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1. 发明申请

WO2012094529A3 GENES IMPLICATED IN RESISTANCE TO SOYBEAN CYST NEMATODE INFECTION AND METHODS OF THEIR USE 审中-公开
标题翻译：影响大豆胞囊线虫感染的基因及其使用方法
公开(公告)号：WO2012094529A3
公开(公告)日：2012-11-22
申请号：PCT/US2012020375
申请日：2012-01-05
申请人： UNIV MISSOURI , MITCHUM MELISSA GOELLNER , KANDOTH PRAMOD KAITHERI , YECKEL GREG , ITHAL NAGABHUSHANA
发明人： MITCHUM MELISSA GOELLNER , KANDOTH PRAMOD KAITHERI , YECKEL GREG , ITHAL NAGABHUSHANA
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C12N15/8285 , C07K14/415 , Y02A40/164
摘要： To gain new insights into the mechanism of soybean resistance to the soybean cyst nematode (Heterodera glycines), gene expression profiles of developing syncytia in soybean near-isogenic lines (NILs) differing at the at Rhg1 locus were compared. Gene expression profiling revealed that 1,447 genes were differentially expressed between the line that is resistant to SCN and the line that is sensitive to SCN infection. These results indicate that syncytia induced in the resistant line are undergoing severe oxidative stress and imbalanced endoplasmic reticulum homeostasis, both of which likely contribute to the resistance reaction. Defense-related genes up-regulated within syncytia of the resistant line included those predominantly involved in apoptotic cell death, the plant hypersensitive response, and salicylic acid (SA)-mediated defense signaling; many of these genes were partially suppressed by a virulent soybean cyst nematode population for successful nematode reproduction and development on the resistant line. Expression of these SCN responsive genes may be manipulated to obtain SCN resistant lines.
摘要翻译：为了获得大豆对大豆胞囊线虫（Heterodera glycines）抗性机制的新见解，比较了在Rhg1基因座处不同的大豆近等基因系（NIL）中发育合胞体的基因表达谱。基因表达谱分析显示，在对SCN有抗性的品系和对SCN感染敏感的品系之间差异表达了1447个基因。这些结果表明，在抗性系中诱导的合胞体正在经历严重的氧化应激和内质网平衡不平衡，这两者都可能有助于抗性反应。在抗性系的合胞体中上调的防御相关基因包括主要参与凋亡细胞死亡，植物超敏反应和水杨酸（SA）介导的防御信号传导的那些基因; 许多这些基因被强毒大豆胞囊线虫种群部分抑制，以用于成功的线虫繁殖和抗性品系的发育。可以操纵这些SCN应答基因的表达以获得SCN抗性系。

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