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1. 发明公开

EP2299900A4 METHOD AND SYSTEM FOR NON-INVASIVE OPTICAL BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA ANALYSIS 有权
标题翻译：方法和系统与SPEKTRALDATENANALYSE非侵入式光学血糖测量
公开(公告)号：EP2299900A4
公开(公告)日：2013-08-28
申请号：EP09751083
申请日：2009-04-17
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： A61B5/145 , A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/6826 , A61B5/6838 , A61B5/7225 , A61B2562/0238 , A61B2576/00
摘要： Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. A variety of techniques are disclosed for improving signal-to-noise ratio in the acquisition of spectral data and calculating attenuance of light attributable to blood in a sample. Disclosed techniques include (1) using a standard deviation operation in conjunction with the logarithm function, (2) using a normalization factor, (3) using a ratio factor, (4) accounting for the effect of temperature on various system components such as resistors, and (5) accounting for dark current in a light detector by performing a calibration.

2. 发明申请

WO2009120600A3 METHOD AND SYSTEM FOR NON-INVASIVE BLOOD GLUCOSE DETECTION UTILIZING SPECTRAL DATA OF ONE OR MORE COMPONENTS OTHER THAN GLUCOSE 审中-公开
标题翻译：一种或多种不同于葡萄糖的组分的非侵入性血液葡萄糖检测方法和系统利用光谱数据
公开(公告)号：WO2009120600A3
公开(公告)日：2009-12-10
申请号：PCT/US2009037805
申请日：2009-03-20
申请人： UNIV MISSOURI , XU ZHI
发明人： XU ZHI
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.
摘要翻译：公开了一种用于检测生物样品中的葡萄糖的方法和系统。这包括用光源照射生物样品，用检测器收集来自样品的透射的，透过的或反射的光，在光谱数据分析装置中产生除了葡萄糖之外的样品中的一个或多个成分的光谱数据，并分析光谱所述一个或多个组件的数据足以从所述光谱数据分析装置提供葡萄糖以外的一种或多种组分的光谱数据进行葡萄糖测量。

3. 发明公开

EP2089687A4 LIQUID CHROMATOGRAPHY DETECTOR AND FLOW CONTROLLER THEREFOR 审中-公开
标题翻译：液相色谱检测器及其控制装置
公开(公告)号：EP2089687A4
公开(公告)日：2010-04-14
申请号：EP07865307
申请日：2007-12-06
申请人： UNIV MISSOURI , GRACE W R & CO
发明人： XU ZHI , BOSE RAKESH , ANDERSON JAMES M
IPC分类号： G01N30/74 , G01N30/84
CPC分类号： G01N30/84 , G01N30/74 , G01N2030/8447 , G01N2030/847 , G01N2030/8494

4. 发明公开

EP1856492A4 ULTRASENSITIVE SPECTROPHOTOMETER 审中-公开
标题翻译： ULTRA SENSIBLES分光光度计
公开(公告)号：EP1856492A4
公开(公告)日：2009-07-01
申请号：EP06717941
申请日：2006-01-11
申请人： UNIV MISSOURI
发明人： LARSEN DAVID W , XU ZHI
IPC分类号： G01J3/42 , G01J3/427
CPC分类号： G01N21/31 , G01J3/02 , G01J3/0224 , G01J3/0262 , G01J3/0286 , G01J3/0291 , G01J3/42 , G01J2003/425 , G01N21/274 , G01N2021/3137 , G01N2201/0227 , G01N2201/0642 , G01N2201/127
摘要： The invention concerns measurements in which light interacts with matter giving rise to changes in light intensity, and preferred embodiment spectrophotometer devices of the invention provide for ultrasensitive measurements through a reflection interaction with matter. The level of light source noise in these measurements can be reduced in accordance with the invention. Preferred embodiments of the invention use sealed housings (112, 600, 700) lacking an internal light source, and reflection based sample and reference cells. In some embodiments a substantially solid thermally conductive housing (600, 700) is used. Other features of preferred embodiments include particular reflection based sample and reference cells. A total internal reflection embodiment includes, for example, a prism (302, 322, 622a, 623 a) including an interaction surface, a detector, a lens that focuses a beam output from the prism onto the detector, and a closed interaction volume having an inlet and an outlet for delivering gas or liquid to the interaction surface. In a specular reflection embodiment, a reflective surface (402, 422) is used instead of a prism. In a diffuse reflection embodiment a matte surface (502, 522) is used instead of a prism and the matte surface produces scattering. Aspects of the invention include identification of noise-contributing components in spectrophotometry and the select set of preferred features in a given embodiment, and noise levels very near the shot noise limit may be realized with application of preferred embodiment devices.

