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1. 发明申请

WO1994019399A1 SINGLE-FILM MEMBRANE, PREPARATION METHOD THEREFOR AND USE THEREOF 审中-公开
标题翻译：单膜，其制备方法及其用途
公开(公告)号：WO1994019399A1
公开(公告)日：1994-09-01
申请号：PCT/BE1994000014
申请日：1994-02-21
申请人： UNIVERSITE LIBRE DE BRUXELLES , EL MOUSSAOUI, Rachid , HURWITZ, Henri
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： C08J05/22
CPC分类号： C08J5/2243 , B01D61/44 , C08J5/225 , C08J2325/04 , C08J2327/18
摘要： A novel single-film membrane including at least one hydrophilic interface for breaking water down into its components H and OH , and comprising one or more inorganic compounds. A method for preparing and using said membrane for producing acids and bases, controlling pH and/or electrodialysing an aqueous solution, is also provided.
摘要翻译：一种新颖的单膜膜，其包括至少一个亲水界面，用于将水破坏成其组分H +和OH - ，并且包含一种或多种无机化合物。还提供了制备和使用所述膜用于生产酸和碱的方法，控制pH和/或电渗析水溶液。

2. 发明申请

WO1988005307A1 LIPOSOMES SENSITIZED TO ANTIGENIC MOLECULES OF INTRACELLULAR PARASITES 审中-公开
标题翻译：感染细菌性PARASITES的抗原分子的脂质体
公开(公告)号：WO1988005307A1
公开(公告)日：1988-07-28
申请号：PCT/BE1988000001
申请日：1988-01-13
申请人： UNIVERSITE LIBRE DE BRUXELLES , LEGROS, Franz , RUYSSCHAERT, Jean-Marie
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： A61K39/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K39/39 , A61K2039/55555 , G01N33/5432 , G01N33/56988 , G01N33/586
摘要： Agents appropriate as diagnostic means and as immunization agents (vaccines) of intracellular parasites, said agents being comprised of liposomes sensitized to antigenic molecules specific to intracellular parasites, for example tuberculin, Old tuberculin, lepromin or HTLV3. The method for producing said sensitized liposomes may consist of an encapsulation of the antigenic molecule or the contacting preformed liposome with said molecule.

3. 发明申请

WO2002019960A2 PURIFICATION, CHARACTERIZATION AND USE OF PROTECTIVE ANTIGENIC STRUCTURES AGAINST TRYPANOSOMES AND RELATED PARASITES 审中-公开
标题翻译：保护性抗原结构的清除，表征和使用对抗原和相关的PARASITES
公开(公告)号：WO2002019960A2
公开(公告)日：2002-03-14
申请号：PCT/BE2001000146
申请日：2001-09-06
申请人： UNIVERSITE LIBRE DE BRUXELLES , BLACK, Samuel, J. , MURPHY, Noel , PEARSON, Terry , PAYS, Etienne , NOLAN, Derek
发明人： UNIVERSITE LIBRE DE BRUXELLES , BLACK, Samuel, J. , MURPHY, Noel , PEARSON, Terry
IPC分类号： A61K
CPC分类号： A61K39/005 , A61K2039/505 , C07K16/20 , H04L29/06027 , H04L67/00 , H04L69/16 , H04L69/329
摘要： The present invention is related to a method for the recovering and the characterization of a surface antigenic structure of a trypanosome flagellar pocket (fp), characterized in that it comprises the following steps:- purifying membrane glycoproteins located on the surface of the flagellar pocket (fp) of said trypanosome, preferably glycoproteins containing linear poly-N-acetyllactosamine (pNAL), from a biological extract comprising said trypanosome,- deglycosylating said glycoproteins into proteins,- obtaining hybridomas secreting monoclonal antibodies directed against said proteins, - screening the resulting hybridomas for selecting a positive hybridoma which secretes an antibody able to inhibit the trypanosome growth (trypanosome activity in vitro), - obtaining said antibody from said positive hybridoma, - selecting and purifying an antigenic structure among the proteins of the trypanosome flagellar pocket (fp) by binding said proteins to said monoclonal antibody, and- possibly identifying the amino acid sequence of said antigenic structure and possibly the nucleotide sequence encoding said antigenic structure.
摘要翻译：本发明涉及一种回收和表征锥虫鞭毛袋（fp）的表面抗原结构的方法，其特征在于包括以下步骤： - 纯化位于鞭毛袋表面上的膜糖蛋白（ fp），优选含有线性聚-N-乙酰乳糖胺（pNAL）的糖蛋白，来自包含所述锥虫体的生物提取物，将所述糖蛋白脱糖基化成蛋白质， - 获得分泌针对所述蛋白质的单克隆抗体的杂交瘤，筛选所得杂交瘤用于选择分泌能够抑制锥虫体生长的抗体（体外锥虫体活性）的阳性杂交瘤， - 从所述阳性杂交瘤获得所述抗体， - 通过以下步骤选择和纯化锥虫体鞭毛袋（fp）的蛋白质中的抗原结构：将所述蛋白质结合到所述单克隆抗体，和 - 可能是ide 确定所述抗原结构的氨基酸序列和可能的编码所述抗原结构的核苷酸序列。

