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1. 发明申请

WO2005062049A2 THE USE OF MICROELECTRONIC STRUCTURES FOR PATTERNED DEPOSITION OF MOLECULES ONTO SURFACES 审中-公开
标题翻译：微电子结构在分子表面图形沉积中的应用
公开(公告)号：WO2005062049A2
公开(公告)日：2005-07-07
申请号：PCT/BE2004/000182
申请日：2004-12-22
申请人： UNIVERSITAIR MICROELEKTRONICA CENTRUM (IMEC) , DE KEERSMAECKER, Koen , BORGHS, Gustaaf
发明人： DE KEERSMAECKER, Koen , BORGHS, Gustaaf
IPC分类号： G01N33/543
CPC分类号： B82Y15/00 , B82Y30/00 , G01N33/54366 , H01L2924/0002 , H01L2924/00
摘要： The present invention is related to the localised/patterned deposition and/or desorption of (bio)molecules using microelectronic structures. Often pre-existing structures needed for proper functioning of the device (e.g. sensors, …) can be used as individually addressable control structures to achieve localised deposition through thermal and/or electrochemical spotting, thereby reducing the need for and simplifying additional processing steps to achieve localised/patterned deposition. If these multi-purpose structures are not available, additional control structures can be implemented, using microelectronic VLSI production technology.
摘要翻译：本发明涉及使用微电子结构的（生物）分子的局部化/图案沉积和/或解吸。通常，设备正常运行所需的预先存在的结构（例如传感器，...）可以用作单独可寻址的控制结构，以通过热和/或电化学点样来实现局部沉积，由此减少对实现附加处理步骤的需要并简化局部化/图案化沉积。如果这些多用途结构不可用，则可以使用微电子VLSI生产技术来实现额外的控制结构。

2. 发明申请

WO2014000806A1 HYPERDRIVE AND NEUROPROBES FOR STIMULATION PURPOSES 审中-公开
标题翻译：用于刺激目的的超临界和神经元
公开(公告)号：WO2014000806A1
公开(公告)日：2014-01-03
申请号：PCT/EP2012/062653
申请日：2012-06-28
申请人： IMEC , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D , VIB , ATLAS NEUROENGINEERING BVBA , MCNAUGHTON, Bruce , BORGHS, Gustaaf , AARTS, Arno , PEUMANS, Peter
发明人： MCNAUGHTON, Bruce , BORGHS, Gustaaf , AARTS, Arno , PEUMANS, Peter
IPC分类号： A61N1/05 , A61B5/0476 , A61B5/04 , A61B5/0478
CPC分类号： A61B5/04001 , A61B2562/0209 , A61B2562/125 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0551
摘要： A kit of parts for electrical stimulation and/or recording of activity of excitable cells in a tissue is described. The kit of parts comprises on the one hand a probe guiding means comprising a plurality of accommodation channels, each channel being adapted for accommodating a probe device having a plurality of stimulation means and/or recording means located on a die. At least one of the plurality of accommodation channels has a curved shape. The kit of parts also comprises at least one probe device for electrical stimulation and/or recording of activity of excitable cells in a tissue, the probe device comprising a plurality of stimulation means and/or recording means located on a die having a thinned and etched surface for providing flexibility to the probe device.
摘要翻译：描述了用于电刺激和/或记录组织中可激活细胞的活性的部件套件。该套件包括一方面包括多个容纳通道的探针引导装置，每个通道适于容纳具有位于模具上的多个刺激装置和/或记录装置的探针装置。多个容纳通道中的至少一个具有弯曲的形状。所述部件套件还包括用于电刺激和/或记录组织中的兴奋细胞的活动的至少一个探针装置，所述探针装置包括位于模具上的多个刺激装置和/或记录装置，所述刺激装置和/或记录装置具有变薄和蚀刻表面，用于为探针装置提供灵活性。

3. 发明申请

WO2010066795A2 A METHOD FOR FORMING A NANOSTRUCTURE PENETRATING A LAYER 审中-公开
标题翻译：一种形成层状纳米结构的方法
公开(公告)号：WO2010066795A2
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066739
申请日：2009-12-09
申请人： IMEC , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D , CHENG, Kai , VAN DORPE, Pol , LAGAE, Liesbet , BORGHS, Gustaaf , CHEN, Chang
发明人： CHENG, Kai , VAN DORPE, Pol , LAGAE, Liesbet , BORGHS, Gustaaf , CHEN, Chang
IPC分类号： G01N21/64
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： The device comprises a substrate, a layer present thereon and a nanostructure penetrating said layer, which nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through the passageway, wherein the nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterisation of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.
摘要翻译：该装置包括基底，存在于其上的层和穿透所述层的纳米结构，该纳米结构限定了待分析的分子穿过该通道的纳米级通道，其中纳米结构在横截面图中具有基本上三角形形状。通过具有限定纳米结构的倾斜侧壁的晶面的外延层的生长，特别地实现了这种形状。它非常适合用于分子结构的光学表征，特别是用于表面等离子体增强透射光谱。

