专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009029317A3 COMPOSITIONS FOR REGULATING OR MODULATING QUORUM SENSING IN BACTERIA, METHODS OF USING THE COMPOUNDS, AND METHODS OF REGULATING OR MODULATING QUORUM SENSING IN BACTERIA 审中-公开
标题翻译：用于调节或调节细菌中的相同感测的组合物，使用该化合物的方法，以及调节或调节细菌感测方法
公开(公告)号：WO2009029317A3
公开(公告)日：2009-08-20
申请号：PCT/US2008066028
申请日：2008-06-06
申请人： UNIV GEORGIA STATE RES FOUND , WANG BINGHE , NI NANTING , WANG JUNFENG , LU CHUNG-DAR , CHOU HAN-TING , LI MINYONG , ZHENG SHILONG , CHENG YUNFENG , PENG HANJING
发明人： WANG BINGHE , NI NANTING , WANG JUNFENG , LU CHUNG-DAR , CHOU HAN-TING , LI MINYONG , ZHENG SHILONG , CHENG YUNFENG , PENG HANJING
IPC分类号： C07D291/08 , A61P31/04 , C07D215/04 , C07D307/91 , C07D333/76
CPC分类号： C07D333/34 , C07F5/025
摘要： The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.
摘要翻译：本公开涵盖可用作用于控制细菌群体感测的特异性AI-2拮抗剂的化合物和组合物。虽然根据本公开的AI-2拮抗剂可能不具有杀菌作用，但是它们减轻毒力，耐药性和/或生物膜形成的能力具有治疗益处。此外，本公开的AI-2拮抗剂也可以用作探针细菌AI-2功能的工具。本公开还包括抑制或减弱微生物毒力，生物膜形成和耐药性的方法。这些方法适合于防止细菌产生和形成广泛的生物膜，这些生物膜可能是健康或卫生危害或物理问题，例如在水或燃料管线的堵塞中。

2. 发明申请

WO2010019847A3 APTAMER INHIBITION OF THROMBUS FORMATION 审中-公开
标题翻译： APTAMER对血栓形成的抑制作用
公开(公告)号：WO2010019847A3
公开(公告)日：2010-05-14
申请号：PCT/US2009053825
申请日：2009-08-14
申请人： UNIV GEORGIA STATE RES FOUND , WANG BINGHE , LI MINYONG , NI NANTING , LIU YIDAN
发明人： WANG BINGHE , LI MINYONG , NI NANTING , LIU YIDAN
IPC分类号： A61K48/00 , A61K31/7088 , A61K38/36 , A61P7/02 , C07H21/00
CPC分类号： C12N15/115 , A61K31/7088 , C12N2310/16
摘要： Boronic acid-modified DNA-based aptamers can be selected to recognize fibrinogen through binding at a glycosylation site and thus are useful for probing the effect of glycosylation pattern changes on the ability for fibrinogen to mediate blood coagulation. In addition, the aptamers of the disclosure also have anticoagulation effects due to their binding to fibrinogen and its cleavage product fibrin. The present disclosure, therefore, encompasses methods for inhibiting fibrin coagulation with an aptamer capable of specifically binding to a glycosylation site of fibrinogen or fibrin. The disclosure further provides oligonucleotide aptamers comprising at least one nucleotide having a boronic acid thereon, where the aptamer is capable of selectively binding to a glycosylation site of fibrinogen, or the derivative thereof.
摘要翻译：可以选择硼酸修饰的基于DNA的适体通过在糖基化位点结合来识别纤维蛋白原，因此可用于探测糖基化模式改变对纤维蛋白原介导血液凝固的能力的影响。此外，本公开的适体由于其与纤维蛋白原及其裂解产物纤维蛋白的结合而具有抗凝作用。因此，本公开内容包括用能够特异性结合纤维蛋白原或纤维蛋白的糖基化位点的适体抑制纤维蛋白凝固的方法。本公开还提供了包含至少一个在其上具有硼酸的核苷酸的寡核苷酸适体，其中适体能够选择性地结合纤维蛋白原或其衍生物的糖基化位点。

