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1. 发明申请

WO9616196A3 Laser deposition of coatings 审中-公开
标题翻译：涂层的激光沉积
公开(公告)号：WO9616196A3
公开(公告)日：1996-07-18
申请号：PCT/GB9502703
申请日：1995-11-20
申请人： UNIV NOTTINGHAM , HOWDLE STEVEN MELVYN , ANTONOV EUGENE NIKOLAEVICH , BAGRATASHVILI VIKTOR NIKOLAIVI , POPOV VLADIMIR KARPOVICH , SOBOL EMIL NAUMOVICH
发明人： HOWDLE STEVEN MELVYN , ANTONOV EUGENE NIKOLAEVICH , BAGATASHVILI VIKTOR NIKOLAIVIC , POPOV VLADIMIR KARPOVICH , SOBOL EMIL NAUMOVICH
IPC分类号： A61F2/00 , A61F2/30 , A61L27/32 , C23C14/02 , C23C14/06 , C23C14/12 , C23C14/28 , C23C14/58 , C23C14/54
CPC分类号： C23C14/28 , A61F2/30767 , A61F2002/3097 , A61F2310/00023 , A61F2310/00796 , A61L27/32 , C23C14/022 , C23C14/06 , C23C14/12 , C23C14/5806 , C23C14/584
摘要： A method of coating a substrate by laser deposition comprises a pre-deposition laser treatment of a surface of the substrate prior to coating. Coating may be carried out on plastics or polymeric materials below the softening temperature. The substrate may be a medical or dental implant, and the coating an apatite or hydroxyapatite. The composition, biocompatibility and stability to dissolution in fluids of the coating may be controlled by selection of at least one laser deposition characteristic.

2. 发明申请

WO03045448B1 IMPREGNATION OF POLYMERIC SUBSTRATES WITH ANTIMICROBIAL SUBSTANCES USING SUPERFICIAL FLUIDS 审中-公开
标题翻译：使用超级流体将聚合物基质与抗微生物物质混合
公开(公告)号：WO03045448B1
公开(公告)日：2003-08-28
申请号：PCT/GB0205208
申请日：2002-11-20
申请人： UNIV NOTTINGHAM , HOWDLE STEVEN MELVYN , BAYSTON ROGER , WEBB PAUL BRIAN
发明人： HOWDLE STEVEN MELVYN , BAYSTON ROGER , WEBB PAUL BRIAN
IPC分类号： A61L2/232 , A61L2/238 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , A61L15/18 , A61L29/10
CPC分类号： A61L29/16 , A61L2/232 , A61L2/238 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/624 , Y10T428/31504
摘要： A method of impregnating a polymeric substrate with an antimicrobial substance or precursor thereto, in which said substance is impregnated into said substrate as a solution, an emulsion or a suspension in a supercritical fluid. Additionally, there is provided a method of impregnating a substantially transparent polymeric substrate with an antimicrobial substance or precursor thereto, wherein the polymeric substrate is capable of being swelled by a swelling agent which contains dissolved, suspended or emulsified therein said antimicrobial substance or precursor thereto, so as to permit impregnation of the polymeric substrate with the antimicrobial substance or precursor thereto. There is also provided a device obtained by such methods.
摘要翻译：一种用抗微生物物质或其前体浸渍聚合物基质的方法，其中所述物质作为溶液浸渍在所述基质中，乳液或悬浮液在超临界流体中。此外，提供了一种用抗微生物物质或其前体浸渍基本上透明的聚合物基质的方法，其中聚合物基质能够被其中含有溶解，悬浮或乳化在其中的抗微生物物质或前体的溶胀剂溶胀，以便允许用抗微生物物质或其前体浸渍聚合物基质。还提供了通过这种方法获得的装置。

3. 发明专利

AU2003209480B2 Polymer composite with internally distributed deposition matter 未知
公开(公告)号：AU2003209480B2
公开(公告)日：2008-07-03
申请号：AU2003209480
申请日：2003-03-10
申请人： UNIV NOTTINGHAM
发明人： WATSON MICHAEL STEVEN , HOWDLE STEVEN MELVYN , SHAKESHEFF KEVIN MORRIS , WHITAKER MARTIN JAMES
IPC分类号： A61K47/30 , A61K9/00 , A61K9/16 , A61L27/00 , C08J3/20 , D06M23/00
摘要： A process for the preparation of a polymer composite comprising internally distributed deposition matter wherein the process comprises providing a deposit of deposition matter at the surface of a solid state polymer substrate, contacting the surface deposited polymer with a plasticising fluid or a mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and internally distribute deposition matter, and releasing the plasticising fluid or fluids to obtain polymer composite.; A polymer composite comprising a porous or non porous polymer throughout which particulate deposition matter as hereinbefore defined is distributed with desired uniformity, preferably with high uniformity in excess of 80% for example in excess of 98%.; A scaffold comprising a polymer composite having internally distributed deposition matter; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

