLY AND COMPANY , UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY
IPC分类号： C07D291/02
CPC分类号： C07D273/00 , C07C229/36 , C07C235/34 , C07C291/02 , C07D291/02
摘要： This invention provides intermediates and processes useful for the preparation of crytophycin compounds.
摘要翻译：本发明提供了可用于制备冷冻霉素化合物的中间体和方法。

3. 发明申请

WO1998006852A1 PURIFIED PROTEINS, RECOMBINANT DNA SEQUENCES AND PROCESSES FOR CONTROLLING THE RIPENING OF COFFEE PLANTS 审中-公开
标题翻译：纯化蛋白质，重组DNA序列和控制咖啡植物焙烤的方法
公开(公告)号：WO1998006852A1
公开(公告)日：1998-02-19
申请号：PCT/US1997014184
申请日：1997-08-11
申请人： UNIVERSITY OF HAWAII
发明人： UNIVERSITY OF HAWAII , STILES, John, I. , MOISYADI, Istefo , NEUPANE, Kabi, Raj
IPC分类号： C12N15/52
CPC分类号： C12N9/0071 , C12N9/88 , C12N15/8249
摘要： Purified proteins, DNA sequences that code on expression therefore and recombinant DNA molecules, including hosts transformed therewith for transforming coffee plants to suppress the expression of enzymes necessary for ethylene synthesis. The DNA sequences and recombinant DNA molecules are characterized in that they code on expression for the enzymes ACC synthase or ACC oxidase that are elements of the pathway for ethylene biosynthesis in coffee plants. Coffee plants are tansformed with vectors containing ACC synthase and/or with ACC oxidate DNA sequences that code on expression for the respective mRNA that is antisense to the mRNA for ACC synthase and/or ACC oxidase. The resulting antisense mRNA binds to XMI mRNA, thereby inactivating the mRNA encoding one or more enzymes in the pathway for ethylene synthesis. The described DNA sequences can also be used to block synthesis of ACC synthase or ACC oxidate using co-suppression. The result in either event is that the transformed plants are incapable of synthesizing ethylene, though other aspects of their metabolism is not affected.
摘要翻译：纯化的蛋白质，因此编码表达的DNA序列和重组DNA分子，包括用其转化的宿主转化咖啡植物以抑制乙烯合成所必需的酶的表达。 DNA序列和重组DNA分子的特征在于它们编码作为咖啡植物中乙烯生物合成途径元素的酶ACC合成酶或ACC氧化酶的表达。用含有ACC合酶和/或ACC氧化DNA序列的载体对咖啡植物进行改造，其编码与ACC合酶和/或ACC氧化酶的mRNA反义的相应mRNA的表达。所得的反义mRNA结合XMI mRNA，从而使编码乙烯合成途径中的一种或多种酶的mRNA失活。所描述的DNA序列也可以用于阻断ACC合成酶或ACC氧化物的合成。在任一事件中的结果是转化的植物不能合成乙烯，尽管其代谢的其它方面不受影响。

4. 发明申请

WO1997008334A1 CRYPTOPHYCINS FROM ABERRANT BIOSYNTHESIS 审中-公开
标题翻译：来自ABERRANT BIOSYNTHESIS的CRYPTOPHYCINS
公开(公告)号：WO1997008334A1
公开(公告)日：1997-03-06
申请号：PCT/US1996014670
申请日：1996-08-30
申请人： UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY , MOORE, Richard, E. , HEMSCHEIDT, Thomas, K.
发明人： UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY
IPC分类号： C12P21/04
CPC分类号： C07D273/00 , C12P21/02
摘要： Methods for producing cryptophycin compounds by bacterial fermentation are disclosed, together with novel compositions produced thereby.
摘要翻译：公开了通过细菌发酵生产隐斜霉素化合物的方法，以及由此产生的新型组合物。

5. 发明申请

WO1996030464A1 CATALYTIC SUPERCRITICAL GASIFICATION OF WET BIOMASS 审中-公开
标题翻译：湿生物质的催化超临界气化
公开(公告)号：WO1996030464A1
公开(公告)日：1996-10-03
申请号：PCT/US1996004439
申请日：1996-03-28
申请人： UNIVERSITY OF HAWAII
发明人： UNIVERSITY OF HAWAII , ANTAL, Michael, J., Jr.
IPC分类号： C10J03/00
CPC分类号： B01J3/008 , C10J3/00 , C10J2200/06 , C10J2300/0916 , C10J2300/0946 , C10J2300/0979 , C10J2300/0986 , C10J2300/1276 , Y02P20/145 , Y02P20/544
摘要： A method for catalytically decomposing organic matter in a reaction medium is presented. Virtually complete gasification is achieved in relatively short periods of time. A hydrogen-rich gas may be formed from feedstocks (12) that include wet biomass, such as water hyacinth or algae, or organic waste or mixtures of biomass and organic waste. The reaction is catalyzed by a carbon-containing catalyst (22). The reaction medium may include supercritical water and is substantially oxygen-free. The carbon-containing catalyst (22) is stable in the environment of a supercritical water medium and maintains activity over long periods of time. Suitable carbon-containing catalysts are activated carbons or charcoals. Reaction products (26) are substantialy free of tars or chars.
摘要翻译：提出了一种在反应介质中催化分解有机物质的方法。几乎完全气化在相对较短的时间内实现。可以由包括湿生物质的原料（12）形成富氢气体，例如水葫芦或藻类，或有机废物或生物质和有机废物的混合物。该反应由含碳催化剂（22）催化。反应介质可以包括超临界水，并且基本上是无氧的。含碳催化剂（22）在超临界水介质的环境中是稳定的，并且长时间保持活性。合适的含碳催化剂是活性炭或木炭。反应产物（26）基本上没有焦油或焦炭。

