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1. 发明专利

CA2251924A1 FLUORESCENT CHELATES AS VISUAL TISSUE SPECIFIC IMAGING AGENTS 未知
公开(公告)号：CA2251924A1
公开(公告)日：1997-10-30
申请号：CA2251924
申请日：1997-04-08
申请人： UNIV TEXAS TECH , DOW CHEMICAL CO
发明人： KIEFER GARRY E , BORNHOP DARRYL J
IPC分类号： A61K49/00 , C07F9/6524 , C07F9/6561 , G01N33/58 , C07F5/00 , A61K49/04
摘要： Fluorescent chelates of terbium and europium with tri- and tetracyclopolyazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents.

2. 发明专利

NO984840A 未知
公开(公告)号：NO984840A
公开(公告)日：1998-12-16
申请号：NO984840
申请日：1998-10-16
申请人： DOW CHEMICAL CO , UNIV TEXAS TECH
发明人： KIEFER GARRY E , BORNHOP DARRYL J
IPC分类号： A61K49/00 , C07F9/6524 , C07F9/6561 , G01N33/58 , C07F
CPC分类号： A61K49/0021 , C07F9/6524 , C07F9/6561 , G01N33/582

3. 发明专利

AU2660697A Fluorescent chelates as visual tissue specific imaging agents 未知
公开(公告)号：AU2660697A
公开(公告)日：1997-11-12
申请号：AU2660697
申请日：1997-04-08
申请人： DOW CHEMICAL CO , UNIV TEXAS TECH
发明人： KIEFER GARRY E , BORNHOP DARRYL J
IPC分类号： A61K49/00 , C07F9/6524 , C07F9/6561 , G01N33/58 , C07F5/00 , A61K49/04
摘要： Fluorescent chelates of terbium and europium with tri- and tetra-cyclopolyazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents.

4. 发明专利

AU719002B2 Fluorescent chelates as visual tissue specific imaging agents 未知
公开(公告)号：AU719002B2
公开(公告)日：2000-05-04
申请号：AU2660697
申请日：1997-04-08
申请人： DOW CHEMICAL CO , UNIV TEXAS TECH
发明人： KIEFER GARRY E , BORNHOP DARRYL J
IPC分类号： A61K49/00 , C07F9/6524 , C07F9/6561 , G01N33/58 , C07F5/00 , A61K49/04
摘要： Fluorescent chelates of terbium and europium with tri- and tetra-cyclopolyazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents.

5. 发明专利

NO984840L 未知
公开(公告)号：NO984840L
公开(公告)日：1998-12-16
申请号：NO984840
申请日：1998-10-16
申请人： DOW CHEMICAL CO , UNIV TEXAS TECH
发明人： KIEFER GARRY E , BORNHOP DARRYL J
IPC分类号： A61K49/00 , C07F9/6524 , C07F9/6561 , G01N33/58 , C07F
摘要： Fluorescent chelates of terbium and europium with tri- and tetra-cyclopolyazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents.

6. 发明专利

CA2251924C FLUORESCENT CHELATES AS VISUAL TISSUE SPECIFIC IMAGING AGENTS 未知
公开(公告)号：CA2251924C
公开(公告)日：2006-05-30
申请号：CA2251924
申请日：1997-04-08
申请人： UNIV TEXAS TECH , DOW CHEMICAL CO
发明人： KIEFER GARRY E , BORNHOP DARRYL J
IPC分类号： C07F9/6524 , A61K49/00 , A61K49/04 , C07F5/00 , C07F9/6561 , G01N33/58
摘要： Fluorescent chelates of terbium and europium with tri- and tetra- cyclopolyazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates ar e tissue specific imaging agents.

7. 发明专利

NO984840D0 未知
公开(公告)号：NO984840D0
公开(公告)日：1998-10-16
申请号：NO984840
申请日：1998-10-16
申请人： DOW CHEMICAL CO , UNIV TEXAS TECH
发明人： KIEFER GARRY E , BORNHOP DARRYL J
IPC分类号： A61K49/00 , C07F9/6524 , C07F9/6561 , G01N33/58 , C07F
摘要： Fluorescent chelates of terbium and europium with tri- and tetra-cyclopolyazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents.

