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1. 发明申请

WO2007062399A2 ONCOGENIC RAS-SPECIFIC CYTOTOXIC COMPOUND AND METHODS OF USE THEREOF 审中-公开
标题翻译： ONCOGENIC RAS-SPECIFIC CYTOTOXIC COMPOUND AND METHODS OF THEREOF
公开(公告)号：WO2007062399A2
公开(公告)日：2007-05-31
申请号：PCT/US2006061219
申请日：2006-11-22
申请人： UNIV TEXAS , FANG BINGLIANG , LIU JINSONG , GUO WEI , WU SHUHONG
发明人： FANG BINGLIANG , LIU JINSONG , GUO WEI , WU SHUHONG
IPC分类号： A61K31/404
CPC分类号： A61K31/404
摘要： Embodiments of the present invention provide for methods and compositions comprising an Oncorasin, such as l-[(4-chlorophenyl)methyl]- lH-Indole-3-carboxaldehyde (oncrasin-1) and/or its analogs or derivatives.
摘要翻译：本发明的实施方案提供了包含Oncorasin，例如1 - [（4-氯苯基）甲基] -1H-吲哚-3-甲醛（oncrasin-1）和/或其类似物或衍生物的方法和组合物。

2. 发明申请

WO9927123A3 MODIFIED SV40 VIRAL VECTORS 审中-公开
标题翻译：修改后的SV40病毒载体
公开(公告)号：WO9927123A3
公开(公告)日：1999-08-12
申请号：PCT/US9825225
申请日：1998-11-25
申请人： UNIV TEXAS , FANG BINGLIANG , HIGHLANDER STEVEN L , CASEMENT KEVIN S , ROTH JACK A
发明人： FANG BINGLIANG , HIGHLANDER STEVEN L , CASEMENT KEVIN S , ROTH JACK A
IPC分类号： A61K48/00 , C12N15/86 , C12N15/87
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/22043
摘要： The present invention provides SV40-based viral vectors for use in the delivery of genes to target cells. The unique combination of multiple viral systems provides for vectors with increased carrying capacity and extended host range when compared to normal SV40 vectors. Uses for the vectors include the expression of proteins in vitro and in vivo.
摘要翻译：本发明提供了用于将基因递送至靶细胞的基于SV40的病毒载体。与正常SV40载体相比，多种病毒系统的独特组合提供了携带能力增加且宿主范围扩大的载体。载体的用途包括体外和体内蛋白质的表达。

3. 发明申请

WO2006099019A3 METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION 审中-公开
标题翻译：与基因表达VIVO成像相关的方法和组合
公开(公告)号：WO2006099019A3
公开(公告)日：2007-04-05
申请号：PCT/US2006008374
申请日：2006-03-09
申请人： UNIV TEXAS , KUNDRA VIKAS , FANG BINGLIANG , JI LINX X , YANG DAN
发明人： KUNDRA VIKAS , FANG BINGLIANG , JI LINX X , YANG DAN
IPC分类号： C12N15/85 , A61K49/00 , C07K14/705
CPC分类号： C12N15/85 , A61K49/0002 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/203
摘要： Disclosed are nucleic acid sequences encoding a recombinant seven transmembrane G-protein associated receptor (GPCR) amino acid sequence operatively coupled to a tissue-selective promoter sequence. Also disclosed are methods of imaging or treating cells in a subject that involve introducing a nucleic acid encoding a reporter detectable in vivo using non-invasive methods operatively coupled to a tissue-selective promoter or amplified tissue specific promoter to the subject, and subjecting the subject to a non-invasive imaging technique or a therapeutic that selectively interacts with the reporter or gene of interest. For example, the subject may be a subject with cancer, and the therapeutic may be an anti-cancer agent. In particular, the hTERT promoter or amplified hTERT promoter drives expression of a reporter such hSSTR2 and/or hSSTR2 derivative) and these may be linked to a gene of interest. Imaging may be performed by a variety of methods including nuclear medicine.
摘要翻译：公开了编码与组织选择性启动子序列可操作偶联的重组七跨膜G蛋白相关受体（GPCR）氨基酸序列的核酸序列。还公开了在受试者中成像或治疗细胞的方法，其涉及使用与受试者的组织选择性启动子或扩增的组织特异性启动子有效连接的非侵入性方法引入编码可体内报道物的核酸的核酸，涉及与感兴趣的报告物或基因选择性相互作用的非侵入性成像技术或治疗剂。例如，受试者可以是具有癌症的受试者，并且治疗剂可以是抗癌剂。特别地，hTERT启动子或扩增的hTERT启动子驱动报道分子如hSSTR2和/或hSSTR2衍生物的表达），并且这些可以与感兴趣的基因连接。成像可以通过包括核医学在内的各种方法进行。