6. 发明申请

WO1998009974A1 PROCESS AND NOVEL INTERMEDIATES 审中-公开
标题翻译：过程和新颖的中介
公开(公告)号：WO1998009974A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015669
申请日：1997-09-05
申请人： ELI LILLY AND COMPANY , UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY , MARTINELLI, Michael, J. , MOHER, Eric, D. , NAYYAR, Naresh, K. , PAWLAK, Joseph, M.
发明人： ELI LILLY AND COMPANY , UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY
IPC分类号： C07F07/08
CPC分类号： C07D303/14 , C07C309/73 , C07F7/1804
摘要： This invention provides processes for preparing intermediates useful for the preparation of cryptophycin compounds.
摘要翻译：本发明提供了制备可用于制备cryptophycin化合物的中间体的方法。

7. 发明申请

WO1998008829A1 PHARMACEUTICAL COMPOUNDS 审中-公开
标题翻译：药物化合物
公开(公告)号：WO1998008829A1
公开(公告)日：1998-03-05
申请号：PCT/US1997015236
申请日：1997-08-28
申请人： ELI LILLY AND COMPANY , UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY , GROSSMAN, Cora, S. , GRUBER, Joseph, M. , SHIH, Chuan
发明人： ELI LILLY AND COMPANY , UNIVERSITY OF HAWAII , WAYNE STATE UNIVERSITY
IPC分类号： C07D273/08
CPC分类号： C07D273/00 , C07D407/06
摘要： The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the novel cryptophycin compounds.
摘要翻译：本发明提供了可用于破坏微管蛋白体系，作为抗肿瘤剂和用于治疗癌症的新颖的cryptophycin化合物。本发明还提供了一种用于施用新型cryptophycin化合物的制剂。

8. 发明申请

WO1997035960A1 PURIFIED PROTEINS, RECOMBINANT DNA SEQUENCES AND PROCESSES FOR PRODUCING CAFFEINE FREE BEVERAGES 审中-公开
标题翻译：纯化蛋白，重组DNA序列和生产无咖啡因饮料的方法
公开(公告)号：WO1997035960A1
公开(公告)日：1997-10-02
申请号：PCT/US1997004982
申请日：1997-03-24
申请人： UNIVERSITY OF HAWAII
发明人： UNIVERSITY OF HAWAII , STILES, John, I. , MOISYADI, Istefo , NEUPANE, Kabi, Raj
IPC分类号： C12N09/00
CPC分类号： C12N9/1007 , C12N15/8243
摘要： Purified proteins, DNA sequences that code on expression therefore and recombinant DNA molecules, including hosts transformed therewith, for transforming coffee plants to suppress the expression of caffeine. The DNA sequences and recombinant DNA molecules are characterized in that they code on expression for an enzyme in the pathway for caffeine synthesis in coffee. Coffee plants transformed with DNA molecules that code on transcription for mRNA that is antisens to mRNA that codes on expression for at least one enzyme in the pathway for caffeine biosynthesis.
摘要翻译：纯化的蛋白质，因此编码表达的DNA序列和重组DNA分子，包括转化的宿主，用于转化咖啡植物以抑制咖啡因的表达。 DNA序列和重组DNA分子的特征在于它们编码咖啡中咖啡因合成途径中酶的表达。用DNA分子转化的咖啡植物，其编码mRNA的转录成为对编码咖啡因生物合成途径中的至少一种酶的mRNA表达的基因。

9. 发明申请

WO1997022687A1 IMPROVED NEUROSPORA HOSTS FOR THE PRODUCTION OF RECOMBINANT PROTEINS, AND METHODS FOR PRODUCING THE SAME 审中-公开
标题翻译：用于生产重组蛋白质的改良神经病原体及其生产方法
公开(公告)号：WO1997022687A1
公开(公告)日：1997-06-26
申请号：PCT/US1996018348
申请日：1996-11-12
申请人： UNIVERSITY OF HAWAII , STUART, W., Dorsey
发明人： UNIVERSITY OF HAWAII
IPC分类号： C12N01/14
CPC分类号： C12R1/645 , C12N15/80
摘要： The present invention provides improved host cells for use in producing secreted recombinant proteins, methods of making the improved hosts and uses thereof. The invention specifically provides strains of Neurospora crassa which produce reduced levels of extracellular proteases when compared with wild-type Neurospora crassa.
摘要翻译：本发明提供了用于产生分泌的重组蛋白质的改进的宿主细胞，制备改进的宿主的方法及其用途。本发明特别提供了与野生型粗糙脉孢菌相比，产生细胞外蛋白酶水平降低的粗糙脉孢菌株。

10. 发明申请

WO1995029261A1 DETECTION AND IDENTIFICATION OF ENTERIC PATHOGENS 审中-公开
标题翻译：肠道病变的检测和鉴定
公开(公告)号：WO1995029261A1
公开(公告)日：1995-11-02
申请号：PCT/US1995004974
申请日：1995-04-21
申请人： UNIVERSITY OF HAWAII
发明人： UNIVERSITY OF HAWAII , ROLL, Bruce
IPC分类号： C12Q01/68
CPC分类号： C12Q1/689 , C12Q2600/16 , Y02A50/451
摘要： The present invention is directed to methods and reagents for the specific detection and presumptive identification of various bacteria associated with waterborne infectious disease. In particular, this invention relates to methods and reagents for the specific detection and identification of Salmonella and Shigella in environmental samples such as water and sewage.
摘要翻译：本发明涉及用于与水传染病相关的各种细菌的特异性检测和推定鉴定的方法和试剂。特别地，本发明涉及在环境样品如水和污水中特异性检测和鉴定沙门氏菌和志贺氏菌的方法和试剂。

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