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1. 发明申请

WO2005034725A3 PHOTONIC SENSOR PARTICLES AND FABRICATION METHODS 审中-公开
标题翻译：光电传感器颗粒和制造方法
公开(公告)号：WO2005034725A3
公开(公告)日：2005-08-04
申请号：PCT/US2004026572
申请日：2004-08-13
申请人： UNIV CALIFORNIA , LINK JAMIE R , SAILOR MICHAEL J
发明人： LINK JAMIE R , SAILOR MICHAEL J
IPC分类号： A61B20060101 , B29D11/00 , G02B6/122
CPC分类号： B29D11/00663 , B82Y20/00 , G01N21/4788 , G01N21/774 , G02B6/1225 , Y10T428/249969
摘要： The invention is related to optical particles (10), use of optical particles in sensing applications, and methods of fabricating optical particles that can target a desired analyte. The invention is also related to the self assembly of individual optical particles. An advantage of the invention is that it includes self-assembling individual photonic crystal sensors onto a target. In an embodiment of the invention, a processed sensor structure having two generally opposing surfaces is provided, wherein each of the opposing surfaces have different surface affinities, with a first optical structure formed on one of the opposing surfaces, and a second optical structure formed on the other of the opposing surfaces. The chemically and optically asymmetric opposing surfaces will spontaneously align at an organic liquid/water interface. Changes in the optical response of at least one of the opposing surfaces indicate the presence of a particular analyte for sensing applications.
摘要翻译：本发明涉及光学粒子（10），光学粒子在感测应用中的应用，以及制造可靶向所需分析物的光学粒子的方法。本发明还涉及单个光学颗粒的自组装。本发明的一个优点是它包括将单独的光子晶体传感器自组装到目标上。在本发明的一个实施例中，提供具有两个大致相对的表面的经处理的传感器结构，其中每个相对表面具有不同的表面亲和力，其中形成在一个相对表面上的第一光学结构和形成在另一个相对的表面。化学和光学上不对称的相对表面将在有机液体/水界面处自发排列。至少一个相对表面的光学响应的变化表示存在用于感测应用的特定分析物。

2. 发明申请

WO2004071949A2 NANOSTRUCTURED CASTING OF ORGANIC AND BIO-POLYMERS IN POROUS SILICON TEMPLATES 审中-公开
标题翻译：有机硅和多孔聚合物在多孔硅片中的纳米结构
公开(公告)号：WO2004071949A2
公开(公告)日：2004-08-26
申请号：PCT/US2004004320
申请日：2004-02-13
申请人： UNIV CALIFORNIA , LI YANGYANG , CUNIN FREDERIQUE , SAILOR MICHAEL J , LINK JAMIE R , GAO TING
发明人： LI YANGYANG , CUNIN FREDERIQUE , SAILOR MICHAEL J , LINK JAMIE R , GAO TING
IPC分类号： C01B20060101 , C01B
CPC分类号： B29D11/00346 , B29D11/0074 , B81B2201/06 , B81B2203/0361 , B81C99/0085 , B81C2201/0115 , B81C2201/034 , Y10S977/921
摘要： A method of generating three-dimensional nanostructures that includes providing a silicon substrate, creating a porous silicon template from the silicon substrate, wherein the template is created to have a predetermined configuration, depositing a predetermined material on the porous silicon template, and removing the porous silicon template from the deposited material to leave a freestanding nanostructure.
摘要翻译：一种产生三维纳米结构的方法，其包括提供硅衬底，从所述硅衬底产生多孔硅模板，其中所述模板被创建为具有预定构型，在所述多孔硅模板上沉积预定材料，以及除去所述多孔硅模板硅模板从沉积的材料离开独立的纳米结构。

