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1. 发明专利

SG11201907917XA PM21 PARTICLES TO IMPROVE BONE MARROW HOMING OF NK CELLS 未知
公开(公告)号：SG11201907917XA
公开(公告)日：2019-09-27
申请号：SG11201907917X
申请日：2018-02-28
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC , RES INST NATIONWIDE CHILDRENS HOSPITAL
发明人： COPIK ALICJA , OYER JEREMIAH , CHAKRAVARTI NITIN , LEE DEAN ANTHONY
IPC分类号： A61K35/17 , A61K38/20 , C12N5/00
摘要： PMg/injection) PM21 (14/injection) .2 , 0,000 .50,000 Lung r, 60,000 .E 40,000 S 20 , 000 Liver o P=0.0003 o 0 0 o o 0 o° = —41 - o 0 0 o 0 800 0 800 PM21 (µg/injection) PM21 (µg/injection) 4;120% - P=0.012 ••\"100% +- 100% 80%-e 80% 60% _O R s . E 60% s ÷: 40%-o - o ( !1, 161 ig 40% 20 0% -1 30 % o 4tiSt 421t, 20%-g 0%- azt, sca, O 800 0 800 0 o ° o 0 P=0.035 00 1 -o P=0.015 0 120%- P=0.018 1 + -1oo: : '4 1 80% - LI g 40%- oo h o o c, 20% Eb?, 0% - e lm imok 0 800 PM21 (µg/injection) PM21 (vg/injection) PM21 (µg/injection) FIG. 5 - 100% 80% ' 4 ,2 - 60% '4, 40% • 20% 0% 0 0 otio PM21 (µg/injection) 80,000 460,000 .E 40,000 20,000 o Spleen Brain 0 0 800 PM21 (µg/injection) 0 800 PM21 (11g/injection) 120%- + 100% 80% a 60% • 40% c, 20% 0% D iz.xc 800 - 0 4E4 800 la 10,000 1 5,000 4 ' 000 f 2 •, 2,000 Bone marrow P=0.044 00 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT 011101010 0111 °nolo omiooliolioomll ono voimIE (10) International Publication Number WO 2018/160673 Al (51) International Patent Classification: A61K 35/17 (2015.01) Cl 2N 5/00 (2006.01) A61K 38/20 (2006.01) (21) International Application Number: PCT/US2018/020187 (22) International Filing Date: 28 February 2018 (28.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/464,747 28 February 2017 (28.02.2017) US (71) Applicants: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US/US]; 12201 Research Parkway, Ste 501, Orlando, Florida 32826 (US). RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL [US/US]; 700 Children's Dri- ve, Columbus, Ohio 43205 (US). (72) Inventors: COPIK, Alicia; 196 Paul McClure Ct., Cassel- berry, Florida 23707 (US). OYER, Jeremiah; 609 Albany Ct., Longwood, Florida 32779 (US). CHAKRAVARTI, Nitin; 2801 River Park Drive, Columbus, Ohio 43220 (US). LEE, Dean Anthony; 2561 Sitterly Road, Canal Winches- ter, Ohio 43110 (US). (74) Agent: LANIER, Gibson, J. et al.; Meunier Carlin & Curf- man LLC, 999 Peachtree Street, NE, Suite 1300, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: PM21 PARTICLES TO IMPROVE BONE MARROW HOMING OF NK CELLS © (57) : Disclosed are compositions and methods for directing NK cells to the bone marrow through the use of PM21 particles. C [Continued on next page] WO 2018/160673 Al MIDEDIMOMMIDIRE1013 0111 VIII 1101 INEHOMOVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))

2. 发明专利

AU2018227801A1 PM21 particles to improve bone marrow homing of NK cells 未知
公开(公告)号：AU2018227801A1
公开(公告)日：2019-09-19
申请号：AU2018227801
申请日：2018-02-28
申请人： RES INST NATIONWIDE CHILDRENS HOSPITAL , UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA , OYER JEREMIAH , CHAKRAVARTI NITIN , LEE DEAN ANTHONY
IPC分类号： A61K35/17 , A61K38/20 , C12N5/00
摘要： Disclosed are compositions and methods for directing NK cells to the bone marrow through the use of PM21 particles.

3. 发明专利

AU2021202439A1 Methods and compositions for natural killer cells 未知
公开(公告)号：AU2021202439A1
公开(公告)日：2021-05-13
申请号：AU2021202439
申请日：2021-04-21
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA , REDDY VIJAY , OYER JEREMIAH
IPC分类号： A61K39/395 , C12N5/00 , C12N5/02
摘要： The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

4. 发明专利

AU2019200525B2 Methods and compositions for natural killer cells 未知
公开(公告)号：AU2019200525B2
公开(公告)日：2021-01-21
申请号：AU2019200525
申请日：2019-01-25
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA , REDDY VIJAY , OYER JEREMIAH
IPC分类号： A61K39/395 , C12N5/00 , C12N5/02
摘要： The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

5. 发明专利

AU2013282353B2 Methods and compositions for natural killer cells 未知
公开(公告)号：AU2013282353B2
公开(公告)日：2018-10-25
申请号：AU2013282353
申请日：2013-06-28
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA , REDDY VIJAY , OYER JEREMIAH
IPC分类号： A61K39/395 , C12N5/00 , C12N5/02
摘要： The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

6. 发明专利

SG11202107904PA COMPOSITIONS AND METHODS FOR STIMULATING NATURAL KILLER CELLS 未知
公开(公告)号：SG11202107904PA
公开(公告)日：2021-08-30
申请号：SG11202107904P
申请日：2020-01-24
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA , PARKS GRIFFITH , OYER JEREMIAH
IPC分类号： A61K35/76 , C07K14/705 , C12N15/86
摘要： Compositions and methods for stimulating NK cell expansion and cytotoxicity are described. Therapeutic compositions and methods using expanded and stimulated NK cells are described.

7. 发明专利

AU2020211456A1 Compositions and methods for stimulating natural killer cells 未知
公开(公告)号：AU2020211456A1
公开(公告)日：2021-08-26
申请号：AU2020211456
申请日：2020-01-24
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA , PARKS GRIFFITH , OYER JEREMIAH
IPC分类号： A61K35/76 , C07K14/705 , C12N15/86
摘要： Compositions and methods for stimulating NK cell expansion and cytotoxicity are described. Therapeutic compositions and methods using expanded and stimulated NK cells are described.

8. 发明专利

AU2019200525A1 Methods and compositions for natural killer cells 未知
公开(公告)号：AU2019200525A1
公开(公告)日：2019-02-14
申请号：AU2019200525
申请日：2019-01-25
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC
发明人： COPIK ALICJA , REDDY VIJAY , OYER JEREMIAH
IPC分类号： A61K39/395 , C12N5/00 , C12N5/02
摘要： The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

9. 发明专利

CA3057211A1 PM21 PARTICLES TO IMPROVE BONE MARROW HOMING OF NK CELLS 未知
公开(公告)号：CA3057211A1
公开(公告)日：2018-09-07
申请号：CA3057211
申请日：2018-02-28
申请人： UNIV CENTRAL FLORIDA RES FOUND INC , RES INST NATIONWIDE CHILDRENS HOSPITAL
发明人： COPIK ALICJA , OYER JEREMIAH , CHAKRAVARTI NITIN , LEE DEAN ANTHONY
IPC分类号： A61K35/17 , A61K38/20 , C12N5/00
摘要： Disclosed are compositions and methods for directing NK cells to the bone marrow through the use of PM21 particles.

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