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1. 发明申请

WO2009064836A3 KYNURENINE-AMINOTRANSFERASE INHIBITORS 审中-公开
标题翻译： KUNURENINE-AMINOTRANSFERASE抑制剂
公开(公告)号：WO2009064836A3
公开(公告)日：2009-07-02
申请号：PCT/US2008083321
申请日：2008-11-13
申请人： UNIV MARYLAND , MITSUBISHI TANABE PHARMA CORP , SCHWARCZ ROBERT , KAJII YASUSHI , ONO SHIN-ICHIRO
发明人： SCHWARCZ ROBERT , KAJII YASUSHI , ONO SHIN-ICHIRO
IPC分类号： C07D401/10 , C07D401/06 , C07D403/02
CPC分类号： C07D498/06 , C07D215/56 , C07D401/04
摘要： Compounds of formula (I) : prodrug derivatives and/or pharmaceutically acceptable salt thereof, selectively inhibit the enzyme kynurenine aminotransferase, thereby reducing the synthesis of kynurenic acid. The compounds are used for the treatment of psychiatric and neurological diseases which benefit from an increase in glutamatergic and/or cholinergic neurotransmission, such as schizophrenia, depression, bipolar illness, anxiety and Alzheimer's disease. Furthermore, the compounds of the invention are useful for stimulating attention, memory and other cognitive processes in normal individuals of any age, including children, adolescents and the elderly. Additionally, the compounds of the invention are also useful for treatment of patients suffering from malaria by preventing parasite gametogenesis and fertility based on reduction of xanthurenic acid formation from its bioprecursor 3 -hydroxy kynurenine.
摘要翻译：式（I）化合物：前药衍生物和/或其药学上可接受的盐选择性地抑制犬尿氨酸转氨酶，由此减少犬尿烯酸的合成。该化合物用于治疗精神病和神经疾病，这些疾病受益于谷氨酸能和/或胆碱能神经传递的增加，如精神分裂症，抑郁症，双相情感障碍，焦虑和阿尔茨海默病。此外，本发明化合物可用于刺激任何年龄的正常个体，包括儿童，青少年和老年人的注意力，记忆力和其他认知过程。此外，本发明化合物还可用于通过防止寄生虫配子发生和基于从其生物前体3-羟基犬尿氨酸形成黄原酸形成的可育性来治疗患有疟疾的患者。

2. 发明公开

EP2222662A4 KYNURENINE-AMINOTRANSFERASE INHIBITORS 审中-公开
标题翻译：抑制剂尿氨酸转氨酶
公开(公告)号：EP2222662A4
公开(公告)日：2011-08-03
申请号：EP08850245
申请日：2008-11-13
申请人： UNIV MARYLAND , MITSUBISHI TANABE PHARMA CORP
发明人： SCHWARCZ ROBERT , KAJII YASUSHI , ONO SHIN-ICHIRO
IPC分类号： C07D401/10
CPC分类号： C07D498/06 , C07D215/56 , C07D401/04

3. 发明专利

JP2009112266A Psychoneurotic disorder-diagnosing marker, method for diagnosing psychoneurotic disorder, and method for evaluating curative for such disorder 审中-公开
标题翻译：心理障碍症状诊断标记，诊断心理障碍的方法，以及评估这种疾病的治疗方法
公开(公告)号：JP2009112266A
公开(公告)日：2009-05-28
申请号：JP2007290176
申请日：2007-11-07
申请人： Mitsubishi Tanabe Pharma Corp , 田辺三菱製薬株式会社
发明人： KAJII YASUSHI , KANZAKI KOJI , MIYAGAWA TAKESHI , YAMAZAKI NOBUYUKI , TOYAMA KEIKO
IPC分类号： C12Q1/68 , A61K45/00 , A61P25/24 , A61P25/28 , C12M1/00 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a new method for examining mental disorders based on biological characteristics, and to provide a method for searching a new substance capable of preventing or treating mental disorders. SOLUTION: A new gene whose expression level varies in a mental disorder was found by the following steps: By hierarchical clustering, clusters accumulated in a mental disorder patient and having a gene expression pattern resembling a CaMKIIα hetero-deletion seen in a model animal of schizophrenia are identified, and the gene expression profile of such a patient contained in the clusters is compared with those in a patient suffering from no mental disorder. Thus, the method for examining mental disorders using the gene and the method for searching a new substance capable of preventing or treating mental disorders are provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种基于生物特征检查精神障碍的新方法，并提供一种搜索能够预防或治疗精神障碍的新物质的方法。解决方案：通过以下步骤发现表达水平在精神障碍中变化的新基因：通过分级聚类，在精神障碍患者中聚集的簇并且具有类似于模型中观察到的CaMKIIα异常缺失的基因表达模式确定精神分裂症动物，并将该群体中包含的这种患者的基因表达谱与不患有精神障碍的患者进行比较。因此，提供了使用该基因检查精神障碍的方法和用于搜索能够预防或治疗精神障碍的新物质的方法。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2014087355A Psychoneurotic disorder-diagnosing marker, method for diagnosing psychoneurotic disorder, and method for evaluating therapeutic agent 有权
标题翻译：心理疾病诊断标记，诊断心理衰竭病症的方法和评估治疗剂的方法
公开(公告)号：JP2014087355A
公开(公告)日：2014-05-15
申请号：JP2013260672
申请日：2013-12-17
申请人： Mitsubishi Tanabe Pharma Corp , 田辺三菱製薬株式会社
发明人： KAJII YASUSHI , KANZAKI KOJI , MIYAGAWA TAKESHI , YAMAZAKI NOBUYUKI , TOYAMA KEIKO
IPC分类号： C12N15/09 , C07K16/18 , C12M1/00 , C12M1/34 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a new method for examining mental disorders based on biological characteristics, and to provide a method for searching for a new substance capable of preventing or treating mental disorders.SOLUTION: A new gene whose expression level varies in a mental disorder was found by the following steps: by hierarchical clustering, a cluster with accumulated mental disorder patients having a gene expression pattern resembling a CaMKIIα hetero-deletion seen in a model animal of schizophrenia is identified, and the gene expression profile of patients contained in the cluster is compared with that in a patient suffering from no mental disorder. Thus, the method for examining mental disorders using the gene and the method for searching for a new substance capable of preventing or treating mental disorders are provided.
摘要翻译：要解决的问题：提供一种基于生物特征检查精神障碍的新方法，并提供一种搜索能够预防或治疗精神障碍的新物质的方法。解决方案：一种新的基因，其表达水平在精神上变化通过以下步骤发现疾病：通过分层聚类，鉴定了在精神分裂症模型动物中观察到的具有类似于CaMKIIα异常缺失的基因表达模式的累积精神障碍患者的群体，并且包含在患者中的患者的基因表达谱与不患有精神障碍的患者进行比较。因此，提供了使用该基因检查精神障碍的方法和用于搜索能够预防或治疗精神障碍的新物质的方法。

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