4. 发明专利

AU2003209480A1 POLYMER COMPOSITE WITH INTERNALLY DISTRIBUTED DEPOSITION MATTER 未知
公开(公告)号：AU2003209480A1
公开(公告)日：2003-09-29
申请号：AU2003209480
申请日：2003-03-10
申请人： UNIV NOTTINGHAM
发明人： HOWDLE STEVEN MELVYN , SHAKESHEFF KEVIN MORRIS , WHITAKER MARTIN JAMES , WATSON MICHAEL STEVEN
IPC分类号： A61K47/30 , A61K9/00 , A61K9/16 , A61L27/00 , C08J3/20 , D06M23/00 , A61K9/14
摘要： A process for the preparation of a polymer composite comprising internally distributed deposition matter wherein the process comprises providing a deposit of deposition matter at the surface of a solid state polymer substrate, contacting the surface deposited polymer with a plasticising fluid or a mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and internally distribute deposition matter, and releasing the plasticising fluid or fluids to obtain polymer composite.; A polymer composite comprising a porous or non porous polymer throughout which particulate deposition matter as hereinbefore defined is distributed with desired uniformity, preferably with high uniformity in excess of 80% for example in excess of 98%.; A scaffold comprising a polymer composite having internally distributed deposition matter; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

5. 发明专利

ES2241134T5 POLIMEROS BIOFUNCIONALES PREPARADOS EN UN FLUIDO SUPERCRITICO. 未知
公开(公告)号：ES2241134T5
公开(公告)日：2010-11-04
申请号：ES98920652
申请日：1998-05-06
申请人： UNIV NOTTINGHAM
发明人： HOWDLE STEVEN MELVYN , POPOV VLADIMIR
IPC分类号： A61K47/32 , A61K6/083 , A61K6/891 , A61K8/00 , A61K8/11 , A61K9/14 , A61K9/16 , A61K47/34 , A61L27/00 , A61L27/44 , A61L27/50 , A61Q11/00 , A61Q90/00 , B05D3/04 , B05D7/02
摘要： Se presenta un proceso para la preparación de una composición que comprende un substrato de polímero biofuncional y un substrato de material biofuncional adaptados para su uso en o en asociación con el cuerpo humano o animal, o materia viva cultivada o no cultivada, en donde el substrato de material biofuncional es básicamente insoluble de manera opcional en el substrato de polímero y/o en un fluido supercrítico, en donde el proceso comprende la puesta en contacto de una mezcla de los substratos o de sus precursores con u fluido supercrítico bajo condiciones supercríticas y condiciones de viscosidad reducida y de mezcla física para plastificar y engrosar el polímero y distribuir el substrato de material biofuncional a través del polímero y la liberación del fluido bajo condiciones subcríticas, en donde los substratos están adaptados para ser aislados en forma de una mezcla sólida que comprende el substrato de material biofuncional en una forma química básicamente sin alterar, y opcionalmente en una forma física básicamente sin alterar, también se presenta la composición obtenida mediante el procedimiento, las matrices poliméricas de la misma y el proceso para su preparación.

6. 发明专利

GB2401867B Polymer composite with internally distributed deposition matter 未知
公开(公告)号：GB2401867B
公开(公告)日：2005-10-05
申请号：GB0420591
申请日：2003-03-10
申请人： UNIV NOTTINGHAM
发明人： HOWDLE STEVEN MELVYN , SHAKESHEFF KEVIN MORRIS , WHITAKER MARTIN JAMES , WATSON MICHAEL STEVEN
IPC分类号： A61K47/30 , A61K9/00 , A61K9/16 , A61L27/00 , C08J3/20 , D06M23/00
摘要： A process for the preparation of a polymer composite comprising internally distributed deposition matter wherein the process comprises providing a deposit of deposition matter at the surface of a solid state polymer substrate, contacting the surface deposited polymer with a plasticising fluid or a mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and internally distribute deposition matter, and releasing the plasticising fluid or fluids to obtain polymer composite.; A polymer composite comprising a porous or non porous polymer throughout which particulate deposition matter as hereinbefore defined is distributed with desired uniformity, preferably with high uniformity in excess of 80% for example in excess of 98%.; A scaffold comprising a polymer composite having internally distributed deposition matter; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