4. 发明申请

WO9946371A9 INDUCTION OF APOPTOTIC OR CYTOTOXIC GENE EXPRESSION BY ADENOVIRAL MEDIATED GENE CODELIVERY 审中-公开
标题翻译：由腺病毒介导的基因编码引起的诱导或细胞毒基因表达的诱导
公开(公告)号：WO9946371A9
公开(公告)日：2000-02-17
申请号：PCT/US9905359
申请日：1999-03-11
申请人： UNIV TEXAS , MCDONNELL TIMOTHY J , SWISHER STEPHEN G , FANG BINGLIANG , BRUCKHEIMER ELIZABETH M , SARKISS MONA G , JI LI , ROTH JACK A
发明人： MCDONNELL TIMOTHY J , SWISHER STEPHEN G , FANG BINGLIANG , BRUCKHEIMER ELIZABETH M , SARKISS MONA G , JI LI , ROTH JACK A
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/861 , C12N15/00 , A01N43/04
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/4747 , C12N2710/10343 , C12N2830/008
摘要： The present invention generally relates to viral vectors and their use as expression vectors for transforming human cells, both in vitro and in vivo. More particularly, the present invention relates to adenoviral vectors containing propapoptotic genes and their use in cancer therapy.
摘要翻译：本发明一般涉及病毒载体及其在体外和体内转化人细胞的表达载体的用途。更具体地，本发明涉及含有促凋亡基因的腺病毒载体及其在癌症治疗中的用途。

5. 发明申请

WO2006096815A3 NOVEL hTMC PROMOTER AND VECTORS FOR THE TUMOR-SELECTIVE AND HIGH-EFFICIENT EXPRESSION OF CANCER THERAPEUTIC GENES 审中-公开
标题翻译：新型hTMC推广者和肿瘤选择性和高效率表达癌症基因的载体
公开(公告)号：WO2006096815A3
公开(公告)日：2007-03-08
申请号：PCT/US2006008502
申请日：2006-03-09
申请人： UNIV TEXAS , FANG BINGLIANG , ROTH JACK A , JI LINX
发明人： FANG BINGLIANG , ROTH JACK A , JI LINX
IPC分类号： C12N15/67 , A61K48/00
CPC分类号： A61K48/0058 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： Promoters that include a tissue-selective promoter sequence and a second promoter sequence operatively coupled to the tissue-selective promoter sequence, wherein the second promoter sequence includes a minimal viral promoter sequence, are disclosed. Nucleic acids and compositions that include these promoter sequences are also disclosed. Also disclosed are methods of improving the function of a tissue-selective promoter, involving operatively coupling a tissue-selective promoter sequence with a second promoter sequence that includes a minimal viral promoter sequence. Also disclosed are methods of delivering a gene into a cell, methods of treating a subject with a hyperproliferative disease, and methods of imaging a cell that involve use of the novel promoter sequences set forth herein.
摘要翻译：包括组织选择性启动子序列和可操作地偶联于组织选择性启动子序列的第二启动子序列的启动子，其中第二启动子序列包括最小病毒启动子序列。还公开了包含这些启动子序列的核酸和组合物。还公开了改善组织选择性启动子功能的方法，其涉及将组织选择性启动子序列与包括最小病毒启动子序列的第二启动子序列可操作地偶联。还公开了将基因递送到细胞中的方法，用过度增殖性疾病治疗受试者的方法，以及涉及使用本文所述的新型启动子序列的细胞成像的方法。

6. 发明申请

WO9927123A9 MODIFIED SV40 VIRAL VECTORS 审中-公开
公开(公告)号：WO9927123A9
公开(公告)日：1999-09-16
申请号：PCT/US9825225
申请日：1998-11-25
申请人： UNIV TEXAS , FANG BINGLIANG , HIGHLANDER STEVEN L , CASEMENT KEVIN S , ROTH JACK A
发明人： FANG BINGLIANG , HIGHLANDER STEVEN L , CASEMENT KEVIN S , ROTH JACK A
IPC分类号： A61K48/00 , C12N15/86 , C12N15/87
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/22043
摘要： The present invention provides SV40-based viral vectors for use in the delivery of genes to target cells. The unique combination of multiple viral systems provides for vectors with increased carrying capacity and extended host range when compared to normal SV40 vectors. Uses for the vectors include the expression of proteins in vitro and in vivo.

