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1. 发明申请

WO2005037209A3 A METHOD FOR THE SEPARATION ANTI-AMYLOID BETA ANTIBODY WITH AMYLOID BETA PEPTIDE 审中-公开
标题翻译：用于分离抗Aβ抗原的抗AMYLOID BETA肽的方法
公开(公告)号：WO2005037209A3
公开(公告)日：2006-03-23
申请号：PCT/US2004033748
申请日：2004-10-14
申请人： UNIV SOUTH FLORIDA , CAO CHUANHAI , LI QINGYOU , MORGAN DAVID G , UGEN KENNETH E
发明人： CAO CHUANHAI , LI QINGYOU , MORGAN DAVID G , UGEN KENNETH E
IPC分类号： G01N33/537 , A61K20060101 , C07K16/06 , C07K16/18 , G01N33/536 , G01N33/564
CPC分类号： C07K16/18 , C07K16/065 , G01N33/537 , G01N33/6854 , G01N33/6896
摘要： The present invention is a method of effectively dissociating an antibody and antigen from the complex they form. The method enables researchers to accurately identify anti-amyloid beta peptide and its antibody from sera samples. It can also be used for the evaluation of the outcome of Alzheimer's patient treatment based on the amyloid peptide load and antibody level in the sera.
摘要翻译：本发明是一种有效地将抗体和抗原与其形成的复合体解离的方法。该方法使研究人员能够从血清样品中准确鉴定抗淀粉样蛋白β肽及其抗体。它还可以用于评估阿尔茨海默病患者治疗结果，基于淀粉样蛋白肽负荷和血清抗体水平。

2. 发明申请

WO2010105035A2 PREVENTION, TREATMENT, AND DIAGNOSIS OF ALZHEIMER'S DISEASE THROUGH ELECTROMAGNETIC FIELD EXPOSURE 审中-公开
标题翻译：通过电磁场暴露预防，治疗和诊断阿尔茨海默病
公开(公告)号：WO2010105035A2
公开(公告)日：2010-09-16
申请号：PCT/US2010026952
申请日：2010-03-11
申请人： UNIV SOUTH FLORIDA , ARENDASH GARY W , CAO CHUANHAI , TAN JUN
发明人： ARENDASH GARY W , CAO CHUANHAI , TAN JUN
IPC分类号： A61N2/02 , A61N5/00
CPC分类号： A61N5/02 , A61N2/006 , A61N2/02
摘要： According to a first embodiment the invention includes a method of treating a neurological disorder, such as Alzheimer's Disease, in a subject in need thereof by positioning an electromagnetic field emitting source proximal to the subject and exposing the subject to an electromagnetic field having a predetermined frequency for a predetermined absorption period. Preferably, each individual treatment (comprising exposure to the predetermined frequency for the predetermined absorption period) is continued at a predetermined schedule (preferably daily) for a predetermined treatment period. The predetermined frequency, according to a preferred embodiment, is about918 MGH with a specific absorption rate (SAR) of about 0.25 W/kg +/-2 dB. The predetermined absorption period of this preferred embodiment is about one hour. The treatment period is long-term, being greater than about 6 months and preferably between about 7 and 9 months.
摘要翻译：根据第一实施方案，本发明包括通过将电磁场发射源定位在受试者的近侧并将受试者暴露于具有预定频率的电磁场的方式来治疗有需要的受试者中的神经系统疾病如阿尔茨海默病达到预定的吸收周期。优选地，每个单独的处理（包括以预定的频率暴露预定的吸收期）以预定的时间表（优选地每天）持续预定的治疗期。根据优选实施例，预定频率为大约918MGH，比吸收率（SAR）为约0.25W / kg +/- 2dB。该优选实施方案的预定吸收周期为约1小时。治疗期是长期的，大于约6个月，优选约7-9个月。

3. 发明申请

WO2008070284A3 AMYLOID BETA PEPTIDES AND METHODS OF USES THEREOF 审中-公开
标题翻译： AMYLOID BETA PEPTIDES及其使用方法
公开(公告)号：WO2008070284A3
公开(公告)日：2008-10-23
申请号：PCT/US2007081235
申请日：2007-10-12
申请人： JOHNNIE B BYRD SR ALZHEIMER S , CAO CHUANHAI
发明人： CAO CHUANHAI
IPC分类号： C07K14/47 , A61K39/00 , A61P25/28
CPC分类号： C07K14/4711
摘要： The application describes several mutant amyloid beta peptides and specific regions which are useful in the therapeutic and diagnostic of neurological diseases. The application further describes methods of using these mutant peptides as treatment and reagents for diagnosis of diseases. The application further describes diagnostic kits and pharmaceutical compositions for use in therapy to treat neurological diseases including but not limited to Alzheimer's disease and various forms of mild cognitive impairments.
摘要翻译：该申请描述了几种可用于治疗和诊断神经疾病的突变淀粉样蛋白β肽和特定区域。本申请进一步描述了使用这些突变肽作为诊断疾病的治疗剂和试剂的方法。本申请进一步描述了用于治疗神经疾病的诊断试剂盒和药物组合物，包括但不限于阿尔茨海默氏病和各种形式的轻度认知障碍。

4. 发明专利

CA3087418A1 DEAD ANTIGEN STIMULATED IMMATURE HETEROGENOUS DENDRITIC CELLS AS THERAPEUTICS FOR DISEASES 未知
公开(公告)号：CA3087418A1
公开(公告)日：2019-07-25
申请号：CA3087418
申请日：2019-01-18
申请人： UNIV SOUTH FLORIDA
发明人： CAO CHUANHAI , LIN XIAOYANG , HONG YUZHU
IPC分类号： A61K39/00 , A61P37/04 , C12N5/0784
摘要： Disclosed herein are exogenous antigen sensitized immature dendritic cells. The dendritic cell may also be dead. The exogenous antigen sensitized immature dendritic cells may be used to elicit an increased immune response. Further provided are vaccines comprising the exogenous antigen sensitized immature dendritic cells, methods, of inducing an immune response in a patient, and methods of treating a disease.

5. 发明专利

CA2542084A1 A METHOD FOR THE SEPARATION ANTI-AMYLOID BETA ANTIBODY WITH AMYLOID BETA PEPTIDE 未知
公开(公告)号：CA2542084A1
公开(公告)日：2005-04-28
申请号：CA2542084
申请日：2004-10-14
申请人： UNIV SOUTH FLORIDA
发明人： CAO CHUANHAI , LI QINGYOU , MORGAN DAVID G
IPC分类号： G01N33/537 , A61K20060101 , C07K16/06 , C07K16/18 , G01N33/536 , G01N33/564
摘要： The present invention is a method of effectively dissociating an antibody and antigen from the complex they form. The method enables researchers to accurately identify anti-amyloid beta peptide and its antibody from sera samples. It can also be used for the evaluation of the outcome of Alzheimer's patient treatment based on the amyloid peptide load and antibody level in the sera.

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