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1. 发明公开

EP2512452A4 ANTITHROMBOTIC NANOPARTICLE 有权
标题翻译：抗血栓纳米粒子
公开(公告)号：EP2512452A4
公开(公告)日：2015-06-24
申请号：EP10842655
申请日：2010-12-17
申请人： UNIV WASHINGTON
发明人： MYERSON JACOB , WICKLINE SAMUEL A
IPC分类号： A61K47/48 , A61K9/14 , A61P7/02
CPC分类号： A61K47/64 , A61K47/48807 , A61K47/544 , A61K47/60 , A61K47/6909
摘要： The present invention encompasses an antithrombotic nanoparticle.

2. 发明公开

EP2120876A4 NANOPARTICLE DELIVERY SYSTEMS FOR MEMBRANE-INTEGRATING PEPTIDES 有权
标题翻译：纳米粒子输出系统用于膜INTEGRATING肽
公开(公告)号：EP2120876A4
公开(公告)日：2012-08-15
申请号：EP08731481
申请日：2008-03-05
申请人： UNIV WASHINGTON
发明人： SCHLESINGER PAUL , SOMAN NEELESH , LANZA GREGORY , WICKLINE SAMUEL A
IPC分类号： A61K9/127 , A61K9/107 , A61K38/16 , A61K38/17 , A61K47/48
CPC分类号： A61K9/1075 , A61K9/127 , A61K38/1767 , A61K47/546 , A61K47/62 , A61K47/6907 , A61K47/6911

3. 发明申请

WO2009151788A3 UNIVERSAL ANCHOR PEPTIDE FOR NANOPARTICLES 审中-公开
标题翻译：通用锚固剂用于纳米颗粒
公开(公告)号：WO2009151788A3
公开(公告)日：2010-06-24
申请号：PCT/US2009041000
申请日：2009-04-17
申请人： UNIV WASHINGTON , WICKLINE SAMUEL A , PAN HUA , SOMAN NEELESH R , LANZA GREGORY M , SCHLESINGER PAUL H
发明人： WICKLINE SAMUEL A , PAN HUA , SOMAN NEELESH R , LANZA GREGORY M , SCHLESINGER PAUL H
IPC分类号： A61K38/00 , A61K9/127
CPC分类号： A61K9/5123 , A61K49/1806
摘要： The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes.
摘要翻译：本发明提供了能够稳定地插入脂质膜中的基本上非裂解性的非细胞毒性锚定肽。特别地，本发明提供包含稳定插入的锚定肽的纳米颗粒，其可以缀合到各种不同的货物配合物。

4. 发明申请

WO2007100715A2 CELL LABELING WITH PERFLUOROCARBON NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY 审中-公开
标题翻译：用于磁共振成像和光谱的全氟碳纳米管的细胞标记
公开(公告)号：WO2007100715A2
公开(公告)日：2007-09-07
申请号：PCT/US2007004823
申请日：2007-02-23
申请人： UNIV WASHINGTON , WICKLINE SAMUEL A , LANZA GREGORY M
发明人： WICKLINE SAMUEL A , LANZA GREGORY M
CPC分类号： A61K49/1896 , B82Y5/00
摘要： Methods of obtaining cells internally labeled with perfluorocarbon nanoparticles suitable for magnetic resonance imaging and spectroscopy are disclosed. Also disclosed are methods for obtaining magnetic resonance imaging data from labeled cells under clinically relevant scan times and field strengths. Finally, the application further discloses methods of specifically detecting and distinguishing magnetic resonance imaging and spectroscopy data from two distinct sets of cells labeled with distinct types of perfluorocarbon nanoparticles.
摘要翻译：公开了获得内部标记有适用于磁共振成像和光谱学的全氟化碳纳米颗粒的细胞的方法。还公开了用于在临床相关扫描时间和场强下从标记细胞获得磁共振成像数据的方法。最后，本申请还公开了用不同类型的全氟化碳纳米颗粒标记的两组不同组的细胞特异性检测和区分磁共振成像和光谱数据的方法。

