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1. 发明申请

WO2008109165A3 MINERALIZED GUIDED BONE REGENERATION MEMBRANES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：矿化引导骨再生膜及其制备方法
公开(公告)号：WO2008109165A3
公开(公告)日：2008-11-27
申请号：PCT/US2008003106
申请日：2008-03-07
申请人： UNIV NEW YORK , LEGEROS RACQUEL Z , CHOU HUNG-KUO , MIJARES DINDO Q , LEGEROS JOHN P
发明人： LEGEROS RACQUEL Z , CHOU HUNG-KUO , MIJARES DINDO Q , LEGEROS JOHN P
IPC分类号： A61F2/28 , A61F2/02
CPC分类号： A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61F2310/00365 , A61L27/446 , A61L31/128 , C08L67/04
摘要： The present invention provides a method for mineralizing commercially available guided bone regeneration membranes. The method comprises the steps of (a) providing a commercially available guided bone regeneration membrane, (b) applying a mineralizing solution, and (c) microwaving the membrane. The method may further comprise (d) rinsing the membrane in a solution such as distilled water and (e) drying the membrane. The mineralizing solution may be a solution capable of supplying or delivering a mineral such as calcium or zinc. The invention further provides guided bone regeneration membranes made by the methods described. The guided bone regeneration membrane comprises a mineral, such as, for instance calcium or zinc at a weight percent of at least 5%, at least 10%, at least 12%, at least 15%, at least 18%, at least 20% or at least 25% (weight percent) of the membrane. Further, the invention provides methods for enhancing bone regeneration and methods for inhibiting bacterial infection and inflammation.
摘要翻译：本发明提供了一种使市售可得的引导的骨再生膜矿化的方法。该方法包括以下步骤：（a）提供可商购的引导的骨再生膜，（b）施加矿化溶液，和（c）对膜进行微波处理。该方法可以进一步包括（d）在诸如蒸馏水的溶液中冲洗该膜，并（e）干燥该膜。矿化溶液可以是能够供应或输送矿物质如钙或锌的溶液。本发明还提供了通过所述方法制备的引导的骨再生膜。引导的骨再生膜包含重量百分比为至少5％，至少10％，至少12％，至少15％，至少18％，至少20％的矿物质，例如钙或锌％或至少25％（重量百分比）的膜。此外，本发明提供了用于增强骨再生的方法和用于抑制细菌感染和炎症的方法。

2. 发明申请

WO2005077049A3 MACROPOROUS, RESORBABLE AND INJECTIBLE CALCIUM PHOSPHATE-BASED CEMENTS (MCPC) FOR BONE REPAIR, AUGMENTATION, REGENERATION, AND OSTEOPOROSIS TREATMENT 审中-公开
标题翻译：用于骨修复，补充，再生和骨质疏松症治疗的大面积，可重复和可注射的磷酸钙化疗（MCPC）
公开(公告)号：WO2005077049A3
公开(公告)日：2007-01-18
申请号：PCT/US2005004084
申请日：2005-02-10
申请人： UNIV NEW YORK , INST NAT SANTE RECH MED , UNIV NANTES , KHAIROUN IBRAHIM , LEGEROS RACQUEL Z , DACULSI GUY , BOULER JEAN-MICHAEL , GUICHEUX JEROME , GAUTHIER OLIVIER
发明人： KHAIROUN IBRAHIM , LEGEROS RACQUEL Z , DACULSI GUY , BOULER JEAN-MICHAEL , GUICHEUX JEROME , GAUTHIER OLIVIER
IPC分类号： C04B12/02 , A61L24/02 , A61L27/12 , C04B28/34
CPC分类号： C04B28/344 , A61L24/02 , A61L27/12 , A61L2430/02 , C04B2111/00836 , C04B11/00 , C04B14/28 , C04B20/0076 , C04B38/0051 , C04B2103/0072
摘要： A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing he timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.
摘要翻译：互连大孔，可吸收和可注射的磷酸钙基水泥（MICPs）的组合物和方法。本发明的组合物在混合粉末组分和水溶液之后设定为不良结晶的磷灰石磷酸钙。水泥中的多相磷酸钙组分以不同的速率吸收，可以及时更换新骨。水泥中相互连接的大孔隙可以使血管形成，生长因子的截留，细胞定植和组织向内生长。该MICPC可用于与骨修复，增强，重建，再生和骨质疏松症治疗相关的牙科和医疗应用，以及用于药物递送以及用作组织工程的支架。

