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1. 发明申请

WO2014123967A2 CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE 审中-公开
标题翻译：用于病毒生产的细胞系和使用方法
公开(公告)号：WO2014123967A2
公开(公告)日：2014-08-14
申请号：PCT/US2014014813
申请日：2014-02-05
申请人： UNIV GEORGIA , US GOV HEALTH & HUMAN SERV , THERMO FISHER SCIENT BIOSCIENCES INC
发明人： KARPILOW JON MICHAEL , OBERSTE MARK STEVEN , TRIPP RALPH A , TOMPKINS STEPHEN M
IPC分类号： C12N15/113
CPC分类号： A61K39/13 , C12N7/00 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12N2770/32021 , C12N2770/32034 , C12N2770/32052 , C12N2770/32351 , C12N2770/32651
摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
摘要翻译：本文提供了工程细胞系。在一些实施方案中，工程改造的细胞系的细胞已经改变了基因的表达和/或miRNA的改变的表达，其中改变的表达导致病毒的产生增加或减少。病毒是诸如脊髓灰质炎病毒或肠病毒71之类的微波病毒病毒。本文还提供了使用工程细胞产生病毒的方法，以及用于治疗患有或有风险患有病毒感染的受试者的方法。

2. 发明申请

WO2007126887A3 IMMUNOGENIC COMPOSITIONS COMPRISING POLYNUCLEOTIDES ENCODING MATRIX PROTEIN 2 AND METHODS OF USE 审中-公开
标题翻译：包含编码基质蛋白2的多核苷酸的免疫组合物及其使用方法
公开(公告)号：WO2007126887A3
公开(公告)日：2008-02-21
申请号：PCT/US2007007679
申请日：2007-03-27
申请人： US GOV HEALTH & HUMAN SERV , EPSTEIN SUZANNE , TOMPKINS STEPHEN M , YE ZHIPING , TUMPEY TERRENCE M , MISPLON JULIA ANN , LO CHIA-YUN
发明人： EPSTEIN SUZANNE , TOMPKINS STEPHEN M , YE ZHIPING , TUMPEY TERRENCE M , MISPLON JULIA ANN , LO CHIA-YUN
IPC分类号： A61K39/145 , A61K48/00 , C07K14/11
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/58 , A61K2039/6081 , C07K14/005 , C12N2710/10343 , C12N2760/16122 , C12N2760/16134
摘要： The disclosure encompasses M2 polypeptides, polynucleotides, variants, and immunogenic fragments thereof. M2 polypeptides and/or polynucleotides are useful in immunogenic compositions. The immunogenic compositions of the disclosure can be administered alone or in combination with other agents useful in the control of influenza infection.
摘要翻译：本公开包括M2多肽，多核苷酸，变体和其免疫原性片段。 M2多肽和/或多核苷酸可用于免疫原性组合物。本公开的免疫原性组合物可以单独施用或与可用于控制流感感染的其它试剂组合施用。

3. 发明申请

WO2012142492A3 METHODS FOR INHIBITING VIRUS REPLICATION 审中-公开
标题翻译：抑制病毒复制的方法
公开(公告)号：WO2012142492A3
公开(公告)日：2012-12-13
申请号：PCT/US2012033631
申请日：2012-04-13
申请人： UNIV GEORGIA , TRIPP RALPH A , TOMPKINS STEPHEN M
发明人： TRIPP RALPH A , TOMPKINS STEPHEN M
IPC分类号： G06Q20/28 , A61K31/045 , A61K31/10 , A61K31/18
CPC分类号： A61K31/195 , A61K31/122 , A61K31/18 , A61K38/10 , A61K45/06 , C07D209/48 , C07D401/12 , C07D487/14 , C07D495/04
摘要： The present invention provides methods for treating a subject having, or at risk of having, a viral infection. The methods include, but are not limited to, the use of 4-(dipropylsulfamoyl) benzoic acid, an inhibitor of CDC25B phosphatase, an inhibitor of ICAM-1, an inhibitor of CamK2B, or a combination thereof.
摘要翻译：本发明提供了用于治疗患有或有风险患有病毒感染的受试者的方法。所述方法包括但不限于使用4-（二丙基氨磺酰基）苯甲酸，CDC25B磷酸酶抑制剂，ICAM-1抑制剂，CamK2B抑制剂或其组合。

