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1. 发明公开

EP3142750A4 COMPOSITIONS COMPRISING AAV EXPRESSING DUAL ANTIBODY CONSTRUCTS AND USES THEREOF 有权
公开(公告)号：EP3142750A4
公开(公告)日：2017-10-18
申请号：EP15792528
申请日：2015-05-13
申请人： UNIV PENNSYLVANIA
发明人： WILSON JAMES M , TRETIAKOVA ANNA
IPC分类号： A61P31/12 , C12N15/861
CPC分类号： C07K16/1018 , A61K48/0008 , A61K2039/507 , C07K2317/14 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/622 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14143 , C12N2830/205 , C12N2830/30 , C12N2830/50 , C12N2840/203

2. 发明申请

WO2015012924A3 TISSUE PREFERENTIAL CODON MODIFIED EXPRESSION CASSETTES, VECTORS CONTAINING SAME, AND USE THEREOF 审中-公开
标题翻译：组织优选代码改性表达载体，含有其的载体及其用途
公开(公告)号：WO2015012924A3
公开(公告)日：2015-03-19
申请号：PCT/US2014035880
申请日：2014-04-29
申请人： UNIV PENNSYLVANIA
发明人： WILSON JAMES M , TRETIAKOVA ANNA
IPC分类号： C12P19/34 , C07H21/04
CPC分类号： C12N15/85 , A61K48/0058 , C12N15/86 , C12N2750/14143 , C12N2800/22 , C12N2830/008
摘要： Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (ORF) for a protein under the control of regulatory sequences which direct expression of the product in cell, which ORF has been modified to preferentially increase expression levels in a selected tissue, wherein the modified ORF is characterized by a triplet frequency of any one of Tables 3 - 12, 16 or 17.
摘要翻译：本文描述了与非分泌性靶组织相比，在分泌中表达不同水平的蛋白质的同义改变的基因序列。一种表达盒，其包含在调节序列控制下的蛋白质的开放阅读框（ORF），所述调节序列指导产物在细胞中的表达，所述ORF已被修饰以优先增加选定组织中的表达水平，其中所述修饰的ORF被表征通过表3-12,16或17中任一个的三重频率。

3. 发明专利

AU2015259188B2 Compositions comprising AAV expressing dual antibody constructs and uses thereof 未知
公开(公告)号：AU2015259188B2
公开(公告)日：2021-07-29
申请号：AU2015259188
申请日：2015-05-13
申请人： UNIV PENNSYLVANIA
发明人： WILSON JAMES M , TRETIAKOVA ANNA
IPC分类号： A61P31/12 , C12N15/861
摘要： A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and a light chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF for a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5 ' and 3 ' ITRs flank the expression cassettes and regulatory sequences.

4. 发明专利

EA037980B1 РЕКОМБИНАНТНЫЙ АДЕНОАССОЦИИРОВАННЫЙ ВИРУС 未知
公开(公告)号：EA037980B1
公开(公告)日：2021-06-18
申请号：EA201692293
申请日：2015-05-13
申请人： UNIV PENNSYLVANIA
发明人： WILSON JAMES M , TRETIAKOVA ANNA
IPC分类号： A61P31/12 , C12N15/861
摘要： Настоящееизобретениеотноситсяк рекомбинантномуаденоассоциированномувирусу (AAV) дляэкспрессиив клеткедвухфункциональныхмоноспецифическихантител, имеющихразныетипыспецифичности. Такжеописанрекомбинантныйаденоассоциированныйвирус (AAV) дляэкспрессиидвухфункциональныхмоноспецифическихантители биспецифическогоантителав клетке. Настоящееизобретениетакжеотноситсяк фармацевтическойкомпозициидляэкспрессиидвухразныхфункциональныхмоноспецифическихантител, имеющихразныетипыспецифичности, вклетке, кспособудоставкидвухфункциональныхмоноспецифическихантител, имеющихразныетипыспецифичности, субъекту, атакжек композициидлядоставкидвухфункциональныхмоноспецифическихантител, имеющихразныетипыспецифичности, субъекту.

5. 发明专利

SI3142750T1 Sestavki, ki vsebujejo AAV izražen dvojni protitelesni konstrukt in uporaba le-tega 未知
公开(公告)号：SI3142750T1
公开(公告)日：2020-11-30
申请号：SI201531359
申请日：2015-05-13
申请人： UNIV PENNSYLVANIA
发明人： WILSON JAMES M , TRETIAKOVA ANNA
IPC分类号： C12N15/00 , A61P31/00

