专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3122759A4 CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES 无效转让
公开(公告)号：EP3122759A4
公开(公告)日：2017-12-13
申请号：EP15768383
申请日：2015-03-23
申请人： UNIV COLUMBIA , GENIA TECH INC
发明人： FULLER CARL W , KUMAR SHIV , JU JINGYUE , DAVIS RANDALL , CHEN ROGER
IPC分类号： C07H19/04
CPC分类号： C12Q1/6874 , C07H17/02 , C07H19/10 , C07H19/20 , C12Q1/6806
摘要： This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.

2. 发明公开

EP2668645A4 SYSTEM FOR COMMUNICATING INFORMATION FROM AN ARRAY OF SENSORS 有权转让
标题翻译：系统ZUR KOMMUNIKATION VON INFORMATIONEN AUS EINER SENSORREIHE
公开(公告)号：EP2668645A4
公开(公告)日：2017-01-04
申请号：EP11857055
申请日：2011-12-12
申请人： GENIA TECH INC
发明人： CHEN ROGER
IPC分类号： G01N33/487
CPC分类号： G01N27/3278 , C12Q1/6874 , G01N27/44791 , G01N33/48721
摘要： A system for communicating information from an array of sensors is disclosed. The system comprises a sensor array that includes a plurality of sensors, wherein each sensor senses a physical property of a material that is in communication with the sensor. The system further comprises signal processing circuitry associated with each sensor that integrates the output of the sensor over time and compares the integrated output to a threshold. The system further comprises a communication network coupled to the signal processing circuitry that outputs information indicating that the integrated output corresponding to a given sensor has reached the threshold.
摘要翻译：公开了一种用于检测分子复合物的电性能的系统。该系统包括电耦合到分子复合物的电极，其输出受分子复合物的电特性影响的电信号，其中分子复合物的电特性对电信号的影响的特征在于期望的带宽。该系统还包括积分放大器电路，其被配置为：从电极接收电信号。积分放大器电路还被配置为在预定带宽内随时间选择性地放大和积分电信号的一部分，其中至少部分地基于预期带宽来选择预定带宽。

3. 发明公开

EP2668258A4 TEMPERATURE REGULATION OF MEASUREMENT ARRAYS 审中-公开
标题翻译： TEMPERATUREGELUNG VON MESSARRAYS
公开(公告)号：EP2668258A4
公开(公告)日：2017-07-26
申请号：EP12739380
申请日：2012-01-10
申请人： GENIA TECH INC
发明人： CHEN ROGER
IPC分类号： G05D23/19 , B01J19/00 , G05D23/20
CPC分类号： B01J19/0046 , B01J2219/00495 , B01J2219/00698 , G05D23/1919 , G05D23/2034 , G05D23/2037
摘要： A system for regulating a temperature of a measurement array is disclosed. The system includes a measurement array including a plurality of sensors, wherein the plurality of sensors are integrated onto an integrated circuit die. The system includes a thermal sensor integrated onto the integrated circuit die, wherein the thermal sensor senses a temperature associated with the plurality of sensors. The system further includes a heat pump coupled to the integrated circuit die, wherein the heat pump is controlled by a feedback control circuit including the thermal sensor.
摘要翻译：公开了一种用于调节测量阵列的温度的系统。该系统包括包含多个传感器的测量阵列，其中多个传感器被集成到集成电路管芯上。该系统包括集成到集成电路管芯上的热传感器，其中热传感器感测与多个传感器相关联的温度。该系统还包括耦合到集成电路管芯的热泵，其中热泵由包括热传感器的反馈控制电路控制。

4. 发明公开

EP2534284A4 SYSTEMS AND METHODS FOR MANIPULATING A MOLECULE IN A NANOPORE 有权转让
标题翻译：系统和方法操纵分子在纳米孔
公开(公告)号：EP2534284A4
公开(公告)日：2017-01-25
申请号：EP11740145
申请日：2011-02-04
申请人： GENIA TECH INC
发明人： CHEN ROGER , DAVIS RANDY
IPC分类号： G01N33/487 , C12Q1/68
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2523/305 , C12Q2563/116 , C12Q2565/631

5. 发明专利

CA2943952A1 CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES 未知
公开(公告)号：CA2943952A1
公开(公告)日：2015-10-01
申请号：CA2943952
申请日：2015-03-23
申请人： THE TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK , GENIA TECH INC
发明人： FULLER CARL W , KUMAR SHIV , JU JINGYUE , DAVIS RANDALL , CHEN ROGER
IPC分类号： C07H19/04
摘要： This disclosure provides systems and methods for attaching nano pore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disdosed tagged nudeotides. Provided herein are nudeotides with attached tags and methods for attaching tags to nudeotides. The tags can be attached by chemical reactions, such as "dick chemistry". In an aspect, the present disdosure provides a tagged nudeotide, comprising: (a) a poly-phosphate moiety having a terminal phosphate; and (b) a tag covalently coupled to the terminal phosphate of the nudeotide by a triazole, a 1,2-diazine, a disulfide, a secondary amine, a hydrazone, a thio-acetamide, or a maleimide-thioadduct.

