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1. 发明申请

WO2006073586A2 RADIATION DOSIMETRY AND BLOCKING ANTIBODIES AND METHODS AND USES THREFOR IN THE TREATMENT OF CANCER 审中-公开
标题翻译：放疗剂量和阻断抗体及其在肿瘤治疗中的应用
公开(公告)号：WO2006073586A2
公开(公告)日：2006-07-13
申请号：PCT/US2005041884
申请日：2005-11-17
申请人： UNIV DUKE , AKABANI-HNEIDE GAMAL , BIGNER DARELL D , ZALUTSKY MICHAEL R , RIZZIERI DAVID A
发明人： AKABANI-HNEIDE GAMAL , BIGNER DARELL D , ZALUTSKY MICHAEL R , RIZZIERI DAVID A
IPC分类号： A61K51/00
CPC分类号： A61K51/1066 , A61N5/1015
摘要： Disclosed is a method for dosimetry estimation for a region of interest at or around a surgically created resection cavity in a subject. These methods enable medical practitioners to estimate the amount of administered Radioimmunotherapy (RIT) agent needed to safely and effectively achieve a final Radiation Absorbed Dose (RAD). Furthermore, computer hardware and software are provided herein, so that the methods according to the invention may be automated for more efficient use. Also disclosed is a method of enhancing delivery of therapeutic antibodies that specifically bind to an extracellular stromal constituent of a tumor in a mammalian subject. The method comprises administering to a subject an effective dosage of a blocking antibody, said blocking antibodies specifically binding to said extracellular stromal constituent and blocking the binding of therapeutic antibodies to non-target tissue.
摘要翻译：公开了一种用于在对象中手术创建的切除空腔处或附近的感兴趣区域进行剂量测定估计的方法。这些方法使医师能够估计安全有效地达到最终的放射性吸收剂量（RAD）所需的放射免疫治疗剂（RIT）的量。此外，这里提供了计算机硬件和软件，使得根据本发明的方法可以被自动化以更有效地使用。还公开了增强哺乳动物受试者中特异性结合肿瘤的细胞外基质成分的治疗性抗体的递送的方法。该方法包括向受试者施用有效剂量的阻断抗体，所述阻断抗体特异性结合所述细胞外基质成分并阻断治疗性抗体与非靶组织的结合。

2. 发明申请

WO2006073586A8 RADIATION DOSIMETRY AND BLOCKING ANTIBODIES AND METHODS AND USES THREFOR IN THE TREATMENT OF CANCER 审中-公开
标题翻译：辐射剂量和阻断抗体及其治疗癌症的方法和用途
公开(公告)号：WO2006073586A8
公开(公告)日：2007-02-22
申请号：PCT/US2005041884
申请日：2005-11-17
申请人： UNIV DUKE , AKABANI-HNEIDE GAMAL , BIGNER DARELL D , ZALUTSKY MICHAEL R , RIZZIERI DAVID A
发明人： AKABANI-HNEIDE GAMAL , BIGNER DARELL D , ZALUTSKY MICHAEL R , RIZZIERI DAVID A
IPC分类号： A61K49/00
CPC分类号： A61K51/1066 , A61N5/1015
摘要： Disclosed is a method for dosimetry estimation for a region of interest at or around a surgically created resection cavity in a subject. These methods enable medical practitioners to estimate the amount of administered Radioimmunotherapy (RIT) agent needed to safely and effectively achieve a final Radiation Absorbed Dose (RAD). Furthermore, computer hardware and software are provided herein, so that the methods according to the invention may be automated for more efficient use. Also disclosed is a method of enhancing delivery of therapeutic antibodies that specifically bind to an extracellular stromal constituent of a tumor in a mammalian subject. The method comprises administering to a subject an effective dosage of a blocking antibody, said blocking antibodies specifically binding to said extracellular stromal constituent and blocking the binding of therapeutic antibodies to non-target tissue.
摘要翻译：公开了一种用于对象中外科手术切除腔处或周围感兴趣区域的剂量测定法的方法。这些方法使医务人员可以估计安全有效地达到最终放射吸收剂量（RAD）所需的放射免疫治疗（RIT）剂量。此外，本文提供了计算机硬件和软件，使得根据本发明的方法可以是自动的，以便更有效地使用。还公开了增强哺乳动物受试者特异性结合肿瘤的细胞外基质成分的治疗性抗体的递送的方法。所述方法包括向受试者施用有效剂量的阻断抗体，所述阻断抗体特异性结合所述细胞外基质成分并阻断治疗性抗体与非靶组织的结合。

