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1. 发明申请

WO2012065751A1 BIO-FUNCTIONALIZED STIMULUS-RESPONSIVE DISSOLVABLE PEG-HYDROGELS 审中-公开
标题翻译：生物功能化刺激性溶解性PEG-氢化物
公开(公告)号：WO2012065751A1
公开(公告)日：2012-05-24
申请号：PCT/EP2011/005820
申请日：2011-11-18
申请人： UNIVERSITÄTSKLINIKUM FREIBURG , ALBERT-LUDWIGS-UNIVERSITAT FREIBURG , STEINBERG, Thorsten , WEBER, Wilfried , GÜBELI, Raphael , TOMAKIDI, Pascal , LAIRD, Dougal
发明人： STEINBERG, Thorsten , WEBER, Wilfried , GÜBELI, Raphael , TOMAKIDI, Pascal , LAIRD, Dougal
IPC分类号： A61K47/48 , A61K9/00 , A61K9/06 , A61P17/02 , A61P43/00 , C07K19/00
CPC分类号： A61K47/48215 , A61K9/0014 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/006 , A61K9/0063 , A61K9/0085 , A61K9/06 , A61K38/16 , A61K38/18 , A61K47/10 , A61K47/60 , A61K47/6903 , C07K2319/20 , C07K2319/30 , C07K2319/33 , Y02A50/473 , Y10S514/801
摘要： The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases. Additionally, the present invention provides a kit comprising the inventive stimulus-responsive dissolvable PEG-hydrogel and optionally further components.
摘要翻译：本发明涉及生物功能化的刺激响应的可溶性PEG-水凝胶。本发明的刺激响应性可溶性PEG-水凝胶包含PEG-聚合物基质，其被修饰为含有至少一种多功能融合蛋白，所述多功能融合蛋白优选包含作为底物结合肽（SBP）的组分，优选地包含重复的RGD- 结合肽和/或ZZ结合结构域，优选用于纯化的标签，以及至少一个N-和/或C-末端连接体。本发明还涉及这种本发明的刺激响应性可溶性PEG-水凝胶在治疗病变中，在外科敷料中的用途，用于伤口治疗，用于软组织和硬组织再生，用于治疗口腔中的伤口，在眼科领域，在牙周缺损等领域。本发明还描述了一种治疗这种疾病的方法。另外，本发明提供了一种试剂盒，其包含本发明的刺激响应性可溶性PEG-水凝胶和任选的其它组分。

2. 发明申请

WO2012089617A1 COVALENTLY ATTACHED ANTIMICROBIAL POLYMERS 审中-公开
标题翻译：共同附着的抗微生物聚合物
公开(公告)号：WO2012089617A1
公开(公告)日：2012-07-05
申请号：PCT/EP2011/073786
申请日：2011-12-22
申请人： UNIVERSITÄTSKLINIKUM FREIBURG , ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG , STEINBERG, Thorsten , LIENKAMP, Karen , TOMAKIDI, Pascal , AL-AHMAD, Ali
发明人： STEINBERG, Thorsten , LIENKAMP, Karen , TOMAKIDI, Pascal , AL-AHMAD, Ali
IPC分类号： C08F291/18 , C08F292/00 , C08F8/00 , A01N25/10
CPC分类号： A01N43/08 , A01N25/10 , A01N25/34 , C08F8/00 , C08F291/18 , C08F292/00 , A01N33/12
摘要： The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol -1 and are preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue- supporting) biomaterial, etc. Covalent bonding may be carried out using a photoreactive crosslinker but also by "grafting onto" or "grafting from". The present invention is also directed to uses of the inventive antimicrobial polymers as defined herein, e.g. for antimicrobially coating a surface of such a substrate with a layer of the inventive antimicrobial polymer.
摘要翻译：本发明涉及包含共价连接的抗微生物聚合物的底物，其作为抗微生物肽（SMAMP）的合成模拟物，并且优选通过开环易位聚合（ROMP）获得。本发明的抗微生物聚合物显示出超过100,000g mol -1的分子量，并且优选共价连接到底物的表面，例如，植入物，医疗装置，医疗设备或（组织支撑）生物材料等。共价键可以使用光反应性交联剂进行，但也可以通过“接枝”或“接枝”。本发明还涉及本文定义的本发明的抗微生物聚合物的用途，例如，用本发明的抗微生物聚合物的一层抗微生物涂覆这种基材的表面。