3. 发明申请

WO2012135426A3 ANTI-BACTERIAL AND MINERALIZING CALCIUM PHOSPHATE COMPOSITIONS 审中-公开
标题翻译：抗细菌和矿化磷酸钙组合物
公开(公告)号：WO2012135426A3
公开(公告)日：2012-12-27
申请号：PCT/US2012031090
申请日：2012-03-29
申请人： UNIV NEW YORK , LEGEROS RACQUEL Z , GU HAIJING , MIJARES DINDO , SAXENA DEEPAK , BONEPUNDI SUDHA
发明人： LEGEROS RACQUEL Z , GU HAIJING , MIJARES DINDO , SAXENA DEEPAK , BONEPUNDI SUDHA
IPC分类号： A61K6/04 , A61K6/02 , A61K6/033 , A61P1/02
CPC分类号： A61K6/0017
摘要： The present invention provides compositions including saturated calcium phosphate (sCaP) solutions, that may be prepared from mixtures of calcium deficient apatite (prepared by precipitation), or any calcium phosphate compounds and one or more of sodium fluoride and zinc chloride, or F or Zn ions. The solutions may be prepared from mixtures of calcium compounds (e.g., calcium carbonate, calcium fluoride) and one or more of sodium or potassium phosphates, sodium or potassium fluoride and zinc salts with, for instance, either phosphoric or hydrochloric acids. The solutions may also be prepared from mixtures of calcium compounds and one or more of sodium or potassium oxalates, sodium or potassium phosphates, sodium or potassium fluoride and zinc salts. Such compositions may be useful for and may be provided in methods for one or more of increasing occlusion of dentin tubules, decreasing bacterial attachment to dentin tubules, decreasing bacterial growth or colonization on tooth surfaces such as enamel and dentin surfaces including on dentin tubules, increasing resistance to acid dissolution, inhibiting dental caries formation and progression and tooth decay and inhibiting development of tooth hypersensitivity. In many instances, the solutions are supersaturated with respect to F- or Zn-substituted calcium phosphates, and in many instances, the solutions are supersaturated with both F- and Zn- substituted calcium phosphates.
摘要翻译：本发明提供包含可由钙缺乏磷灰石（通过沉淀制备）或任何磷酸钙化合物和一种或多种氟化钠和氯化锌或F或Zn的混合物制备的饱和磷酸钙（sCaP）溶液的组合物离子。该溶液可以由钙化合物（例如碳酸钙，氟化钙）和一种或多种磷酸钠或磷酸钾，氟化钠或氟化钾和锌盐与例如磷酸或盐酸的混合物制备。该溶液也可以由钙化合物与一种或多种草酸钠或草酸钾，磷酸钠或磷酸钾，氟化钠或氟化钾和锌盐的混合物制备。这样的组合物可以用于以及可以用于一种或多种增加牙本质小管闭塞，减少细菌附着于牙本质小管，减少牙齿表面如牙釉质和牙本质表面包括牙本质小管上的细菌生长或定居，抗酸溶解性，抑制龋齿形成和进展以及龋齿并抑制牙齿过敏症的发展。在许多情况下，溶液相对于F-或Zn取代的磷酸钙过饱和，并且在许多情况下，溶液用F-和Zn-取代的磷酸钙过饱和。

4. 发明申请

WO2004098436A3 METHOD FOR PRODUCING ADHERENT COATINGS 审中-公开
标题翻译：生产涂料的方法
公开(公告)号：WO2004098436A3
公开(公告)日：2005-06-09
申请号：PCT/US2004013613
申请日：2004-05-03
申请人： UNIV NEW YORK , LEGEROS RACQUEL Z , LEGEROS JOHN P , LI SHUJIE
发明人： LEGEROS RACQUEL Z , LEGEROS JOHN P , LI SHUJIE
IPC分类号： A61C8/00 , A61C13/00 , A61L27/06 , A61L27/32 , C25D5/18
CPC分类号： A61C8/0013 , A61C8/0012 , A61C13/0012 , A61L27/06 , A61L27/32
摘要： A method for forming a highly adherent coating of a desired calcium phosphate phase on titanium-based substrates for use as orthopedic and dental implants. The calcium phosphate phase coating is electrochemically deposited onto the substrate from a metastable calcium phosphate electrolyte solution using a modulated electrical potential under pH, temperature and electrolyte composition and concentration conditions favorable for forming the desired calcium phosphate.
摘要翻译：一种用于在钛基基底上形成所需磷酸钙相的高附着性涂层以用作矫形和牙科植入物的方法。在pH，温度和电解质组成以及有利于形成所需磷酸钙的浓度条件下，使用调制电位，从亚稳态磷酸钙电解质溶液中将磷酸钙相涂层电化学沉积到基底上。

