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1. 发明申请

WO02065896A9 SYSTEMS AND METHODS FOR REVERSIBLY BLOCKING NERVE ACTIVITY 审中-公开
标题翻译：用于可逆阻塞神经活动的系统和方法
公开(公告)号：WO02065896A9
公开(公告)日：2004-04-08
申请号：PCT/US0204887
申请日：2002-02-20
申请人： UNIV CASE WESTERN RESERVE , KILGORE KEVIN L , GRILL WARREN M , MCINTYRE CAMERON C , MORTIMER JOHN THOMAS
发明人： KILGORE KEVIN L , GRILL WARREN M , MCINTYRE CAMERON C , MORTIMER JOHN THOMAS
IPC分类号： A61N1/32 , A61N1/34
CPC分类号： A61N1/32 , A61N1/36071
摘要： A system and method for blocking nerve impulses using an implanted electrode located on or around a nerve. A specific waveform (34) is used that causes the nerve membrane to become incapable of transmitting an action potential. The waveform has a first phase (36) that produces subthreshold depolarization of the nerve membrane, and a second phase (38) having a shorter duration. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve for chronic condition. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers.
摘要翻译：使用位于神经周围或周围的植入电极阻断神经冲动的系统和方法。使用使神经膜变得不能传递动作电位的特定波形（34）。波形具有产生神经膜的亚阈值去极化的第一相（36）和具有较短持续时间的第二相（38）。膜仅在电极下方受影响，效果立即完全可逆。该波形具有低振幅并且可以进行电荷平衡，对于慢性疾病，神经的安全性很高。可以选择性地阻止混合神经中较大的（运动）神经纤维，同时允许感官信息穿过未受影响的神经纤维。

2. 发明申请

WO02065896A2 SYSTEMS AND METHODS FOR REVERSIBLY BLOCKING NERVE ACTIVITY 审中-公开
标题翻译：用于可逆阻塞神经活动的系统和方法
公开(公告)号：WO02065896A2
公开(公告)日：2002-08-29
申请号：PCT/US0204887
申请日：2002-02-20
申请人： UNIV CASE WESTERN RESERVE , KILGORE KEVIN L , GRILL WARREN M , MCINTYRE CAMERON C , MORTIMER JOHN THOMAS
发明人： KILGORE KEVIN L , GRILL WARREN M , MCINTYRE CAMERON C , MORTIMER JOHN THOMAS
IPC分类号： A61N1/32 , A61N1/34 , A61B
CPC分类号： A61N1/32 , A61N1/36071
摘要： A system and method for blocking nerve impulses using an implanted electrode located on or around a nerve. A specific waveform (34) is used that causes the nerve membrane to become incapable of transmitting an action potential. The waveform has a first phase (36) that produces subthreshold depolarization of the nerve membrane, and a second phase (38) having a shorter duration. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve for chronic condition. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers.
摘要翻译：使用位于神经周围或周围的植入电极阻断神经冲动的系统和方法。使用使神经膜变得不能传递动作电位的特定波形（34）。波形具有产生神经膜的亚阈值去极化的第一相（36）和具有较短持续时间的第二相（38）。膜仅在电极下方受影响，效果立即完全可逆。该波形具有低振幅并且可以进行电荷平衡，对于慢性疾病，神经的安全性很高。可以选择性地阻止混合神经中较大的（运动）神经纤维，同时允许感官信息穿过未受影响的神经纤维。

3. 发明申请

WO2005032332A3 SYSTEMS AND METHODS FOR STIMULATING THE PUDENDAL NERVE FOR ACHIEVING SELECTIVE RESPONSES. 审中-公开
标题翻译：用于刺激用于实现选择性反应的PUDENDAL神经的系统和方法。
公开(公告)号：WO2005032332A3
公开(公告)日：2005-08-11
申请号：PCT/US2004028322
申请日：2004-09-01
申请人： UNIV CASE WESTERN RESERVE , BOGGS JOSEPH W II , WENZEL BRIAN J , GUSTAFSON KENNETH J , GRILL WARREN M
发明人： BOGGS JOSEPH W II , WENZEL BRIAN J , GUSTAFSON KENNETH J , GRILL WARREN M
IPC分类号： A61N1/18 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36196 , A61N1/36007 , A61N1/37247
摘要： Systems and method control physiological functions of the urinary tract using at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve. The systems and methods apply an electrical signal to the electrode at a selected frequency to stimulate the targeted component. The selected frequency is a first frequency or range of frequencies for achieving a first physiologic response (e.g., controlling urinary continence) and a second frequency or range of frequencies, different than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition).
摘要翻译：系统和方法控制尿道的生理功能，其使用至少一个电极，其尺寸和构造设置在位于阴部神经的目标成分之上，之中或附近。系统和方法以选定的频率将电信号施加到电极以刺激目标成分。所选择的频率是用于实现与第一生理学不同的第一生理反应（例如，控制尿路）和频率不同于第一频率的第二频率或频率范围的第一频率或频率范围反应（例如控制排尿）。

4. 发明申请

WO02078592A3 SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING COMPONENTS IN, ON, OR NEAR THE PUDENDAL NERVE OR ITS BRANCHES TO ACHIEVE SELECTIVE PHYSIOLOGIC RESPONSES 审中-公开
标题翻译：选择性选择性生理反应的选择性刺激组件，在或附近的分支神经或其分支的组织和方法
公开(公告)号：WO02078592A3
公开(公告)日：2003-03-06
申请号：PCT/US0209908
申请日：2002-03-29
申请人： UNIV CASE WESTERN RESERVE
发明人： GRILL WARREN M , GUSTAFSON KENNETH J , CREASEY GRAHAM H
IPC分类号： A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired responses in persons. The systems and methods use a multiple electrode array, or individual electrodes (18, 20, 22, and 24), placed on, in, or near the pudendal nerve.
摘要翻译：系统和方法选择性地刺激阴部神经的部分远离骶骨根以唤起人们期望的反应。该系统和方法使用多个电极阵列或放置在阴部神经中或其附近的单个电极（18,20,22和24）。

