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1. 发明申请

WO2010081862A2 METHODS AND PREPARATIONS FOR PROTECTING CRITICALLY ILL PATIENTS 审中-公开
标题翻译：保护关键病人的方法和准备
公开(公告)号：WO2010081862A2
公开(公告)日：2010-07-22
申请号：PCT/EP2010050426
申请日：2010-01-14
申请人： UNIV LEUVEN KATH , UNIV GRAZ , JOANNEUM RES FORSCHUNGSGMBH , WINDERICKX JORIS , VAN DEN BERGHE GREET , GUNST JAN , VANHOREBEEK ILSE , LANGOUCHE LIES , EISENBERG TOBIAS , MADEO FRANK , MAGNES CHRISTOPHE , SINNER FRANK
发明人： WINDERICKX JORIS , VAN DEN BERGHE GREET , GUNST JAN , VANHOREBEEK ILSE , LANGOUCHE LIES , EISENBERG TOBIAS , MADEO FRANK , MAGNES CHRISTOPHE , SINNER FRANK
IPC分类号： A61K31/132 , A61K31/198 , A61K45/06 , A61P3/00 , A61P21/00 , A61P43/00
CPC分类号： A61K31/132 , A61K31/198 , A61K31/7004 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a polyamine or a salt, solvate, or derivative thereof, such as spermine or spermidine for the treatment or prevention of a life threatening condition, such as multiple organ failure, in a critically ill patient with a non-infectuous disorder.
摘要翻译：本发明涉及多胺或其盐，溶剂化物或其衍生物如精胺或亚精胺用于治疗或预防危及生命的疾病如多器官功能衰竭的患者，不良反应

2. 发明申请

WO2012061907A2 OSTEOCLAST ACTIVITY 审中-公开
标题翻译： OSTEOCLAST活动
公开(公告)号：WO2012061907A2
公开(公告)日：2012-05-18
申请号：PCT/BE2011000064
申请日：2011-11-10
申请人： UNIV LEUVEN KATH , GUNST JAN , OWEN HELEN , VAN DEN BERGHE GREET , VANHOREBEEK LISE
发明人： GUNST JAN , OWEN HELEN , VAN DEN BERGHE GREET , VANHOREBEEK LISE
CPC分类号： A61K45/06 , A61K31/13 , A61K31/132 , A61K31/436 , A61K31/5415
摘要： The invention relates to medicaments and novel methods of treating metabolic bone diseases, and more particularly for treating or preventing Critical Illness Related Metabolic Bone Disease or of critical illness induced Osteopenia [ICD-10 M85.8, ICD-9 733.90, DiseasesDB 29870 or MeSH D001851] secondary to ICU Admission by sufficient autophagy inducing compound to inhibit or suppressing critical illness [MeSH Descriptor: C23.550.291.625] enhanced osteoclastogenesis or increased osteoclast differentiation. The disclosed therapeutic methods include administering of a autophagy activating compound to a mammal to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) maintain bone mass and/or bone quality or (5) inhibit bone resorption in particularly by inhibiting or reducing a process by which osteoclasts break down bone and release the minerals resulting in a transfer of calcium from bone fluid to the blood. The invention also provides methods for administering the autophagy activating compound to treat a bone disorder of hyperresorption of bone and/or enhanced activation of osteoclasts.
摘要翻译：本发明涉及治疗代谢性骨疾病的药物和新方法，更具体地涉及治疗或预防重症疾病相关代谢性骨病或关键疾病引起的骨质减退症[ICD-10 M85.8，ICD-9 733.90，DiseasesDB 29870或MeSH D001851]继发于ICU通过足够的自噬诱导化合物抑制或抑制危重疾病[MeSH Descriptor：C23.550.291.625]增强破骨细胞形成或破骨细胞分化增加。所公开的治疗方法包括向哺乳动物施用自噬活化化合物以：（1）治疗或预防骨退行性疾病; （2）慢骨退化; （3）恢复失骨; （4）保持骨质量和/或骨质量，或（5）特别是通过抑制或减少破骨细胞分解骨并释放矿物质导致钙从骨液转移至血液的过程来抑制骨吸收。本发明还提供了用于施用自噬活化化合物以治疗骨骼的过度吸收和/或增强的破骨细胞活化的骨病症的方法。

3. 发明专利

CO2019007531A2 3-hidroxibutirato solo o en combinación para su uso en el tratamiento de cuidados intensivos 未知
公开(公告)号：CO2019007531A2
公开(公告)日：2020-01-17
申请号：CO2019007531
申请日：2019-07-15
申请人： UNIV LEUVEN KATH
发明人： GOOSSENS CHLOË , LANGOUCHE LIES , VAN DEN BERGHE GREET , VANHOREBEEK ILSE
IPC分类号： A61K31/22 , A61K31/195 , A61K31/198 , A61K31/23 , A61K31/232 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61P43/00
摘要： RESUMEN Esta invención se refiere generalmente a métodos y composiciones para el tratamiento o prevención de miopatía por enfermedades graves y polineuropatía por enfermedad crítica y de la miopatía por enfermedades graves y polineuropatía por enfermedad crítica causada por enfermedades críticas que incluyen sepsis, sepsis crítica, sepsis crítica con choque séptico, y particularmente al uso de una combinación de suministro parenteral o enteral con un 3-hidroxibutirato.

4. 发明专利

AU2017381059A1 3-hydroxybutyrate alone or in combination for use in the treatment of critical care treatment 未知
公开(公告)号：AU2017381059A1
公开(公告)日：2019-07-25
申请号：AU2017381059
申请日：2017-12-04
申请人： UNIV LEUVEN KATH
发明人： GOOSSENS CHLOË , LANGOUCHE LIES , VAN DEN BERGHE GREET , VANHOREBEEK ILSE
IPC分类号： A61K31/22 , A61K31/195 , A61K31/198 , A61K31/23 , A61K31/232 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61P43/00
摘要： This invention relates generally to methods and compositions for the treatment or prevention of critical illness myopathy and critical illness polyneuropathy and of critical illness myopathy and critical illness polyneuropathy caused by critical illnesses including sepsis, severe sepsis, severe sepsis with septic shock, and particularly to the use of a combination of parenteral or enteral feeding with a 3-hydroxybutyrate.

5. 发明专利

CA3047362A1 3-HYDROXYBUTYRATE ALONE OR IN COMBINATION FOR USE IN THE TREATMENT OF CRITICAL CARE TREATMENT 未知
公开(公告)号：CA3047362A1
公开(公告)日：2018-06-28
申请号：CA3047362
申请日：2017-12-04
申请人： UNIV LEUVEN KATH
发明人： GOOSSENS CHLOE , LANGOUCHE LIES , VAN DEN BERGHE GREET , VANHOREBEEK ILSE
IPC分类号： A61K31/22 , A61K31/195 , A61K31/198 , A61K31/23 , A61K31/232 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61P43/00
摘要： This invention relates generally to methods and compositions for the treatment or prevention of critical illness myopathy and critical illness polyneuropathy and of critical illness myopathy and critical illness polyneuropathy caused by critical illnesses including sepsis, severe sepsis, severe sepsis with septic shock, and particularly to the use of a combination of parenteral or enteral feeding with a 3-hydroxybutyrate.

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