5. 发明公开

EP2522026A4 METHOD AND APPARATUS FOR HIGH RESOLUTION PHOTON DETECTION BASED ON EXTRAORDINARY OPTOCONDUCTANCE (EOC) EFFECTS 审中-公开
标题翻译： VERFAHREN UND VORRICHTUNG ZURHOCHAUFLÖSENDENPHOTONENDETEKTION AUF GRUNDLAGE DER EFFEKTEAUSSERGEWÖHNLICHEROPTISCHERLEITFÄHIGKEIT
公开(公告)号：EP2522026A4
公开(公告)日：2017-05-03
申请号：EP11732218
申请日：2011-01-07
申请人： UNIV WASHINGTON
发明人： SOLIN STUART A , WICKLINE SAMUEL A , NEWAZ AKM SHAH , WALLACE KIRK D
IPC分类号： H01L31/09 , H01L27/144
CPC分类号： H01L27/14665 , B82Y15/00 , H01L27/1446 , H01L31/0304 , H01L31/09 , H01L31/108 , Y02E10/544

6. 发明申请

WO2006096499A3 MR CORONARY ANGIOGRAPHY WITH A FLUORINATED NANOPARTICLE CONTRAST AGENT AT 1.5 T 审中-公开
标题翻译：与1.5T的氟化纳米对比剂的冠状动脉造影
公开(公告)号：WO2006096499A3
公开(公告)日：2007-04-05
申请号：PCT/US2006007579
申请日：2006-03-03
申请人： UNIV WASHINGTON , WICKLINE SAMUEL A , LANZA GREGORY M
发明人： WICKLINE SAMUEL A , LANZA GREGORY M
IPC分类号： A61K51/12
CPC分类号： B82Y5/00 , A61K49/1806
摘要： Disclosed herein is a medical imaging technique that uses a fluorinated nanoparticle contrast agent for imaging of an interior portion of a body. The fluorinated nanoparticles preferably comprise nontargeted intravascular fluorocarbon or perfluorocarbon nanoparticles. The interior body portion may be a patient's vasculature, and the medical imaging is preferably noninvasive MR angiography, which may encompass (either for 2D imaging or 3D imaging) MR coronary angiography, MR carotid angiography, MR peripheral angiography, MR cerebral angiography, MR arterial angiography, and MR venous angiography. Coils tuned to match to the 19 F signal can be used, or dual tuned coils for 19 F and 1 H imaging can be used. Clinical field strengths (e.g.. 1.5T) and clinical doses may be used while still providing effective images.
摘要翻译：本文公开了一种医疗成像技术，其使用氟化纳米颗粒造影剂来成像身体的内部部分。氟化纳米颗粒优选包含非靶向的血管内碳氟化合物或全氟化碳纳米颗粒。内部主体部分可以是患者的脉管系统，并且医学成像优选为非侵入性MR血管造影术，其可以包括（用于2D成像或3D成像）MR冠状动脉造影，MR颈动脉血管造影术，MR外周血管造影术，MR脑血管造影术，MR动脉血管造影和MR静脉血管造影。可以使用调谐到与^{19F信号相匹配的线圈，或者可以使用用于<20> F和<1> H / H成像的双调谐线圈。可以使用临床场强（例如1.5T）和临床剂量，同时仍然提供有效图像。}

7. 发明申请

WO2011085220A3 METHOD AND APPARATUS FOR HIGH RESOLUTION PHOTON DETECTION BASED ON EXTRAORDINARY OPTOCONDUCTANCE (EOC) EFFECTS 审中-公开
标题翻译：基于非特异性光电效应（EOC）效应的高分辨光子检测方法和装置
公开(公告)号：WO2011085220A3
公开(公告)日：2011-10-27
申请号：PCT/US2011020545
申请日：2011-01-07
申请人： UNIV WASHINGTON , SOLIN STUART A , WICKLINE SAMUEL A , NEWAZ AKM SHAH , WALLACE KIRK D
发明人： SOLIN STUART A , WICKLINE SAMUEL A , NEWAZ AKM SHAH , WALLACE KIRK D
IPC分类号： H01L31/08
CPC分类号： H01L27/14665 , B82Y15/00 , H01L27/1446 , H01L31/0304 , H01L31/09 , H01L31/108 , Y02E10/544
摘要： The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06xl011 cmvHz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.
摘要翻译：发明人公开了一种新型高性能光学传感器，优选纳米级尺寸，其在室温下基于金属 - 半导体混合（MSH）中的异常光电导（EOC）现象，优选反向EOC（I-EOC））结构具有半导体/金属界面。这样的设计显示了光电探测效率，而不是裸露的半导体。在对示例性实施例的实验中，使用氦 - 氖激光辐射的超高空间分辨率4点光电导测量揭示了惊人的大的光电导性质，对于250nm器件来说观察到的9460％EOC的最大测量值。这样的示例性EOC装置对于632nm照明还表现出高于5.06×10 11 cmvHz / W的特定检测灵敏度和40dB的高动态响应，使得这种传感器在广泛的实际应用中在技术上具有竞争力。

