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1. 发明公开

EP2214573A4 SYSTEM FOR TREATMENT AND IMAGING USING ULTRASONIC ENERGY AND MICROBUBBLES AND RELATED METHOD THEREOF 有权
标题翻译：系列紫外线灭菌器
公开(公告)号：EP2214573A4
公开(公告)日：2011-08-03
申请号：EP08841415
申请日：2008-10-24
申请人： UNIV VIRGINIA PATENT FOUND
发明人： HOSSACK JOHN A , WAMHOFF BRIAN R , KLIBANOV ALEXANDER L
IPC分类号： A61B17/20
CPC分类号： A61N7/00 , A61B8/12 , A61B8/445 , A61B8/481 , A61B17/2202 , A61B2017/22088 , A61B2017/22089 , A61B2090/3782 , A61K41/0028 , A61K49/223 , A61M37/0092
摘要： A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.
摘要翻译：用于在受试者的一个或多个位置（例如脉管系统）向治疗部位提供治疗的方法和相关系统，例如狭窄或其他脉管系统疾病。该方法包括：将超声导管推进到受试者的治疗部位或其附近; 将微泡注入或接近治疗部位; 并从超声导管输送超声波能量。超声波能量可以适用于：对治疗部位进行成像，将微泡翻译成治疗部位或其附近和/或破裂微泡。

2. 发明公开

EP1549221A4 AN INTUITIVE ULTRASONIC IMAGING SYSTEM AND RELATED METHOD THEREOF 有权
标题翻译：直观的超声系统和相关操作
公开(公告)号：EP1549221A4
公开(公告)日：2006-03-29
申请号：EP03716289
申请日：2003-03-06
申请人： UNIV VIRGINIA
发明人： WALKER WILLIAM F , HOSSACK JOHN A , BLALOCK TRAVIS N
IPC分类号： A61B8/00 , A61B8/06 , A61B8/08 , A61B18/14 , G01S7/52 , G01S15/89
CPC分类号： A61B8/5215 , A61B5/415 , A61B5/418 , A61B5/4818 , A61B8/06 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/13 , A61B8/14 , A61B8/4427 , A61B8/4455 , A61B8/462 , A61B8/466 , A61B8/483 , A61B8/488 , A61B2562/028 , G01S7/52038 , G01S7/52061 , G01S7/52071 , G01S7/5208 , G01S15/8925 , G01S15/8979 , G01S15/8993 , G01S15/8995
摘要： A hand held ultrasonic instrument (10) is provided in a portable unit that performs C-Mode imaging and collects 3D image data. In a preferred embodiment a transducer array (60), display unit (20), beamformer (40), power system, and image processor are integrated in one enclosure weighing less than three pounds. In operation, the portable unit is scanned across a target and the displayed image is conveniently presented to the operator whereby the displayed image corresponds exactly to the target, or a scaled fashion if desired.

3. 发明公开

EP2861154A4 ULTRASOUND IMAGING OF SPECULAR-REFLECTING TARGET 有权
标题翻译：超声成像镜面反射靶的
公开(公告)号：EP2861154A4
公开(公告)日：2016-01-20
申请号：EP13803513
申请日：2013-06-13
申请人： UNIV VIRGINIA PATENT FOUND
发明人： MAULDIN JR F WILLIAM , HOSSACK JOHN A , OWEN KEVIN
IPC分类号： A61B8/14 , A61B8/00
CPC分类号： A61B8/4461 , A61B8/0875 , A61B8/145 , A61B8/4209 , A61B8/4218 , A61B8/4281 , A61B8/4466 , A61B8/4477 , A61B8/4494 , A61B8/461 , A61B8/483 , A61B8/5207 , A61B8/523 , A61B8/5253
摘要： Ultrasound apparatus or techniques can include obtaining reflected ultrasound echo information, which can be used to construct a two-dimensional or three-dimensional representation of an at least approximately specular reflected target, such as bone. In an example, echo information can be obtained from spatially-overlapping tissue regions, such as using one or more of an array of ultrasonic transducers, or mechanically-scanning one or more ultrasonic transducers. In an example, one or more of a deformable housing or a deformable coupling pad can be used, such as to couple ultrasonic energy between one or more transducers and a tissue region.

