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1. 发明公开

EP1941031A4 ISOLATED EMBRYONIC-LIKE STEM CELLS DERIVED FROM HUMAN UMBILICAL CORD BLOOD 有权
标题翻译：隔离胚胎干细胞脐血
公开(公告)号：EP1941031A4
公开(公告)日：2009-06-10
申请号：EP06825367
申请日：2006-10-03
申请人： UNIV ILLINOIS , ZHAO YONG , MAZZONE THEODORE
发明人： ZHAO YONG , MAZZONE THEODORE
IPC分类号： C12N5/074 , C12N5/0783
CPC分类号： C12N5/0607 , A61K2035/122 , C12N5/0636 , C12N2501/23 , C12N2501/59 , C12N2502/03

2. 发明专利

ES2454021T3 Células madre de tipo embrionario aisladas de sangre de cordón umbilical humano 未知
公开(公告)号：ES2454021T3
公开(公告)日：2014-04-09
申请号：ES06825367
申请日：2006-10-03
申请人： UNIV ILLINOIS , ZHAO YONG , MAZZONE THEODORE
发明人： ZHAO YONG , MAZZONE THEODORE
IPC分类号： C12N5/073 , C12N5/071 , C12N5/074 , C12N5/0783
摘要： Células madre de tipo embrionario aisladas de sangre de cordón umbilical humano caracterizadas por: (a) mostrar características de células madre embrionarias que comprenden la capacidad de proliferación y la capacidad de diferenciarse a diversos tipos de células, (b) mostrar características de las células hematopoyéticas que comprenden la expresión de CD45; (c) fenotípicamente distintas de linfocitos, macrófagos y monocitos por ser negativas para los marcadores CD3, CD20, CD11b/Mac-1 y CD14; (d) fenotípicamente distintas de las células madre hematopoyéticas por ser negativas para el marcador CD34, (e) mostrar baja inmunogenicidad mediante la expresión de moléculas del complejo mayor de histocompatibilidad (MHC) asociadas con baja inmunogenicidad, y (f) mostrar una regulación inmunitaria por inhibición de la proliferación de linfocitos estimulada por mitógenos, para su uso en la terapia basada en células madre.

3. 发明专利

DK1941031T3 ISOLEREDE EMBRYONISK-LIGNENDE STAMCELLER AFLEDT FRA HUMANT NAVLESTRENGSBLOD 未知
公开(公告)号：DK1941031T3
公开(公告)日：2014-03-31
申请号：DK06825367
申请日：2006-10-03
申请人： UNIV ILLINOIS , ZHAO YONG , MAZZONE THEODORE
发明人： ZHAO YONG , MAZZONE THEODORE
IPC分类号： C12N5/073 , C12N5/071 , C12N5/074 , C12N5/0783

4. 发明申请

WO2007044314A3 ISOLATED EMBRYONIC-LIKE STEM CELLS DERIVED FROM HUMAN UMBILICAL CORD BLOOD 审中-公开
标题翻译：来自人脐带血的分离的胚胎样干细胞
公开(公告)号：WO2007044314A3
公开(公告)日：2007-09-13
申请号：PCT/US2006038524
申请日：2006-10-03
申请人： UNIV ILLINOIS , ZHAO YONG , MAZZONE THEODORE
发明人： ZHAO YONG , MAZZONE THEODORE
IPC分类号： C12N5/074 , C12N5/0783
CPC分类号： C12N5/0607 , A61K2035/122 , C12N5/0636 , C12N2501/23 , C12N2501/59 , C12N2502/03
摘要： The present invention is related generally to embryonic-like stem cells isolated from human umbilical cord blood, designated herein as cord blood-stem cells (CB-SCs), which display the characteristics of embryonic stem cells and hematopoietic cells. These cells have the capability of proliferation and are able to differentiate to multiple types of cells. In addition, the CB-SC display low immunogenicity and immune regulation. These cells are, therefore, suitable for use in stem cell-based therapies for the treatment of diseases such as Parkinson's disease, diabetes, spinal cord damage, multiple sclerosis, cardiovascular disease, stroke and birth defects.
摘要翻译：本发明一般涉及从人脐带血分离的胚胎样干细胞，本文称为脐带血干细胞（CB-SC），其显示胚胎干细胞和造血细胞的特征。这些细胞具有增殖能力并能够分化为多种类型的细胞。此外，CB-SC显示低免疫原性和免疫调节。因此，这些细胞适用于基于干细胞的治疗，用于治疗诸如帕金森病，糖尿病，脊髓损伤，多发性硬化症，心血管疾病，中风和出生缺陷等疾病。