8. 发明申请

WO03020701A9 MULTI-USE MULTIMODAL IMAGING CHELATES 审中-公开
公开(公告)号：WO03020701A9
公开(公告)日：2003-09-12
申请号：PCT/US0227800
申请日：2002-09-04
申请人： UNIV TEXAS TECH
发明人： BORNHOP DARRYL J , MANNING CHARLES H , GOEBEL TIMOTHY
IPC分类号： A61K31/675 , A61K49/00 , A61K49/10 , A61K31/33 , C07D225/00 , C07D257/02
CPC分类号： A61K31/675 , A61K49/0002 , A61K49/106 , A61K51/0482
摘要： Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10, tetraazacyclododecane ("cyclen") having varying chelating ions, phosphoester chains, and light harvesting moieties. By changing the chelating ion, phosphoester chain length and/or the light harvesting moiety different imaging techniques, such as MRI, CT, fluorescence and absorption, x-ray and NIR, may be employed to image the tissue cells. Additionally, the cyclen-based chelates may be conjugated to provide for site-specific delivery of the cyclen-based chelate to the desired tissue cells. The cyclen-based chelates may also be delivered to the tissue cells by attaching the cyclen-based chelates to a polymeric delivery vehicle. Although these cyclen-based chelates have a wide variety of application, the preferred use is for imaging of cancers cells, such as brain cancer, for improving resection of a cancerous tissue.

9. 发明申请

WO03020701A3 MULTI-USE MULTIMODAL IMAGING CHELATES 审中-公开
标题翻译：多用途多模式成像螯合
公开(公告)号：WO03020701A3
公开(公告)日：2003-07-31
申请号：PCT/US0227800
申请日：2002-09-04
申请人： UNIV TEXAS TECH
发明人： BORNHOP DARRYL J , MANNING CHARLES H , GOEBEL TIMOTHY
IPC分类号： A61K31/675 , A61K49/00 , A61K49/10 , A61K31/33 , C07D225/00 , C07D257/02
CPC分类号： A61K31/675 , A61K49/0002 , A61K49/106 , A61K51/0482
摘要： Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10, tetraazacyclododecane ("cyclen") having varying chelating ions, phosphoester chains, and light harvesting moieties. By changing the chelating ion, phosphoester chain length and/or the light harvesting moiety different imaging techniques, such as MRI, CT, fluorescence and absorption, x-ray and NIR, may be employed to image the tissue cells. Additionally, the cyclen-based chelates may be conjugated to provide for site-specific delivery of the cyclen-based chelate to the desired tissue cells. The cyclen-based chelates may also be delivered to the tissue cells by attaching the cyclen-based chelates to a polymeric delivery vehicle. Although these cyclen-based chelates have a wide variety of application, the preferred use is for imaging of cancers cells, such as brain cancer, for improving resection of a cancerous tissue.
摘要翻译：基于Cyclen的螯合物可以用作组织细胞的多模式成像的造影剂。基于cyclen的螯合物优选为由具有不同螯合离子，磷酸酯链和光捕获部分的1,4,7,10，四氮杂环十二烷（“cyclen”）形成的聚氮杂大环分子。通过改变螯合离子，可以采用不同的成像技术，例如MRI，CT，荧光和吸收，X射线和NIR来对组织细胞成像，磷酸酯链长度和/或光捕获部分。另外，可以将基于循环的螯合物缀合以提供基于循环的螯合物到所需组织细胞的位点特异性递送。基于循环的螯合物也可以通过将基于循环的螯合物连接至聚合物递送载体而递送至组织细胞。尽管这些基于循环的螯合物具有广泛的应用，但优选用于癌症细胞例如脑癌的成像以改善癌组织的切除。

10. 发明公开

EP1210581A4 INTERFEROMETRIC DETECTION SYSTEM AND METHOD 有权
标题翻译：装置及方法干涉检测
公开(公告)号：EP1210581A4
公开(公告)日：2006-03-29
申请号：EP00959154
申请日：2000-08-17
申请人： UNIV TEXAS TECH
发明人： BORNHOP DARRYL J , SWINNEY KELLY , MARKOV DMITRY
IPC分类号： G01N21/45 , G01N25/48 , G01N27/447 , G01N30/60 , G01N30/74 , G01N35/08 , G01N21/41
CPC分类号： G01N30/74 , G01N21/45 , G01N25/4813 , G01N27/44721 , G01N30/6095 , G01N35/085
摘要： An optical detection scheme for on-chip, high sensitivity refractive index detection is based on micro-interferometry, and allows for picoliter detection volumes and universal analyte sensitivity. The invention employs three main elements: a source (12) of coherent light, such as a VCSEL, laser diode or He-Ne laser; an etched channel (22) of capillary dimensions in a substrate (20) for reception of a sample to be analyzed; and a photodetector (25) for detecting laser light reflected off of the channel (22). The laser source (12) generates an unfocused laser beam (14) that is incident on the etched channel (22). A unique multi-pass optical configuration is inherently created by the channel characteristics, and is based on the interaction of the unfocused laser beam (14) and the curved surface of the channel (22), that allows RI measurments in small volumes at high sensitivity. The entire device, including the laser source (12) and the photodetector (25) can be formed on a single microchip. The detector has numerous applications, including universal/RI detection for CE (capillary electrophoresis), CEC (capillary electrochromatography) and FIA, physiometry, cell sorting/detection by scatter, ultra micro calorimetry, flow rate sensing and temperature sensing.

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