专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005085471A3 METHOD AND MEANS FOR DIFFERENTIAL DIAGNOSIS OF THYROID TUMOURS 审中-公开
标题翻译：的方法和手段对甲状腺肿瘤的鉴别诊断
公开(公告)号：WO2005085471A3
公开(公告)日：2006-03-02
申请号：PCT/DE2005000421
申请日：2005-03-03
申请人： UNIV LEIPZIG , FUEHRER DAGMAR , PASCHKE RALF , ESZLINGER MARKUS , KROHN KNUT
发明人： PASCHKE RALF , ESZLINGER MARKUS , KROHN KNUT
IPC分类号： C12Q1/68
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： The invention relates to a method and agent for differential diagnosis of thyroid tumours, particularly for distinguishing benign thyroid nodules from thryroid carcinomas. The method and the agents are used in clinical diagnosis of tumours. By comparatively analysing gene expression in thyroid carcinomas and benevolent thyroid nodules, it is possible to identify differentially expressed genes, whose expression in the case of thyroid carcinomas or benevolent thyroid nodules, is specifically increased or reduced. The inventive method, wherein RNA is isolated from a tissue sample of the thyroid and the expression of at least one of the differentially expressed genes is quantified in the isolated RNA, makes it possible to distinguish between benevolent thyroid nodules and thyroid carcinomas. The percentage of thyroid punctures, wherein no sufficient judgement is possible according to prior art, is minimized and unnecessary operations on the thyroid can be avoided.
摘要翻译：本发明涉及一种方法和装置，用于甲状腺肿瘤的鉴别诊断，尤其是对于良性甲状腺的分化结节甲状腺癌。该方法和装置上的应用的临床诊断肿瘤的被使用。通过基因表达的甲状腺癌和良性甲状腺结节的比较分析鉴定差异表达的基因，其表达在甲状腺癌或良性甲状腺结节特异性增加或减少。其中来自甲状腺的组织样品并在分离的RNA分离的RNA的本发明的方法进行量化的差异表达的基因中的至少一种的表达，有利地良性甲状腺结节可以从甲状腺癌区分开来。因此，甲状腺穿刺的百分比，其中，现有技术没有提供足够的评价，并因此最小化，可避免不必要的甲状腺手术。

2. 发明专利

DE102005011003B4 未知
公开(公告)号：DE102005011003B4
公开(公告)日：2008-07-31
申请号：DE102005011003
申请日：2005-03-03
申请人： UNIV LEIPZIG
发明人： PASCHKE RALF , ESZLINGER MARKUS , KROHN KNUT , FUEHRER DAGMAR
IPC分类号： C07H21/04 , C12N15/11 , C12Q1/68 , G01N33/50

3. 发明专利

DE102005011003B9 未知
公开(公告)号：DE102005011003B9
公开(公告)日：2009-02-26
申请号：DE102005011003
申请日：2005-03-03
申请人： UNIV LEIPZIG
发明人： PASCHKE RALF , ESZLINGER MARKUS , KROHN KNUT , FUEHRER DAGMAR
IPC分类号： C07H21/04 , C12N15/11 , C12Q1/68 , G01N33/50

4. 发明专利

DE102005011003A1 Differentiating between different forms of malignant and benign thyroid tumors, based on altered expression of selected genes in thyroid tissue 未知
公开(公告)号：DE102005011003A1
公开(公告)日：2005-10-20
申请号：DE102005011003
申请日：2005-03-03
申请人： UNIV LEIPZIG
发明人： PASCHKE RALF , ESZLINGER MARKUS , KROHN KNUT , FUEHRER DAGMAR
IPC分类号： C07H21/04 , C12N15/11 , C12Q1/68 , G01N33/50
摘要： Differentiating between benign and malignant tumors of the thyroid comprising isolating RNA from thyroid tissue and quantifying mRNA transcripts, is new. Differentiating between benign and malignant tumors of the thyroid comprises isolating RNA from thyroid tissue and quantifying mRNA transcripts from at least one of 153 genes (all listed by name and NCBI accession number). An increase in transcripts from 18 of these genes, or a reduction in transcripts from 14 of them indicates a benign tumor, while an increase from 77 of them or reduction from 52 of them indicates a malignant tumor. Independent claims are also included for: (1) differentiating any one of benign hot nodules, benign cold nodules, malignant follicular carcinoma and maligant papillar carcinoma from the other three; (2) diagnostic kit for the new processes; and (3) hybridization probes (SEQ ID NO.19) and (SEQ ID NO.20).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式