3. 发明专利

AU6407094A Method of treating tumors with antibodies 未知
公开(公告)号：AU6407094A
公开(公告)日：1994-10-11
申请号：AU6407094
申请日：1994-03-14
申请人： BIGNER DARELL D , CARREL STEFAN , ZALUTSKY MICHAEL R
发明人： BIGNER DARELL D , ZALUTSKY MICHAEL R , CARREL STEFAN
IPC分类号： A61K38/00 , A61K51/10 , C07K16/30 , A61K39/395 , A61K43/00 , C07H21/00
摘要： Methods of treating solid or cystic tumors are disclosed. The method comprises administering to a human subject afflicted with a tumor an antibody in a therapeutically effective amount, wherein the antibody is monoclonal antibody Me1-14 or an antibody which binds to the epitope bound by monoclonal antibody Me1-14, and wherein the Fc receptor of the antibody is deleted. When the tumor is a brain tumor, the antibody may be administered by intrathecal injection. If the brain tumor is a cystic brain tumor, and the administering step may be carried out by depositing the antibody in the cyst cavity of the cystic brain tumor. Particularly preferred is a monoclonal antibody Me1-14 F(ab')2 fragment coupled to 131I.

4. 发明申请

WO2011028507A3 COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE 审中-公开
标题翻译：用于测定烷基转移酶的组合物，方法和试剂盒
公开(公告)号：WO2011028507A3
公开(公告)日：2011-07-14
申请号：PCT/US2010046432
申请日：2010-08-24
申请人： UNIV DUKE , ZALUTSKY MICHAEL R , VAIDYANATHAN GANESAN
发明人： ZALUTSKY MICHAEL R , VAIDYANATHAN GANESAN
IPC分类号： C07D473/18 , C07D403/12 , C07K7/06 , C12Q1/48 , G01N33/58
CPC分类号： C12Q1/48 , A61K51/088 , C07D473/18 , C07K7/06 , C07K14/485 , C07K14/68 , C07K2319/01 , G01N2333/91005
摘要： The present invention relates to novel compounds as well as to compositions, methods, and kits comprising the compounds for determining an alkyltransferase (ATase), in particular an alkylguanine-DNA alkyl transferase (AGT). In general, the novel compounds provide for determining ATase levels, in particular for in vivo applications including, but not limited to, theranostic applications, in particular to cancer- related applications.
摘要翻译：本发明涉及新化合物以及包含用于测定烷基转移酶（ATase），特别是烷基鸟嘌呤-DNA烷基转移酶（AGT）的化合物的组合物，方法和试剂盒。通常，新化合物提供测定ATase水平，特别是用于体内应用，包括但不限于特异性应用，特别是癌症相关应用。

5. 发明专利

CA2606008A1 COMBINATION THERAPY IN THE TREATMENT OF CANCER 未知
公开(公告)号：CA2606008A1
公开(公告)日：2006-11-09
申请号：CA2606008
申请日：2006-05-03
申请人： UNIV DUKE
发明人： ZALUTSKY MICHAEL R , BIGNER DARELL D
IPC分类号： C07K1/00 , A61K35/14 , C07K14/00 , C07K16/00 , C07K17/00 , C07K17/14 , C12P21/08
摘要： Disclosed herein is a method of treating a tumor by administering to the subject a treatment effective amount of a therapeutic antibody and an alkylating agent.

6. 发明公开

EP2470535A4 COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE 审中-公开
标题翻译：组合物，方法和试剂盒用于确定alkyltransferase
公开(公告)号：EP2470535A4
公开(公告)日：2014-01-01
申请号：EP10814228
申请日：2010-08-24
申请人： UNIV DUKE
发明人： ZALUTSKY MICHAEL R , VAIDYANATHAN GANESAN
IPC分类号： C07D473/18 , C07D403/12 , C07K7/06 , C07K14/485 , C07K14/68 , C12Q1/48 , G01N33/58
CPC分类号： C12Q1/48 , A61K51/088 , C07D473/18 , C07K7/06 , C07K14/485 , C07K14/68 , C07K2319/01 , G01N2333/91005

