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1. 发明申请

WO2009032477A3 VEGFR-1/NRP-1 TARGETING PEPTIDES 审中-公开
标题翻译： VEGFR-1 / NRP-1靶向肽
公开(公告)号：WO2009032477A3
公开(公告)日：2011-01-13
申请号：PCT/US2008072675
申请日：2008-08-08
申请人： UNIV TEXAS , PASQUALINI RENATA , ARAP WADIH , GIORDANO RICARDO , CARDO-VILA MARINA , VALENTE ANA PAULA , CENEVIVA LACERDA DE ALMEIDA FABIO , UNIV RIO DE JANEIRO
发明人： PASQUALINI RENATA , ARAP WADIH , GIORDANO RICARDO , CARDO-VILA MARINA , VALENTE ANA PAULA , CENEVIVA LACERDA DE ALMEIDA FABIO
IPC分类号： C07K5/08 , C07K7/08
CPC分类号： C12N15/62 , A61K47/66 , B82Y5/00 , C07K5/0806 , C07K5/0808 , C07K5/0817 , C07K7/06 , C07K7/08 , C07K14/001
摘要： The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-1 and NRP-1 expressing cells. Targeted molecules in accordance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
摘要翻译：本发明涉及治疗剂的分子药物和靶向递送领域。更具体地，本发明涉及结合选择性靶向VEGFR-1和NRP-1表达细胞的氨基酸Leu-Pro-Arg（LPR），特别是D（LPR）的新肽序列的鉴定。根据本发明的靶向分子可用于治疗和检测新生血管或血管生成VEGF相关疾病，包括但不限于癌症，肥胖症，糖尿病，哮喘，关节炎，肝硬化和眼部疾病。

2. 发明申请

WO2009032477A2 VEGFR-1/NRP-1 TARGETING PEPTIDES 审中-公开
标题翻译： VEGFR-1 / NRP-1靶向肽
公开(公告)号：WO2009032477A2
公开(公告)日：2009-03-12
申请号：PCT/US2008072675
申请日：2008-08-08
申请人： UNIV TEXAS , PASQUALINI RENATA , ARAP WADIH , GIORDANO RICARDO , CARDO-VILA MARINA , VALENTE ANA PAULA , CENEVIVA LACERDA DE ALMEIDA FA
发明人： PASQUALINI RENATA , ARAP WADIH , GIORDANO RICARDO , CARDO-VILA MARINA , VALENTE ANA PAULA , CENEVIVA LACERDA DE ALMEIDA FABIO
CPC分类号： C12N15/62 , A61K47/66 , B82Y5/00 , C07K5/0806 , C07K5/0808 , C07K5/0817 , C07K7/06 , C07K7/08 , C07K14/001
摘要： The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-I and NRP-I expressing cells. Targeted molecules in accordance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
摘要翻译：本发明涉及治疗剂的分子药物和靶向递送领域。更具体地，本发明涉及结合选择性靶向VEGFR-1和NRP-1表达细胞的氨基酸Leu-Pro-Arg（LPR），特别是D（LPR）的新肽序列的鉴定。根据本发明的靶向分子可用于治疗和检测新生血管或血管生成VEGF相关疾病，包括但不限于癌症，肥胖症，糖尿病，哮喘，关节炎，肝硬化和眼部疾病。

3. 发明申请

WO2011097633A3 EGF RECEPTOR MIMICKING PEPTIDES 审中-公开
标题翻译： EGF受体MIMICKING PEPTIDES
公开(公告)号：WO2011097633A3
公开(公告)日：2011-12-29
申请号：PCT/US2011024073
申请日：2011-02-08
申请人： UNIV TEXAS , CARDO-VILA MARINA , GIORDANO RICARDO J , MENDELSOHN JOHN , ARAP WADIH , PASQUALINI RENATA
发明人： CARDO-VILA MARINA , GIORDANO RICARDO J , MENDELSOHN JOHN , ARAP WADIH , PASQUALINI RENATA
IPC分类号： C07K5/08 , A61K47/42 , A61K49/14 , C07K5/12 , C07K7/00 , C07K7/64
CPC分类号： A61K49/14 , A61K51/088 , C07K7/06
摘要： Provided are peptides which can mimic the epidermal growth factor receptor (EGFR), e.g., by selectively binding TGF-a and/or EGF. In certain embodiments, the peptides are retro-inverted peptides. The peptides may be used as soluble decoys for TGF-a and/or EGF, and anti-cancer properties of peptides are demonstrated both in vitro and in vivo. The peptides may be administered alone or comprised in a fusion construct, imaging construct, and/or a therapeutic construct, e.g., for the treatment of a cancer.
摘要翻译：提供可以模拟表皮生长因子受体（EGFR）的肽，例如通过选择性结合TGF-α和/或EGF。在某些实施方案中，肽是逆转肽。肽可以用作TGF-α和/或EGF的可溶性诱饵，并且在体外和体内都证明了肽的抗癌特性。肽可以单独施用或包含在融合构建体，成像构建体和/或治疗构建体中，例如用于治疗癌症。

