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1. 发明申请

WO2021004993A1 SELF-BLOWING ISOCYANATE-FREE POLYURETHANE FOAMS 审中-公开
公开(公告)号：WO2021004993A1
公开(公告)日：2021-01-14
申请号：PCT/EP2020/068962
申请日：2020-07-06
申请人： UNIVERSITÉ DE LIÈGE
发明人： DETREMBLEUR, Christophe , THOMASSIN, Jean-Michel , GRIGNARD, Bruno , MONIE, Florent , JEROME, Christine
IPC分类号： C08G71/04 , C08J9/02 , C08G101/00
摘要： The present invention relates to a curable isocyanate-free formulation for preparing a polyurethane self-blowing foam comprising at least one multifunctional cyclic carbonate having at least two cyclic carbonate groups at the end of the chain (compound A), at least one multifunctional amine (compound B), at least one multifunctional thiol (compound C) and at least one catalyst (compound D), to a process for preparing said foams and to the thus obtained foams.

2. 发明申请

WO2022180235A1 NEW ANTIMICROBIAL AND ANTITHROMBOGENIC MEDICAL DEVICE 审中-公开
公开(公告)号：WO2022180235A1
公开(公告)日：2022-09-01
申请号：PCT/EP2022/054854
申请日：2022-02-25
申请人： UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE
发明人： LANCELLOTTI, Patrizio , OURY, Cécile , JEROME, Christine , DETREMBLEUR, Christophe , AQIL, Abdelhafid , MELO, Sofia , PIERRARD, Anna
IPC分类号： C08G71/04 , C08G18/75 , C08G18/48 , C08G18/24 , C09D175/04
摘要： A medical device comprising one or more polyhydroxyurethane (PHU) and a method of manufacturing thereof.Use of the medical device to load and release or graft bioactive molecules, particularly antimicrobial,anti-thrombotic and anticalcification molecules

3. 发明公开

EP1984462A1 ELECTROGRAFTING METHOD FOR FORMING AND REGULATING A STRONG ADHERENT NANOSTRUCTURED POLYMER COATING 有权
标题翻译： ELEKTROPFROPFVERFAHREN教育和一个粗概不负责纳米结构的聚合物涂层的调控
公开(公告)号：EP1984462A1
公开(公告)日：2008-10-29
申请号：EP07704279.4
申请日：2007-01-31
申请人： Université de Liège
发明人： JEROME, Robert , JEROME, Christine , SERWAS, Harry , VOCCIA, Samuel
IPC分类号： C09D5/44
CPC分类号： C09D5/4476 , B01L3/5027 , B81C1/00206 , B81C2201/0197 , C25D15/00
摘要： Electrografting method for forming and regulating a strongly adherent nanostructured polymer coating onto an electro-conductive surface profile characterized in that the surface profile is regulated by electrodeposition of nanometre- and/or micrometre-scale nuclei onto the surface profile prior to or simultaneously to the formation of the polymer coating.

4. 发明公开

EP4298151A1 NEW ANTIMICROBIAL AND ANTITHROMBOGENIC MEDICAL DEVICE 审中-实审
公开(公告)号：EP4298151A1
公开(公告)日：2024-01-03
申请号：EP22709674.0
申请日：2022-02-25
申请人： Université de Liège , Centre Hospitalier Universitaire de Liège
发明人： LANCELLOTTI, Patrizio , OURY, Cécile , JEROME, Christine , DETREMBLEUR, Christophe , AQIL, Abdelhafid , MELO, Sofia , PIERRARD, Anna
IPC分类号： C08G71/04 , C08G18/75 , C08G18/48 , C08G18/24 , C09D175/04

5. 发明公开

EP2575905A1 CHITOSAN BIOMIMETIC SCAFFOLDS AND METHODS FOR PREPARING THE SAME 有权
标题翻译：维多利亚州自然保护联盟
公开(公告)号：EP2575905A1
公开(公告)日：2013-04-10
申请号：EP11721057.5
申请日：2011-05-24
申请人： Université de Liège
发明人： FILEE, Patrice , FREICHELS, Astrid , JEROME, Christine , AQIL, Abdelhafid , COLIGE, Alain , TCHEMTCHOUA TATEU, Victor
IPC分类号： A61L15/28 , A61L15/42
CPC分类号： A61F13/00008 , A61F13/00012 , A61F13/00063 , A61L15/28 , A61L15/425 , A61L15/64 , A61L27/20 , A61L27/48 , A61L27/56 , A61L27/58 , A61L27/60 , A61L2400/12 , C08L5/08
摘要： The invention concerns chitosan-based biomimetic scaffolds and methods for modulating their intrinsic properties such as rigidity, elasticity, resistance to mechanical stress, porosity, biodegradation and absorbance of exudates. Therefore, the present invention relates to a layered chitosan-based scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one layer consists of a chitosan nanofiber scaffold membrane and at least one of the other layers of a porous chitosan scaffold support layer. Moreover, the present invention provides a layered chitosan-based scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan-based scaffold.Finally, the present invention provides the use of the layered electrospun chitosan-based scaffold of the invention or the layered electrospun chitosan-based scaffold produced by the process of the invention as a wound dressing, in tissue engineering or for biomedical applications.
摘要翻译：本发明涉及基于壳聚糖的仿生支架和用于调节其固有性质的方法，例如刚性，弹性，抗机械应力，孔隙率，生物降解和渗出物的吸光度。因此，本发明涉及层状壳聚糖类支架，其中所述层状支架包括至少两个熔融层，其中至少一层由壳聚糖纳米纤维支架膜和多孔壳聚糖支架支架的至少一层层。此外，本发明提供了一种基于层状壳聚糖的支架，其特征在于：（i）多孔和纳米纤维层之间良好的粘附性，（ii）通过调节纳米纤维之间的距离来调节纳米纤维层的可调孔隙率，（iii）稳定的纳米纤维和多孔形态，即使浸入水或其他溶剂中，以及制备这种层状壳聚糖类支架的方法。最后，本发明提供了本发明的层状静电纺丝壳聚糖基支架或层状电纺壳聚糖基于本发明的方法生产的作为伤口敷料，组织工程或生物医学应用的支架。