5. 发明公开

EP2194846A4 OPTICAL DEVICE COMPONENTS 审中-公开
标题翻译：成分的光学设备
公开(公告)号：EP2194846A4
公开(公告)日：2013-05-22
申请号：EP08830786
申请日：2008-09-12
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/6826 , A61B5/6838

6. 发明公开

EP2198268A4 OPTICAL DEVICE COMPONENTS 有权转让
标题翻译：光学设备的组件
公开(公告)号：EP2198268A4
公开(公告)日：2016-04-06
申请号：EP08836010
申请日：2008-10-03
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： G01N21/00 , A61B5/145 , A61B5/1455 , G01N21/359 , G01N21/47
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , G01N21/474

7. 发明申请

WO2007015954A3 FOCUSED DROPLET NEBULIZER FOR EVAPORATIVE LIGHT SCATTERING DETECTOR 审中-公开
标题翻译：用于蒸发式光散射检测器的聚焦滴管接头
公开(公告)号：WO2007015954A3
公开(公告)日：2008-10-30
申请号：PCT/US2006028289
申请日：2006-07-21
申请人： UNIV MISSOURI , LARSON DAVID W , XU ZHI
发明人： LARSON DAVID W , XU ZHI
IPC分类号： G01N15/02 , G01B9/08 , G01B11/00 , G01J3/40 , G01J3/46 , G01J3/52 , G01J4/00 , G01N21/00 , G01N21/25 , G01N21/84 , G01N21/85 , G01N21/90
CPC分类号： A61M11/005 , A61M11/001 , A61M16/1095 , G01N30/74 , G01N30/84 , G01N2030/847 , G01N21/47
摘要： A focused droplet nebulizer (104) of the invention produces substantially uniform droplets (210) of a predetermined size. Droplets (210) are pushed out through a small outlet orifice (306) by the contraction of a chamber. The droplets (210) can b'e carried on a substantially non-divergent path in a drift tube (108). A piezo-controlled membrane micro pump (202) acts in response to an electrical control signal to force a droplet out of the outlet orifice (306). The nebulizer can operate at frequencies permitting a stream of individual droplets (210) of the predetermined size to be sent along the substantially non-divergent path in the drift tube (108) in a preferred embodiment ELSD device.
摘要翻译：本发明的聚焦液滴雾化器（104）产生具有预定尺寸的基本均匀的液滴（210）。通过腔室的收缩将液滴（210）通过小出口孔（306）推出。液滴（210）可以在漂移管（108）中的基本上不发散的路径上承载。压电控制膜微泵（202）响应于电控制信号而起作用以迫使液滴离开出口孔（306）。雾化器可以在允许在预定尺寸的单个液滴（210）的流中沿着优选实施例ELSD装置中的漂移管（108）中的基本上非发散路径发送的频率下操作。