6. 发明专利

PE20170261A1 COMPOSICIONES QUE COMPRENDEN VIRUS ADENOASOCIADO (AAV) QUE EXPRESA CONSTRUCTOS DE ANTICUERPOS DUALES Y SUS USOS 未知
公开(公告)号：PE20170261A1
公开(公告)日：2017-04-12
申请号：PE2016002227
申请日：2015-05-13
申请人： UNIV PENNSYLVANIA
发明人： WILSON JAMES M , TRETIAKOVA ANNA
IPC分类号： A61P31/12 , C12N15/861
摘要： Se describe un virus adenoasociado (AAV) recombinante que tiene una capside de AAV y empaquetado en ella un acido nucleico heterologo que expresa dos constructos de anticuerpos funcionales en una celula. Tambien se describen anticuerpos que comprenden una cadena pesada y una cadena ligera procedentes de un anticuerpo heterologo. En una realizacion, los anticuerpos se coexpresan a partir de un vector que contiene: un primer casete de expresion que codifica al menos un primer marco de lectura abierto (ORF) para una primera inmunoglobulina controlado por las secuencias de control reguladoras que dirigen su expresion; un segundo casete de expresion que comprende un segundo ORF, un conector y un tercer ORF controlados por secuencias de control reguladoras que dirigen su expresion, donde el segundo y el tercer ORF codifican para un segundo y un tercer constructo de inmunoglobulina; el vector que coexpresa estos dos constructos de anticuerpos es en una realizacion un AAV, en el cual las ITR de 5' y 3' flanquean los casetes de expresion y las secuencias reguladoras

7. 发明专利

SA518391787B1 تركيبة لعلاج متلازمة كريغلر نجار 未知
公开(公告)号：SA518391787B1
公开(公告)日：2022-08-28
申请号：SA518391787
申请日：2018-06-12
申请人： UNIV PENNSYLVANIA
发明人： TRETIAKOVA ANNA , SIDRANE JENNY , WILSON JAMES
摘要： يقدمالاختراعمتواليةبولينيكلوتيد‏polynucleotide‏ (مثلا،جين،مثلا،حمضنوويريبوزي‏منقوصالأكسجين‏Deoxyribonucleic acid‏‏‎(DNA)‎‏أوحمضنوويريبوزي‏Ribonucleic acid‏‏‎(RNA)‎‏) ترمزيوريديندايفوسفاتجلوكورونوسيلترانسفيراز‏‎1A1‎‏‏uridine diphosphate ‎glucuronosyl transferase 1A1‎‏‏‎(UGT1A1)‎‏ (مثلا،تعبرعنيوريديندايفوسفات‏جلوكورونوسيلترانسفيراز‏‎1A1‎‏بشري). يقدمالاختراعأيضاموجه،مثلموجه‏vector‏فيروس‏مرتبطغديا‏adeno-associated virus‏ (‏AAV‏) (مثلا،فيروسمرتبطغديا 8) لهجينومموجه‏vector genome‏يتضمنمتوالياتتكرارطرفيةمحولة‏inverted terminal repeat sequences‏‏ومتواليةترميز‏coding sequence‏يوريديندايفوسفاتجلوكورونوسيلترانسفيراز‏‎1A1‎‏مرتبط‏بشكلعمليبواحدأوأكثرمنمتوالياتتعبيرمقارنة‏expression control sequences‏ (مثلا،‏متوالياتتعبيرمقارنةتتضمنمعززانتقائيللكبد‏liver-specific promoter‏). أيضاتمتقديم‏تركيباتتحتويعلىموجهاتفيروسمرتبطغدياهذهوطرقعلاجمتلازمة‏syndrome‏كريغلر‏نجار‏CRIGLER-Nijjar‏منالنوع‏I،متلازمة

8. 发明专利

AU2021204630A1 Compositions comprising AAV expressing dual antibody constructs and uses thereof 未知
公开(公告)号：AU2021204630A1
公开(公告)日：2021-07-29
申请号：AU2021204630
申请日：2021-07-01
申请人： UNIV PENNSYLVANIA
发明人： WILSON JAMES M , TRETIAKOVA ANNA
IPC分类号： A61P31/12 , C12N15/861
摘要： A recombinant adeno-associated virus (AAV) having an AAV capsid and 5 packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and a light chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of 10 regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF for a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5' and 3' 15 ITRs flank the expression cassettes and regulatory sequences.

9. 发明专利

DK3142750T3 SAMMENSÆTNINGER OMFATTENDE AAV, SOM UDTRYKKER DOBBELT-ANTISTOFKONSTRUKTER OG ANVENDELSER DERAF 未知
公开(公告)号：DK3142750T3
公开(公告)日：2020-09-14
申请号：DK15792528
申请日：2015-05-13
申请人： UNIV PENNSYLVANIA
发明人： TRETIAKOVA ANNA , WILSON JAMES M
IPC分类号： A61P31/12 , C12N15/861

10. 发明专利

PH12016502239B1 COMPOSITIONS COMPRISING AAV EXPRESSING DUAL ANTIBODY CONSTRUCTS AND USES THEREOF 未知
公开(公告)号：PH12016502239B1
公开(公告)日：2017-01-09
申请号：PH12016502239
申请日：2016-11-10
申请人： UNIV PENNSYLVANIA
发明人： WILSON JAMES M , TRETIAKOVA ANNA
IPC分类号： A61P31/12 , C12N15/861
摘要： A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and a light chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF for a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5 ' and 3 ' ITRs flank the expression cassettes and regulatory sequences.

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