4. 发明申请

WO2013166264A3 METHODS FOR ALTERING VIRUS REPLICATION 审中-公开
标题翻译：改变病毒复制的方法
公开(公告)号：WO2013166264A3
公开(公告)日：2014-01-16
申请号：PCT/US2013039234
申请日：2013-05-02
申请人： UNIV GEORGIA
发明人： TRIPP RALPH A , TOMPKINS STEPHEN M , BAKRE ABHIJEET
IPC分类号： C12N15/113
CPC分类号： A61K48/00 , C12N15/1137 , C12N2310/141 , C12N2320/11 , C12N2320/12 , C12N2760/16122 , C12N2760/18022
摘要： Provided herein are methods for altering viral replication in a cell. The virus may be a member of the family Orthomyxoviridae, such as an influenza virus, or a member of the family Paramyxoviridae, such as human respiratory syncytial virus. Altering viral replication is accomplished through the use of polynucleotides. In one embodiment, a polynucleotide decreases expression of a polypeptide, such as a protease or a kinase. In one embodiment, a polynucleotide is an miRNA or an miRNA inhibitor. In some embodiments viral replication is decreased, and in other embodiments viral replication is increased. Also included are methods for treating a subject, and genetically modified cells having the characteristic of altered virus replication compared to a control cell.
摘要翻译：本文提供了改变细胞中病毒复制的方法。病毒可以是正粘病毒科的一个成员，例如流感病毒，或副粘病毒科的成员，例如人呼吸道合胞病毒。通过使用多核苷酸来改变病毒复制。在一个实施方案中，多核苷酸降低多肽如蛋白酶或激酶的表达。在一个实施方案中，多核苷酸是miRNA或miRNA抑制剂。在一些实施方案中，病毒复制减少，并且在其它实施方案中病毒复制增加。还包括用于治疗受试者的方法，以及具有与对照细胞相比改变的病毒复制特征的遗传修饰的细胞。

5. 发明专利

CA2899928A1 CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE 未知
公开(公告)号：CA2899928A1
公开(公告)日：2014-08-14
申请号：CA2899928
申请日：2014-02-05
申请人： UNIV GEORGIA , US HEALTH , THERMO FISCHER SCIENT INC
发明人： KARPILOW JON MICHAEL , OBERSTE MARK STEVEN , TRIPP RALPH A , TOMPKINS STEPHEN M
IPC分类号： C12N15/113 , C12N5/00
摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.

6. 发明专利

HK1219975A1 用於病毒生產的細胞系和使用方法未知
公开(公告)号：HK1219975A1
公开(公告)日：2017-04-21
申请号：HK16106481
申请日：2016-06-07
申请人： UNIV GEORGIA
发明人： KARPILOW JON MICHAEL , OBERSTE MARK STEVEN , TRIPP RALPH A , TOMPKINS STEPHEN M
IPC分类号： C12N20060101

7. 发明专利

AU2014215025A1 Cell lines for virus production and methods of use 未知
公开(公告)号：AU2014215025A1
公开(公告)日：2015-07-09
申请号：AU2014215025
申请日：2014-02-05
申请人： THERMO FISHER SCIENTIFIC INC , UNIV GEORGIA , US HEALTH
发明人： KARPILOW JON MICHAEL , OBERSTE MARK STEVEN , TRIPP RALPH A , TOMPKINS STEPHEN M
IPC分类号： C12N15/113
摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.

8. 发明专利

AU2014215025B2 Cell lines for virus production and methods of use 未知
公开(公告)号：AU2014215025B2
公开(公告)日：2018-08-30
申请号：AU2014215025
申请日：2014-02-05
申请人： THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY , THERMO FISHER SCIENTIFIC INC , UNIV GEORGIA
发明人： KARPILOW JON MICHAEL , OBERSTE MARK STEVEN , TRIPP RALPH A , TOMPKINS STEPHEN M
IPC分类号： C12N15/113
摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.

9. 发明专利

MX2015010017A LINEAS CELULARES PARA LA PRODUCCION DE VIRUS Y METODOS DE USO. 未知
公开(公告)号：MX2015010017A
公开(公告)日：2016-03-04
申请号：MX2015010017
申请日：2014-02-05
申请人： UNIV GEORGIA
发明人： KARPILOW JON MICHAEL , OBERSTE MARK STEVEN , TRIPP RALPH A , TOMPKINS STEPHEN M
IPC分类号： C12N15/113 , C12N5/00
摘要： Se proporcionan en la presente líneas celulares manipuladas. En algunas modalidades, las células de una línea celular manipulada tienen expresión alterada de un gen y/o expresión alterada de un miARN, en donde la expresión alterada resulta en una producción aumentada o reducida de un virus. Ese virus es un picornavirus, tal como un virus poliomielítico o Enterovirus 71. También se proporcionan en la presente métodos para uso de las células manipuladas para producir virus y métodos para tratar a un sujeto que tiene corre el riesgo de tener una infección viral.

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