4. 发明公开

EP2324337A4 FRONT END CIRCUITRY FOR IMAGING SYSTEMS AND METHODS OF USE 审中-公开
标题翻译： FRONTSCHALTUNGFÜRBILDGEBUNGSSYSTEME UND VERWENDUNGSVERFAHREN
公开(公告)号：EP2324337A4
公开(公告)日：2012-02-22
申请号：EP09808508
申请日：2009-08-18
申请人： UNIV VIRGINIA PATENT FOUND
发明人： WALKER WILLIAM F , FULLER MICHAEL I , RANGANATHAN KARTHIK , HOSSACK JOHN A , BLALOCK TRAVIS N
IPC分类号： G01N9/24 , A61B8/00 , G01N29/06 , G01S7/52 , G01S15/89
CPC分类号： G01N29/0654 , A61B8/00 , A61B8/4483 , G01N2291/02475 , G01S7/52026 , G01S7/52046 , G01S7/52079 , G01S15/8959
摘要： Pulse-echo imaging systems and methods are provided, including a transmit code sequencer and a pulse generation circuit, The transmit code sequencer is configured to input a transmit code sequence to the pulse generation circuit. A transducer is configured to receive electrical signals provided as pulses using coded excitation according to the transmit code sequence, and to transduce the electrical signals to pulses of energy other than electrical signals. The transducer is further configured to receive echoes of the pulses of energy other than electrical signals and convert the echoes to received electrical signals generate using coded excitation. A receive circuit is configured to receive the received electrical signals generate using coded excitation, perform analog sampling of the received electrical signals generate using coded excitation, and provide a weighted, summed digital signal by processing the analog samples. At least one example of a pulse imaging system described is configured for ultrasonic pulse-echoes. At least one example of a pulse imaging system described is a medical diagnostic imaging system.
摘要翻译：提供脉冲回波成像系统和方法，包括发射码序列器和脉冲发生电路。发射码排序器被配置为向脉冲发生电路输入发射码序列。换能器被配置为接收根据发射码序列使用编码激励的脉冲提供的电信号，并将电信号转换成电信号以外的能量脉冲。换能器还被配置为接收除电信号之外的能量脉冲的回波，并将回波转换成使用编码激励产生的接收电信号。接收电路被配置为接收使用编码激励产生的接收的电信号，对使用编码激励产生的接收电信号执行模拟采样，并通过处理模拟采样来提供加权的相加的数字信号。所描述的脉冲成像系统的至少一个示例被配置用于超声脉冲回波。所描述的脉冲成像系统的至少一个示例是医学诊断成像系统。

