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1. 发明申请

WO2004100888A2 METHODS FOR PREVENTING AND TREATING CANCER USING N-THIOLATED beta-LACTAM COMPOUNDS AND ANALOGS THEREOF 审中-公开
标题翻译：使用N-硫代β-乳糖化合物及其类似物预防和治疗癌症的方法
公开(公告)号：WO2004100888A2
公开(公告)日：2004-11-25
申请号：PCT/US2004014460
申请日：2004-05-06
申请人： UNIV SOUTH FLORIDA , DOU Q PING , TUROS EDWARD , SMITH DAVID M
发明人： DOU Q PING , TUROS EDWARD , SMITH DAVID M
IPC分类号： C07D205/08 , C07D491/04 , A61K
CPC分类号： C07D491/04 , C07D205/08
摘要： The subject invention concerns N-thiolated beta-lactam compounds, their analogs and pharmaceutically acceptable salts, esters and amides thereof. The subject invention also concerns methods for inducing tumor cell death or inhibiting tumor cell proliferation, and methods for inducing DNA damage, inhibiting DNA replication, activating p38 MAP kinase, or activating caspase cascade activation, or releasing cytochrome C from mitochondria into the cytoplasm in a tumor cell. Methods for treating cancer using N-thiolated beta-lactam compounds, as well as pharmaceutical compositions comprising the same are further disclosed.
摘要翻译：本发明涉及N-硫醇化的β-内酰胺化合物，其类似物和药学上可接受的盐，酯和酰胺。本发明还涉及诱导肿瘤细胞死亡或抑制肿瘤细胞增殖的方法，以及用于诱导DNA损伤，抑制DNA复制，激活p38 MAP激酶或激活胱天蛋白酶级联活化或将细胞色素C从线粒体释放到细胞质中的方法肿瘤细胞。使用N-硫醇化β-内酰胺化合物治疗癌症的方法以及包含其的药物组合物进一步公开。

2. 发明专利

CA13056A IMPROVEMENTS ON SEWING BOOKS AND IN MACHINERY THEREFOR 未知
公开(公告)号：CA13056A
公开(公告)日：1881-07-05
申请号：CA13056D
申请人： SMITH DAVID M
发明人： SMITH DAVID M

3. 发明申请

WO2006110485A3 METHOD AND SYSTEM FOR HANDLING LARGE DATA SETS IN A STATISTICAL LANGUAGE 审中-公开
标题翻译：用于处理统计语言中的大数据集的方法和系统
公开(公告)号：WO2006110485A3
公开(公告)日：2007-03-22
申请号：PCT/US2006012891
申请日：2006-04-07
申请人： INSIGHTFUL CORP , SMITH DAVID M , SANNELLA MICHAEL J , ROOSEN CHARLES B , DUNLAP WILLIAM W
发明人： SMITH DAVID M , SANNELLA MICHAEL J , ROOSEN CHARLES B , DUNLAP WILLIAM W
IPC分类号： G06F12/00
CPC分类号： G06K9/6253 , G06F17/18
摘要： Methods and systems for providing support for large data sets are provided. Example embodiments provide a Big Data Object Library "BDOL," which defines data structures and routines for handling big data objects using out of memory techniques. In one embodiment, the BDOL defines a bdFrame object which stores the data in binary form in a cache on an external storage medium, such as a file on a disk. The example BDOL provides support for user defined block processing a bdFrames using a pipeline engine. Also, the BDOL provides for Trellis plots, and other charts, of big data objects using hexagonal binning. This abstract is provided to comply with rules requiring an abstract, and it is submitted with the intention that it will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：提供了用于为大数据集提供支持的方法和系统。示例性实施例提供了一种大数据对象库“BDOL”，其定义了使用缺失内存技术来处理大数据对象的数据结构和例程。在一个实施例中，BDOL定义了一个bdFrame对象，该对象将二进制形式的数据存储在外部存储介质（例如盘上的文件）的高速缓存中。示例BDOL提供对使用流水线引擎的用户定义块处理bdFrames的支持。此外，BDOL为使用六边形分组的大型数据对象提供了网格图和其他图表。提供本摘要以符合要求摘要的规则，并提交其意图是不会用于解释或限制权利要求书的范围或含义。