4. 发明申请

WO2007118245A3 METHODS AND COMPOSITIONS RELATED TO ADENOASSOCIATED VIRUS-PHAGE PARTICLES 审中-公开
标题翻译：方法和组合物相关的腺病毒病毒颗粒
公开(公告)号：WO2007118245A3
公开(公告)日：2008-11-13
申请号：PCT/US2007066265
申请日：2007-04-09
申请人： UNIV TEXAS , PASQUALINI RENATA , ARAP WADIH , GELOVANI JURI , MARINI FRANK C III , HAJITOU AMIN , ALAUDDIN MIAN , TREPEL MARTIN
发明人： PASQUALINI RENATA , ARAP WADIH , GELOVANI JURI , MARINI FRANK C III , HAJITOU AMIN , ALAUDDIN MIAN , TREPEL MARTIN
IPC分类号： A01N43/04 , A01N63/00 , A61B5/055 , A61K49/00 , C07H21/04 , C12N15/00
CPC分类号： A61K47/6455 , A61K47/48238 , A61K47/48776 , A61K47/62 , A61K47/6901 , A61K48/00 , C12N15/86 , C12N2750/14143 , C12N2750/14145 , C12N2795/14143 , C12N2810/405 , C12N2810/85
摘要： Embodiments of the invention are generally directed to compositions and methods of delivering one or more transgene to a target cell, such as a tumor cell, in a site-specific manner to achieve enhanced expression and to constructs and compositions useful in such applications. In certain aspects, expression from a therapeutic nucleic acid may be assessed prior to administration of a treatment or diagnostic procedure to or on a subject.
摘要翻译：本发明的实施方案通常涉及以位点特异性方式将一种或多种转基因递送至靶细胞（例如肿瘤细胞）以实现增强的表达的组合物和方法以及用于这种应用的构建体和组合物。在某些方面，可以在对受试者施用治疗或诊断程序之前评估来自治疗性核酸的表达。

5. 发明申请

WO2013040472A8 COMPOSITIONS AND METHODS RELATED TO DNA DAMAGE REPAIR 审中-公开
标题翻译：与DNA损伤修复相关的组合物和方法
公开(公告)号：WO2013040472A8
公开(公告)日：2013-10-17
申请号：PCT/US2012055598
申请日：2012-09-14
申请人： UNIV TEXAS , STAQUICINI FERNANDA I , PASQUALINI RENATA , ARAP WADIH
发明人： STAQUICINI FERNANDA I , PASQUALINI RENATA , ARAP WADIH
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/28 , A61K41/0038 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/33 , C07K2317/56 , C07K2317/73 , C07K2317/76
摘要： The present invention provides compositions and methods for treating a cancer associated with elevated expression and/or activity of receptor typrosine kinases (e.g., Eph receptors), such as EphA5. In some embodiments, the present invention provides compositions and methods for identifying elevated expression or activity of receptor tyrosine kinases (e.g., Eph receptors), such as EphA5.
摘要翻译：本发明提供了用于治疗与受体型酪氨酸激酶（例如Eph受体）如EphA5的表达和/或活性升高相关的癌症的组合物和方法。在一些实施方案中，本发明提供了用于鉴定受体酪氨酸激酶（例如Eph受体）如EphA5的升高的表达或活性的组合物和方法。