8. 发明申请

WO2008115258A3 MULTIFUNCTIONAL NANOSCOPY FOR IMAGING CELLS 审中-公开
标题翻译：多功能纳米成像细胞
公开(公告)号：WO2008115258A3
公开(公告)日：2009-05-22
申请号：PCT/US2007074864
申请日：2007-07-31
申请人： UNIV WASHINGTON , SOLIN STUART A , WALLACE KIRK D , WICKLINE SAMUEL A , HUGHES MICHAEL S
发明人： SOLIN STUART A , WALLACE KIRK D , WICKLINE SAMUEL A , HUGHES MICHAEL S
IPC分类号： G06F19/00
CPC分类号： G01N27/04 , G01N15/1031 , G01N2015/0038 , G01R27/02 , G01R33/09 , G01R33/095 , G01R33/1269 , G11C11/161 , G11C11/18 , G11C13/0019
摘要： Disclosed herein is an apparatus for sensing characteristics of an object. In a preferred embodiment, the apparatus comprises an array, wherein the array comprises a plurality of nanoscale hybrid semiconductor/metal devices which are in proximity to an object, each hybrid semiconductor/metal device being configured to produce a voltage in response to a perturbation, wherein the produced voltage is indicative of a characteristic of the object. Any of a variety of nanoscale EXX sensors can be selected as the hybrid semiconductor/ metal devices in the array. With such an array, ultra high resolution images of nanoscopic resolution can be generated of objects such as living cells, wherein the images are indicative of a variety of cell biologic processes.
摘要翻译：本文公开了一种用于感测物体的特性的装置。在优选实施例中，该装置包括阵列，其中阵列包括接近物体的多个纳米级混合半导体/金属器件，每个混合半导体/金属器件被配置为响应于扰动产生电压，其中所产生的电压表示物体的特性。可选择各种纳米级EXX传感器中的任何一种作为阵列中的混合半导体/金属器件。利用这样的阵列，可以生成诸如活细胞的物体的纳米分辨率的超高分辨率图像，其中图像指示各种细胞生物过程。

9. 发明申请

WO2008109712A3 NANOPARTICLE DELIVERY SYSTEMS FOR MEMBRANE-INTEGRATING PEPTIDES 审中-公开
标题翻译：用于膜整合肽的纳米颗粒传递系统
公开(公告)号：WO2008109712A3
公开(公告)日：2008-12-11
申请号：PCT/US2008055969
申请日：2008-03-05
申请人： UNIV WASHINGTON , SCHLESINGER PAUL , SOMAN NEELESH , LANZA GREGORY , WICKLINE SAMUEL A
发明人： SCHLESINGER PAUL , SOMAN NEELESH , LANZA GREGORY , WICKLINE SAMUEL A
IPC分类号： A61K9/127 , A61K38/16
CPC分类号： A61K9/1075 , A61K9/127 , A61K38/1767 , A61K47/546 , A61K47/62 , A61K47/6907 , A61K47/6911
摘要： Compositions which comprise emulsions of nanoparticles for delivery of membrane-integrating peptides are described. The nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer which contains the membrane-integrating peptides. Methods to use such compositions are also described.
摘要翻译：描述了包含用于递送膜整合肽的纳米颗粒乳剂的组合物。纳米颗粒包含涂覆有含有膜整合肽的脂质/表面活性剂层的液体疏水核心。还描述了使用这种组合物的方法。

10. 发明公开

EP2941273A4 COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE TRANSFECTION 有权
标题翻译：组合物和方法用于转染的多核苷酸
公开(公告)号：EP2941273A4
公开(公告)日：2017-01-04
申请号：EP14735277
申请日：2014-01-03
申请人： UNIV WASHINGTON
发明人： WICKLINE SAMUEL A , HOU KIRK
IPC分类号： A61K47/42 , A61K38/04 , A61K38/16 , A61K48/00 , A61P19/02 , A61P35/00 , C07K14/00
CPC分类号： A61K47/48323 , A61K31/713 , A61K38/00 , A61K47/42 , A61K47/6455 , C07K19/00 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , Y10T428/2982
摘要： A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
摘要翻译：一种药物组合物，包含一种肽，多核苷酸复合物，以及它们的使用方法。

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