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1. 发明专利

CO2022009852A2 Inhibidores de la proteína leucemia once-diecinueve (enl)/af9 yeats 未知
公开(公告)号：CO2022009852A2
公开(公告)日：2022-10-11
申请号：CO2022009852
申请日：2022-07-13
申请人： UNIV ROCKEFELLER , BRIDGE MEDICINES LLC
发明人： KHAN TANWEER A , LIVERTON NIGEL , FUKASE YOSHIYUKI , MICHINO MAYAKO , STAMFORD ANDREW W , MILLER MICHAEL W , HUGGINS DAVID , MEINKE PETER , ALLIS C DAVID , WAN LILING , VACCA JOSEPH , LADDUWAHETTY TAMMY
IPC分类号： A61K31/409 , A61P35/00 , C07D209/00 , C07D487/04
摘要： Se describen métodos y composiciones para tratar la leucemia. 6-aminoindoles acilados, 6-aminopirrolopiridinas aciladas y 3-aminopirrolo[3,2-c]piridazinas aciladas de la siguiente fórmula inhiben ENL/AF9 YEATS y, por lo tanto, son útiles para tratar la leucemia.

2. 发明专利

AU2020407589A1 Inhibitors of ENL/AF9 YEATS 未知
公开(公告)号：AU2020407589A1
公开(公告)日：2022-07-21
申请号：AU2020407589
申请日：2020-12-17
申请人： BRIDGE MEDICINES LLC , FUKASE YOSHIYUKI , HUGGINS DAVID , KHAN TANWEER A , LIVERTON NIGEL , MEINKE PETER , MICHINO MAYAKO , MILLER MICHAEL W , STAMFORD ANDREW W , THE ROCKEFELLER UNIV
发明人： KHAN TANWEER A , LIVERTON NIGEL , FUKASE YOSHIYUKI , MICHINO MAYAKO , STAMFORD ANDREW W , MILLER MICHAEL W , HUGGINS DAVID , MEINKE PETER , ALLIS C DAVID , WAN LILING , VACCA JOSEPH , LADDUWAHETTY TAMMY
IPC分类号： A61K31/409 , A61P35/00 , C07D209/00 , C07D487/04
摘要： Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF

3. 发明申请

WO2010033667A3 WSTF REGULATES THE DNA DAMAGE RESPONSE OF H2A.X VIA NOVEL TYROSINE KINASE ACTIVITY 审中-公开
标题翻译： WSTF通过新的酪氨酸激酶活性调节H2A.X的DNA损伤反应
公开(公告)号：WO2010033667A3
公开(公告)日：2010-06-03
申请号：PCT/US2009057263
申请日：2009-09-17
申请人： UNIV ROCKEFELLER , ALLIS C DAVID , XIAO ANDREW
发明人： ALLIS C DAVID , XIAO ANDREW
IPC分类号： G01N33/53
CPC分类号： C12N9/12 , C12Q1/485 , G01N33/6842 , G01N2500/02
摘要： The present invention relates to methods of detecting and regulating cellular DNA damage as well as methods of screening compounds suitable for modulating cellular DNA damage. The methods of the present invention utilize antibodies that selectively bind to a phosphorylated tyrosine residue in a SQEY tyrosine phosphorylation motif sequence or a phosphorylated serine residue in a KENSSQ phosphorylation motif sequence, where the phosphorylated serine residue is closest to the glutamine residue. Also encompassed by the present invention are methods of treating a subject having cancer. These methods involve the administration of an agent that modulates the phosphorylation of the tyrosine residue in a SQEY motif. Suitable agents for modulating the phosphorylation of the tyrosine residue of the SQEY motif are also disclosed.
摘要翻译：本发明涉及检测和调节细胞DNA损伤的方法以及筛选适于调节细胞DNA损伤的化合物的方法。本发明的方法利用选择性结合SQEY酪氨酸磷酸化基序序列中的磷酸化酪氨酸残基或KENSSQ磷酸化基序序列中的磷酸化丝氨酸残基的抗体，其中磷酸化丝氨酸残基最接近谷氨酰胺残基。本发明还包括治疗患有癌症的受试者的方法。这些方法涉及施用调节SQEY基序中酪氨酸残基的磷酸化的试剂。还公开了用于调节SQEY基元的酪氨酸残基磷酸化的合适试剂。