6. 发明专利

CA2864125C METHODS FOR CREATING BILAYERS FOR USE WITH NANOPORE SENSORS 未知
公开(公告)号：CA2864125C
公开(公告)日：2021-08-31
申请号：CA2864125
申请日：2013-02-15
申请人： GENIA TECH INC
发明人： DAVIS RANDALL , CHEN ROGER
IPC分类号： C12Q1/68 , C12N15/11
摘要： The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and inserting the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.

7. 发明专利

CA2995178A1 SYSTEMS AND METHODS FOR MANIPULATING A MOLECULE IN NANOPORE 未知
公开(公告)号：CA2995178A1
公开(公告)日：2011-08-11
申请号：CA2995178
申请日：2011-02-04
申请人： GENIA TECH INC
发明人： CHEN ROGER , DAVIS RANDY
IPC分类号： C12Q1/68 , B82Y5/00 , C12M1/34 , C12Q1/6869 , G01N33/483
摘要： Techniques for manipulating a molecule in a nanopore embedded in a lipid bilayer are described. In one example, an acquiring electrical stimulus level is applied across a lipid bilayer wherein a region of the lipid bilayer containing the nanopore is characterized by a resistance and wherein the acquiring electrical stimulus level tends to draw the molecule from a surrounding fluid into the nanopore, a change in the resistance of the lipid bilayer resulting from the acquisition of at least a portion of a molecule into the nanopore is detected, the acquiring electrical stimulus level is changed to a holding electrical stimulus level wherein the portion of the molecule remains in the nanopore upon the changing of the acquiring electrical stimulus level to the holding electrical stimulus level.

8. 发明专利

ES2732256T3 Procedimientos para crear bicapas para su uso con sensores con nanoporos 未知
公开(公告)号：ES2732256T3
公开(公告)日：2019-11-21
申请号：ES13748712
申请日：2013-02-15
申请人： GENIA TECH INC
发明人： DAVIS RANDALL , CHEN ROGER
IPC分类号： C12Q1/6869 , C12N15/11 , G01N27/327 , G01N33/487 , G01N33/543
摘要： Un procedimiento para formar una bicapa lipídica para su uso en un sensor con nanoporos, que comprende: (a) dirigir una solución amortiguadora en uno o más canales de flujo que comprenden un electrodo que tiene una capa de material sobre el mismo, en el que dicha solución amortiguadora es eléctricamente conductora y en el que dicha capa de material comprende uno o más lípidos; (b) poner dicha solución amortiguadora en contacto con dicha capa de material; (c) medir una corriente a través de dicho electrodo para determinar si al menos una parte de dicha capa de material ha formado una bicapa lipídica contigua a dicho electrodo; y (d) basándose en la determinación de (c), aplicar un estímulo a dicho electrodo para inducir que al menos dicha parte de la capa de material forme dicha bicapa lipídica contigua a dicho electrodo.

9. 发明专利

CA2788331C SYSTEMS AND METHODS FOR MANIPULATING A MOLECULE IN NANOPORE 未知
公开(公告)号：CA2788331C
公开(公告)日：2018-04-03
申请号：CA2788331
申请日：2011-02-04
申请人： GENIA TECH INC
发明人： CHEN ROGER , DAVIS RANDY
IPC分类号： C12Q1/68 , B82B3/00 , B82Y40/00 , C08J9/30 , C09D191/00 , C12M1/34 , C12M1/42 , C12Q1/6869 , C40B20/00 , C40B30/00 , G01N33/483
摘要： Techniques for manipulating a molecule in a nanopore embedded in a lipid bilayer are described. In one example, an acquiring electrical stimulus level is applied across a lipid bilayer wherein a region of the lipid bilayer containing the nanopore is characterized by a resistance and wherein the acquiring electrical stimulus level tends to draw the molecule from a surrounding fluid into the nanopore, a change in the resistance of the lipid bilayer resulting from the acquisition of at least a portion of a molecule into the nanopore is detected, the acquiring electrical stimulus level is changed to a holding electrical stimulus level wherein the portion of the molecule remains in the nanopore upon the changing of the acquiring electrical stimulus level to the holding electrical stimulus level.

10. 发明专利

CA3113744A1 NUCLEIC ACID SEQUENCING USING TAGS 未知
公开(公告)号：CA3113744A1
公开(公告)日：2014-05-15
申请号：CA3113744
申请日：2013-11-07
申请人： GENIA TECH INC
发明人： DAVIS RANDALL , CHEN ROGER , BIBILLO ARKADIUSZ , KORENBLUM DANIEL , DORWART MICHAEL
IPC分类号： C12Q1/6869 , C12M1/34 , C12M1/40
摘要： The present invention relates to a method for nucleic acid sequencing, the method comprising: (a) providing a single stranded nucleic acid; (b) providing a plurality of probes; (c) polymerizing the plurality of probes in an order determined by hybridization of the hybridization moieties with the single stranded nucleic acid to be sequenced; (d) cleaving the cleavable groups to provide an expanded thread to be sequenced; (e) threading the expanded thread through a nanopore, wherein the gates prevent the expanded thread from threading through the nanopore in the reverse direction; and (f) detecting, with the aid of the nanopore, the loop structures of the expanded thread in the order determined by hybridization of the hybridization moieties with the single stranded nucleic acid to be sequenced, thereby sequencing the single stranded nucleic acid to be sequenced.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式