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1. 发明申请

WO2007053648A3 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 审中-公开
标题翻译：治疗和诊断癌症的组合物和方法
公开(公告)号：WO2007053648A3
公开(公告)日：2007-07-12
申请号：PCT/US2006042561
申请日：2006-10-31
申请人： UNIV MICHIGAN , CLARKE MICHAEL F , HOEY TIM , WANG XINHAO , DYLLA SCOTT , GURNEY AUSTIN , DALERBA PIERRO , CHEN GRACE , PRINCE MARK
发明人： CLARKE MICHAEL F , HOEY TIM , WANG XINHAO , DYLLA SCOTT , GURNEY AUSTIN , DALERBA PIERRO , CHEN GRACE , PRINCE MARK
IPC分类号： C12N5/02 , C12N5/095 , G06K9/00
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译：本发明涉及用于表征，治疗和诊断癌症的组合物和方法。具体而言，本发明提供了癌症干细胞概况以及可用于癌症的诊断，表征，预后和治疗，特别是实体瘤干细胞的靶向的新型干细胞癌症标志物。

2. 发明申请

WO2012016136A2 MICROSCALE AND NANOSCALE STRUCTURES FOR MANIPULATING PARTICLES 审中-公开
标题翻译：用于操纵颗粒的微观和纳米级结构
公开(公告)号：WO2012016136A2
公开(公告)日：2012-02-02
申请号：PCT/US2011045880
申请日：2011-07-29
申请人： GEN HOSPITAL CORP , MASSACHUSETTS INST TECHNOLOGY , CHEN GRACE , FACHIN FABIO , TONER MEHMET , WARDLE BRIAN
发明人： CHEN GRACE , FACHIN FABIO , TONER MEHMET , WARDLE BRIAN
IPC分类号： G01N33/48 , G01N35/08
CPC分类号： C12M25/16 , B01L3/502707 , B01L3/502746 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0896 , B01L2400/086 , G01N15/1404 , G01N2015/1413
摘要： The devices and systems described herein include one or more fluid paths, e.g., channels, and one or more selectively permeable obstacles arranged in the fluid path(s), each including a plurality of aligned nanostructures, e.g., nanotubes or nanorods, defining an outer surface of the obstacle and an internal network of voids. The obstacle(s) can further include binding moieties applied to the outer surface and/or to the surfaces of the individual nanostructures within the obstacle(s). The devices can be manufactured by forming the dense groupings of nanostructures to extend outwards and upwards from a substrate; forming a fluidic channel, bonding the fluidic channel to the substrate; and optionally applying binding moieties to the obstacles. The devices can be used to manipulate cells within fluid samples.
摘要翻译：这里描述的装置和系统包括布置在流体路径中的一个或多个流体路径（例如通道）和一个或多个选择性渗透障碍物，每个包括多个对准的纳米结构（例如纳米管或纳米棒）障碍物的表面和空隙的内部网络。障碍物还可以包括施加到障碍物内的外表面和/或各个纳米结构的表面的结合部分。这些器件可以通过形成密集的纳米结构组从衬底向外和向上延伸来制造; 形成流体通道，将所述流体通道结合到所述衬底; 并任选地将结合部分应用于障碍物。这些设备可以用来操纵流体样本中的细胞。

3. 发明申请

WO2012064878A3 COUNTING PARTICLES USING AN ELECTRICAL DIFFERENTIAL COUNTER 审中-公开
标题翻译：使用电动微分计数器计算粒子
公开(公告)号：WO2012064878A3
公开(公告)日：2012-08-16
申请号：PCT/US2011060041
申请日：2011-11-09
申请人： GEN HOSPITAL CORP , MASSACHUSETTS INST TECHNOLOGY , UNIV ILLINOIS , DAKTARI DIAGNOSTICS INC , WATKINS NICHOLAS , BASHIR RASHID , RODRIGUEZ WILLIAM , CHENG XUANHONG , TONER MEHMET , CHEN GRACE , OPPENHEIMER AARON
发明人： WATKINS NICHOLAS , BASHIR RASHID , RODRIGUEZ WILLIAM , CHENG XUANHONG , TONER MEHMET , CHEN GRACE , OPPENHEIMER AARON
IPC分类号： G01N33/53 , C12M1/34 , G01N21/17 , G01N33/52
CPC分类号： G01N27/02 , B01L2200/0652 , B01L2300/0877 , C12M41/36 , G01N15/12 , G01N15/1245 , G01N33/56972 , G01N2015/1006 , G01N2015/1486
摘要： This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples.
摘要翻译：本公开涉及用于对感兴趣的粒子（诸如细胞）进行计数的方法和设备。该方法包括获得可能含有感兴趣颗粒的流体样品; 使用第一电差分计数器对所述样本的一部分中的所有类型的粒子进行计数以生成第一总和; 从流体样品的该部分去除任何感兴趣的颗粒; 在移除感兴趣的颗粒以产生第二总数之后，使用第二电差分计数器对留在流体样本的该部分中的任何颗粒进行计数; 以及通过从所述第一总数中减去所述第二总数来计算原始在所述流体样本中的感兴趣粒子的数量，其中所述差值是所述样本中的所述感兴趣粒子的数量。例如，可以使用这些方法和相关装置来产生用于全血样品中CD4 + T细胞计数的稳健，便宜的诊断试剂盒。

