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1. 发明专利

MXPA06013721A ADHESIVO MEDICO Y METODOS DE ADHESION DE TEJIDO. 未知
公开(公告)号：MXPA06013721A
公开(公告)日：2007-04-17
申请号：MXPA06013721
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , BUCKLEY MICHAEL , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00
摘要： Un adhesivo que incluye una mezcla de moleculas terminadas en isocianato formada al hacer reaccionar moleculas funcionales multi-isocianato con moleculas precursoras multi-funcionales que incluyen grupos funcionales terminales seleccionados del grupo que consiste de un grupo hidroxilo, un grupo amino primario y un grupo amino secundario. De preferencia, los grupos funcionales son grupos hidroxilo. Los compuestos precursores multi-funcionales son biocompatibles. Los precursores funcionales multiamina de las moleculas funcionales multi-isocianato tambien son biocompatibles. Como se discutio, en lo anterior, la mezcla de moleculas de preferencia tiene una funcionalidad de isocianato promedio de por lo menos 2.1 y, mas de preferencia, tiene una funcionalidad de isocianato promedio de por lo menos 2.5. Como tambien se describio en lo anterior, la mezcla de moleculas de preferencia tiene una viscosidad en el intervalo de aproximadamente 1 a aproximadamente 100 centipoises. La mezcla de moleculas forma una red polimerica reticulada en el contacto con el tejido organico en la presencia de agua. La red polimerica reticulada es biocompatible y biodegradable. La red polimerica reticulada se degrada en productos de degradacion que incluyen las moleculas precursoras y los precursores funcionales multiamina.

2. 发明专利

AU2004320265A2 Medical adhesive and methods of tissue adhesion 未知
公开(公告)号：AU2004320265A2
公开(公告)日：2005-12-15
申请号：AU2004320265
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BUCKLEY MICHAEL , BECKMAN ERIC J , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00

3. 发明专利

NZ550970A Medical adhesive and methods of tissue adhesion 未知
公开(公告)号：NZ550970A
公开(公告)日：2010-01-29
申请号：NZ55097004
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , BUCKLEY MICHAEL , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： C08G18/00 , A61L24/00 , A61L24/04
摘要： Disclosed is the use of a moisture-curable, isocyanate-functional composition in the manufacture of an adhesive for adhering tissue, the isocyanate-functional composition comprising the reaction product of a reaction mixture consisting essentially of: (a) a stoichiometric excess of multi-isocyanate functional molecules derived from multi-functional amino acid precursors; and (b) a multi-functional reactant selected from the group consisting of a saccharide, a polysaccharide, a steroid, glycerol, ascorbic acid, an amino acid, and combinations thereof, the multi-functional reactant having at least two isocyanate-reactive functional groups, wherein the reaction product has an average isocyanate functionality of at least 2.1.

4. 发明专利

AU2004320265B2 Medical adhesive and methods of tissue adhesion 未知
公开(公告)号：AU2004320265B2
公开(公告)日：2011-03-03
申请号：AU2004320265
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BUCKLEY MICHAEL , BECKMAN ERIC J , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00
摘要： An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group. Preferably, the functional groups are hydroxyl groups. The multi-functional precursor compounds are biocompatible. Multiamine functional precursors of the multi-isocyanate functional molecules are also biocompatible. As discussed, above, the mixture of molecules preferably has an average isocyanate functionality of at least 2.1 and, more preferably, has an average isocyanate functionality of at least 2.5. As also described above, the mixture of molecules preferably has a viscosity in the range of approximately 1 to approximately 100 centipoise. The mixture of molecules forms a crosslinked polymer network upon contact with the organic tissue in the presence of water. The crosslinked polymer network is biocompatible and biodegradable. The crosslinked polymer network degrades into degradation products including the precursor molecules and the multi-amine functional precursors.

5. 发明专利

BRPI0418804A 未知
公开(公告)号：BRPI0418804A
公开(公告)日：2007-10-16
申请号：BRPI0418804
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , BUCKLEY MICHAEL , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00

6. 发明专利

CA2576223A1 MEDICAL ADHESIVE AND METHODS OF TISSUE ADHESION 未知
公开(公告)号：CA2576223A1
公开(公告)日：2005-12-15
申请号：CA2576223
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , AGARWAL SUDHA , BUCKLEY MICHAEL , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00

7. 发明专利

AU2004320265A1 Medical adhesive and methods of tissue adhesion 未知
公开(公告)号：AU2004320265A1
公开(公告)日：2005-12-15
申请号：AU2004320265
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BUCKLEY MICHAEL , BECKMAN ERIC J , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00

8. 发明专利

CA2576223C A MOISTURE CURABLE, ISOCYANATE-FUNCTIONAL MEDICAL ADHESIVE AND METHODS OF TISSUE ADHESION 未知
公开(公告)号：CA2576223C
公开(公告)日：2013-10-08
申请号：CA2576223
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , BUCKLEY MICHAEL , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00
摘要： An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group. Preferably, the functional groups are hydroxyl groups. The multi-functional precursor compounds are biocompatible. Multiamine functional precursors of the multi-isocyanate functional molecules are also biocompatible. As discussed, above, the mixture of molecules preferably has an average isocyanate functionality of at least 2.1 and, more preferably, has an average isocyanate functionality of at least 2.5. As also described above, the mixture of molecules preferably has a viscosity in the range of approximately 1 to approximately 100 centipoise. The mixture of molecules forms a crosslinked polymer network upon contact with the organic tissue in the presence of water. The crosslinked polymer network is biocompatible and biodegradable. The crosslinked polymer network degrades into degradation products including the precursor molecules and the multi-amine functional precursors.

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