专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006135431A3 INHIBITION OF METALLO-BETA-LACTAMASE BY RNA 审中-公开
标题翻译：通过RNA抑制METALLO-BETA-LACTAMASE
公开(公告)号：WO2006135431A3
公开(公告)日：2007-05-24
申请号：PCT/US2005037706
申请日：2005-10-19
申请人： UNIV TEXAS TECH SYSTEM , SHAW ROBERT W , KIM KYU MEE
发明人： SHAW ROBERT W , KIM KYU MEE
IPC分类号： A61K31/43 , A61K31/545 , A61K48/00 , A61P31/04 , C12N15/10 , C12N15/115 , C12Q1/68
CPC分类号： C12N15/115 , C12Y305/02006
摘要： Compositions and methods for identifying polyribonucleotides that binds with high affinity to a metallo-ß-lactamase. The polyribonucleotides inhibit the activity of the metallo-ß-lactamase.
摘要翻译：用于鉴定以高亲和力结合金属β-内酰胺酶的多核糖核苷酸的组合物和方法。多核糖核苷酸抑制金属β-内酰胺酶的活性。

2. 发明申请

WO2004031142A3 INHIBITION OF METALLO-BETA-LACTAMASE 审中-公开
标题翻译： METALLO-BETA-LACTAMASE的抑制作用
公开(公告)号：WO2004031142A3
公开(公告)日：2005-04-21
申请号：PCT/US0328782
申请日：2003-09-12
申请人： UNIV TEXAS TECH SYSTEM , SHAW ROBERT W , KIM SUNG-KUN
发明人： SHAW ROBERT W , KIM SUNG-KUN
IPC分类号： C12N15/10 , C12P19/34 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/1048 , C12Q1/6811 , C12Q2541/101 , C12Q2527/137
摘要： A method to identify a high affinity nucleic acid ligand to inhibit the activity of a lactamase enzyme. The method comprises several steps that initially involve preparing a candidate mixture of nucleic acids. The candidate mixture of nucleic acids is then allowed to make contact with the lactamase enzyme under controlled conditions of temperature, ionic strength and pH; the combination forms a candidate-enzyme mixture. The target nucleic acids are partitioned from the remainder of the candidate mixture. The target nucleic acids that have been partitioned are amplified to yield a pool of nucleic acids enriched with target nucleic acid sequences. The enriched pool of target nucleic acids have a relatively higher affinity and specificity for binding to the lactamase, whereby nucleic acid ligand of the lactamase are identified. Nucleic acid ligands that inhibit an activity of lactamase. The lactamase includes class B, metallo-beta-lactamase.
摘要翻译：鉴定高亲和力核酸配体以抑制内酰胺酶活性的方法。该方法包括几个步骤，其最初涉及制备核酸的候选混合物。然后允许核酸的候选混合物在温度，离子强度和pH的受控条件下与内酰胺酶接触; 该组合形成候选酶混合物。靶核酸与候选混合物的其余部分分开。已经分配的靶核酸被扩增以产生富含靶核酸序列的核酸库。靶核酸的富集池对于结合内酰胺酶具有相对较高的亲和性和特异性，由此鉴定出内酰胺酶的核酸配体。抑制内酰胺酶活性的核酸配体。内酰胺酶包括B类金属β-内酰胺酶。

3. 发明专利

AU2003299137A1 INHIBITION OF METALLO-BETA-LACTAMASE 未知
公开(公告)号：AU2003299137A1
公开(公告)日：2004-04-23
申请号：AU2003299137
申请日：2003-09-12
申请人： UNIV TEXAS TECH SYSTEM
发明人： SHAW ROBERT W , KIM SUNG-KUN
IPC分类号： C12N15/10 , C12P19/34 , C12Q1/68

4. 发明专利

AU2003299137A8 Inhibition of metallo-beta-lactamase 未知
公开(公告)号：AU2003299137A8
公开(公告)日：2004-04-23
申请号：AU2003299137
申请日：2003-09-12
申请人： UNIV TEXAS TECH SYSTEM
发明人： SHAW ROBERT W , KIM SUNG-KUN
IPC分类号： C12N15/10 , C12P19/34 , C12Q1/68 , C07H21/04

5. 发明专利

CA480033A SOLE OF A SHOE 未知
公开(公告)号：CA480033A
公开(公告)日：1952-01-08
申请号：CA480033D
申请人： SHAW ROBERT W
发明人： SHAW ROBERT W

6. 发明专利

CA326682A INSOLE 未知
公开(公告)号：CA326682A
公开(公告)日：1932-10-11
申请号：CA326682D
申请人： SHAW ROBERT W
发明人： SHAW ROBERT W

7. 发明专利

CA89415A VENTILATING AND HEATING SYSTEM 未知
公开(公告)号：CA89415A
公开(公告)日：1904-10-04
申请号：CA89415D
申请日：1904-09-16
申请人： SHAW ROBERT W
发明人： SHAW ROBERT W

