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1. 发明申请

WO2016010610A3 IMIDAZOLE AND THIAZOLE COMPOSITIONS FOR MODIFYING BIOLOGICAL SIGNALING 审中-公开
标题翻译：用于改善生物信号的咪唑和噻唑组合物
公开(公告)号：WO2016010610A3
公开(公告)日：2016-04-07
申请号：PCT/US2015029487
申请日：2015-05-06
申请人： UNIV OHIO
发明人： GOETZ DOUGLAS , BERGMEIER STEPHEN C , MCMILLS MARK C , ORAC CRINA M
IPC分类号： A61K31/427 , A61K31/4166 , A61K31/428 , A61P33/00
CPC分类号： A61K31/4439 , A61K31/155 , A61K31/4166 , A61K31/427 , A61K31/428 , A61K45/06 , C07D233/84 , C07D277/16 , C07D277/36 , C07D277/84 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof; R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from -H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.
摘要翻译：具有通式（I）或通式（II）的化合物：其中R 1选自C 1至C 10脂族基或杂脂族基团，任选被一个或多个芳基取代的芳基，杂芳基，取代的杂芳基或其组合 ; R2选自芳族部分，取代的芳族部分，杂芳族部分，取代的杂芳族部分和香豆素; R3选自-H，C1至C10脂族或杂脂族基团，苯基或取代的苯基，其中脂族或杂脂族基团任选被一个或多个苯基，芳基，杂芳基，取代的杂芳基或其组合取代，并且其中所述脂族或杂脂族基团任选地与R 2结合形成环; X是S或O; 和Y是S或NH，可以用于改变生物信号传导过程的药物组合物或用于生物测定的试剂。

2. 发明申请

WO2008033793A3 SYNTHESIS OF METHYL NONACTATE DERIVATIVES 审中-公开
标题翻译：非离子表面活性剂衍生物的合成
公开(公告)号：WO2008033793A3
公开(公告)日：2008-10-09
申请号：PCT/US2007078095
申请日：2007-09-11
申请人： UNIV OHIO , BERGMEIER STEPHEN C , PRIESTLEY NIGEL D
发明人： BERGMEIER STEPHEN C , PRIESTLEY NIGEL D
IPC分类号： C07D249/04
CPC分类号： C07D405/06 , C07D405/14
摘要： Methyl nonactate is converted into a variety of different triazoloamide antibacterial agents by a reaction scheme involving (1) inversion of the secondary alcohol of the methyl nonactate to produce the corresponding azidoester, (2) converting the azido ester to the corresponding azidoamide, and (3) converting the azido group of the azidoamide to a triazole to produce the corresponding triazoloamide.
摘要翻译：通过涉及（1）反应非甲酸甲酯的仲醇以生成相应的叠氮酯，（2）将叠氮基酯转化为相应的叠氮基酰胺，以及（3）将叠氮基甲酸酯转化成各种不同的三唑酰胺抗菌剂）将叠氮基酰胺的叠氮基转化成三唑以产生相应的三唑酰胺。

3. 发明申请

WO2007062030A3 QUINUCLIDINONE DERIVATIVES AS ANTICANCER AGENTS 审中-公开
标题翻译：喹诺酮衍生物作为抗癌剂
公开(公告)号：WO2007062030A3
公开(公告)日：2008-01-24
申请号：PCT/US2006045045
申请日：2006-11-21
申请人： UNIV OHIO , BERGMEIER STEPHEN C , EVANS SUSAN C
发明人： BERGMEIER STEPHEN C , EVANS SUSAN C
IPC分类号： A01N43/26 , A01N43/12 , A61K31/335
CPC分类号： C07D491/20
摘要： New compounds of formula (I): wherein R 1 and R 2 may be the same or different and are selected from H, halo, alkyl, cycloalkyl, haloalkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, hydroxyl, acetate, ketal, alkoxy, and combinations thereof, and combinations thereof, or R 1 and R 2 may form a ring, as with an alkyl, alkenyl, substituted alkyl or substituted alkenyl bridge, and R 3 is O or hydroxyl. Also encompassed are derivatives, metabolites, and prodrugs thereof. Also provided are methods for preparing the quinuclidinone analogs disclosed herein. Further provided are methods of treating, preventing or delaying the onset of a cancer in a subject in need of such treatment by administering a an effective amount of a compound of formula (I), or a derivative, metabolite or prodrug thereof to a subject diagnosed with cancer or at risk of developing cancer.
摘要翻译：式（I）的新化合物：其中R 1和R 2可以相同或不同，并且选自H，卤素，烷基，环烷基，卤代烷基，芳基，卤代芳基，烷基芳基，烷氧基芳基，羟基，乙酸酯，缩酮，烷氧基及其组合，及其组合，或R 1和R 2可以形成环，烷基，烯基，取代的烷基或取代的烯基桥，R 3是O或羟基。还包括其衍生物，代谢物和前药。还提供了制备本文公开的奎宁环酮类似物的方法。还提供了通过将有效量的式（I）化合物或其衍生物，代谢物或前药给予被诊断的受试者来治疗，预防或延迟需要这种治疗的受试者的癌症发作的方法患有癌症或有发展癌症的风险。

4. 发明专利

CA2955582C IMIDAZOLE AND THIAZOLE COMPOSITIONS FOR MODIFYING BIOLOGICAL SIGNALING 未知
公开(公告)号：CA2955582C
公开(公告)日：2021-03-16
申请号：CA2955582
申请日：2015-05-06
申请人： UNIV OHIO
发明人： GOETZ DOUGLAS , BERGMEIER STEPHEN C , MCMILLS MARK C , ORAC CRINA M
IPC分类号： C07D417/06 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , C07D277/36 , C07D277/70 , C07D417/04
摘要： Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof; R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from -H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.

5. 发明专利

CA2955582A1 IMIDAZOLE AND THIAZOLE COMPOSITIONS FOR MODIFYING BIOLOGICAL SIGNALING 未知
公开(公告)号：CA2955582A1
公开(公告)日：2016-01-21
申请号：CA2955582
申请日：2015-05-06
申请人： UNIV OHIO
发明人： GOETZ DOUGLAS , BERGMEIER STEPHEN C , MCMILLS MARK C , ORAC CRINA M
IPC分类号： A61K31/427 , A61K31/4166 , A61K31/428 , A61P33/00
摘要： Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof; R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from -H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.

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