7. 发明公开

EP1877420A4 COMBINATION THERAPY IN THE TREATMENT OF CANCER 审中-公开
标题翻译：综合疗法治疗癌症的
公开(公告)号：EP1877420A4
公开(公告)日：2010-03-17
申请号：EP06758931
申请日：2006-05-03
申请人： UNIV DUKE
发明人： BIGNER DARELL D , ZALUTSKY MICHAEL R
IPC分类号： C07K1/00 , A61K31/395 , A61K31/53 , A61K35/14 , C07K14/00 , C07K16/00 , C07K17/00 , C07K17/14 , C12P21/08
CPC分类号： A61K39/395 , A61K31/395 , A61K31/53 , A61K39/39558 , A61K45/06 , A61K51/1045 , A61K2300/00

8. 发明公开

EP1817062A4 RADIATION DOSIMETRY AND BLOCKING ANTIBODIES AND METHODS AND USES THREFOR IN THE TREATMENT OF CANCER 审中-公开
标题翻译：辐射剂量和阻断抗体和方法及用途在癌症治疗
公开(公告)号：EP1817062A4
公开(公告)日：2010-01-20
申请号：EP05856975
申请日：2005-11-17
申请人： UNIV DUKE
发明人： AKABANI-HNEIDE GAMAL , BIGNER DARELL D , ZALUTSKY MICHAEL R , RIZZIERI DAVID A
IPC分类号： A61K49/00 , A61K51/10
CPC分类号： A61K51/1066 , A61N5/1015

9. 发明申请

WO0185221A3 ASSESSING LEVELS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE IN VIVO 审中-公开
标题翻译：评估VIVO中O6-氨基嘌呤-DNA烷基转移酶的水平
公开(公告)号：WO0185221A3
公开(公告)日：2002-08-15
申请号：PCT/US0115370
申请日：2001-05-14
申请人： UNIV DUKE
发明人： ZALUTSKY MICHAEL R , COLVIN MICHAEL , VAIDYANATHAN GANESAN
IPC分类号： A61K51/04
CPC分类号： A61K51/0491 , A61K51/04
摘要： Radiolabeled O6-derivatized guanine molecules can be used to form radiolabeled AGT molecules which can be detected in vivo assessment of AGT levels is useful for optimizing the efficacy of chemotherapy. In addition, assessing AGT levels in tumors in vivo permits selection of patients most likely to benefit from such chemotherapy and enables clinicians to monitor the effect of known and potential chemotherapeutic agents. In particular, methods have been developed for the efficient syntheses of [18F]FBG and [131I]IBG, both of which bind specifically to purified AGT. These two radiolabeled O6 benzylguanine analogues can be used to assess levels of AGT in vivo.
摘要翻译：放射性标记的O6衍生的鸟嘌呤分子可用于形成放射性标记的AGT分子，其可以在体内检测AGT水平的评估用于优化化疗的功效。此外，在体内评估肿瘤中的AGT水平允许选择最有可能受益于这种化学疗法的患者，并使临床医生能够监测已知和潜在的化学治疗剂的作用。特别地，已经开发了用于[18F] FBG和[131I] IBG的有效合成的方法，两者都特异性结合纯化的AGT。这两种放射性标记的O6苄基鸟嘌呤类似物可用于评估体内AGT的水平。

10. 发明申请

WO0032240B1 RADIOCONJUGATION OF INTERNALIZING ANTIBODIES 审中-公开
标题翻译：内分泌抗体的放射免疫
公开(公告)号：WO0032240B1
公开(公告)日：2001-03-01
申请号：PCT/US9928167
申请日：1999-11-30
申请人： UNIV DUKE
发明人： ZALUTSKY MICHAEL R
IPC分类号： A61K49/00 , A61K51/10
CPC分类号： A61K49/0058 , A61K51/1093
摘要： Antibodies to cell surface ligands such as EGFRvIII can be used to therapeutically or diagnosticallly deliver a radiolabel to tumor cells with high selectivity. The utility of radioconjugated internalizing antibodies is limited, however, by release of the label and its reuptake into normal cells. The invention provides new technology for radioconjugation of internalizing antibodies which reduces the release of label and improves retention of radioconjugated antibodies in lysosomes, where radiation is more effectively and selectively delivered to the nucleus of tumor cells.
摘要翻译：细胞表面配体如EGFRvIII的抗体可用于治疗或诊断性地以高选择性向肿瘤细胞递送放射性标记。然而，放射性缀合的内化抗体的效用是有限的，但是通过释放标记物并将其再吸收到正常细胞中。本发明提供了用于内化抗体的放射性缀合的新技术，其减少标记的释放并改善放射性缀合的抗体在溶酶体中的保留，其中辐射被更有效地选择性递送到肿瘤细胞的核。

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