5. 发明申请

WO2006044842A2 HUMAN STEM CELL MATERIALS AND METHODS 审中-公开
标题翻译：人类细胞材料和方法
公开(公告)号：WO2006044842A2
公开(公告)日：2006-04-27
申请号：PCT/US2005037341
申请日：2005-10-13
申请人： UNIV CHICAGO , HUBERMAN ELIEZER , ZHAO YONG
发明人： HUBERMAN ELIEZER , ZHAO YONG
IPC分类号： A61K35/39 , A61K48/00 , C12N5/071 , C12N5/0786
CPC分类号： A61K35/15 , C12N5/0607 , C12N5/0645 , C12N5/0676 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2506/03 , C12N2506/115
摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals are provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease, including disorders or diseases associated with aberrant function or presence (i.e., level) of pancreatic islet ß-cell-like macrophages.
摘要翻译：提供从哺乳动物的外周血分离的单核细胞来源的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其差异衍生物的方法。这些生物材料的用途包括治疗疾病或疾病的方法，以及改善与任何此类疾病或疾病相关的症状的方法，包括与胰岛β细胞异常功能或存在（即水平）相关的疾病或疾病，细胞样巨噬细胞。

6. 发明申请

WO2005046570A3 HUMAN STEM CELL MATERIALS AND METHODS 审中-公开
标题翻译：人类细胞材料和方法
公开(公告)号：WO2005046570A3
公开(公告)日：2006-12-07
申请号：PCT/US2004016790
申请日：2004-05-26
申请人： UNIV CHICAGO , HUBERMAN ELIEZER , ZHAO YONG
发明人： HUBERMAN ELIEZER , ZHAO YONG
IPC分类号： A61K35/28 , A61K20060101 , A61K35/26 , A61K48/00 , C12N5/00 , C12N5/02 , C12N5/071 , C12N5/074 , C12N5/0783 , C12N5/0786 , C12N5/0793 , E02D27/42 , G01N33/53
CPC分类号： C12N5/0635 , A61K35/12 , A61K2035/124 , C12N5/0607 , C12N5/0619 , C12N5/0636 , C12N5/0645 , C12N5/067 , C12N5/069 , C12N2501/11 , C12N2501/12 , C12N2501/13 , C12N2501/165 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2501/52 , C12N2501/599 , C12N2503/02 , C12N2506/03 , C12N2506/115 , G01N33/5073
摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals are provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease including disorders or diseases associated with platelets.
摘要翻译：提供从哺乳动物的外周血分离的单核细胞来源的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其差异衍生物的方法。这些生物材料的用途包括治疗疾病或疾病的方法，以及改善与任何此类疾病或疾病相关的症状（包括与血小板相关的疾病或疾病）的方法。

7. 发明申请

WO2012154832A3 OBJECT TRACKING 审中-公开
标题翻译：对象追踪
公开(公告)号：WO2012154832A3
公开(公告)日：2013-03-21
申请号：PCT/US2012037094
申请日：2012-05-09
申请人： GOOGLE INC , GOSSWEILER III RICHARD C , ZHAO YONG
发明人： GOSSWEILER III RICHARD C , ZHAO YONG
IPC分类号： G06T7/20
CPC分类号： G06K9/00241 , G06K9/00261
摘要： In general, the subject matter described in this specification can be embodied in methods, systems, and program products. A computing system accesses an indication of a first template that includes a region of a first image. The region of the first image includes a graphical representation of a face. The computing system receives a second image. The computing system identifies indications of multiple candidate templates. Each respective candidate template from the multiple candidate templates includes a respective candidate region of the second image. The computing system compares at least the first template to each of the multiple candidate templates, to identify a matching template from among the multiple candidate templates that includes a candidate region that matches the region of the first image that includes the graphical representation of the face.
摘要翻译：通常，本说明书中描述的主题可以体现在方法，系统和程序产品中。计算系统访问包括第一图像的区域的第一模板的指示。第一图像的区域包括面部的图形表示。计算系统接收第二个图像。计算系统识别多个候选模板的指示。来自多个候选模板的每个候选模板包括第二图像的相应候选区域。所述计算系统至少将所述第一模板与所述多个候选模板中的每一个进行比较，以从所述多个候选模板中识别匹配模板，所述匹配模板包括与包括所述面部的图形表示的所述第一图像的区域相匹配的候选区域。