3. 发明申请

WO2014011753A3 ANTHRAQUINONE ANALOGS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：蒽醌类似物及其制备和使用方法
公开(公告)号：WO2014011753A3
公开(公告)日：2014-04-17
申请号：PCT/US2013049898
申请日：2013-07-10
申请人： UNIV GEORGIA STATE RES FOUND , UNIV EMORY , CHILDRENS HEALTHCARE ATLANTA
发明人： WANG BINGHE , DAI CHAOFENG , DRAGANOV ALEXANDER , YANG XIAOCHUAN , SUN GUOJING , YANG CHUNHAO , CHEN WEIXUAN , NI NANTING , ZHOU MUXIANG , GU LUBING
IPC分类号： C07C50/34 , C07C50/38 , C07C69/95 , C07C225/24 , C07C233/31 , C07C233/33 , C07C235/84 , C07C237/04 , C07C247/04 , C07C247/10 , C07C255/27 , C07C311/08 , C07C323/22 , C07D211/06 , C07D213/50
CPC分类号： C07C233/33 , C07C66/02 , C07C69/95 , C07C225/36 , C07C233/31 , C07C235/16 , C07C235/84 , C07C237/04 , C07C247/04 , C07C247/10 , C07C247/12 , C07C255/19 , C07C311/08 , C07C323/60 , C07C2603/24 , C07D213/56 , C07D213/61 , C07D213/70 , C07D261/08 , C07D267/12 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.
摘要翻译：本文描述了表现出抗增殖活性，特别是抗癌细胞的大黄酸类似物。在一些实施方案中，化合物含有平坦或平面环体系。这样的环体系通过促进化合物与DNA复合物的非共价结合，例如通过插入。在一些实施方案中，化合物含有如上所述的平坦或平面环体系和一个或多个烷基化部分，亲电子基团或迈克尔受体或包含一个或多个烷基化部分，亲电子基团和/或迈克尔受体的基团的取代基。本文所述的化合物还可以含有一个或多个官能团以改善化合物的溶解度。

4. 发明公开

EP2310054A4 APTAMER INHIBITION OF THROMBUS FORMATION 审中-公开
标题翻译：扑热息痛对血栓形成的抑制作用
公开(公告)号：EP2310054A4
公开(公告)日：2013-01-09
申请号：EP09807338
申请日：2009-08-14
申请人： UNIV GEORGIA STATE RES FOUND
发明人： WANG BINGHE , LI MINYONG , NI NANTING , LIU YIDAN
IPC分类号： A61K48/00 , A61K31/7088 , A61K38/36 , A61P7/02 , C07H21/00
CPC分类号： C12N15/115 , A61K31/7088 , C12N2310/16

5. 发明公开

EP2155705A4 COMPOSITIONS FOR REGULATING OR MODULATING QUORUM SENSING IN BACTERIA, METHODS OF USING THE COMPOUNDS, AND METHODS OF REGULATING OR MODULATING QUORUM SENSING IN BACTERIA 审中-公开
标题翻译：用于调节或调制的法定人数，感知过度在细菌中，方法使用该化合物和调节方法或调制的组成法定人数感知过度IN细菌
公开(公告)号：EP2155705A4
公开(公告)日：2012-02-15
申请号：EP08828361
申请日：2008-06-06
申请人： UNIV GEORGIA STATE RES FOUND
发明人： WANG BINGHE , NI NANTING , WANG JUNFENG , LU CHUNG-DAR , CHOU HAN-TING , LI MINYONG , ZHENG SHILONG , CHENG YUNFENG , PENG HANJING
IPC分类号： A61P31/04 , A61K31/69 , C07C39/10 , C07C317/44 , C07D279/20 , C07D333/34 , C07F5/00 , C07F5/02
CPC分类号： C07D333/34 , C07F5/025

6. 发明专利

CA2878837A1 ANTHRAQUINONE ANALOGS AND METHODS OF MAKING AND USING THEREOF 未知
公开(公告)号：CA2878837A1
公开(公告)日：2014-01-16
申请号：CA2878837
申请日：2013-07-10
申请人： UNIV GEORGIA STATE RES FOUND , UNIV EMORY , CHILDREN S HEATLHCARE OF ATLANTA INC
发明人： WANG BINGHE , DAI CHAOFENG , DRAGANOV ALEXANDER , YANG XIAOCHUAN , SUN GUOJING , YANG CHUNHAO , CHEN WEIXUAN , NI NANTING , ZHOU MUXIANG , GU LUBING
IPC分类号： C07C50/34 , C07C50/38 , C07C69/95 , C07C225/24 , C07C233/31 , C07C233/33 , C07C235/84 , C07C237/04 , C07C247/04 , C07C247/10 , C07C255/27 , C07C311/08 , C07C323/22 , C07D211/06 , C07D213/50
摘要： Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

