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2. 发明申请

WO2008109521A3 METHOD OF TREATMENT USING ATRANORIN 审中-公开
标题翻译：使用ATRANORIN治疗方法
公开(公告)号：WO2008109521A3
公开(公告)日：2008-12-24
申请号：PCT/US2008055655
申请日：2008-03-03
申请人： UNIV SOUTH FLORIDA , TAN JUN , SHYTLE ROLAND DOUGLAS , OBREGON DEMIAN
发明人： TAN JUN , SHYTLE ROLAND DOUGLAS , OBREGON DEMIAN
IPC分类号： C11B9/02
CPC分类号： A61K31/353 , A61K31/7048 , A61K36/09 , A61K2300/00
摘要： Disclosed herein is a method of treating a neurodegenerative disease, comprising the step of administering a therapeutically effective amount of Atranorin, or a closely related compound thereof. The neurodegenerative disease is Alzheimer's disease in one embodiment. The closely related compound is selected from the group consisting of chloroatranorin, evernic acid, barbatic acid, 4-O-demethyl-barbatic acid, lecanoric acid, diffratic acid and gyrophoric acid. Also disclosed is a method of treating a cellular proliferative disease, comprising the step of administering a therapeutically effective amount of Atranorin, or a closely related compound thereof. The cellular proliferative disease is cancer in one embodiment. The method of claim 1 wherein the closely related compound is selected from the group consisting of chloroatranorin, evernic acid, barbatic acid, 4-O-demethyl-barbatic acid, lecanoric acid, diffratic acid and gyrophoric acid
摘要翻译：本文公开了一种治疗神经退行性疾病的方法，其包括施用治疗有效量的阿特兰林或其紧密相关化合物的步骤。在一个实施方案中，神经变性疾病是阿尔茨海默氏病。密切相关的化合物选自氯丙酰胺，海藻酸，巴氏酸，4-O-去甲基 - 酸性酸，氨磺酸，异柠檬酸和旋花酸。还公开了一种治疗细胞增殖性疾病的方法，其包括施用治疗有效量的阿特兰林或其紧密相关的化合物的步骤。在一个实施方案中，细胞增殖性疾病是癌症。 2.根据权利要求1所述的方法，其中所述紧密相关的化合物选自氯化氨基葡萄糖苷，海藻酸，巴氏酸，4-O-去甲基 - 酸性酸，左旋肉碱酸，异柠檬酸和富马酸

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