5. 发明公开

EP1622514A4 ULTRASOUND IMAGING BEAM-FORMER APPARATUS AND METHOD 有权
标题翻译： ULTRASCHALL-STRAHLENFORMER-GERÄTUND VERFAHREN
公开(公告)号：EP1622514A4
公开(公告)日：2009-06-24
申请号：EP04702168
申请日：2004-01-14
申请人： UNIV VIRGINIA
发明人： BLALOCK TRAVIS N , WALKER WILLIAM F , HOSSACK JOHN A
IPC分类号： A61B8/02 , A61B20060101 , A61B8/00 , A61B8/14 , G01S15/89 , G10K11/34
CPC分类号： A61B8/4494 , A61B8/00 , A61B8/145 , A61B8/4483 , A61B8/4488 , A61B8/461 , A61B8/5207 , G01S7/52028 , G01S7/52034 , G01S7/5208 , G01S7/52085 , G01S15/8915 , G01S15/8959 , G01S15/8995 , G10K11/346
摘要： In some illustrative embodiments, an incoming signal from a transducer (110) in an ultrasound imaging beam-former apparatus (100) is applied to an in-phase sample-and-hold (120) and a quadrature sample-and-hold (130). The quadrature sample-and-hold (130) may be clocked a quarter period behind the in-phase sample-and-hold (120). The output of the sample-and-holds are applied to in-phase and quadrature analog-to-digital converters (126). A magnitude calculator (138) receives the in-phase and quadrature digital values, and outputs a magnitude. A phase calculator (142) receives the in-phase and quadrature digital values, and outputs a phase. An apodizer (146) applies a difference between an amplitude of the outgoing signal and the magnitude and applies a first illumination (150-1) to a image point (154) in substantial proportion to the difference, and a phase rotator (152) applies a second illumination (150-2) to the image point (154) in substantial proportion to the phase.
摘要翻译：在一些说明性实施例中，来自超声波成像束形成装置中的换能器的输入信号被施加到同相采样保持和正交采样保持。正交采样保持可以在同相取样和保持后的四分之一时间内进行计时。采样和保持的输出应用于同相和正交模数转换器。幅度计算器接收同相和正交数字值，并输出幅度。相位计算器接收同相和正交数字值，并输出相位。变迹器应用输出信号的幅度和幅度之间的差异，并且以与该差异相当大比例的方式将第一照明施加到图像点，并且相位旋转器以与该相位相当大的比例向图像点施加第二照明。

6. 发明申请

WO2004064620A3 ULTRASONIC TRANSDUCER DRIVE 审中-公开
标题翻译：超声波传感器驱动
公开(公告)号：WO2004064620A3
公开(公告)日：2004-10-21
申请号：PCT/US2004000888
申请日：2004-01-14
申请人： UNIV VIRGINIA , BLALOCK TRAVIS N , WALKER WILLIAM F , HOSSACK JOHN A
发明人： BLALOCK TRAVIS N , WALKER WILLIAM F , HOSSACK JOHN A
IPC分类号： A61B20060101 , A61B8/00 , A61B8/14 , G01S15/89 , G10K11/34
CPC分类号： A61B8/4494 , A61B8/00 , A61B8/145 , A61B8/4483 , A61B8/4488 , A61B8/461 , A61B8/5207 , G01S7/52028 , G01S7/52034 , G01S7/5208 , G01S7/52085 , G01S15/8915 , G01S15/8959 , G01S15/8995 , G10K11/346
摘要： In some illustrative embodiments, an ultrasonic transducer drive (200) includes a signal generator (202) for producing an outgoing signal (204) and a transducer (206) for converting the outgoing signal (204) to outgoing ultrasound (208). The transducer (204) may also convert at least a portion of ultrasound reflected (210) by an object to an incoming signal (212). The transducer (206) may have a transmit side (214) connected conductably to the signal generator (202) during at least a first predetermined period of time and a receive side (216) connected conductably to a signal receiver (224) during at least a second predetermined period of time.
摘要翻译：在一些说明性实施例中，超声换能器驱动器（200）包括用于产生输出信号（204）的信号发生器（202）和用于将输出信号（204）转换为输出超声波（208）的换能器（206）。换能器（204）还可以将被物体反射的超声波（210）的至少一部分转换为输入信号（212）。换能器（206）可以具有在至少第一预定时间段期间可传导地连接到信号发生器（202）的发射侧（214），并且至少在至少第一预定时间段内可接收与信号接收器（224）连接的接收侧第二预定时间段。

