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1. 发明专利

SG11201602331QA COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS 未知
公开(公告)号：SG11201602331QA
公开(公告)日：2016-04-28
申请号：SG11201602331Q
申请日：2014-09-26
申请人： UNIV SINGAPORE , SILVER DAVID LAWRENCE
发明人： NGUYEN NAM LONG , ZAHLER ROBERT , SILVER DAVID LAWRENCE
IPC分类号： C07K14/00
摘要： The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.

2. 发明专利

AU2014324651B2 Compositions and methods utilizing lysophosphatidylcholine scaffolds 未知
公开(公告)号：AU2014324651B2
公开(公告)日：2019-03-14
申请号：AU2014324651
申请日：2014-09-26
申请人： NAT UNIV SINGAPORE , SILVER DAVID LAWRENCE
发明人： SILVER DAVID LAWRENCE , NGUYEN NAM LONG , ZAHLER ROBERT
IPC分类号： G01N33/50 , C07K14/00
摘要： The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.

3. 发明专利

CA2925613A1 COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS 未知
公开(公告)号：CA2925613A1
公开(公告)日：2015-04-02
申请号：CA2925613
申请日：2014-09-26
申请人： UNIV SINGAPORE , SILVER DAVID LAWRENCE
发明人： SILVER DAVID LAWRENCE , NGUYEN NAM LONG , ZAHLER ROBERT
IPC分类号： C07K14/00
摘要： The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.

4. 发明公开

EP3049429A4 COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS 有权转让
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN UNTER VERWENDUNG VONLYSOPHOSPHATIDYLCHOLINGERÜSTEN
公开(公告)号：EP3049429A4
公开(公告)日：2017-08-02
申请号：EP14847279
申请日：2014-09-26
申请人： NAT UNIV SINGAPORE
发明人： SILVER DAVID LAWRENCE , NGUYEN NAM LONG , ZAHLER ROBERT
IPC分类号： C07K14/00
CPC分类号： G01N33/92 , A01K67/0276 , A01K2227/105 , A01K2267/03 , A23L33/10 , A23V2002/00 , A61K31/685 , A61K49/0008 , A61K49/0052 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/502 , G01N33/5088 , G01N2333/705 , G01N2405/04 , G01N2500/10
摘要： The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.
摘要翻译：本发明涉及利用溶血磷脂酰胆碱支架的组合物和方法。该组合物和方法可以用于LPC介导的脂肪酸和其他分子的递送; 筛选和鉴定用于肠外营养的脂肪酸制剂; 以及用于活体动物器官成像等用途。本发明还提供了利用人Mfsd2a中的突变和多态性作为神经缺陷标志物的组合物和方法。

5. 发明专利

AU2021269324A1 Compositions and methods utilizing lysophosphatidylcholine scaffolds 未知
公开(公告)号：AU2021269324A1
公开(公告)日：2021-12-09
申请号：AU2021269324
申请日：2021-11-16
申请人： NAT UNIV SINGAPORE
发明人： SILVER DAVID LAWRENCE , NGUYEN NAM LONG , ZAHLER ROBERT
IPC分类号： G01N33/50 , C07K14/00
摘要： COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE Abstract The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.

6. 发明专利

AU2019201000A1 Compositions and methods utilizing lysophosphatidylcholine scaffolds 未知
公开(公告)号：AU2019201000A1
公开(公告)日：2019-03-07
申请号：AU2019201000
申请日：2019-02-13
申请人： NAT UNIV SINGAPORE
发明人： SILVER DAVID LAWRENCE , NGUYEN NAM LONG , ZAHLER ROBERT
IPC分类号： G01N33/50 , C07K14/00
摘要： COMPOSITIONS AND METHODS UTILIZING LYSOPHOSPHATIDYLCHOLINE SCAFFOLDS The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.

7. 发明专利

AU2014324651A1 Compositions and methods utilizing lysophosphatidylcholine scaffolds 未知
公开(公告)号：AU2014324651A1
公开(公告)日：2016-04-14
申请号：AU2014324651
申请日：2014-09-26
申请人： SILVER DAVID , UNIV SINGAPORE
发明人： SILVER DAVID LAWRENCE , NGUYEN NAM LONG , ZAHLER ROBERT
IPC分类号： C07K14/00
摘要： The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for LPC-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. The invention also provides compositions and methods for utilizing mutations and polymorphisms in human Mfsd2a as markers for neurological deficits.

8. 发明专利

ES2806751T3 Composiciones y métodos utilizando andamios de lisofosfatidilcolina 未知
公开(公告)号：ES2806751T3
公开(公告)日：2021-02-18
申请号：ES14847279
申请日：2014-09-26
申请人： NAT UNIV SINGAPORE
发明人： SILVER DAVID , NGUYEN NAM , ZAHLER ROBERT
IPC分类号： C07K14/00
摘要： Un método para seleccionar uno o más compuestos o ácidos grasos para determinar el transporte mediado por lisofosfatidilcolina (LPC) del uno o más compuestos o ácidos grasos a través de la proteína Mfsd2a, en donde el uno o más compuestos o ácidos grasos comprende un grupo de cabeza zwitteriónica y una cadena de acilo o alquilo, comprendiendo el método: (a) poner en contacto una mezcla biológica que comprende dicho uno o más compuestos o ácidos grasos con un ratón genéticamente modificado que comprende en su genoma una alteración homocigótica del gen Mfsd2a (ratón KO) y un ratón de tipo salvaje; (b) medir la cantidad de dicho uno o más compuestos o ácidos grasos en un tejido o fluido del ratón KO y el ratón de tipo salvaje; y (c) comparar la cantidad de dicho uno o más compuestos o ácidos grasos en el tejido o fluido del ratón KO y el ratón de tipo salvaje, en donde cantidades mayores de dicho uno o más compuestos o ácido graso en el ratón de tipo salvaje en comparación con el ratón KO, es una indicación de transporte del compuesto o ácido graso a través de la proteína Mfsd2a, en donde el tejido o fluido es cerebro u ojo.

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