5. 发明申请

WO2007022211A3 ZINC-RELEASING ZINC-CALCIUM PHOSPHATE DENTAL COATING 审中-公开
标题翻译： ZINC-RELEASING ZINC-CALCUM PHOSPHATE DENTAL COATING
公开(公告)号：WO2007022211A3
公开(公告)日：2007-11-08
申请号：PCT/US2006031888
申请日：2006-08-15
申请人： UNIV NEW YORK , LEGEROS RACQUEL Z , LEGEROS JOHN P , PARK JAE HYUN , MIJARES DINDO
发明人： LEGEROS RACQUEL Z , LEGEROS JOHN P , PARK JAE HYUN , MIJARES DINDO
IPC分类号： B05D3/02
CPC分类号： A61C8/0012 , A61C7/00
摘要： The invention discloses compositions of Zn-releasing calcium phosphate (Zn-CaP) compounds for use as anti-bacterial coatings for both orthodontic brackets and dental implants. These methods for providing these compositions are also disclosed. Antibacterial coatings on orthodontic brackets will minimize the problems associated with orthodontic appliance, i.e., decalcification or caries formation around and under the orthodontic appliance and calculus formation around the orthodontic appliance. When applied as anti-bacterial coatings on dental implants they minimize the incidence of peri-implantitis that often lead to implant failure and eliminate the costly process of providing a smooth section in the implant. (While roughness is necessary for better osseointegration of the implant, the same roughness facilitates bacterial adhesion and colonization). Anti-bacterial coating on roughened Ti or Ti alloy substrate will also reduce the cost of implant manufacture since applying the coating will reduce the cost of the process of polishing part of the implant to provide a smooth surface less conducive to bacterial adhesion. The invention thus benefits the patients in two areas of dentistry: orthodontics and implant dentistry in terms of health and cost.
摘要翻译：本发明公开了用作正牙托槽和牙种植体的抗菌涂层的Zn释放磷酸钙（Zn-CaP）化合物的组合物。还公开了用于提供这些组合物的这些方法。正畸托架上的抗菌涂层将最小化与正畸器具相关的问题，即正畸器具周围和下方的脱钙或龋齿形成以及正畸器具周围的结石形成。当作为牙科植入物上的抗菌涂层使用时，它们可以最小化植入物周围炎的发生率，从而导致植入物失效，并消除在植入物中提供平滑部分的昂贵的过程。（虽然粗糙度对于植入物的更好的骨整合是必要的，但相同的粗糙度有助于细菌粘附和定植）。在粗糙化的Ti或Ti合金基材上的抗菌涂层也将降低植入物制造的成本，因为施加涂层将降低抛光部分植入物的过程的成本，以提供较少有利于细菌粘附的光滑表面。因此，本发明在两个牙科领域中的患者受益：正畸和植入牙科在健康和成本方面。

6. 发明申请

WO2005032466A3 CALCIUM PHOSPHATE-BASED MATERIALS CONTAINIG ZINC, MAGNESIUM, FLUORIDE AND CARBONATE 审中-公开
标题翻译：基于磷酸钙的材料包含锌，镁，氟和碳酸
公开(公告)号：WO2005032466A3
公开(公告)日：2005-12-22
申请号：PCT/US2004031780
申请日：2004-09-29
申请人： UNIV NEW YORK , LEGEROS RACQUEL Z
发明人： LEGEROS RACQUEL Z
IPC分类号： A61F2/28 , A61K20060101 , A61K6/033 , A61K31/315 , A61K33/06 , A61K33/16 , A61K33/42
CPC分类号： A61K31/315 , A61K33/06 , A61K33/16 , A61K33/30 , A61K33/42 , A61L27/12 , A61K2300/00
摘要： Compositions useful in the prevention and treatment of osteoporosis and for bone and fracture repair. Slow-releasing calcium phosphate-based materials are disclosed, incorporating Mg, Zn, F and carbonate, which will promote bone formation and inhibit bone resorption and thus be agents for the cited uses.
摘要翻译：用于预防和治疗骨质疏松症以及骨和骨折修复的组合物。公开了缓释磷酸钙基材料，其包括Mg，Zn，F和碳酸盐，其将促进骨形成并抑制骨吸收，因此是所引用的用途的试剂。