4. 发明申请

WO2008048373A2 COMPOUNDS AND METHODS FOR MODULATING PROTEIN DEGRADATION 审中-公开
标题翻译：调节蛋白质降解的化合物和方法
公开(公告)号：WO2008048373A2
公开(公告)日：2008-04-24
申请号：PCT/US2007009205
申请日：2007-04-12
申请人： HARVARD COLLEGE , GOLDBERG ALFRED L , SMITH DAVID M
发明人： GOLDBERG ALFRED L , SMITH DAVID M
IPC分类号： A61K38/55
CPC分类号： A61K38/55 , A61K38/07
摘要： Compositions and methods for altering protein degradation by the 20S proteasome are provided. Screening assays for identifying compounds that modulate protein degradation are provided. Methods of treating disorders by modulating protein degradation are also provided.
摘要翻译：提供了20S蛋白酶体改变蛋白质降解的组合物和方法。提供了用于鉴定调节蛋白质降解的化合物的筛选测定法。还提供了通过调节蛋白质降解来治疗疾病的方法。

5. 发明申请

WO2010120913A2 UNIVERSAL MULTIPLE APERTURE MEDICAL ULTRASOUND PROBE 审中-公开
标题翻译：通用多孔医疗超声探头
公开(公告)号：WO2010120913A2
公开(公告)日：2010-10-21
申请号：PCT/US2010031075
申请日：2010-04-14
申请人： MAUI IMAGING INC , SMITH DAVID M , ADAM SHARON L , SPECHT DONALD F , LUNSFORD JOHN P , BREWER KENNETH D
发明人： SMITH DAVID M , ADAM SHARON L , SPECHT DONALD F , LUNSFORD JOHN P , BREWER KENNETH D
IPC分类号： A61B8/08 , G01N29/24
CPC分类号： A61B8/4218 , A61B8/00 , A61B8/12 , A61B8/145 , A61B8/4254 , A61B8/4444 , A61B8/445 , A61B8/4455 , A61B8/4477 , A61B8/4488 , A61B8/4494 , A61B8/54 , G01S15/003 , G01S15/8929
摘要： A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate physical apertures. Construction of probes can vary by medical application. That is, a general radiology probe can contain multiple transducers that maintain separate physical points of contact with the patient's skin, allowing multiple physical apertures. A cardiac probe may contain only two transmitters and receivers where the probe fits simultaneously between two or more intracostal spaces. An intracavity version of the probe can space transmit and receive transducers along the length of the wand, while an intravenous version can allow transducers to be located on the distal length the catheter and separated by mere millimeters. Algorithms can solve for variations in tissue speed of sound, thus allowing the probe apparatus to be used virtually anywhere in or on the body.
摘要翻译：多孔超声成像（MAUI）探针或换能器独特地能够从单独的物理孔径同时成像感兴趣区域。探针的构建因医疗应用而异。也就是说，一般的放射学探针可以包含多个换能器，其保持与患者皮肤分开的物理接触点，允许多个物理孔径。心脏探针可以仅包含两个发射器和接收器，其中探针同时在两个或更多个腔内空间之间配合。探针的腔内版本可以沿着棒的长度放置发射和接收换能器，而静脉内的形式可以使换能器位于导管的远端长度上并且分开仅仅毫米。算法可以解决声音组织速度的变化，从而允许探针设备实际上用于身体内部或身体的任何位置。

6. 发明申请

WO2013009994A3 RAIDED MEMORY SYSTEM 审中-公开
标题翻译： RAIDED存储系统
公开(公告)号：WO2013009994A3
公开(公告)日：2013-04-25
申请号：PCT/US2012046487
申请日：2012-07-12
申请人： VIOLIN MEMORY INC , BENNETT JON C R , SMITH DAVID M , BIEDERMAN DANIEL C
发明人： BENNETT JON C R , SMITH DAVID M , BIEDERMAN DANIEL C
IPC分类号： G06F13/14 , G06F13/16
CPC分类号： G06F3/0688 , G06F3/0611 , G06F3/0614 , G06F3/0659 , G06F3/0689
摘要： A memory system and a method for managing the system is described. The system is configured such a plurality of system controllers, which may be RAID controllers, receive requests from the external environment and distribute the requests to a plurality of memory modules such that data may be stored in the memory modules. A global sequence number is assigned to the data of a data stripe so that the operations related to the data stripe are performed in an ordered manner so that the data remains consistent. A plurality of system controllers may comprise a domain and access a plurality of memory controllers and a plurality of domains may include at least one common memory module.
摘要翻译：描述了一种用于管理该系统的存储器系统和方法。该系统被配置为使得多个系统控制器（其可以是RAID控制器）接收来自外部环境的请求并将请求分配给多个存储器模块，使得数据可以被存储在存储器模块中。将全局序列号分配给数据条带的数据，以便与数据条带相关的操作以有序的方式执行，以使数据保持一致。多个系统控制器可以包括域并访问多个存储器控制器，并且多个域可以包括至少一个公共存储器模块。