7. 发明申请

WO2004065978A3 SYSTEM AND METHOD FOR ULTRASOUND C-SCANNING 审中-公开
标题翻译：超声C扫描的系统和方法
公开(公告)号：WO2004065978A3
公开(公告)日：2004-10-14
申请号：PCT/US2004001002
申请日：2004-01-15
申请人： UNIV VIRGINIA , HOSSACK JOHN A , WALKER WILLIAM F , BLALOCK TRAVIS N
发明人： HOSSACK JOHN A , WALKER WILLIAM F , BLALOCK TRAVIS N
IPC分类号： A61B8/02 , G01S20060101 , G01S15/89
CPC分类号： G01S15/8925 , A61B8/13 , A61B8/483 , G01S7/52085 , G01S7/52095 , G01S15/8993
摘要： An ultrasound system and related method for forming 2D C-scan images and/or collecting 3D image data from 2D transducer arrays. The system including in part a 2D transducer array of elements (50), transmit voltage generation means (51) for each element, a memory buffer (56) with or part of channels for each element, and a receive beamformer (58). On a time serial or sequential basis, several times for each line of firing, the contents of the per element memory buffer are read into the beamformer with different focusing values for each buffer reading cycle. In this way, the beamformer can calculate beamformed image values for multiple points per line firing cycle-or per each line of signals between the transducer array and receive beamformer.
摘要翻译：用于形成2D C扫描图像和/或从2D换能器阵列收集3D图像数据的超声系统和相关方法。该系统部分地包括元件（50）的2D换能器阵列，每个元件的发射电压产生装置（51），具有每个元件的通道的一部分的存储器缓冲器（56）和接收波束形成器（58）。在时间序列或顺序的基础上，对于每一次触发行，几次，每个缓冲区读取周期的每个元素存储器缓冲器的内容被读入具有不同聚焦值的波束形成器。以这种方式，波束形成器可以计算每行发射周期的多个点的波束形成图像值，或者计算换能器阵列和接收波束形成器之间的每一行信号。

8. 发明申请

WO2004064619A3 ULTRASOUND IMAGING BEAM-FORMER APPARATUS AND METHOD 审中-公开
标题翻译：超声波成像光束成像装置及方法
公开(公告)号：WO2004064619A3
公开(公告)日：2005-01-06
申请号：PCT/US2004000887
申请日：2004-01-14
申请人： UNIV VIRGINIA , BLALOCK TRAVIS N , WALKER WILLIAM F , HOSSACK JOHN A
发明人： BLALOCK TRAVIS N , WALKER WILLIAM F , HOSSACK JOHN A
IPC分类号： A61B20060101 , A61B8/00 , A61B8/14 , G01S15/89 , G10K11/34
CPC分类号： A61B8/4494 , A61B8/00 , A61B8/145 , A61B8/4483 , A61B8/4488 , A61B8/461 , A61B8/5207 , G01S7/52028 , G01S7/52034 , G01S7/5208 , G01S7/52085 , G01S15/8915 , G01S15/8959 , G01S15/8995 , G10K11/346
摘要： In some illustrative embodiments, an incoming signal from a transducer (110) in an ultrasound imaging beam-former apparatus (100) is applied to an in-phase sample-and-hold (120) and a quadrature sample-and-hold (130). The quadrature sample-and-hold (130) may be clocked a quarter period behind the in-phase sample-and-hold (120). The output of the sample-and-holds are applied to in-phase and quadrature analog-to-digital converters (126). A magnitude calculator (138) receives the in-phase and quadrature digital values, and outputs a magnitude. A phase calculator (142) receives the in-phase and quadrature digital values, and outputs a phase. An apodizer (146) applies a difference between an amplitude of the outgoing signal and the magnitude and applies a first illumination (150-1) to a image point (154) in substantial proportion to the difference, and a phase rotator (152) applies a second illumination (150-2) to the image point (154) in substantial proportion to the phase.
摘要翻译：在一些说明性实施例中，来自超声成像束形成装置（100）中的来自换能器（110）的输入信号被施加到同相采样保持（120）和正交采样保持（130））。正交采样保持（130）可以在同相采样保持（120）之后的四分之一周期内被计时。采样和保持的输出应用于同相和正交模数转换器（126）。幅度计算器（138）接收同相和正交数字值，并输出幅度。相位计算器（142）接收同相和正交数字值，并输出相位。变迹器（146）施加输出信号的振幅和幅度之间的差异，并以与差值相当大的比例对第一照明（150-1）施加到图像点（154），并且相位旋转器（152）应用第二照明（150-2）与图像点（154）大致成比例地相位。