6. 发明授权

EP1984462B1 ELECTROGRAFTING METHOD FOR FORMING AND REGULATING A STRONG ADHERENT NANOSTRUCTURED POLYMER COATING 有权
标题翻译： ELEKTROPFROPFVERFAHREN教育和一个粗概不负责纳米结构的聚合物涂层的调控
公开(公告)号：EP1984462B1
公开(公告)日：2012-07-04
申请号：EP07704279.4
申请日：2007-01-31
申请人： Université de Liège
发明人： JEROME, Robert , JEROME, Christine , SERWAS, Harry , VOCCIA, Samuel
IPC分类号： C09D5/44 , C25D15/00 , B81C1/00
CPC分类号： C09D5/4476 , B01L3/5027 , B81C1/00206 , B81C2201/0197 , C25D15/00
摘要： Electrografting method for forming and regulating a strongly adherent nanostructured polymer coating onto an electro-conductive surface profile characterized in that the surface profile is regulated by electrodeposition of nanometre- and/or micrometre-scale nuclei onto the surface profile prior to or simultaneously to the formation of the polymer coating.

7. 发明公开

EP3994201A1 SELF-BLOWING ISOCYANATE-FREE POLYURETHANE FOAMS 有权
公开(公告)号：EP3994201A1
公开(公告)日：2022-05-11
申请号：EP20737003.2
申请日：2020-07-06
申请人： Université de Liège
发明人： DETREMBLEUR, Christophe , THOMASSIN, Jean-Michel , GRIGNARD, Bruno , MONIE, Florent , JEROME, Christine
IPC分类号： C08G71/04 , C08J9/02 , C08G101/00

8. 发明公开

EP3438139A1 POLYVINYL ALCOHOL AND METHOD FOR PRODUCING SAME 有权
公开(公告)号：EP3438139A1
公开(公告)日：2019-02-06
申请号：EP17775507.1
申请日：2017-03-30
申请人： Kuraray Co., Ltd. , Université de Liège
发明人： TAKAYAMA, Takumi , AMANO, Yusuke , MAEKAWA, Kazuhiko , DETREMBLEUR, Christophe , DEBUIGNE, Antoine , JEROME, Christine
IPC分类号： C08F16/06 , C08F6/08 , C08F18/08
摘要： A polyvinyl alcohol is produced in a method comprising: a polymerization step comprising polymerizing vinyl ester monomers by controlled radical polymerization in the presence of a radical initiator and an organic cobalt complex to obtain a polymer solution containing a polyvinyl ester; an extraction step comprising extracting a cobalt complex from the polymer solution by contacting an aqueous solution containing a water-soluble ligand with the polymer solution; and a saponification step comprising saponifying the polyvinyl ester after the extraction step to obtain a polyvinyl alcohol. A method for producing a polyvinyl alcohol is thus provided that has a narrow molecular weight distribution and a high number-average molecular weight with good hue and further good solubility in water.

9. 发明授权

EP2575905B1 CHITOSAN BIOMIMETIC SCAFFOLDS AND METHODS FOR PREPARING THE SAME 有权
公开(公告)号：EP2575905B1
公开(公告)日：2018-05-30
申请号：EP11721057.5
申请日：2011-05-24
申请人： Université de Liège
发明人： FILEE, Patrice , FREICHELS, Astrid , JEROME, Christine , AQIL, Abdelhafid , COLIGE, Alain , TCHEMTCHOUA TATEU, Victor
IPC分类号： A61L15/64 , A61L27/56 , A61L27/58 , A61L27/60 , A61L27/20 , A61L27/48 , A61F13/00 , A61L15/28 , A61L15/42
CPC分类号： A61F13/00008 , A61F13/00012 , A61F13/00063 , A61L15/28 , A61L15/425 , A61L15/64 , A61L27/20 , A61L27/48 , A61L27/56 , A61L27/58 , A61L27/60 , A61L2400/12 , C08L5/08
摘要： The invention concerns chitosan-based biomimetic scaffolds and methods for modulating their intrinsic properties such as rigidity, elasticity, resistance to mechanical stress, porosity, biodegradation and absorbance of exudates. Therefore, the present invention relates to a layered chitosan-based scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one layer consists of a chitosan nanofiber scaffold membrane and at least one of the other layers of a porous chitosan scaffold support layer. Moreover, the present invention provides a layered chitosan-based scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan-based scaffold.Finally, the present invention provides the use of the layered electrospun chitosan-based scaffold of the invention or the layered electrospun chitosan-based scaffold produced by the process of the invention as a wound dressing, in tissue engineering or for biomedical applications.

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