7. 发明申请

WO2010120907A2 MULTIPLE APERTURE ULTRASOUND ARRAY ALIGNMENT FIXTURE 审中-公开
标题翻译：多孔超声波阵列对准装置
公开(公告)号：WO2010120907A2
公开(公告)日：2010-10-21
申请号：PCT/US2010031067
申请日：2010-04-14
申请人： MAUI IMAGING INC , SPECHT DONALD F , BREWER KENNETH D , SMITH DAVID M , ADAM SHARON L , LUNSFORD JOHN P
发明人： SPECHT DONALD F , BREWER KENNETH D , SMITH DAVID M , ADAM SHARON L , LUNSFORD JOHN P
IPC分类号： A61B8/08 , G01N29/24
CPC分类号： A61B8/42 , A61B8/00 , A61B8/0883 , A61B8/4218 , A61B8/4444 , A61B8/4477 , A61B8/587 , G01S7/5205 , G01S15/8913 , Y10T29/49778
摘要： Increasing the effective aperture of an ultrasound imaging probe by including more than one probe head and using the elements of all of the probes to render an image can greatly improve the lateral resolution of the generated image. In order to render an image, the relative positions of all of the elements must be known precisely. A calibration fixture is described in which the probe assembly to be calibrated is placed above a test block and transmits ultrasonic pulses through the test block to an ultrasonic sensor. As the ultrasonic pulses are transmitted though some or all of the elements in the probe to be tested, the differential transit times of arrival of the waveform are measured precisely. From these measurements the relative positions of the probe elements can be computed and the probe can be aligned.
摘要翻译：通过包括多于一个探针头并使用所有探针的元件来渲染图像来增加超声成像探针的有效孔径可以极大地改善所产生的图像的横向分辨率。为了呈现图像，必须精确地知道所有元素的相对位置。描述了一种校准夹具，其中要校准的探针组件放置在测试块上方，并将超声波脉冲通过测试块传送到超声波传感器。由于超声波脉冲通过要测试的探头中的一些或全部元件传输，波形的到达差分传递时间被精确地测量。通过这些测量，可以计算探针元件的相对位置，并且可以对准探针。

8. 发明申请

WO2008054500A2 INTEGRATED ENGINE EXHAUST SYSTEMS AND METHODS FOR DRAG AND THERMAL STRESS REDUCTION 审中-公开
标题翻译：集成式发动机排气系统及其应用和减少热应力的方法
公开(公告)号：WO2008054500A2
公开(公告)日：2008-05-08
申请号：PCT/US2007008696
申请日：2007-04-06
申请人： BOEING CO , SHMILOVICH ARVIN , YADLIN YORAM , SMITH DAVID M , CLARK ROGER W
发明人： SHMILOVICH ARVIN , YADLIN YORAM , SMITH DAVID M , CLARK ROGER W
CPC分类号： B64D33/06 , F02K1/06 , F02K3/06 , F05D2250/14 , Y02T50/671
摘要： Integrated engine exhaust systems and methods for reducing drag and thermal loads are disclosed. In one embodiment, a propulsion system includes an engine installation configured to be mounted on a wing assembly of an aircraft. The engine installation includes an engine, and an exhaust system operatively coupled to the engine. The exhaust system includes at least one nozzle configured to exhaust an exhaust flow from the engine. The nozzle includes a variable portion configured to vary an exit aperture of the nozzle from a first shape to a second shape to change a flowfield shape of at least a portion of the nozzle flowfield proximate the wing assembly, thereby reducing at least one of drag and thermal loading on the wing assembly. In a further embodiment, the exhaust system includes an inner nozzle that exhausts a core exhaust flow, and an outer nozzle that exhausts a secondary exhaust flow, the outer nozzle having the variable portion configured to vary the exit aperture of the outer nozzle.
摘要翻译：公开了用于减少阻力和热负荷的集成发动机排气系统和方法。在一个实施例中，推进系统包括构造成安装在飞行器的翼组件上的发动机装置。发动机安装包括发动机和可操作地联接到发动机的排气系统。排气系统包括至少一个喷嘴，其构造成排出来自发动机的排气流。喷嘴包括可变部分，其被配置为将喷嘴的出口孔从第一形状改变到第二形状，以改变靠近翼组件的喷嘴流场的至少一部分的流场形状，从而减少阻力和机翼组件上的热负荷。在另一个实施例中，排气系统包括排出核心排气流的内部喷嘴和排出二次排气流的外部喷嘴，外部喷嘴具有可变部分，以改变外部喷嘴的出口孔径。