3. 发明申请

WO2012151306A3 ELECTROADSORPTION AND CHARGE BASED BIOMOLECULE SEPARATION AND DETECTION IN POROUS SENSORS 审中-公开
标题翻译：多孔传感器中的电吸收和电荷分离生物分离与检测
公开(公告)号：WO2012151306A3
公开(公告)日：2013-03-28
申请号：PCT/US2012036163
申请日：2012-05-02
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , CHEN MICHELLE Y
发明人： SAILOR MICHAEL J , CHEN MICHELLE Y
IPC分类号： G01N27/02 , G01N21/45 , G01N35/00
CPC分类号： G01N27/447
摘要： Electroadsorption and charged based biomolecule separation, concentration and detection with porous biosensors. In preferred embodiments, a potential is applied to a porous electrode to separate and concentrate molecules from solution. The bimolecular analytes are captured by the porous electrode itself, the same electrode that is used to generate the electric field for electroadsorption. In additional preferred embodiments, pH of the solution is adjusted to separate and concentrate biomolecules. Setting the pH equal to the protein isoelectric point was determined by the inventors to maximize concentration of biomolecules into the porous biosensor. The methods include simultaneously optically detecting charged molecules captured by the porous electrode. Methods of the invention are benign to biomolecules of interest, which are demonstrated to retain a high percentage of their activity after being released from the biosensor. Methods of the invention provide label-free detection. Advantageously, small voltages and ultrasmall volumes of solution are used in methods of the invention.
摘要翻译：电吸收和带电的生物分子分离，浓度和多孔生物传感器的检测。在优选的实施方案中，将电位施加到多孔电极以从溶液中分离和浓缩分子。双分子分析物被多孔电极本身捕获，这是用于产生电吸附电场的相同电极。在另外的优选实施方案中，调节溶液的pH以分离和浓缩生物分子。通过发明人确定等于蛋白质等电点的pH以使生物分子的浓度最大化到多孔生物传感器中。所述方法包括同时光学检测由多孔电极捕获的带电分子。本发明的方法对于感兴趣的生物分子是良性的，其被证明在从生物传感器释放后保留其高活性百分比。本发明的方法提供无标记检测。有利地，在本发明的方法中使用小电压和超小体积的溶液。

4. 发明申请

WO2010008876A3 METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF 审中-公开
标题翻译：制备用于治疗和诊断应用的胶束杂合纳米颗粒的方法及其组合物
公开(公告)号：WO2010008876A3
公开(公告)日：2010-05-14
申请号：PCT/US2009048404
申请日：2009-06-24
申请人： UNIV CALIFORNIA , MASSACHUSETTS INST TECHNOLOGY , SAILOR MICHAEL J , BHATIA SANGEETA N , ROUSLAHTI ERKKI , PARK JI-HO , VON MALTZAHN GEOFFREY A
发明人： SAILOR MICHAEL J , BHATIA SANGEETA N , ROUSLAHTI ERKKI , PARK JI-HO , VON MALTZAHN GEOFFREY A
IPC分类号： A61K9/127 , A61K49/06 , A61P35/00
CPC分类号： A61K9/1271 , A61K49/0002 , A61K49/0019 , A61K49/0067 , A61K49/0082 , A61K49/1806 , A61K49/1839 , A61K49/1887
摘要： The disclosure provides a long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single polyethylene glycol (PEG) -phospholipid micelle and provide the first examples of simultaneous targeted drug delivery and dual-mode NIR- fluorescent and MR imaging of diseased tissue in vitro and in vivo.
摘要翻译：本公开提供了在单一聚乙二醇（PEG） - 磷脂胶束内含有MN，QD和抗癌药物多柔比星（DOX）的长循环，胶束混合纳米颗粒（MHN），并提供了同时靶向药物的第一实例在体外和体内递送和双模NIR荧光和病变组织的MR成像。

5. 发明申请

WO2008027090A2 CONTROL OF MATERIALS AND POROUS MAGNETIC PARTICLES 审中-公开
标题翻译：材料和多孔磁性颗粒的控制
公开(公告)号：WO2008027090A2
公开(公告)日：2008-03-06
申请号：PCT/US2007011727
申请日：2007-05-16
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , PARK JI-HO , DERFUS AUSTIN M , SEGAL ESTER , VECCHIO KENNETH S , BHATIA SANGEETA N
发明人： SAILOR MICHAEL J , PARK JI-HO , DERFUS AUSTIN M , SEGAL ESTER , VECCHIO KENNETH S , BHATIA SANGEETA N
IPC分类号： H01J37/02
CPC分类号： H01F1/0063 , B01J2219/00466 , B01J2219/00495 , B01J2219/005 , B01J2219/00502 , B01J2219/00563 , B01J2219/00576 , B01L3/502761 , B01L3/502792 , B01L7/52 , B01L2300/0896 , B01L2300/1816 , B01L2400/0415 , B01L2400/043 , B82Y25/00 , B82Y30/00
摘要： The present invention uses externally applied electromagnetic stimulus to control and heat porous magnetic particles and material associated with the particles. The particles contain magnetic material, such as superparamagnetic iron oxide and are associated with a material. Application of a DC magnetic field allows them to be moved with their associated material, and application of an AC RF electromagnetic field allows them to be heated with their associated material. The material can be associated with the particles by being contained in the pores of the particles, or in other cases the particles can adhere to the associated material, which can be an aqueous droplet. The present invention also provides a multi-layer porous magnetic particle. The particle includes a host layer having pores sized to accept magnetic nanoparticles. Magnetic nanoparticles are infused within pores of the host layer. An encoding layer includes pores that define a spectral code. The pores in the encoding layer are sized to substantially exclude the magnetic nanoparticles. The encoding layer can also be a multi-layer, exhibiting, for example, a complex spectral code.
摘要翻译：本发明使用外部施加的电磁刺激来控制和加热与颗粒相关联的多孔磁性颗粒和材料。颗粒含有磁性材料，例如超顺磁性氧化铁，并与材料相关联。 DC磁场的应用允许它们与其相关材料一起移动，并且AC RF电磁场的应用允许它们与其相关材料一起被加热。该材料可以通过包含在颗粒的孔中与颗粒相关联，或者在其它情况下，颗粒可以附着到可以是水性液滴的相关材料上。本发明还提供一种多层多孔磁性颗粒。颗粒包括具有尺寸以接受磁性纳米颗粒的孔的主体层。磁性纳米颗粒注入主体层的孔内。编码层包括限定光谱代码的孔。编码层中的孔的大小被确定为基本排除磁性纳米颗粒。编码层也可以是多层，表现出例如复谱谱。