7. 发明申请

WO9946371A3 INDUCTION OF APOPTOTIC OR CYTOTOXIC GENE EXPRESSION BY ADENOVIRAL MEDIATED GENE CODELIVERY 审中-公开
标题翻译：腺病毒介导的基因编码诱导细胞凋亡或细胞毒基因表达
公开(公告)号：WO9946371A3
公开(公告)日：2000-08-24
申请号：PCT/US9905359
申请日：1999-03-11
申请人： UNIV TEXAS , MCDONNELL TIMOTHY J , SWISHER STEPHEN G , FANG BINGLIANG , BRUCKHEIMER ELIZABETH M , SARKISS MONA G , JI LI , ROTH JACK A
发明人： MCDONNELL TIMOTHY J , SWISHER STEPHEN G , FANG BINGLIANG , BRUCKHEIMER ELIZABETH M , SARKISS MONA G , JI LI , ROTH JACK A
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/861 , C12N15/00 , A01N43/04
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/4747 , C12N2710/10343 , C12N2830/008
摘要： The present invention generally relates to viral vectors and their use as expression vectors for transforming human cells, both in vitro and in vivo. More particularly, the present invention relates to adenoviral vectors containing propapoptotic genes and their use in cancer therapy.
摘要翻译：本发明一般涉及病毒载体及其在体外和体内作为转化人细胞的表达载体的用途。更具体地说，本发明涉及含有促凋亡基因的腺病毒载体及其在癌症治疗中的应用。

8. 发明申请

WO2006099019A8 METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION 审中-公开
标题翻译：与基因表达VIVO成像相关的方法和组合
公开(公告)号：WO2006099019A8
公开(公告)日：2008-01-24
申请号：PCT/US2006008374
申请日：2006-03-09
申请人： UNIV TEXAS , KUNDRA VIKAS , FANG BINGLIANG , JI LIN X , YANG DAN
发明人： KUNDRA VIKAS , FANG BINGLIANG , JI LIN X , YANG DAN
IPC分类号： C12N15/85 , A61K49/00 , C07K14/705
CPC分类号： C12N15/85 , A61K49/0002 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/203
摘要： Disclosed are nucleic acid sequences encoding a recombinant seven transmembrane G-protein associated receptor (GPCR) amino acid sequence operatively coupled to a tissue-selective promoter sequence. Also disclosed are methods of imaging or treating cells in a subject that involve introducing a nucleic acid encoding a reporter detectable in vivo using non-invasive methods operatively coupled to a tissue-selective promoter or amplified tissue specific promoter to the subject, and subjecting the subject to a non-invasive imaging technique or a therapeutic that selectively interacts with the reporter or gene of interest. For example, the subject may be a subject with cancer, and the therapeutic may be an anti-cancer agent. In particular, the hTERT promoter or amplified hTERT promoter drives expression of a reporter such hSSTR2 and/or hSSTR2 derivative) and these may be linked to a gene of interest. Imaging may be performed by a variety of methods including nuclear medicine.
摘要翻译：公开了编码与组织选择性启动子序列可操作偶联的重组七跨膜G蛋白相关受体（GPCR）氨基酸序列的核酸序列。还公开了在受试者中成像或治疗细胞的方法，其涉及使用与受试者的组织选择性启动子或扩增的组织特异性启动子有效偶联的非侵入性方法引入编码可体内报道物的核酸的核酸，涉及与感兴趣的报告物或基因选择性相互作用的非侵入性成像技术或治疗剂。例如，受试者可以是具有癌症的受试者，并且治疗剂可以是抗癌剂。特别地，hTERT启动子或扩增的hTERT启动子驱动报道分子如hSSTR2和/或hSSTR2衍生物的表达），并且这些可以与感兴趣的基因连接。成像可以通过包括核医学在内的各种方法进行。

9. 发明公开

EP1956910A4 ONCOGENIC RAS-SPECIFIC CYTOTOXIC COMPOUND AND METHODS OF USE THEREOF 有权
标题翻译：致癌RAS特异性细胞毒性CONNECTION及其使用方法
公开(公告)号：EP1956910A4
公开(公告)日：2010-03-24
申请号：EP06840010
申请日：2006-11-22
申请人： UNIV TEXAS
发明人： FANG BINGLIANG , LIU JINSONG , GUO WEI , WU SHUHONG
IPC分类号： A01N43/38 , A61K31/405
CPC分类号： A61K31/404

10. 发明公开

EP1070122A4 INDUCTION OF APOPTIC OR CYTOTOXIC GENE EXPRESSION BY ADENOVIRAL MEDIATED GENE CODELIVERY 审中-公开
标题翻译：诱导细胞凋亡，细胞毒性基因表达腺病毒SWITCHED根共转移
公开(公告)号：EP1070122A4
公开(公告)日：2004-11-10
申请号：EP99913854
申请日：1999-03-11
申请人： UNIV TEXAS
发明人： MCDONNELL TIMOTHY J , SWISHER STEPHEN G , FANG BINGLIANG , BRUCKHEIMER ELIZABETH M , SARKISS MONA G , JI LI , ROTH JACK A
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/861 , C12N15/00 , A01N43/04 , A61P35/00 , C12N15/86
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/4747 , C12N2710/10343 , C12N2830/008
摘要： The present invention generally relates to viral vectors and their use as expression vectors for transforming human cells, both in vitro and in vivo. More particularly, the present invention relates to adenoviral vectors containing propapoptotic genes and their use in cancer therapy.

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