4. 发明申请

WO2010033658A3 CATHEPSIN L PROTEOLYTICALLY PROCESSES HISTONE H3 DURING MOUSE EMBROYONIC STEM CELL DIFFERENTIATION 审中-公开
标题翻译： CATHEPSIN L在小鼠胚胎干细胞分化过程中蛋白H3
公开(公告)号：WO2010033658A3
公开(公告)日：2010-07-15
申请号：PCT/US2009057249
申请日：2009-09-17
申请人： UNIV ROCKEFELLER , ALLIS C DAVID , DUNCAN ELIZABETH
发明人： ALLIS C DAVID , DUNCAN ELIZABETH
IPC分类号： A01K43/04 , A61K31/70
CPC分类号： A61K38/05 , A61K38/06 , A61K38/08
摘要： Methods and agents useful for modulating histone proteolysis, stem cell differentiation, and gene transcription and for treating cancer are disclosed. Antibodies or antigen binding fragments that selectively bind to histone- 3 cleavage products and are useful for diagnosing cancer and monitoring a subject's response to cancer treatment are also disclosed.
摘要翻译：公开了用于调节组蛋白蛋白水解，干细胞分化和基因转录和治疗癌症的方法和试剂。还公开了选择性结合组蛋白-3切割产物并且可用于诊断癌症并监测受试者对癌症治疗的反应的抗体或抗原结合片段。

5. 发明申请

WO2015157310A3 MODULATING CELL PROLIFERATION AND PLURIPOTENCY 审中-公开
标题翻译：调节细胞增殖和增殖
公开(公告)号：WO2015157310A3
公开(公告)日：2015-12-10
申请号：PCT/US2015024749
申请日：2015-04-07
申请人： SLOAN KETTERING INST CANCER , UNIV ROCKEFELLER
发明人： FINLEY LYDIA W S , CAREY BRYCE W , THOMPSON CRAIG B , ALLIS C DAVID
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071
CPC分类号： C12N5/0606 , A61K31/194 , C12N5/0696 , C12N2500/30 , C12N2501/727
摘要： Disclosed herein are compositions, systems, and methods for modulating proliferation, differentiation and pluripotency of cells.
摘要翻译：本文公开了用于调节细胞的增殖，分化和多能性的组合物，系统和方法。

6. 发明专利

AU2015243936A1 Modulating cell proliferation and pluripotency 未知
公开(公告)号：AU2015243936A1
公开(公告)日：2016-10-27
申请号：AU2015243936
申请日：2015-04-07
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , UNIV ROCKEFELLER
发明人： FINLEY LYDIA W S , CAREY BRYCE W , THOMPSON CRAIG B , ALLIS C DAVID
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071 , G06F19/00 , H01L35/02
摘要： Disclosed herein are compositions, systems, and methods for modulating proliferation, differentiation and pluripotency of cells.

7. 发明公开

EP3129466A4 MODULATING CELL PROLIFERATION AND PLURIPOTENCY 有权
标题翻译： MODULIERUNG VON ZELLPROIFERATION UND -PLURIPOTENZ
公开(公告)号：EP3129466A4
公开(公告)日：2017-09-20
申请号：EP15777539
申请日：2015-04-07
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , UNIV ROCKEFELLER
发明人： FINLEY LYDIA W S , CAREY BRYCE W , THOMPSON CRAIG B , ALLIS C DAVID
IPC分类号： A61K31/194 , C12N5/00 , C12N5/02 , C12N5/071 , C12N5/0735 , C12N5/074
CPC分类号： C12N5/0606 , A61K31/194 , C12N5/0696 , C12N2500/30 , C12N2501/727
摘要： Disclosed herein are compositions, systems, and methods for modulating proliferation, differentiation and pluripotency of cells.
摘要翻译：本文公开了用于调节细胞的增殖，分化和多能性的组合物，系统和方法。

8. 发明专利

AU2015243936B2 Modulating cell proliferation and pluripotency 未知
公开(公告)号：AU2015243936B2
公开(公告)日：2021-08-05
申请号：AU2015243936
申请日：2015-04-07
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , UNIV ROCKEFELLER
发明人： FINLEY LYDIA W S , CAREY BRYCE W , THOMPSON CRAIG B , ALLIS C DAVID
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071 , H01L35/02
摘要： Disclosed herein are compositions, systems, and methods for modulating proliferation, differentiation and pluripotency of cells.

9. 发明专利

CA2945027A1 MODULATING CELL PROLIFERATION AND PLURIPOTENCY 未知
公开(公告)号：CA2945027A1
公开(公告)日：2015-10-15
申请号：CA2945027
申请日：2015-04-07
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , UNIV ROCKEFELLER
发明人： FINLEY LYDIA W S , CAREY BRYCE W , THOMPSON CRAIG B , ALLIS C DAVID
IPC分类号： H01L35/02 , C12N5/02 , C12N5/071 , G06F19/00
摘要： Disclosed herein are compositions, systems, and methods for modulating proliferation, differentiation and pluripotency of cells.

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