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1. 发明申请

WO2008077949A1 CYTOCOMPATIBLE STABLE GEL COMPOSITIONS AS SUPPORTS FOR CELL GROWTH 审中-公开
标题翻译：可溶性凝胶凝胶组合物作为细胞生长的支持
公开(公告)号：WO2008077949A1
公开(公告)日：2008-07-03
申请号：PCT/EP2007/064478
申请日：2007-12-21
申请人： UNIVERSITA' DEGLI STUDI DI PARMA , ROMANI, Antonello , BORGHETTI, Angelo , BETTINI, Ruggero
发明人： ROMANI, Antonello , BORGHETTI, Angelo , BETTINI, Ruggero
IPC分类号： C08B37/00 , C08L5/08 , A61K47/38
CPC分类号： C08L5/08 , A61K9/7007 , A61L27/20 , A61L27/52 , C08B37/003 , C08J3/075 , C08J2305/08
摘要： Gels of high cytocompatibility and stability are described, obtained from chitosan, specific sugars, alkaline or alkaline-earth metal phosphates and chlorides.
摘要翻译：描述了从壳聚糖，特定糖，碱金属或碱土金属磷酸盐和氯化物获得的高细胞相容性和稳定性的凝胶。

2. 发明申请

WO2014102596A2 NEW CYCLIC CATIONIC PEPTIDES WITH ANTIMICROBIAL ACTIVITY 审中-公开
标题翻译：具有抗微生物活性的新型循环阳离子肽
公开(公告)号：WO2014102596A2
公开(公告)日：2014-07-03
申请号：PCT/IB2013/002893
申请日：2013-12-30
申请人： UNIVERSITA' DEGLI STUDI DI PARMA , AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA
发明人： BARONI, Maria Cristina , CABASSI, Clotilde Silvia , ROMANI, Antonello
IPC分类号： A61K38/04
CPC分类号： C07K7/08 , A61K38/00 , A61K38/04 , A61K38/10 , A61K38/16 , C07K7/50 , C07K14/00 , Y02A50/401 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： A series of cationic cyclic peptides, useful for the treatment of infectious diseases in both human and veterinary clinical/surgical environment are described herein. The peptides of the invention have a length of 15 to 21 amino acids, and are cyclizable via formation of a disulfide bridge between two amino acids containing sulfur, suitably located in proximity to -NH 2 terminal and -COOH terminal regions of the peptide. Additionally, the central portion of the peptide is characterized by the presence of a number of charged amino acids, partly or totally alternate with neutral amino acids. More specifically, the peptides show a sequence A-B-C-D C'-B'-A', where units A and A' correspond to -NH 2 terminal and -COOH terminal regions; units B and B' correspond to amino acids containing sulfur; units C and C are sequences of 5 or 6 amino acids selected among hydrophobic amino acids and basic amino acids and amino acids forming hydrogen bonds; unit D corresponds to the amino acid glycine. Said peptides show significant antibacterial activity, associated with high stability and resistance to the action of bacterial endopeptidases, and weak or null toxicity against eukaryotic cells. In particular, the disposition of hydrophobic amino acids in discrete regions, separate from charged amino acids, gives the peptides high activity, also associated with significant salt-insensitivity. The invention also relates to the synthesis of said peptides, relative pharmaceutical compositions, and the use of said peptides in the treatment of infections caused by bacteria, fungi and /or yeasts.
摘要翻译：本文描述了一系列用于治疗人和兽医临床/手术环境中的感染性疾病的阳离子环肽。本发明的肽具有15至21个氨基酸的长度，并且可通过在两个含硫氨基酸之间形成二硫键在适当位于肽的-NH 2末端和-COOH末端区域附近环化。此外，肽的中心部分的特征在于存在多个带电荷的氨基酸，部分或完全与中性氨基酸交替。更具体地，肽显示序列A-B-C-D C'-B'-A'，其中单元A和A'对应于-NH 2末端和-COOH末端区; 单元B和B'对应于含硫的氨基酸; 单元C和C是选自疏水性氨基酸和碱性氨基酸中的5或6个氨基酸和形成氢键的氨基酸的序列; 单元D对应于氨基酸甘氨酸。所述肽显示出显着的抗菌活性，与细菌内肽酶的作用具有高稳定性和抗性，对真核细胞具有弱或无毒性。特别地，在离开带电氨基酸的离散区域中疏水性氨基酸的配置给出了肽高活性，也与显着的盐不敏感性有关。本发明还涉及所述肽的合成，相对药物组合物以及所述肽在治疗由细菌，真菌和/或酵母引起的感染中的用途。

3. 发明授权

EP2115011B1 CYTOCOMPATIBLE STABLE GEL COMPOSITIONS AS SUPPORTS FOR CELL GROWTH 有权
标题翻译： AS SUPPORT用于细胞生长ZYTOKOMPATIBLE STABLE凝胶组合物
公开(公告)号：EP2115011B1
公开(公告)日：2011-07-27
申请号：EP07858089.1
申请日：2007-12-21
申请人： UNIVERSITA' DEGLI STUDI DI PARMA
发明人： ROMANI, Antonello , BORGHETTI, Angelo , BETTINI, Ruggero
IPC分类号： C08B37/00 , C08L5/08 , A61K47/38
CPC分类号： C08L5/08 , A61K9/7007 , A61L27/20 , A61L27/52 , C08B37/003 , C08J3/075 , C08J2305/08
摘要： Gels of high cytocompatibility and stability are described, obtained from chitosan, specific sugars, alkaline or alkaline-earth metal phosphates and chlorides.

4. 发明公开

EP2115011A1 CYTOCOMPATIBLE STABLE GEL COMPOSITIONS AS SUPPORTS FOR CELL GROWTH 有权
标题翻译： AS SUPPORT用于细胞生长ZYTOKOMPATIBLE稳定的凝胶组合物
公开(公告)号：EP2115011A1
公开(公告)日：2009-11-11
申请号：EP07858089.1
申请日：2007-12-21
申请人： UNIVERSITA' DEGLI STUDI DI PARMA
发明人： ROMANI, Antonello , BORGHETTI, Angelo , BETTINI, Ruggero
IPC分类号： C08B37/00 , C08L5/08 , A61K47/38
CPC分类号： C08L5/08 , A61K9/7007 , A61L27/20 , A61L27/52 , C08B37/003 , C08J3/075 , C08J2305/08
摘要： Gels of high cytocompatibility and stability are described, obtained from chitosan, specific sugars, alkaline or alkaline-earth metal phosphates and chlorides.

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