9. 发明申请

WO2012051305A3 MULTIPLE APERTURE PROBE INTERNAL APPARATUS AND CABLE ASSEMBLIES 审中-公开
标题翻译：多孔探头内部装置和电缆组件
公开(公告)号：WO2012051305A3
公开(公告)日：2012-08-16
申请号：PCT/US2011055973
申请日：2011-10-12
申请人： MAUI IMAGING INC , ADAM SHARON L , SMITH DAVID M , SPECHT DONALD F , BREWER KENNETH D
发明人： ADAM SHARON L , SMITH DAVID M , SPECHT DONALD F , BREWER KENNETH D
IPC分类号： A61B8/00 , G01N29/24 , H01B7/04
CPC分类号： A61B8/12 , A61B8/4477 , A61B8/4483 , G01S7/52047 , G01S7/52079 , G01S15/8915 , G01S15/8927 , G10K11/004
摘要： A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate physical apertures of ultrasound arrays. The probe can include separate backing plates configured to secure the ultrasound arrays in predetermined positions and orientations relative to one another. Some embodiments of the probe include flex circuit connected to the ultrasound arrays. In additional embodiments, a flex/PC board comprising flex connectors and an array of terminals is connected to the ultrasound arrays. Algorithms can solve for variations in tissue speed of sound, thus allowing the probe apparatus to be used virtually anywhere in or on the body.
摘要翻译：多孔超声成像（MAUI）探头或换能器独特地能够同时从超声阵列的物理孔径成像感兴趣的区域。探针可以包括被配置为将超声阵列固定在相对于彼此的预定位置和取向的单独背板。探针的一些实施例包括连接到超声阵列的柔性电路。在另外的实施例中，包括柔性连接器和端子阵列的柔性/ PC板连接到超声阵列。算法可以解决声音组织速度的变化，从而允许探针设备实际上用于身体内部或身体的任何位置。

10. 发明申请

WO2012051305A8 MULTIPLE APERTURE PROBE INTERNAL APPARATUS AND CABLE ASSEMBLIES 审中-公开
标题翻译：多孔探头内部设备和电缆组件
公开(公告)号：WO2012051305A8
公开(公告)日：2012-07-05
申请号：PCT/US2011055973
申请日：2011-10-12
申请人： MAUI IMAGING INC , ADAM SHARON L , SMITH DAVID M , SPECHT DONALD F , BREWER KENNETH D
发明人： ADAM SHARON L , SMITH DAVID M , SPECHT DONALD F , BREWER KENNETH D
IPC分类号： A61B8/00 , G01N29/24 , H01B7/04
CPC分类号： A61B8/12 , A61B8/4477 , A61B8/4483 , G01S7/52047 , G01S7/52079 , G01S15/8915 , G01S15/8927 , G10K11/004
摘要： A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate physical apertures of ultrasound arrays. The probe can include separate backing plates configured to secure the ultrasound arrays in predetermined positions and orientations relative to one another. Some embodiments of the probe include flex circuit connected to the ultrasound arrays. In additional embodiments, a flex/PC board comprising flex connectors and an array of terminals is connected to the ultrasound arrays. Algorithms can solve for variations in tissue speed of sound, thus allowing the probe apparatus to be used virtually anywhere in or on the body.
摘要翻译：多孔径超声成像（MAUI）探头或换能器独特地能够同时成像来自超声阵列的单独物理孔径的感兴趣区域。探针可以包括单独的背板，其被构造成将超声阵列相对于彼此固定在预定的位置和方向上。探针的一些实施例包括连接到超声阵列的柔性电路。在另外的实施例中，包括柔性连接器和端子阵列的柔性/ PC板连接到超声阵列。算法可以解决组织声速变化的问题，从而使探头装置几乎可以用在身体内部或身体上的任何地方。

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