3. 发明申请

WO2012136701A1 BIOCOMPATIBLE AND BIODEGRADABLE GRADIENT LAYER SYSTEM FOR REGENERATIVE MEDICINE AND FOR TISSUE SUPPORT 审中-公开
标题翻译：用于再生医学和组织支持的生物可降解和生物降解梯度系统
公开(公告)号：WO2012136701A1
公开(公告)日：2012-10-11
申请号：PCT/EP2012/056155
申请日：2012-04-04
申请人： UNIVERSITÄTSKLINIKUM FREIBURG , ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG , STEINBERG, Thorsten , TOMAKIDI, Pascal , SCHULZ, Simon , ANGARANO, Marco , MÜLHAUPT, Rolf , FABRITIUS, Martin
发明人： STEINBERG, Thorsten , TOMAKIDI, Pascal , SCHULZ, Simon , ANGARANO, Marco , MÜLHAUPT, Rolf , FABRITIUS, Martin
IPC分类号： A61L27/34 , A61L27/38 , A61L27/50 , A61L27/58
CPC分类号： A61L26/0095 , A61L27/34 , A61L27/3804 , A61L27/50 , A61L27/58 , A61L31/125 , A61L31/16 , A61L2420/08 , C08L89/06
摘要： The present invention is directed to a biocompatible and preferably biodegradable gradient layer system comprising at least one set of layers comprising a biocompatible and preferably biodegradable cross-linked polymer and at least one biocompatible and preferably biodegradable support layer, wherein a gradient is preferably formed with respect to the mechanical and/or physical properties of one or more layers of the at least one set of layers comprising a biocompatible and biodegradable cross-linked polymer and/or the at least one biocompatible and preferably biodegradable support layer. The at least one support layer preferably comprises a biocompatible and preferably biodegradable meltable polymer and/or a biocompatible and incorporable material. This biocompatible and preferably biodegradable gradient layer system may be used as a biomaterial for regenerative medicine, particularly as a wound dressing or for tissue support. The present invention also provides means utilizing said inventive gradient layer system and methods for producing same.
摘要翻译：本发明涉及生物相容且优选可生物降解的梯度层系统，其包括至少一组包含生物相容性且优选可生物降解的交联聚合物和至少一种生物相容且优选可生物降解的支撑层的层，其中优选地形成梯度涉及包含生物相容性和可生物降解的交联聚合物的至少一组层的一层或多层的机械和/或物理性质和/或至少一种生物相容性并且优选可生物降解的支撑层。所述至少一个支撑层优选包含生物相容性且优选可生物降解的可熔融聚合物和/或生物相容性和可结合材料。该生物相容性优选可生物降解的梯度层系统可用作再生医学的生物材料，特别是作为伤口敷料或用于组织支持。本发明还提供利用本发明的梯度层系统及其制造方法的方法。

4. 发明申请

WO2012131036A1 METHOD FOR MODIFYING AN ELECTRICALLY NON-CONDUCTIVE WORKPIECE VIA SPARK EROSION 审中-公开
标题翻译：通过火花腐蚀修改电气非导电性工件的方法
公开(公告)号：WO2012131036A1
公开(公告)日：2012-10-04
申请号：PCT/EP2012/055788
申请日：2012-03-30
申请人： UNIVERSITÄTSKLINIKUM FREIBURG , ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG , STEINBERG, Thorsten , TOMAKIDI, Pascal , HÖSEL, Tim , REINECKE, Holger , KOHAL, Ralf
发明人： STEINBERG, Thorsten , TOMAKIDI, Pascal , HÖSEL, Tim , REINECKE, Holger , KOHAL, Ralf
IPC分类号： B23H1/00 , B23H1/06 , B23H9/00
CPC分类号： B23H1/06 , B23H1/00 , B23H9/00
摘要： The present invention relates to a method for modifying an electrically non-conductive workpiece via spark erosion. The inventive method comprises the following steps: a) providing a workpiece comprising an electrically non-conductive surface; b) providing a first working electrode facing the workpiece at a region to be modified such that a gap is provided between the workpiece and the first working electrode; c) providing a dielectric comprising conductive particles, wherein the conductive particles are obtained via a burn-off from a second working electrode in a dielectric liquid; d) flushing the dielectric comprising the conductive particles to the workpiece, preferably continuously, such that the conductive particles of the dielectric liquid are deposited at the region to be modified and form an assisting electrode on the electrically non-conductive surface, wherein the dielectric liquid preferably fills the gap between the workpiece and the first working electrode; and e) applying an electric current to the first working electrode such that a plasma channel is generated between the first working electrode and the assisting electrode at the region to be modified, thereby modifying the workpiece via spark erosion.
摘要翻译：本发明涉及一种通过火花腐蚀来修饰不导电的工件的方法。本发明的方法包括以下步骤：a）提供包括非导电表面的工件; b）在被修改的区域处提供面向工件的第一工作电极，使得在工件和第一工作电极之间设置间隙; c）提供包含导电颗粒的电介质，其中所述导电颗粒通过介电液体中的第二工作电极的燃尽而获得; d）将包含导电颗粒的电介质优选地连续地冲洗到工件上，使得介电液体的导电颗粒沉积在待改性的区域上并在非导电表面上形成辅助电极，其中介电液体优选地填充工件和第一工作电极之间的间隙; 以及e）向所述第一工作电极施加电流，使得在所述第一工作电极和所述辅助电极之间在所述待修改区域处产生等离子体通道，从而通过火花侵蚀来修改所述工件。