8. 发明申请

WO2009122153A3 ELECTROLUMINESCENT DISPLAYS 审中-公开
标题翻译：电致发光显示器
公开(公告)号：WO2009122153A3
公开(公告)日：2010-02-18
申请号：PCT/GB2009000835
申请日：2009-03-27
申请人： PELIKON LTD , ZHAO YONG , EVANS CHRISTOPHER MILES
发明人： ZHAO YONG , EVANS CHRISTOPHER MILES
IPC分类号： G02F1/13357
CPC分类号： G02F1/133603 , G02F1/1334 , G02F2201/50
摘要： An electroluminescent display comprising a mask defining the information to be displayed and an electroluminescent (EL) backlight. The mask compress a layer (13) of physically-stabilised liquid crystal switchable to define the information to be displayed mounted in front of an EL layer (16) of the backlight. At least one pair of electrodes (12, 20) are arranged to generate, in use, an electric field across both the EL layer (16) and the LC layer (13). A barrier layer (15) is provided between the LC layer (13) and the EL layer (16) that restricts migration of liquid crystal from the LC layer (13) to the EL layer (16).
摘要翻译：一种电致发光显示器，其包括限定要显示的信息的掩模和电致发光（EL）背光。掩模压缩物理稳定的液晶层（13），其可切换以限定安装在背光源的EL层（16）前面的要显示的信息。至少一对电极（12,20）被布置成在使用中产生穿过EL层（16）和LC层（13）的电场。阻挡层（15）设置在LC层（13）和EL层（16）之间，其限制液晶从LC层（13）向EL层（16）的迁移。

9. 发明申请

WO2008033951A3 DELIVERY OF MOBILE TERMINATED CALL DURING INTER-VLR LOCATION UPDATE 审中-公开
标题翻译：在VLR位置更新期间传送移动终端呼叫
公开(公告)号：WO2008033951A3
公开(公告)日：2008-07-10
申请号：PCT/US2007078309
申请日：2007-09-12
申请人： ALCATEL LUCENT , ZHANG YIBO , TIAN LU , ZHAO YONG , LANDAIS BRUNO
发明人： ZHANG YIBO , TIAN LU , ZHAO YONG , LANDAIS BRUNO
IPC分类号： G06F15/16
CPC分类号： H04W8/12 , H04W8/06 , H04W60/04 , H04W76/02
摘要： A mobile terminated call is delivered to a mobile device during an inter- VLR location update by first routing the mobile terminated call to the old mobile switching center/visitor location register (MSC/VLR), determining that the mobile device is performing a location update to a new MSC/VLR at the old MSC/VLR, and then routing the mobile terminated call to the new MSC/VLR directly from the old MSC/VLR or via the gateway mobile switching center (GMSC) for connection of the mobile terminated call to the mobile device.
摘要翻译：通过首先将移动终止的呼叫路由到旧的移动交换中心/访问者位置寄存器（MSC / VLR），确定移动设备正在执行位置更新，在VLR位置更新期间将移动终止的呼叫传送到移动设备到旧的MSC / VLR的新的MSC / VLR，然后直接从旧的MSC / VLR或经由网关移动交换中心（GMSC）将移动终止的呼叫路由到新的MSC / VLR，用于连接移动终止的呼叫到移动设备。

10. 发明公开

EP2510084A4 STEM CELL IMMUNE MODULATION METHODS OF USE AND APPARATUS 有权
标题翻译：干细胞免疫调节，使用和设备的方法，
公开(公告)号：EP2510084A4
公开(公告)日：2015-04-08
申请号：EP10843462
申请日：2010-12-08
申请人： UNIV ILLINOIS
发明人： ZHAO YONG
IPC分类号： C12M3/00 , A61K35/12 , A61K35/26 , A61P37/00 , C12M1/12 , C12M1/34 , C12M1/42 , C12N5/0735 , C12N5/078 , C12N5/0783
CPC分类号： A61M1/3489 , A61K2035/122 , A61M1/3472 , A61M2202/0407 , C12M25/08 , C12M35/08 , C12N5/0634 , C12N2502/11
摘要： Methods and apparatus are disclosed co-culturing stem cells with mononuclear cells and/or lymphocytes to modulate their function. The invention also discloses the use of stem cells to educate autoreactive immune cells as a mechanism to treat autoimmune diseases and immune disorder-related diseases, such as diabetes. In one aspect of the invention, bioreactors are disclosed closed for modulating lymphocytes and suppressing autoreactive T cells. The bioreactors can include a chamber having at least one positively charged and/or hydrophobic substrate surface, a population of stem cells attached to the substrate surface, an inlet conduit for introducing lymphocytes into the chamber, and an outlet conduit for extracting treated lymphocytes following co-culturing with the stem cells.

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