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1. 发明公开

EP2762147A4 PHARMACEUTICAL COMPOSITION CONTAINING PUERARIAE FLOS EXTRACTS AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ENDOMETRIOSIS 失效
标题翻译：与葛根FLOS提取物药物组合物，子宫内膜异位症的预防和处理剂
公开(公告)号：EP2762147A4
公开(公告)日：2014-08-06
申请号：EP12833704
申请日：2012-09-24
申请人： UNIV KYUNG HEE UNIV IND COOP GROUP
发明人： CHOI JUNG-HYE , KIM JI-HYYUN
IPC分类号： A61K36/488 , A61K36/00 , A61P15/00
CPC分类号： A61K36/488 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition containing Puerariae Flos extracts as active ingredients for preventing or treating endometriosis and the complications thereof. More particularly, Puerariae Flos extracts exhibit the activity of inhibiting the migration and adhesion of endometriosis cells, inhibiting the expressions of MMP-2 and MMP-9, which are factors associated with migration and adhesion, inhibiting the expression of COX-2, which is a factor associated with pain, and inhibiting the expression of MCP-1, which is a cytokine associated with inflammation, and RANTES. Therefore, the Puerariae Flos extracts of the present invention can be effectively used as active ingredients for a pharmaceutical composition for preventing and treating endometriosis and the complications thereof, and for a health food.

2. 发明申请

WO2013043011A3 PHARMACEUTICAL COMPOSITION CONTAINING PUERARIAE FLOS EXTRACTS AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ENDOMETRIOSIS 审中-公开
标题翻译：含有普鲁兰酶提取物作为活性成分的药物组合物作为预防和治疗子宫内膜异位症的活性成分
公开(公告)号：WO2013043011A3
公开(公告)日：2013-05-23
申请号：PCT/KR2012007653
申请日：2012-09-24
申请人： UNIV KYUNG HEE UNIV IND COOP GROUP
发明人： CHOI JUNG-HYE , KIM JI-HYYUN
IPC分类号： A61K36/488 , A61P15/00
CPC分类号： A61K36/488 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition containing Puerariae flos extracts as active ingredients for preventing or treating endometriosis and the complications thereof. More particularly, Puerariae flos extracts exhibit the activity of inhibiting the migration and adhesion of endometrial cells, inhibiting the expression of MMP-2 and MMP-9, which are factors associated with migration and adhesion, inhibiting the expression of COX-2, which is a factor associated with pain, and inhibiting the expression of MCP-1, which is a cytokine associated with inflammation and RANTES. Therefore, the Puerariae flos extracts of the present invention can be effectively used as active ingredients for a pharmaceutical composition for preventing and treating endometriosis and the complications thereof, and for a health food.
摘要翻译：本发明涉及含有葛根提取物作为活性成分的药物组合物，用于预防或治疗子宫内膜异位症及其并发症。更具体地说，葛根提取物具有抑制子宫内膜细胞迁移和粘附的活性，抑制作为迁移和粘附相关因子的MMP-2和MMP-9的表达，抑制COX-2的表达，其是与疼痛相关的因素，并抑制与炎症和RANTES相关的细胞因子MCP-1的表达。因此，本发明的葛根提取物可以有效地用作预防和治疗子宫内膜异位症及其并发症和保健食品的药物组合物的活性成分。

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