6. 发明申请

WO0220724A2 ADENOVIRAL TARGETING AND MANIPULATION OF IMMUNE SYSTEM RESPONSE USING TARGETING PEPTIDES 审中-公开
标题翻译：使用目标肽进行免疫系统反应的腺病毒靶向和操作
公开(公告)号：WO0220724A2
公开(公告)日：2002-03-14
申请号：PCT/US0128045
申请日：2001-09-07
申请人： UNIV TEXAS , ARAP WADIH , PASQUALINI RENATA
发明人： ARAP WADIH , PASQUALINI RENATA
IPC分类号： C12N15/09 , A61K31/225 , A61K31/23 , A61K31/56 , A61K31/683 , A61K31/685 , A61K31/688 , A61K31/713 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/395 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61K49/00 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P13/02 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P43/00 , C07K1/04 , C07K5/08 , C07K5/10 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/005 , C07K14/47 , C07K14/52 , C07K16/08 , C07K16/18 , C07K19/00 , C12N7/02 , C12N15/10 , C12N15/861 , C12N15/864 , C12Q1/02 , C12Q1/70 , G01N33/50 , G01N33/53 , G01N33/566 , C12N
CPC分类号： C07K14/52 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K1/047 , C07K7/06 , C12N15/1037 , C12N2810/40
摘要： The present invention concerns compositions and methods relating to the identification and use of targeting peptides. Such targeting peptides selectively home to specific organs or tissues in vivo. The novel targeting sequences disclosed herein are of use for the targeted delivery of various therapeutic agents to the targeted organ or tissue. In particular embodiments, the present invention concerns bispecific targeting reagents comprising an organ targeting peptide attached to a molecule, such as a Fab fragment, that binds to a gene therapy vector or other therapeutic agent. In alternative embodiments, bispecific targeting peptides containing an organ targeting moiety and a gene therapy or therpeutic agent targeting moiety may be obtained and used for targeted delivery. Other embodiments concern modulation of host immune system function through the targeted delivery of antigens or other molecules to lymph nodes. Numerous examples of targeting peptide sequences against adenovirus or lymph node tissue are disclosed herein.
摘要翻译：本发明涉及与靶向肽的鉴定和使用相关的组合物和方法。这种靶向肽在体内选择性地归属于特定器官或组织。本文公开的新靶向序列可用于将靶向的器官或组织靶向递送各种治疗剂。在具体实施方案中，本发明涉及包含与分子结合的器官靶向肽（例如Fab片段）结合基因治疗载体或其它治疗剂的双特异性靶向试剂。在替代实施方案中，可以获得含有器官靶向部分和基因治疗或治疗剂靶向部分的双特异性靶向肽并用于靶向递送。其他实施方案涉及通过将抗原或其它分子靶向递送至淋巴结来调节宿主免疫系统功能。本文公开了针对腺病毒或淋巴结组织的靶向肽序列的许多实例。

7. 发明申请

WO2007046818A3 COMPOSITIONS AND METHODS RELATED TO SYNCHRONOUS SELECTION OF HOMING PEPTIDES FOR MULTIPLE TISSUES BY IN VIVO PHAGE DISPLAY 审中-公开
标题翻译：通过血液动力学显示同步选择多种组织的嗜酸性粒细胞相关的组合物和方法
公开(公告)号：WO2007046818A3
公开(公告)日：2009-04-23
申请号：PCT/US2005041702
申请日：2005-11-16
申请人： UNIV TEXAS , KOLONIN MIKHAIL , ARAP WADIH , PASQUALINI RENATA
发明人： KOLONIN MIKHAIL , ARAP WADIH , PASQUALINI RENATA
IPC分类号： C40B10/00 , C12Q1/68
CPC分类号： C12N15/1037
摘要： Embodiments of the invention include methods for selecting in parallel (i.e., synchronously or simultaneously) peptides that target a number of organs, in which each peptide targets distinct tissues or organs. Typically, the methods of the invention provide for peptide selection in a Minimal number of subjects and still provides a selectively binding peptide. In certain aspects, methods of identifying peptides that bind to multiple selected tissues or organs of an organism may comprise the steps of administering a phage display library to a first subject; obtaining a sample of two or more selected tissues; obtaining phage displaying peptides that bind to the samples from the first subject; enriching for peptides by administering phage isolated from the samples of the first subject to a second subject; obtaining a sample of two or more selected tissues from the second subject; and identifying the peptides displayed.
摘要翻译：本发明的实施方案包括并行（即，同时或同时）选择靶向多个器官的肽的方法，其中每个肽靶向不同的组织或器官。通常，本发明的方法提供了在最少数目受试者中的肽选择，并且还提供了选择性结合肽。在某些方面，鉴定结合生物体的多个选定组织或器官的肽的方法可包括以下步骤：向第一受试者施用噬菌体展示文库; 获得两个或多个选定组织的样品; 获得显示与来自第一受试者的样品结合的肽的噬菌体; 通过将从第一受试者的样品分离的噬菌体施用于第二受试者来富集肽; 从第二受试者获得两个或更多个选定组织的样本; 并鉴定显示的肽。

