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1. 发明申请

WO2014072432A1 CELL CULTURE DEVICE FOR GENERATING AND CULTIVATING CELL AGGREGATES, METHOD OF PRODUCING SAID DEVICE AND USE OF SAID DEVICE 审中-公开
标题翻译：用于产生和培养细胞聚集体的细胞培养装置，产生装置的方法和使用装置
公开(公告)号：WO2014072432A1
公开(公告)日：2014-05-15
申请号：PCT/EP2013/073307
申请日：2013-11-07
申请人： UNIVERSITÄTSKLINIKUM FREIBURG
发明人： THOMSEN, Andreas , NANKO, Norbert , NIEDERMANN, Gabriele , HENKE, Michael
IPC分类号： C12M1/32 , C12M1/00 , C12M1/34
CPC分类号： C12M23/12 , C12M21/08 , C12M23/20 , C12M23/34 , C12M41/46
摘要： The invention relates to a cell culture device for generating and cultivating cell aggregates, the device comprising, a cell repellent hydrogel substrate, a surface (112), at least a first (101) and a second recession (102) for receiving cells for generating and cultivating cell aggregates, wherein the first (101) and the second recessions (102) are spatially separated, and wherein the surface (112) between the first (101) and the second recession (102) is a sloped surface and wherein the first (101) and the second recessions (102) comprise an upper part (106) and a bottom part (114) and wherein the upper part (106) has the shape of an truncated cone (302) with an opening angle of 12 to 36 ° and the ratio of the depth of the upper part (106) to the diameter of the widest end of the upper part (106) is at least 1.5 : 1. The invention also relates to a method of producing said device and to the use of said device for substance and/or testing of irradiation effect.
摘要翻译：本发明涉及一种用于产生和培养细胞聚集体的细胞培养装置，该装置包括细胞排斥水凝胶基质，表面（112），至少第一（101）和第二衰退（102），用于接收用于产生的细胞并且培养细胞聚集体，其中第一（101）和第二凹陷（102）在空间上分离，并且其中第一（101）和第二凹陷（102）之间的表面（112）是倾斜表面，并且其中第一（101）和所述第二凹部（102）包括上部（106）和底部（114），并且其中所述上部（106）具有截头圆锥体（302）的形状，所述截头圆锥体的开启角度为12至36 °，并且上部（106）的深度与上部（106）的最宽端的直径的比率至少为1.5:1。本发明还涉及一种制造所述装置的方法和用途的所述物质和/或照射效果的测试装置。

2. 发明申请

WO2014128185A1 RECOMBINANT BISPECIFIC ANTIBODY THAT BINDS TO THE CD133 ANTIGEN ON TUMOR CELLS AND TO THE HUMAN CD3 T CELL RECEPTOR 审中-公开
标题翻译：与肿瘤细胞和人CD3 CD3细胞受体上的CD133抗原结合的重组双重抗体
公开(公告)号：WO2014128185A1
公开(公告)日：2014-08-28
申请号：PCT/EP2014/053269
申请日：2014-02-20
申请人： UNIVERSITÄTSKLINIKUM FREIBURG
发明人： NIEDERMANN, Gabriele , PRASAD, Shruthi , GAEDICKE, Simone , HETTICH, Michael , FIRAT, Elke
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/2896 , C07K2317/31 , C07K2317/626 , C07K2317/73 , C07K2317/92
摘要： The present invention relates to recombinant bispecific antibodies that bind specifically to the CD133 surface antigen, which is expressed on tumor cells and that bind also to T cells via the CD3 receptor.
摘要翻译：本发明涉及特异性结合CD133表面抗原的重组双特异性抗体，其在肿瘤细胞上表达并且也通过CD3受体结合T细胞。

3. 发明公开

EP2917326A1 CELL CULTURE DEVICE FOR GENERATING AND CULTIVATING CELL AGGREGATES, METHOD OF PRODUCING SAID DEVICE AND USE OF SAID DEVICE 有权转让
标题翻译：于产生细胞培养装置和电池单元文化，方法用于制造这种装置的这种装置及使用
公开(公告)号：EP2917326A1
公开(公告)日：2015-09-16
申请号：EP13792291.0
申请日：2013-11-07
申请人： Universitätsklinikum Freiburg
发明人： THOMSEN, Andreas , NANKO, Norbert , NIEDERMANN, Gabriele , HENKE, Michael
IPC分类号： C12M1/32 , C12M1/00 , C12M1/34
CPC分类号： C12M23/12 , C12M21/08 , C12M23/20 , C12M23/34 , C12M41/46
摘要： A microstructured matrix for generating and. cultivating uniform cell aggregations is provided. Between two adjacent recessions, which can be used for receiving cells for generating and cultivating the uniform cell aggregations, a partition wall is provided. The partition wall has a shape, which facilitates a transport of cells by gravity from a distal end of the partition wall into at least one of the first recession and the second recession. Consequently, sedimentation of cells on horizontal parts of the partition wall is avoided. Such matrix geometry can advantageously be provided by the production method as presented herein. The method also comprises the step of providing a solid state body which is then processed by machining into a matrix model. The mechanical aspects of producing such a model, which arc presented herein, allow for advantageous geometries of the matrix on a very small scale. Particularly in view of the embodiments described in the figures, an improved matrix for facilitating the generation and. cultivation of cell aggregations and the optical read-out is provided.
摘要翻译：提供一种用于产生和。培养细胞均匀聚合的微结构化的基质。两个相邻的衰退，其可以是用于接收用于产生和培养细胞均匀聚合单元之间，提供了一种分隔壁。隔壁的形状，其通过重力从分隔壁的远端到第一衰退中的至少一个和第二衰退便于细胞的运输。因此，避免了在隔壁的水平部的细胞的沉降。搜索矩阵几何可有利地通过所述制造方法，在呈现中提供。因此，该方法包括：提供固态体的所有其然后通过机械加工加工成矩阵模型的步骤。产生这些机械方面寻找一个模型，该模型弧介绍，允许在一个非常小规模的矩阵的有利的几何形状。特别是考虑在附图中描述的，改进的基质关于促进生成的实施例的与细胞聚集和光学读出的。培养提供。

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