7. 发明专利

AU2004285747A1 Preparing active polymer extrudates 未知
公开(公告)号：AU2004285747A1
公开(公告)日：2005-05-12
申请号：AU2004285747
申请日：2004-10-22
申请人： UNIV NOTTINGHAM
发明人： SHAKESHEFF KEVIN MORRIS , HAO JIANYUAN , HOWDLE STEVEN MELVYN , WHITAKER MARTIN JAMES
IPC分类号： C08J7/06 , B01J3/00 , B29C44/12 , C08J3/205 , C08J9/12 , C08J9/14
摘要： Process for preparing active polymer extrudate comprising polymer matrix and guest matter, the process comprising contacting a polymer substrate and guest matter with a plasticising fluid under dense phase, sub critical or supercritical plasticising conditions of elevated temperature and/or pressure to plasticise the polymer substrate and incorporate guest matter and extruding polymer substrate incorporating guest matter under dense phase, sub critical or supercritical conditions via an extrusion orifice into a collection zone or a mould with simultaneous or subsequent release of pressure, whereby extrudate is obtained comprising a solid admixture of polymer matrix and guest matter in form conferred by the orifice or the mould; a novel extrudate; composition thereof and apparatus for the preparation thereof, and use thereof in fibre processing techniques, medical applications such as in delivery of drugs and other agents such as imaging and diagnostic agents, tissue engineering, and as medical devices or aids such as delivery devices or aids for drugs, imaging and diagnostic agents, as tissue engineering devices or aids such as sutures, and the like; as an anti-microbial for example having bacteria-static or -cidal activity; as a natural or synthetic barrier capable of immobilising e.g. naturally occurring or artificially introduced poisons or toxins by e.g. absorption, interaction or reaction; in agrochemical or crop protection applications; in the processing of thermally labile fibres for use in dying, textiles, electronics etc below the polymer Tg, Tm or viscosity; in incorporation of dyes and other thermally labile materials into polymers that cannot be formed by traditional processes e.g. melt extrusion and the like; or in incorporation of surfactants into fibres to control polymer properties.

8. 发明专利

AU2002343039A1 IMPREGNATION OF POLYMERIC SUBSTRATES WITH ANTIMICROBIAL SUBSTANCES USING SUPERFICIAL FLUIDS 未知
公开(公告)号：AU2002343039A1
公开(公告)日：2003-06-10
申请号：AU2002343039
申请日：2002-11-20
申请人： UNIV NOTTINGHAM
发明人： WEBB PAUL BRIAN , HOWDLE STEVEN MELVYN , BAYSTON ROGER
IPC分类号： A61L2/232 , A61L2/238 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , A61L15/18 , A61L29/10
摘要： A method of impregnating a polymeric substrate with an antimicrobial substance or precursor thereto, in which said substance is impregnated into said substrate as a solution, an emulsion or a suspension in a supercritical fluid. Additionally, there is provided a method of impregnating a substantially transparent polymeric substrate with an antimicrobial substance or precursor thereto, wherein the polymeric substrate is capable of being swelled by a swelling agent which contains dissolved, suspended or emulsified therein said antimicrobial substance or precursor thereto, so as to permit impregnation of the polymeric substrate with the antimicrobial substance or precursor thereto. There is also provided a device obtained by such methods.

9. 发明专利

DE60307066D1 未知
公开(公告)号：DE60307066D1
公开(公告)日：2006-09-07
申请号：DE60307066
申请日：2003-03-11
申请人： UNIV NOTTINGHAM
发明人： HOWDLE STEVEN MELVYN , SHAKESHEFF KEVIN MORRIS , WHITAKER MARTIN JAMES , ROSE FELICITY ROSAMARI
IPC分类号： A61L27/38 , C12N11/02 , A61K6/083 , A61K6/891 , A61K6/893 , A61K6/898 , A61K8/64 , A61K8/73 , A61K8/96 , A61K8/97 , A61K8/98 , A61K9/16 , A61K35/12 , A61L27/00 , A61L27/56 , A61P43/00 , C08J3/20

10. 发明专利

HK1072779A1 Polymer composite with internally distributed deposition matter 未知
公开(公告)号：HK1072779A1
公开(公告)日：2005-09-09
申请号：HK05103309
申请日：2005-04-19
申请人： UNIV NOTTINGHAM
发明人： HOWDLE STEVEN MELVYN , SHAKESHEFF KEVIN MORRIS , WHITAKER MARTIN JAMES , WATSON MICHAEL STEVEN
IPC分类号： A61K47/30 , A61K9/00 , A61K9/16 , A61L27/00 , C08J3/20 , D06M23/00 , C08J
摘要： A process for the preparation of a polymer composite comprising internally distributed deposition matter wherein the process comprises providing a deposit of deposition matter at the surface of a solid state polymer substrate, contacting the surface deposited polymer with a plasticising fluid or a mixture of plasticising fluids under plasticising conditions to plasticise and/or swell the polymer and internally distribute deposition matter, and releasing the plasticising fluid or fluids to obtain polymer composite.; A polymer composite comprising a porous or non porous polymer throughout which particulate deposition matter as hereinbefore defined is distributed with desired uniformity, preferably with high uniformity in excess of 80% for example in excess of 98%.; A scaffold comprising a polymer composite having internally distributed deposition matter; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

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