8. 发明专利

CA2116484A1 CYCLOPENTADIENE DERIVATIVES 未知
公开(公告)号：CA2116484A1
公开(公告)日：1994-09-02
申请号：CA2116484
申请日：1994-02-25
申请人： SCOTT RICHARD M , SHAW ROBERT W
发明人： SCOTT RICHARD M , SHAW ROBERT W
IPC分类号： C09K23/16 , C07C47/445 , C07C61/29 , C07C211/18 , C07C211/19 , C07C211/25 , C07C211/38 , C07C225/20 , C07C243/20 , C07C271/24 , C07D209/48 , C07D209/52 , C07D209/56 , C07D209/70 , C07D209/72 , C07D209/74 , C07D209/76 , C07D307/93 , C09K23/22 , C09K23/32 , C10L1/18 , C10L1/22 , C10L10/08 , C10L10/18 , C10M105/70 , C10M133/06 , C10M133/16 , C10M133/18 , C10M133/20 , C10M133/46 , C10M133/50 , C10M133/56 , C10N30/04
摘要： CYCLOPENTADIENE DERIVATIVES The invention provides compounds of the general formula (I) in which R1 and R2 each represent a hydrogen atom, or together represent a carbon-carbon single bond; each of R4 and R5 independently represents a hydrogen atom, or a C1-C20 alkyl or phenyl group, each of which may be optionally substituted; R6 represents a hydrogen atom, or a C1-C20 alkyl or phenyl group, each of which may be optionally substituted and R represents a group -CH2-NHR8 in which R8 represents an optionally substituted alkyl group, or a group -COX wherein X represents an optionally substituted alkoxy group or -NHR8 where R8 is as defined above; or R6 and R7 together represent a group , , or where R8 is as defined above; x is 1 to 6; and each R3 independently represents an optionally substituted alkyl or alkenyl group or a group of formula (II), (IIIA) or (IIIB) wherein m is in the range 0 to 25, n is in the range 1 to 20, each R9 independently represents a hydrogen atom or a methyl or ethyl group, D is derived from a saturated or unsaturated hydrocarbon containing from 20 to 500 carbon atoms, and Y represents a group of formula (IV) in which R1, R2, R4, R5 and R6 are as defined above; x' is 0 to 5; R3' is as defined for R3 other than a group of formula II, IIIA or IIIB, R7' represents a group R7 as defined above or a group -CHO or -COOH, or R6 and R7' together represent a group , , or , where R8 is as defined above, each group R3 containing a total of up to 550 carbon atoms, with the provisos that up to a maximum of 3 R3 groups can each simultaneously contain a total of greater than 40 carbon atoms and that the groups R3 taken together contain a total of greater than 20 carbon atoms; a process for their preparation; novel intermediates; lubricating oil compositions, fuel compositions and additive concentrates containing the formula I compounds; and the use of the formula I compounds as dispersant additives.

9. 发明专利

CA2116482A1 ADDITIVE CONCENTRATES 未知
公开(公告)号：CA2116482A1
公开(公告)日：1994-09-02
申请号：CA2116482
申请日：1994-02-25
申请人： SCOTT RICHARD M , SHAW ROBERT W
发明人： SCOTT RICHARD M , SHAW ROBERT W
IPC分类号： C10L1/22 , C07D209/76 , C10L1/18 , C10L1/222 , C10L1/224 , C10L1/2383 , C10L10/08 , C10L10/18 , C10M133/06 , C10M133/16 , C10M133/18 , C10M133/40 , C10M133/56 , C10M159/12 , C10N30/04 , C10N40/25
摘要： ADDITIVE CONCENTRATES The invention provides an additive concentrate comprising an inert carrier fluid and from 10 to 80%w, based on the total concentrate, of a compound of the general formula (I) in which R1 and R2 each represent a hydrogen atom, or together represent a carbon-carbon single bond; each of R4 and R5 independently represents a hydrogen atom, or a C1-C20 alkyl or phenyl group, each of which may be optionally substituted; R6 represents a hydrogen atom, or a C1-C20 alkyl or phenyl group, each of which may be optionally substituted and R7 represents a group -CH2-NHR8 in which R8 represents an optionally substituted alkyl group, or a group -COX wherein X represents an optionally substituted alkoxy group or -NHR8 where R8 is as defined above; or R6 and R7 together represent a group , , where R8 is as defined above; x is 1 to 6, and each R3 independently represents an optionally substituted alkyl or alkenyl group or a group of formula (II), (IIIA) or (IIIB) wherein m is in the range 0 to 25, n is in the range 1 to 20, each R9 independently represents a hydrogen atom or a methyl or ethyl group, D is derived from a saturated or unsaturated hydrocarbon containing from 20 to 500 carbon atoms, and Y represents a group of formula (IV) in which R1, R2, R4, R5 and R6 are as defined above; x' is 0 to 5; R3' is as defined for R3 other than a group of formula II, IIIA or IIIB, R7' represents a group R7 as defined above or a group -CHO or -COOH, or R6 and R7' together represent a group , , or where R8 is as defined above, each group R3 containing a total of up to 550 carbon atoms, with the proviso that up to a maximum of 3 R3 groups can each simultaneously contains a total of greater than 40 carbon atoms; lubricating oil and fuel compositions containing the formula I compounds; and the use of the formula I compounds as dispersant additives.

10. 发明专利

CA150377A CUSHION WHEEL 未知
公开(公告)号：CA150377A
公开(公告)日：1913-09-09
申请号：CA150377D
申请日：1912-04-10
申请人： SHAW ROBERT W
发明人： SHAW ROBERT W

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式