4. 发明申请

WO1996036880A1 METHOD FOR DETECTING AND/OR QUANTIFYING LIGANDS SPECIFIC TO A PATHOLOGIE ASSOCIATED TO AN ALLERGIC OR AUTO-IMMUNE REACTION OR TO LUNG CANCER 审中-公开
标题翻译：用于检测和/或定量与特定于与过敏反应或自身免疫反应或肺癌相关的病理学的配体的方法
公开(公告)号：WO1996036880A1
公开(公告)日：1996-11-21
申请号：PCT/BE1996000052
申请日：1996-05-20
申请人： UNIVERSITE LIBRE DE BRUXELLES , DUCHATEAU, Jean , CASIMIR, Georges , SERVAIS, Geneviève
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： G01N33/574
CPC分类号： G01N33/564 , G01N33/57423 , G01N33/6854
摘要： The present invention relates to a method for detecting and/or quantifying ligands specific to a pathology such as pathologies associated to an allergic or autoimmune réaction and lung cancer, and which are present in a body fluid of a patient, characterized in that a sample of body fluid is taken from the patient; the ligands present in the sample are reacted in a competitive test with other discriminatable ligands, the latter reacting with at least one antigenic structure specific to said pathology; and the inhibition of the reaction between the discriminatable ligands and the antigenic structures specific to the pathology is detected and/or quantified by the ligands present in the sample.
摘要翻译：本发明涉及一种用于检测和/或定量特异于病理学的配体的方法，例如与过敏或自身免疫反应和肺癌相关的病理学，并且其存在于患者的体液中，其特征在于，体液从患者身上取出; 存在于样品中的配体在竞争性测试中与其他可鉴别的配体反应，后者与至少一种对所述病理学特异性的抗原结构反应; 并且通过样品中存在的配体检测和/或定量鉴定性配体与病理特异性抗原结构之间的反应的抑制。

5. 发明申请

WO1998002453A2 PEPTIDIC LIGANDS HAVING A HIGHER SELECTIVITY FOR THE VIP1 RECEPTOR THAN FOR THE VIP2 RECEPTOR 审中-公开
标题翻译： VIP2受体对VIP1受体具有更高选择性的亲和配体
公开(公告)号：WO1998002453A2
公开(公告)日：1998-01-22
申请号：PCT/BE1997000084
申请日：1997-07-15
申请人： UNIVERSITE LIBRE DE BRUXELLES , GOURLET, Philippe , ROBBERECHT, Patrick , VANDERMEERS, André , WOELBROECK, Magali
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： C07K14/00
CPC分类号： C07K14/57563 , A61K38/00
摘要： The present invention is related to a peptidic ligand having a higher selectivity for the VIP1 receptor than for the VIP2 receptor. The present invention is also related to the diagnostic device, the pharmaceutical composition comprising said ligand and to their use.
摘要翻译：本发明涉及对VIP1受体具有比VIP2受体更高选择性的肽配体。本发明还涉及诊断装置，包含所述配体的药物组合物及其用途。

6. 发明申请

WO1997007208A1 NUCLEIC ACID MOLECULES ENCODING PEPTIDES HAVING PRONOCICEPTIVE PROPERTIES 审中-公开
标题翻译：核酸分子编码具有特异性的肽
公开(公告)号：WO1997007208A1
公开(公告)日：1997-02-27
申请号：PCT/BE1996000087
申请日：1996-08-14
申请人： UNIVERSITE LIBRE DE BRUXELLES , PARMENTIER, Marc , VASSART, Gilbert , MEUNIER, Jean-Claude , MOLLEREAU, Catherine
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： C12N15/12
CPC分类号： C07K14/665 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The present invention is related to nucleic acid molecules, the peptides encoded by said nucleic acid molecules and the inhibitors directed against said nucleic acid molecules or said peptides. The present invention concerns also the pharmaceutical composition, the diagnostic and/or dosage device comprising said products and methods for identifying the inhibitors according to the invention.
摘要翻译：本发明涉及核酸分子，由所述核酸分子编码的肽和针对所述核酸分子或所述肽的抑制剂。本发明还涉及药物组合物，包含所述产物的诊断和/或剂量装置以及鉴定本发明抑制剂的方法。