7. 发明公开

EP1761472A4 MACROPOROUS, RESORBABLE AND INJECTIBLE CALCIUM PHOSPHATE-BASED CEMENTS (MCPC) FOR BONE REPAIR, AUGMENTATION, REGENERATION, AND OSTEOPOROSIS TREATMENT 有权
标题翻译：大孔，可吸收与水泥注射磷酸钙骨修复，GAIN，再生，治疗骨质疏松症基于（MCPC）
公开(公告)号：EP1761472A4
公开(公告)日：2010-01-20
申请号：EP05713191
申请日：2005-02-10
申请人： UNIV NEW YORK , INST NAT SANTE RECH MED , UNIV NANTES
发明人： KHAIROUN IBRAHIM , LEGEROS RACQUEL Z , DACULSI GUY , BOULER JEAN-MICHAEL , GUICHEUX JEROME , GAUTHIER OLIVIER
IPC分类号： C04B12/02 , A61L24/02 , A61L27/12 , C04B28/34
CPC分类号： C04B28/344 , A61L24/02 , A61L27/12 , A61L2430/02 , C04B2111/00836 , C04B11/00 , C04B14/28 , C04B20/0076 , C04B38/0051 , C04B2103/0072

8. 发明专利

BRPI0507569A 未知
公开(公告)号：BRPI0507569A
公开(公告)日：2007-07-03
申请号：BRPI0507569
申请日：2005-02-10
申请人： UNIV NEW YORK , INST NAT SANTE RECH MED , UNIV NANTES
发明人： KHAIROUN IBRAHIM , LEGEROS RACQUEL Z , DACULSI GUY , BOULER JEAN-MICHAEL , GUICHEUX JEROME , GAUTHIER OLIVIER
IPC分类号： C04B12/02 , A61L24/02 , A61L27/12 , C04B28/34
摘要： A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.

9. 发明专利

AU2005211732B2 Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment 未知
公开(公告)号：AU2005211732B2
公开(公告)日：2010-09-30
申请号：AU2005211732
申请日：2005-02-10
申请人： INST NAT SANTE RECH MED , UNIV NEW YORK , THE UNIV OF NANTES
发明人： KHAIROUN IBRAHIM , DACULSI GUY , LEGEROS RACQUEL Z , GUICHEUX JEROME , GAUTHIER OLIVIER , BOULER JEAN-MICHAEL
IPC分类号： A61L24/02 , A61L27/12 , C04B12/02 , C04B28/34
摘要： A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.

10. 发明专利

CA2555379A1 MACROPOROUS, RESORBABLE AND INJECTIBLE CALCIUM PHOSPHATE-BASED CEMENTS (MCPC) FOR BONE REPAIR, AUGMENTATION, REGENERATION, AND OSTEOPOROSIS TREATMENT 未知
公开(公告)号：CA2555379A1
公开(公告)日：2005-08-25
申请号：CA2555379
申请日：2005-02-10
申请人： INST NAT SANTE RECH MED , UNIV NANTES , UNIV NEW YORK
发明人： GAUTHIER OLIVIER , KHAIROUN IBRAHIM , GUICHEUX JEROME , BOULER JEAN-MICHAEL , DACULSI GUY , LEGEROS RACQUEL Z
IPC分类号： A61L27/12 , A61L24/02 , A61L27/54 , C04B12/02 , C04B28/34
摘要： A composition and method for producing interconnective macroporous, resorbab le and injectable calcium phosphate-based cements (MICPs). The composition of t he invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing he timely replacement by new bone. The interconnected macroporosity in the cement allo ws for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.

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