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    • 2. 发明申请
    • PLATINUM COMPLEXES FOR TARGETED DRUG DELIVERY
    • 用于定向药物递送的铂复合物
    • WO2007008247A3
    • 2007-07-05
    • PCT/US2005041129
    • 2005-11-10
    • UNIV SOUTH FLORIDAKAY HEIDI
    • KAY HEIDI
    • C07F15/00
    • C07F15/0093
    • The subject invention concerns biotin-conjugated platinum complexes that exhibit direct and indirect (immunological) antitumor cell activity. The subject invention also concerns the biotin-platinum complexes of the invention that have another molecule, such as an antibody, a ligand, a receptor, etc., bound to the biotin moiety. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.
    • 本发明涉及显示直接和间接(免疫)抗肿瘤细胞活性的生物素 - 缀合的铂络合物。 本发明还涉及具有与生物素部分结合的另一分子例如抗体,配体,受体等的本发明的生物素 - 铂络合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物在体内或体外的感染。