7. 发明申请

WO1996013723A2 MARKER FOR PATHOLOGIES COMPRISING AN AUTO-IMMUNE REACTION AND/OR FOR INFLAMMATORY DISEASES 审中-公开
标题翻译：包含自动免疫反应和/或用于炎症疾病的病理学标记
公开(公告)号：WO1996013723A2
公开(公告)日：1996-05-09
申请号：PCT/BE1995000100
申请日：1995-10-30
申请人： UNIVERSITE LIBRE DE BRUXELLES , SERVAIS, Geneviève , DUCHATEAU, Jean
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , Y10S435/975 , Y10S436/811
摘要： The present invention comprises a marker for inflammatory diseases and/or pathologies comprising an auto-immune reaction, which is the plasmatic membrane and/or a portion thereof, in particular the plasmatic DNA. The present invention concerns also the method to obtain said marker and the diagnostic device which comprises said marker.
摘要翻译：本发明包括用于炎性疾病和/或病症的标志物，其包含自身免疫反应，其为血浆膜和/或其一部分，特别是血浆DNA。本发明还涉及获得所述标记物的方法和包括所述标记物的诊断装置。

8. 发明申请

WO1997006784A1 LIPOSOMES PREPARATION METHOD AND PLANT 审中-公开
标题翻译：脂质体制备方法和植物
公开(公告)号：WO1997006784A1
公开(公告)日：1997-02-27
申请号：PCT/BE1996000086
申请日：1996-08-14
申请人： UNIVERSITE LIBRE DE BRUXELLES , BENAMEUR, Hassan , MOES, André
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： A61K09/127
CPC分类号： A61K9/1277 , Y10T428/2984
摘要： Process for the preparation of liposomes, comprising the steps of: lipid film formation on a ceramic filter, preferably an asymmetric ceramic filter; hydration of the lipid film obtained; recovering of the liposomes formed. The present invention concerns also a plant for the preparation of liposomes.
摘要翻译：制备脂质体的方法包括以下步骤：在陶瓷过滤器上形成脂质膜，优选不对称陶瓷过滤器; 获得的脂质膜的水合; 回收形成的脂质体。本发明还涉及用于制备脂质体的植物。

9. 发明申请

WO1995033871A1 DEVICE FOR THE PRODUCTION OF ULTRAFINE POWDERS 审中-公开
标题翻译：用于生产超细粉的装置
公开(公告)号：WO1995033871A1
公开(公告)日：1995-12-14
申请号：PCT/BE1995000050
申请日：1995-05-23
申请人： UNIVERSITE LIBRE DE BRUXELLES , REISSE, Jacques , DEPLANCKE, Jean-Luc , WINAND, René
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： C25C05/00
CPC分类号： C25C5/00 , C25B1/00 , C25C5/02
摘要： Process and device for the production of ultrafine powders, whereby there is provided, in an electrolysis cell (1), an electrolytic bath (2) wherein electrodes (3 and 4) are dipped and containing elements in solution for forming said powders, a high density pulsed electrolysis current being generated between said electrodes (3 and 4) and pressure waves being emitted from the electrode (3) next to which the powder is formed.
摘要翻译：用于生产超细粉末的方法和装置，其中在电解槽（1）中提供电解槽（2），其中电极（3和4）被浸渍并且在用于形成所述粉末的溶液中含有元素，高在所述电极（3和4）之间产生的密度脉冲电解电流和从形成粉末的电极（3）发射的压力波。

10. 发明申请

WO1993025479A1 METHOD OF ELIMINATING POLYCYCLIC AND/OR ALIPHATIC HYDROCARBON DERIVATIVES FROM INDUSTRIAL EFFLUENTS 审中-公开
标题翻译：消除工业废水中多环烯烃和/或二烃基烃衍生物的方法
公开(公告)号：WO1993025479A1
公开(公告)日：1993-12-23
申请号：PCT/BE1993000014
申请日：1993-03-17
申请人： UNIVERSITE LIBRE DE BRUXELLES , JASPERS, Charles , DELAUNOIS, Paul
发明人： UNIVERSITE LIBRE DE BRUXELLES
IPC分类号： C02F01/28
CPC分类号： C02F1/5263 , C02F1/286 , C02F2103/28 , C02F2103/30
摘要： A method of eliminating polycyclic and/or aliphatic hydrocarbons from industrial effluents having a pH preferably higher than 5 is characterised in that at least one protein compound, preferably solubilised, is added to the industrial effluent and that the mixture obtained is precipitated by giving it an acid pH, and in that the precipitate is removed from the effluent.
摘要翻译：从pH值优选高于5的工业废水中除去多环和/或脂肪烃的方法的特征在于，将至少一种优选溶解的蛋白质化合物加入到工业流出物中，并将获得的混合物沉淀酸性pH值，并且从流出物中除去沉淀物。

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