4. 发明申请

WO2008111047A1 MICRO-NAILS FOR USE IN ELECTRICAL INTERACTION WITH CELLS 审中-公开
标题翻译：用于与细胞电相互作用的微钉
公开(公告)号：WO2008111047A1
公开(公告)日：2008-09-18
申请号：PCT/IL2008/000313
申请日：2008-03-09
申请人： IMEC VZW , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , SPIRA, Micha , YITZCHAIK, Shlomo , SHAPPIR, Joseph , BARTIC, Carmen , BORGHS, Gustaaf
发明人： SPIRA, Micha , YITZCHAIK, Shlomo , SHAPPIR, Joseph , BARTIC, Carmen , BORGHS, Gustaaf
IPC分类号： G01N33/487 , C12Q1/02 , G01N33/543
CPC分类号： G01N33/5005 , G01N33/483
摘要： An electrical device is presented for interaction with cells. The device comprises at least one micro-nail structure protruding from a surface, where at least a region of the micro-nail structure has cellular-interaction promoting properties. The micro-nail comprises a channel running along a longitudinal axis of the micro-nail, thereby enabling at least one of chemical and electrical interactions between the micro-nail and the cell's cytoplasm through said channel.
摘要翻译：呈现电气设备与细胞的相互作用。该装置包括从表面突出的至少一个微指甲结构，其中微指甲结构的至少一个区域具有细胞相互作用促进特性。微指甲包括沿着微指甲的纵向轴线延伸的通道，由此通过所述通道使微指甲和细胞的细胞质之间的化学和电学相互作用中的至少一种相互作用。

5. 发明申请

WO2007134410A1 DETECTION OF RESONANT TAGS BY UWB RADAR 审中-公开
标题翻译：通过UWB雷达检测共振标签
公开(公告)号：WO2007134410A1
公开(公告)日：2007-11-29
申请号：PCT/BE2007/000049
申请日：2007-05-22
申请人： INTERUNIVERSITAIR MICROELEKTRONICA CENTRUM VZW , LAGAE, Liesbet , BORGHS, Gustaaf
发明人： LAGAE, Liesbet , BORGHS, Gustaaf
IPC分类号： G01S13/02
CPC分类号： G01S13/0209 , A61N1/403 , G01S7/411 , G01S13/75 , G01S13/753 , H04B1/7163
摘要： A detection system has a receiver for detecting a material having a magnetic resonance response to illumination by pulses of UWB electromagnetic radiation, the receiver having: a detector (40,45) for detecting the pulses after they have interacted with the material, and a discriminator (55) arranged to identify in the detected pulses the magnetic resonance response of the material. By scanning an item tagged with a tag (20) having a material having a magnetic resonant response, by illuminating the item with UWB pulses and identifying in detected pulses the magnetic resonance response of the material, items can be located, imaged, or activated. The magnetic resonance response of the tag can cause activation of the tag. The tag can have a magnetic resonance response arranged to provide an identifiable magnetic resonance signature such that different tags can be identified and distinguished by their signatures.
摘要翻译：检测系统具有用于检测具有对UWB电磁辐射的脉冲的照明的磁共振响应的材料的接收器，所述接收器具有：用于在与材料相互作用后检测脉冲的检测器（40,45），以及鉴别器（55），其布置成在检测到的脉冲中识别材料的磁共振响应。通过扫描具有具有磁共振响应的材料的标签（20）标记的物品，通过用UWB脉冲照亮物品并且在检测到的脉冲中识别物质的磁共振响应，可以定位，成像或激活物品。标签的磁共振响应可能导致标签的激活。标签可以具有布置成提供可识别的磁共振签名的磁共振响应，使得可以通过其签名来识别和区分不同的标签。