9. 发明申请

WO2012148985A8 BONE SURFACE IMAGE RECONSTRUCTION USING ULTRASOUND 审中-公开
标题翻译：使用超声波的骨表面图像重建
公开(公告)号：WO2012148985A8
公开(公告)日：2013-12-19
申请号：PCT/US2012034945
申请日：2012-04-25
申请人： UNIV VIRGINIA PATENT FOUND , MAULDIN F WILLIAM JR , HOSSACK JOHN A , OWEN KEVIN
发明人： MAULDIN F WILLIAM JR , HOSSACK JOHN A , OWEN KEVIN
IPC分类号： A61B8/14
CPC分类号： A61B8/0875 , A61B8/0841 , A61B8/4245 , A61B8/4254 , A61B8/4433 , A61B8/4455 , A61B8/4466 , A61B8/4483 , A61B8/466 , A61B8/483 , A61B34/20 , A61B2017/3413 , A61B2034/2048 , A61B2034/2051 , A61B2034/2055 , A61B2090/378 , A61B2090/3937 , G01S7/52073 , G01S7/5208 , G01S15/60 , G01S15/8915 , G01S15/899
摘要： An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4lambda2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about 1/2lambda, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.
摘要翻译：超声波换能器元件可以被配置为产生被引导到对象的组织中的超声能量，并且被配置为接收由位于组织内的目标反射的超声能量的一部分。超声波换能器可以包括被配置为提供或接收超声能量的表面，该表面包括大于或等于约4λ2的面积，或者超声波换能器元件可以被包括在具有至少两个相邻超声波之间的间隔的阵列中小于或等于约1 /2λ的元件，并且阵列包括在两个轴线中至少近似对称的孔。可以经由显示器呈现目标的至少一部分的位置，形状或取向中的一个或多个的三维表示。

10. 发明申请

WO2008154632A3 SYSTEM AND METHOD FOR COMBINED ECG-ECHO FOR CARDIAC DIAGNOSIS 审中-公开
标题翻译：用于心脏诊断的组合ECG-ECHO的系统和方法
公开(公告)号：WO2008154632A3
公开(公告)日：2010-01-07
申请号：PCT/US2008066711
申请日：2008-06-12
申请人： UNIV VIRGINIA , GARSON ARTHUR JR , WALKER WILLIAM F , HOSSACK JOHN A , BLALOCK TRAVIS N
发明人： GARSON ARTHUR JR , WALKER WILLIAM F , HOSSACK JOHN A , BLALOCK TRAVIS N
IPC分类号： A61B8/00
CPC分类号： A61B8/0858 , A61B8/0883 , A61B8/483
摘要： A system and related method for obtaining volumetric cardiac data of a subject. The data is generated by forming a plurality of focused ultrasound images corresponding to a series of ranges, generating myocardial boundary data for each of the plurality of ultrasound images, calculating the area of the region defined by said myocardial boundary data for each of the plurality of ultrasound images, multiplying the area for each of the plurality of ultrasound images by a slice depth corresponding to said ultrasound image to obtain the slice volume of each slice, and summing the slice volumes to obtain a total volume. In an alternative embodiment the system and related method combine an automated volumetric ultrasound system for finding chamber volumes and myocardial thicknesses, with a diagnostic electrocardiogram system to enable simultaneous diagnosis of mechanical and electrical cardiac problems.
摘要翻译：用于获得受试者体积心脏数据的系统和相关方法。通过形成对应于一系列范围的多个聚焦超声图像来生成数据，为多个超声图像中的每一个生成心肌边界数据，计算由多个超声图像中的每一个的所述心肌边界数据定义的区域的面积超声图像，将所述多个超声图像中的每一个的面积乘以对应于所述超声图像的切片深度，以获得每个切片的切片体积，并且对切片体积求和以获得总体积。在替代实施例中，系统和相关方法结合了用于发现腔室体积和心肌厚度的自动化体积超声系统，其具有诊断心电图系统，以能够同时诊断机械和电学心脏问题。

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