8. 发明申请

WO2006076353A3 ULTRASENSITIVE SPECTROPHOTOMETER 审中-公开
标题翻译：超声波分光光度计
公开(公告)号：WO2006076353A3
公开(公告)日：2007-01-11
申请号：PCT/US2006000805
申请日：2006-01-11
申请人： UNIV MISSOURI , LARSEN DAVID W , XU ZHI
发明人： LARSEN DAVID W , XU ZHI
IPC分类号： G01J3/42 , G01J3/427
CPC分类号： G01N21/31 , G01J3/02 , G01J3/0224 , G01J3/0262 , G01J3/0286 , G01J3/0291 , G01J3/42 , G01J2003/425 , G01N21/274 , G01N2021/3137 , G01N2201/0227 , G01N2201/0642 , G01N2201/127
摘要： The invention concerns spectrophotometer devices that provide for ultrasensitive measurements through a reflection interaction with matter. Embodiments of the invention use sealed housings (112, 600, 700) lacking an internal light source, and reflection based sample and reference cells. In some embodiments a substantially solid thermally conductive housing (600, 700) is used. Oilier features of preferred embodiments include particular reflection based sample and reference cells. A total internal reflection embodiment includes a prism (302, 322, 622a, 623a) including an interaction surface, a detector, a lens that focuses a beam output from the prism onto the detector, and a closed interaction volume having an inlet and an outlet for delivering gas or liquid to the interaction surface. In a specular reflection embodiment, a reflective surface (402, 422) is used. In a diffuse reflection embodiment a matte surface (502, 522) is used and the matte surface produces scattering.
摘要翻译：本发明涉及通过与物质的反射相互作用提供超灵敏测量的分光光度计装置。本发明的实施例使用缺少内部光源的密封壳体（112,600,700）和基于反射的样品和参考单元。在一些实施例中，使用基本上固体的导热壳体（600,700）。优选实施方案的更大的特征包括特定的基于反射的样品和参比细胞。全内反射实施例包括包括相互作用表面的棱镜（302,322,622a，623a），检测器，将从棱镜输出的光束聚焦到检测器上的透镜以及具有入口和出口用于将气体或液体输送到相互作用表面。在镜面反射实施例中，使用反射表面（402,422）。在漫反射实施例中，使用无光泽表面（502,522），并且无光泽表面产生散射。

9. 发明申请

WO2008070776A3 LIQUID CHROMATOGRAPHY DETECTOR AND FLOW CONTROLLER THEREFOR 审中-公开
标题翻译：液相色谱检测器及其流量控制器
公开(公告)号：WO2008070776A3
公开(公告)日：2008-07-31
申请号：PCT/US2007086641
申请日：2007-12-06
申请人： UNIV MISSOURI , GRACE W R & CO , XU ZHI , BOSE RAKESH , ANDERSON JAMES M
发明人： XU ZHI , BOSE RAKESH , ANDERSON JAMES M
IPC分类号： G01N1/00
CPC分类号： G01N30/84 , G01N30/74 , G01N2030/8447 , G01N2030/847 , G01N2030/8494
摘要： A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector.
摘要翻译：用于液相色谱检测器的流量控制器。流量控制器包括流动通道，其包括入口部分，与入口部分连通的控制通道部分和与所述控制通道部分连通的出口部分。控制通道部分的横截面积小于液相色谱检测器的漂移管的横截面面积，用于将液滴流通过较小的横截面积。流量控制器的形状和尺寸可以减小液相色谱检测器液滴流中的压力波动和湍流。

10. 发明申请

WO2008070775A2 LIQUID CHROMATOGRAPHY DETECTOR AND FLOW CONTROLLER THEREFOR 审中-公开
标题翻译：液相色谱检测器及其流量控制器
公开(公告)号：WO2008070775A2
公开(公告)日：2008-06-12
申请号：PCT/US2007086640
申请日：2007-12-06
申请人： UNIV MISSOURI , XU ZHI
发明人： XU ZHI
IPC分类号： B05B1/24
CPC分类号： G01N30/74 , G01N30/84 , G01N2030/847 , G01N2030/8494
摘要： A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector
摘要翻译：用于液相色谱检测器的流量控制器。流量控制器包括流动通道，其包括入口部分，与入口部分连通的控制通道部分和与所述控制通道部分连通的出口部分。控制通道部分的横截面积小于液相色谱检测器的漂移管的横截面面积，用于将液滴流通过较小的横截面积。流量控制器的形状和尺寸可以减小液相色谱检测器液滴流中的压力波动和湍流

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