6. 发明申请

WO2006000064A2 DEVICE FOR CONTROLLING THE FLOW OF CHARGED CARRIERS THROUGH A NANOPORE IN A MEBMRANE AND METHOD FOR THE FABRICATION OF SUCH A DEVICE 审中-公开
标题翻译：用于控制通过纳米孔在带电粒子中的带电载流子流动的装置及用于制造这种装置的方法
公开(公告)号：WO2006000064A2
公开(公告)日：2006-01-05
申请号：PCT/BE2005/000102
申请日：2005-06-28
申请人： INTERUNIVERSITAIR MICROELEKTRONICA CENTRUM VZW , BORGHS, Gustaaf , BARTIC, Carmen , DE GREVE, Kristiaan
发明人： BORGHS, Gustaaf , BARTIC, Carmen , DE GREVE, Kristiaan
CPC分类号： H01L51/0508
摘要： The present invention provides a nanofluidic device for controlling the flow of charged carriers through a nanopore extending through a membrane hereby forming a channel connecting a first side of the membrane with a second, opposite side of the membrane and a method for the manufacturing of such a device. The device comprises a first electrode positioned at the first side of the membrane, a second electrode positioned at the second side of the membrane and a third electrode integrated in the nanopore. By applying suitable voltages to the first, second and third electrode, the electrical potential distribution inside the nanopore can be modified and in that way the flow of charge carriers can be controlled.
摘要翻译：本发明提供了纳米流体装置，用于控制带电载流子通过延伸通过膜的纳米孔的流动，由此形成连接膜的第一侧与膜的第二相对侧的通道，以及一种用于制造这种装置的方法。该装置包括位于膜第一侧的第一电极，位于膜第二侧的第二电极和结合在纳米孔中的第三电极。通过向第一，第二和第三电极施加合适的电压，可以修改纳米孔内的电势分布，并且以这种方式可以控制电荷载体的流动。

7. 发明申请

WO2010066794A1 SINGLE MOLECULE OPTICAL SPECTROSCOPY IN SOLID-STATE NANOPORES IN A TRANSMISSION-BASED APPROACH 审中-公开
标题翻译：基于传输方式的固体纳米光子中的单分子光学光谱
公开(公告)号：WO2010066794A1
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066737
申请日：2009-12-09
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D , IMEC , VAN DORPE, Pol , DE VLAMINCK, Iwijn , LAGAE, Liesbet , BORGHS, Gustaaf
发明人： VAN DORPE, Pol , DE VLAMINCK, Iwijn , LAGAE, Liesbet , BORGHS, Gustaaf
IPC分类号： G01N21/64
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： Methods and apparatus in the field of single molecule sensing are described, e.g. for molecular analysis of analytes such as molecular analytes, e.g. nucleic acids, proteins, polypeptides, peptides, lipids and polysaccharides. Molecular spectroscopy on a molecule translocating through a solid-state nanopore is described. Optical spectroscopic signals are enhanced by plasmonic field-confinement and antenna effects and probed in transmission by plasmon-enabled transmission of light through an optical channel that overlaps with the physical channel.
摘要翻译：描述了单分子感测领域的方法和装置，例如用于分析物如分子分析物的分子分析。核酸，蛋白质，多肽，肽，脂质和多糖。描述了通过固态纳米孔易位的分子的分子光谱。光谱信号通过等离激元场约束和天线效应增强，并通过等离子体激发的光透过与物理信道重叠的光信道进行传输。

8. 发明申请

WO2008011688A2 GROWTH OF MONOCRYSTALLINE GeN ON A SUBSTRATE 审中-公开
标题翻译：基底上单晶GeN的生长
公开(公告)号：WO2008011688A2
公开(公告)日：2008-01-31
申请号：PCT/BE2007/000087
申请日：2007-07-20
申请人： INTERUNIVERSITAIR MICRO-ELEKTRONICA CENTRUM , VRIJE UNIVERITEIT BRUSSEL , LIETEN, Ruben , DEGROOTE, Stefan , BORGHS, Gustaaf
发明人： LIETEN, Ruben , DEGROOTE, Stefan , BORGHS, Gustaaf
IPC分类号： H01L21/318
CPC分类号： C30B23/025 , C30B23/02 , C30B29/403 , H01L21/02381 , H01L21/02433 , H01L21/02439 , H01L21/02521 , H01L21/02614
摘要： The present invention relates a method for forming a monocrystalline GeN layer (4) on a substrate (1) comprising at least a Ge surface (3). The method comprises, while heating the substrate (1) to a temperature between 550°C and 940°C, exposing the substrate (1 ) to a nitrogen gas flow. The present invention furthermore provides a structure comprising a monocrystalline GeN layer (4) on a substrate (1 ). The monocrystalline GeN formed by the method according to embodiments of the invention allows passivation of surface states present at the Ge surface (3).
摘要翻译：本发明涉及在至少包括Ge表面（3）的基片（1）上形成单晶GeN层（4）的方法。该方法包括在将衬底（1）加热到550℃和940℃之间的温度的同时，将衬底（1）暴露于氮气流中。本发明还提供一种包括在基底（1）上的单晶GeN层（4）的结构。通过根据本发明的实施方案的方法形成的单晶GeN允许钝化存在于Ge表面（3）处的表面状态。

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