7. 发明专利

AU2013290277A1 Anthraquinone analogs and methods of making and using thereof 未知
公开(公告)号：AU2013290277A1
公开(公告)日：2015-01-22
申请号：AU2013290277
申请日：2013-07-10
申请人： CHILDRENS HEALTHCARE ATLANTA INC , UNIV GEORGIA STATE RES FOUND , UNIV EMORY
发明人： WANG BINGHE , DAI CHAOFENG , DRAGANOV ALEXANDER , YANG XIAOCHUAN , SUN GUOJING , YANG CHUNHAO , CHEN WEIXUAN , NI NANTING , ZHOU MUXIANG , GU LUBING
IPC分类号： C07C50/34 , C07C50/38 , C07C69/95 , C07C225/24 , C07C233/31 , C07C233/33 , C07C235/84 , C07C237/04 , C07C247/04 , C07C247/10 , C07C255/27 , C07C311/08 , C07C323/22 , C07D211/06 , C07D213/50
摘要： Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

8. 发明专利

HK1210460A1 ANTHRAQUINONE ANALOGS AND METHODS OF MAKING AND USING THEREOF 未知
公开(公告)号：HK1210460A1
公开(公告)日：2016-04-22
申请号：HK15111200
申请日：2015-11-13
申请人： UNIV GEORGIA STATE RES FOUND
发明人： WANG BINGHE , DAI CHAOFENG , DRAGANOV ALEXANDER , YANG XIAOCHUAN , SUN GUOJING , YANG CHUNHAO , CHEN WEIXUAN , NI NANTING , ZHOU MUXIANG , GU LUBING
IPC分类号： C07C20060101 , C07D20060101
摘要： Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

9. 发明专利

CA2878837C ANTHRAQUINONE ANALOGS AND METHODS OF MAKING AND USING THEREOF 未知
公开(公告)号：CA2878837C
公开(公告)日：2019-07-30
申请号：CA2878837
申请日：2013-07-10
申请人： UNIV GEORGIA STATE RES FOUND , UNIV EMORY , CHILDRENS HEATLHCARE OF ATLANTA
发明人： WANG BINGHE , DAI CHAOFENG , DRAGANOV ALEXANDER , YANG XIAOCHUAN , SUN GUOJING , YANG CHUNHAO , CHEN WEIXUAN , NI NANTING , ZHOU MUXIANG , GU LUBING
IPC分类号： C07C50/34 , C07C50/38 , C07C69/95 , C07C225/24 , C07C233/31 , C07C233/33 , C07C235/84 , C07C237/04 , C07C247/04 , C07C247/10 , C07C255/27 , C07C311/08 , C07C323/22 , C07D211/06 , C07D213/50
摘要： Rhein analogues according to the chemical structure: (see diagram) exhibit anti-proliferative activity, particularly against cancer cells. Methods of making and using such rhein analogues are described herein. In particular, the rhein analogues contain a flat or planar ring system having thereon one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors and also contain one more functional groups thereon to improve the solubility of the rhein analogues described.

10. 发明专利

CA2732809A1 APTAMER INHIBITION OF THROMBUS FORMATION 未知
公开(公告)号：CA2732809A1
公开(公告)日：2010-02-18
申请号：CA2732809
申请日：2009-08-14
申请人： UNIV GEORGIA STATE RES FOUND
发明人： WANG BINGHE , LI MINYONG , NI NANTING , LIU YIDAN
IPC分类号： A61K48/00 , A61K31/7088 , A61K38/36 , A61P7/02 , C07H21/00
摘要： Boronic acid-modified DNA-based aptamers can be selected to recognize fibrinogen through binding at a glycosy-lation site and thus are useful for probing the effect of glycosylation pattern changes on the ability for fibrinogen to mediate blood coagulation. In addition, the aptamers of the disclosure also have anticoagulation effects due to their binding to fibrinogen and its cleavage product fibrin. The present disclosure, therefore, encompasses methods for inhibiting fibrin coagulation with an aptamer capable of specifically binding to a glycosylation site of fibrinogen or fibrin. The disclosure further provides oligonucleotide ap-tamers comprising at least one nucleotide having a boronic acid thereon, where the aptamer is capable of selectively binding to a glycosylation site of fibrinogen, or the derivative thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式