5. 发明申请

WO2013127536A1 TEST-APPARATUR ZUR TESTUNG DER MIKROBIELLEN AKTIVITÄT AUF OBERFLÄCHEN 审中-公开
标题翻译：测试设备，用于微生物的活性表面上测试
公开(公告)号：WO2013127536A1
公开(公告)日：2013-09-06
申请号：PCT/EP2013/000605
申请日：2013-03-01
申请人： UNIVERSITÄTSKLINIKUM FREIBURG , STEINBERG, Thorsten , AL-AHMAD, Ali , LIENKAMP, Karen , NANKO, Norbert
发明人： STEINBERG, Thorsten , AL-AHMAD, Ali , LIENKAMP, Karen , NANKO, Norbert
IPC分类号： C12M1/12 , C12M1/26 , C12M1/34 , C12Q1/18
CPC分类号： C12Q1/18 , C12M25/06 , C12M33/04 , C12M41/36 , G01N1/28 , G01N30/32
摘要： Die vorliegende Erfindung betrifft eine Vorrichtung, umfassend eine Probenaufnahmeeinrichtung, eine Aufnahmeneinrichtung für Prüforganismen, vorzugsweise für eine Suspension umfassend Prüforganismen, insbesondere für eine Bakteriensuspension, und eine Strahlpumpeinrichtung, wobei die Strahlpumpeinrichtung in Wirkverbindung mit der Aufnahmeeinrichtung steht oder bringbar ist, und wobei die Strahlpumpeinrichtung ausgelegt und eingerichtet ist, um mittels eines Treibmedium mit einem höheren Druck als der Luftdruck am Aufstellort der Vorrichtung Prüforganismen in Form eines Aerosol in Richtung der Probeaufnahmeeinrichtung zu versprühen, wobei die Vorrichtung eine Einrichtung zur Steuerung eines reproduzierbaren Drucks des Treibmediums während des Versprühens der Prüforganismen aufweist sowie die Verwendung einer erfindungsgemäßen Vorrichtung.
摘要翻译：本发明涉及一种包括样品接收装置，用于测试生物的接收装置中，优选在喷射泵设计用于在悬浮液，其包括测试生物体，特别是用于悬浮的细菌，以及一个喷射泵装置的装置，所述喷射泵装置是或可操作地连接到所述接收装置是可接合的，并且其中并适于通过接收设备，其中所述设备包括用于将测试生物的喷涂期间控制驱动介质的可重复的压力以比在样品的方向以气溶胶的形式的设备的测试生物体的安装现场的空气压力高的压力的动力流体的装置进行喷雾，并根据本发明所述的装置的使用。

6. 发明公开

EP2658888A1 COVALENTLY ATTACHED ANTIMICROBIAL POLYMERS 审中-公开
标题翻译：共价结合抗微生物聚合物
公开(公告)号：EP2658888A1
公开(公告)日：2013-11-06
申请号：EP11799290.9
申请日：2011-12-22
申请人： Universitätsklinikum Freiburg , Albert-Ludwigs-Universität Freiburg
发明人： STEINBERG, Thorsten , LIENKAMP, Karen , TOMAKIDI, Pascal , AL-AHMAD, Ali
IPC分类号： C08F291/18 , C08F292/00 , C08F8/00 , A01N25/10
CPC分类号： A01N43/08 , A01N25/10 , A01N25/34 , C08F8/00 , C08F291/18 , C08F292/00 , A01N33/12
摘要： The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol -1 and are preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. Covalent bonding may be carried out using a photoreactive crosslinker but also "grafting onto" or "grafting from". The present invention is also directed to uses of the inventive antimicrobial polymers as defined herein, e.g. for antimicrobially coating a surface of such a substrate with a layer of the inventive antimicrobial polymer.