8. 发明申请

WO2007118245A8 METHODS AND COMPOSITIONS RELATED TO ADENOASSOCIATED VIRUS-PHAGE PARTICLES 审中-公开
标题翻译：与ADENOASSOCIATEDVIVES-PHAGE颗粒相关的方法和组合物
公开(公告)号：WO2007118245A8
公开(公告)日：2008-10-02
申请号：PCT/US2007066265
申请日：2007-04-09
申请人： UNIV TEXAS , PASQUALINI RENATA , ARAP WADIH , GELOVANI JURI , MARINI FRANK C III , HAJITOU AMIN , ALAUDDIN MIAN , TREPEL MARTIN
发明人： PASQUALINI RENATA , ARAP WADIH , GELOVANI JURI , MARINI FRANK C III , HAJITOU AMIN , ALAUDDIN MIAN , TREPEL MARTIN
IPC分类号： A01N43/04 , A01N63/00 , A61B5/055 , A61K49/00 , C07H21/04 , C12N15/00
CPC分类号： A61K47/6455 , A61K47/48238 , A61K47/48776 , A61K47/62 , A61K47/6901 , A61K48/00 , C12N15/86 , C12N2750/14143 , C12N2750/14145 , C12N2795/14143 , C12N2810/405 , C12N2810/85
摘要： Embodiments of the invention are generally directed to compositions and methods of delivering one or more transgene to a target cell, such as a tumor cell, in a site-specific manner to achieve enhanced expression and to constructs and compositions useful in such applications. In certain aspects, expression from a therapeutic nucleic acid may be assessed prior to administration of a treatment or diagnostic procedure to or on a subject.
摘要翻译：本发明的实施方案通常涉及将一种或多种转基因以位点特异性方式递送至靶细胞例如肿瘤细胞以实现增强的表达的组合物和方法以及用于此类应用的构建体和组合物。在某些方面，可以在向受试者施用治疗或诊断程序之前评估来自治疗性核酸的表达。

9. 发明申请

WO0220723A2 COMPOSITIONS AND METHODS FOR TARGETING PEPTIDES IN HUMANS IN VIVO 审中-公开
标题翻译：用于在人体内靶向肽的组合物和方法
公开(公告)号：WO0220723A2
公开(公告)日：2002-03-14
申请号：PCT/US0128044
申请日：2001-09-07
申请人： UNIV TEXAS , ARAP WADIH , PASQUALINI RENATA
发明人： ARAP WADIH , PASQUALINI RENATA
IPC分类号： C12N15/09 , A61K31/225 , A61K31/23 , A61K31/56 , A61K31/683 , A61K31/685 , A61K31/688 , A61K31/713 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/395 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61K49/00 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P13/02 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P43/00 , C07K1/04 , C07K5/08 , C07K5/10 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/005 , C07K14/47 , C07K14/52 , C07K16/08 , C07K16/18 , C07K19/00 , C12N7/02 , C12N15/10 , C12N15/861 , C12N15/864 , C12Q1/02 , C12Q1/70 , G01N33/50 , G01N33/53 , G01N33/566 , C12N
CPC分类号： C07K14/52 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K1/047 , C07K7/06 , C12N15/1037 , C12N2810/40
摘要： The present invention concerns methods and compositions for identifying human targeting peptides sequences. In preferred embodiments, a primary phage library is administered to a human in vivo and phage bearing targeting peptides are collected from selected organs, tissues or cells types. In more preferred embodiments, collected phage are amplified, pooled and administered to a second human for another round of selection. The peptides are of use for targeted delivery of therapeutic agents, including gene therapy vectors. Such targeted delivery may be used for detection, diagnosis or treatment of human diseases. In certain embodiments, the peptide may be attached to an imaging agent and administered to a human to obtain an image or to diagnose a disease state. Also disclosed are a large number of targeting peptide sequences and consensus motifs that are selective for human organs or tissues, obtained by the methods of the present invention.
摘要翻译：本发明涉及用于鉴定人靶向肽序列的方法和组合物。在优选的实施方案中，将一级噬菌体文库施用于体内，并从选定的器官，组织或细胞类型收集含有靶向肽的噬菌体。在更优选的实施方案中，将收集的噬菌体扩增，合并并施用于第二人进行另一轮选择。肽可用于靶向递送治疗剂，包括基因治疗载体。这种靶向递送可用于人类疾病的检测，诊断或治疗。在某些实施方案中，肽可以连接到成像剂并施用于人以获得图像或诊断疾病状态。还公开了通过本发明的方法获得的大量针对人器官或组织选择性的靶向肽序列和共有基序。

10. 发明申请

WO2013040472A3 COMPOSITIONS AND METHODS RELATED TO DNA DAMAGE REPAIR 审中-公开
公开(公告)号：WO2013040472A3
公开(公告)日：2013-05-10
申请号：PCT/US2012055598
申请日：2012-09-14
申请人： UNIV TEXAS , STAQUCINI FERNANDA I , ARAP WADIH , PASQUALINI RENATA
发明人： STAQUCINI FERNANDA I , ARAP WADIH , PASQUALINI RENATA
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/28 , A61K41/0038 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/33 , C07K2317/56 , C07K2317/73 , C07K2317/76
摘要： The present invention provides compositions and methods for treating a cancer associated with elevated expression and/or activity of receptor typrosine kinases (e.g., Eph receptors), such as EphA5. In some embodiments, the present invention provides compositions and methods for identifying elevated expression or activity of receptor tyrosine kinases (e.g., Eph receptors), such as EphA5.

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