4. 发明申请

WO2005008446A3 CASHLESS PAYMENT SYSTEM 审中-公开
标题翻译：无偿支付系统
公开(公告)号：WO2005008446A3
公开(公告)日：2006-08-17
申请号：PCT/US2004023103
申请日：2004-07-16
申请人： ECOMMLINK , CHEN GRACE
发明人： CHEN GRACE
IPC分类号： G06Q40/00 , G06Q20/00 , G06Q30/00 , G07F7/08
CPC分类号： G07F7/0866 , G06Q20/04 , G06Q20/10 , G06Q20/108 , G06Q20/18 , G06Q20/20 , G06Q20/204 , G06Q20/363 , G06Q20/4014 , G06Q20/403 , G06Q30/06
摘要： A payment system that does not rely on credit or debit cards, does not require the merchant and purchaser to have compatible memberships to complete a transaction, and does not limit single transactions to a single account provides a wide range of flexibility permitting debit, credit, pre-paid and payroll cards to be accommodated in a seamless and invisible manner to the electronic transaction network. The transaction may be verified and approved at the point-of-sale whether or not the merchant is a member of a specific financial transaction system. Specifically, the point-of-sale transaction system permits an identified customer to use any of a variety of payment options to complete the transaction without requiring the merchant to pre-approve the type of payment selected by the customer. In one configuration, and in order to take advantage of the widespread use of the ATM/POS network, the invention uses a typical credit/debit card format to provide the identifying information in a stored value card. When a transaction is to be completed, the user enters the identifying information carried on the card at the point-of-sale. The system supports numerous types of identification methods from typical credit card structures with magnetic data strips to various biometric systems such as finger prints, facial recognition and the like. Specifically, once the user is identified, the transaction is managed by his membership data on record with the transaction processing system.
摘要翻译：不依赖信用卡或借记卡的付款系统不要求商家和购买者拥有相关的会员资格来完成交易，并且不将单一交易限制在一个帐户中，提供了广泛的灵活性，允许借记卡，信用卡，预付费和工资卡可以无缝和隐形的方式接纳到电子交易网络。该交易可以在销售点进行验证和批准，无论商家是否是特定金融交易系统的成员。特别地，销售点交易系统允许识别的客户使用各种支付选项中的任一种来完成交易，而不要求商家预先批准客户选择的支付类型。在一种配置中，为了利用ATM / POS网络的广泛使用，本发明使用典型的信用卡/借记卡格式在存储卡中提供识别信息。当交易完成时，用户在销售点输入卡上携带的识别信息。该系统支持从具有磁数据带的典型信用卡结构到各种生物特征系统（例如手指印刷，面部识别等）的多种识别方法。具体来说，一旦用户被识别，交易由他的交易处理系统记录的成员数据管理。

5. 发明专利

AU2006308847C1 Compositions and methods for treating and diagnosing cancer 未知
公开(公告)号：AU2006308847C1
公开(公告)日：2012-05-10
申请号：AU2006308847
申请日：2006-10-31
申请人： ONCOMED PHARM INC , UNIV MICHIGAN REGENTS
发明人： GURNEY AUSTIN , CHEN GRACE , HOEY TIM , CLARKE MICHAEL F , DALERBA PIERRO , PRINCE MARK , WANG XINHAO , DYLLA SCOTT
IPC分类号： C12N5/02 , C12N5/095 , G06K9/00
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.

6. 发明专利

CA2628255A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 未知
公开(公告)号：CA2628255A1
公开(公告)日：2007-05-10
申请号：CA2628255
申请日：2006-10-31
申请人： UNIV MICHIGAN
发明人： GURNEY AUSTIN , DALERBA PIERRO , HOEY TIM , WANG XINHAO , CLARKE MICHAEL F , DYLLA SCOTT , PRINCE MARK , CHEN GRACE
IPC分类号： C12N5/02 , C12N5/095 , G06K9/00

7. 发明专利

CA2628255C COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 未知
公开(公告)号：CA2628255C
公开(公告)日：2016-04-19
申请号：CA2628255
申请日：2006-10-31
申请人： UNIV MICHIGAN , ONCOMED PHARM INC
发明人： CLARKE MICHAEL F , HOEY TIM , WANG XINHAO , DYLLA SCOTT , GURNEY AUSTIN , DALERBA PIERO , CHEN GRACE , PRINCE MARK
IPC分类号： C12N5/02 , C12N5/095 , G06K9/00
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.

8. 发明专利

AU2006308847A1 Compositions and methods for treating and diagnosing cancer 未知
公开(公告)号：AU2006308847A1
公开(公告)日：2007-05-10
申请号：AU2006308847
申请日：2006-10-31
申请人： UNIV MICHIGAN
发明人： GURNEY AUSTIN , CHEN GRACE , HOEY TIM , CLARKE MICHAEL F , DALERBA PIERRO , PRINCE MARK , WANG XINHAO , DYLLA SCOTT
IPC分类号： C12N5/02 , C12N5/095 , G06K9/00

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