7. 发明授权

EP2820118B1 TEST-APPARATUR ZUR TESTUNG DER MIKROBIELLEN AKTIVITÄT AUF OBERFLÄCHEN 失效
公开(公告)号：EP2820118B1
公开(公告)日：2019-01-09
申请号：EP13707818.4
申请日：2013-03-01
申请人： Universitätsklinikum Freiburg
发明人： STEINBERG, Thorsten , AL-AHMAD, Ali , LIENKAMP, Karen , NANKO, Norbert
IPC分类号： C12M1/12 , C12M1/26 , C12M1/34 , C12Q1/18

9. 发明公开

EP2820118A1 TEST-APPARATUR ZUR TESTUNG DER MIKROBIELLEN AKTIVITÄT AUF OBERFLÄCHEN 失效
标题翻译：测试设备，用于微生物的活性表面上测试
公开(公告)号：EP2820118A1
公开(公告)日：2015-01-07
申请号：EP13707818.4
申请日：2013-03-01
申请人： Universitätsklinikum Freiburg
发明人： STEINBERG, Thorsten , AL-AHMAD, Ali , LIENKAMP, Karen , NANKO, Norbert
IPC分类号： C12M1/12 , C12M1/26 , C12M1/34 , C12Q1/18
CPC分类号： C12Q1/18 , C12M25/06 , C12M33/04 , C12M41/36 , G01N1/28 , G01N30/32
摘要： The present invention relates to a device comprising a sample receiving appliance, a receiving appliance for test organisms, preferably for a suspension comprising test organisms, in particular for a bacterial suspension, and a jet pump appliance, wherein the jet pump appliance is, or can be brought, into active connection with the receiving appliance, and wherein the jet pump appliance is designed and installed in order, by means of a propellant medium having a higher pressure than atmospheric pressure at the location of installation of the device to spray test organisms in the form of an aerosol in the direction of the sample receiving installation, wherein the device has an installation for controlling a reproducible pressure of the propellant medium during the spraying of the test organisms and also the use of a device according to the invention.

10. 发明公开

EP2694124A1 BIOCOMPATIBLE AND BIODEGRADABLE GRADIENT LAYER SYSTEM FOR REGENERATIVE MEDICINE AND FOR TISSUE SUPPORT 有权转让
标题翻译：生物相容性与生物降解GRADIENTENSCHICHTSYSTEM再生医学以及组织支持
公开(公告)号：EP2694124A1
公开(公告)日：2014-02-12
申请号：EP12715344.3
申请日：2012-04-04
申请人： Universitätsklinikum Freiburg , Albert-Ludwigs-Universität Freiburg
发明人： STEINBERG, Thorsten , TOMAKIDI, Pascal , SCHULZ, Simon , ANGARANO, Marco , MÜLHAUPT, Rolf , FABRITIUS, Martin
IPC分类号： A61L27/34 , A61L27/38 , A61L27/50 , A61L27/58
CPC分类号： A61L26/0095 , A61L27/34 , A61L27/3804 , A61L27/50 , A61L27/58 , A61L31/125 , A61L31/16 , A61L2420/08 , C08L89/06
摘要： The present invention is directed to a biocompatible and preferably biodegradable gradient layer system comprising at least one set of layers comprising a biocompatible and preferably biodegradable cross-linked polymer and at least one biocompatible and preferably biodegradable support layer, wherein a gradient is preferably formed with respect to the mechanical and/or physical properties of one or more layers of the at least one set of layers comprising a biocompatible and biodegradable cross-linked polymer and/or the at least one biocompatible and preferably biodegradable support layer. The at least one support layer preferably comprises a biocompatible and preferably biodegradable meltable polymer and/or a biocompatible and incorporable material. This biocompatible and preferably biodegradable gradient layer system may be used as a biomaterial for regenerative medicine, particularly as a wound dressing or for tissue support. The present invention also provides means utilizing said inventive gradient layer system and methods for producing same.
摘要翻译：本发明涉及一种生物相容的，优选生物可降解的梯度层系统，其包括层中的至少一组，其包括生物相容的，优选生物可降解的交联聚合物和至少一种生物相容的，优选生物可降解的载体层，worin梯度优选地相对于FORMED 到的层的至少一组包含生物相容和生物可降解交联聚合物和/或至少一种生物相容和可生物降解的优选支撑层的一个或多个层的机械和/或物理性质。所述至少一个支撑层优选地包括生物相容的和可生物降解的优选可熔融的聚合物和/或生物相容的和结合的材料。这种生物相容的和可生物降解的优选梯度层系统可被用作用于再生医学的生物材料，特别是作为伤口敷料或用于组织支持。本发明因此提供了手段利用所述本发明的梯度层的系统及其制造方法相同。

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