5. 发明申请

WO2005016446A2 AN ELECTRODE ARRAY FOR USE IN MEDICAL STIMULATION AND METHODS THEREOF 审中-公开
标题翻译：用于医学刺激的电极阵列及其方法
公开(公告)号：WO2005016446A2
公开(公告)日：2005-02-24
申请号：PCT/US2004026301
申请日：2004-08-13
申请人： UNIV CASE WESTERN RESERVE
发明人： GRILL WARREN M
IPC分类号： A61N1/05 , A61N
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/0553
摘要： An electrode array for use in medical stimulation includes one or more electrodes along an array body and one or more leads. Each of the electrodes has one or more conductive sections and each of the conductive sections has an outer surface which is substantially exposed from the array body for coupling to tissue. At least one of the electrodes has at least one of adjacent pairs of the conductive sections separated by an insulating section; the conductive section having at least one portion which is spaced in from other portions of the conductive section and which substantially extends all the way around or all along a length of the conductive section; at least one substantially non-planar end; and a substantially planar shape with a substantially non-linear outer edge. Each of the electrodes has at least one of the leads coupled to each of the conductive sections of the electrode.
摘要翻译：用于医疗刺激的电极阵列包括沿阵列体和一个或多个引线的一个或多个电极。每个电极具有一个或多个导电部分，并且每个导电部分具有基本上从阵列体暴露以耦合到组织的外表面。电极中的至少一个具有由绝缘部分隔开的相邻成对的导电部分中的至少一个; 所述导电部分具有与所述导电部分的其它部分间隔开的至少一个部分，并且所述至少一个部分基本上沿所述导电部分的长度全部地延伸或全部延伸; 至少一个基本上非平面的端部; 以及具有基本上非线性的外边缘的基本平坦的形状。每个电极具有耦合到电极的每个导电部分的引线中的至少一个。

6. 发明公开

EP1372780A4 SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING COMPONENTS IN, ON, OR NEAR THE PUDENDAL NERVE OR ITS BRANCHES TO ACHIEVE SELECTIVE PHYSIOLOGIC RESPONSES 审中-公开
标题翻译：系统和上或附近的阴部神经构成因素的影响，进行选择性增产方法及其分支机构，以获得选择性生理学反应的
公开(公告)号：EP1372780A4
公开(公告)日：2006-06-14
申请号：EP02715240
申请日：2002-03-29
申请人： UNIV CASE WESTERN RESERVE
发明人： GRILL WARREN M , GUSTAFSON KENNETH J , CREASEY GRAHAM H
IPC分类号： A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired responses in persons. The systems and methods use a multiple electrode array, or individual electrodes (18, 20, 22, and 24), placed on, in, or near the pudendal nerve.

7. 发明专利

CA2438541A1 SYSTEMS AND METHODS FOR REVERSIBLY BLOCKING NERVE ACTIVITY 未知
公开(公告)号：CA2438541A1
公开(公告)日：2002-08-29
申请号：CA2438541
申请日：2002-02-20
申请人： UNIV CASE WESTERN RESERVE
发明人： KILGORE KEVIN L , MORTIMER JOHN THOMAS , MCINTYRE CAMERON C , GRILL WARREN M
IPC分类号： A61N1/32 , A61N1/34
摘要： A system and method for blocking nerve impulses using an implanted electrode located on or around a nerve. A specific waveform (34) is used that causes t he nerve membrane to become incapable of transmitting an action potential. The waveform has a first phase (36) that produces subthreshold depolarization of the nerve membrane, and a second phase (38) having a shorter duration. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve fo r chronic condition. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers.

8. 发明专利

AU2007200136A1 Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 未知
公开(公告)号：AU2007200136A1
公开(公告)日：2007-02-01
申请号：AU2007200136
申请日：2007-01-12
申请人： UNIV CASE WESTERN RESERVE
发明人： CREASEY GRAHAM H , GUSTAFSON KENNETH J , GRILL WARREN M
IPC分类号： A61N1/36 , A61N1/05 , A61N1/32

9. 发明专利

AU2007200136C1 Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 未知
公开(公告)号：AU2007200136C1
公开(公告)日：2010-04-15
申请号：AU2007200136
申请日：2007-01-12
申请人： UNIV CASE WESTERN RESERVE
发明人： CREASEY GRAHAM H , GUSTAFSON KENNETH J , GRILL WARREN M
IPC分类号： A61N1/36 , A61N1/05 , A61N1/32

10. 发明专利

CA2538799A1 SYSTEMS AND METHODS FOR STIMULATING THE PUDENDAL NERVE FOR ACHIEVING SELECTIVE RESPONSES. 未知
公开(公告)号：CA2538799A1
公开(公告)日：2005-04-14
申请号：CA2538799
申请日：2004-09-01
申请人： UNIV CASE WESTERN RESERVE
发明人： BOGGS JOSEPH W II , GRILL WARREN M , GUSTAFSON KENNETH J , WENZEL BRIAN J
IPC分类号： A61N1/36 , A61N1/18 , A61N1/32
摘要： Systems and method control physiological functions of the urinary tract usin g at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve. The systems and methods apply an electrical signal to the electrode at a selected frequency to stimulate the targeted component. The selected frequency is a first frequency or range of frequencies for achieving a first physiologic response (e.g., controlling urinary continence) and a second frequency or range of frequencies, differen t than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition ).

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