6. 发明申请

WO2007008211A3 MAGNETIC POROUS PHOTONIC CRYSTAL PARTICLES AND METHOD OF MAKING 审中-公开
标题翻译：磁性多孔光子晶体颗粒及其制备方法
公开(公告)号：WO2007008211A3
公开(公告)日：2007-05-31
申请号：PCT/US2005025383
申请日：2005-07-18
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , LI YANGYANG , TRUJILLO NATHAN , DORVEE JASON
发明人： SAILOR MICHAEL J , LI YANGYANG , TRUJILLO NATHAN , DORVEE JASON
IPC分类号： H01L21/00 , B28B19/00 , H01F1/06 , H01F7/00 , H01F10/00 , H01F13/00
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention produces porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure (12) that produces a predetermined optical response and magnetic material (14) adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved, and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译：本发明产生产生预定光学响应且可以磁性操作的多孔颗粒。本发明的优选颗粒具有产生预定光学响应的多孔结构（12）和粘附到颗粒上的磁性材料（14）。另一个优选的颗粒是两亲性的。由本发明的颗粒提供的光学响应使得本发明的颗粒可用于感测，标记，信号传递，显示和许多其它应用。本磁性颗粒的磁性使颗粒本身受到操纵，例如振动，移动和重新取向。多孔颗粒也可用于控制，移动和/或传送与颗粒相关的小体积的液体和固体。

7. 发明申请

WO2010096733A3 LUMINESCENT POROUS SILICON NANOPARTICLES, METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：发光多孔硅纳米粒子，其制造方法和使用方法
公开(公告)号：WO2010096733A3
公开(公告)日：2010-11-18
申请号：PCT/US2010024848
申请日：2010-02-20
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , GU LUO , PARK JI-HO
发明人： SAILOR MICHAEL J , GU LUO , PARK JI-HO
IPC分类号： C09K11/59 , A61K49/00 , B82B1/00 , B82B3/00 , C09K11/02
CPC分类号： C09K11/59 , A61K49/0017 , A61K49/0067 , A61K49/0093 , C09K11/02 , C09K11/025 , Y10T428/2982
摘要： The disclosure relates to imaging agents and drug delivery systems.
摘要翻译：本公开涉及成像剂和药物递送系统。

8. 发明申请

WO2007008211A9 MAGNETIC POROUS PHOTONIC CRYSTAL PARTICLES AND METHOD OF MAKING 审中-公开
标题翻译：磁性多孔光子晶体颗粒及其制备方法
公开(公告)号：WO2007008211A9
公开(公告)日：2007-02-22
申请号：PCT/US2005025383
申请日：2005-07-18
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , LI YANGYANG , TRUJILLO NATHAN , DORVEE JASON
发明人： SAILOR MICHAEL J , LI YANGYANG , TRUJILLO NATHAN , DORVEE JASON
IPC分类号： H01L31/0256
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention provides porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure (12, 12a, 18) that produces a predetermined optical response and magnetic material (14) adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译：本发明提供产生预定光学响应且可以磁性操作的多孔颗粒。本发明的优选颗粒具有产生预定光学响应的多孔结构（12,12a，18）和粘附到颗粒上的磁性材料（14）。另一个优选的颗粒是两亲性的。由本发明的颗粒提供的光学响应使得本发明的颗粒可用于感测，标记，信号传递，显示和许多其它应用。本磁性颗粒的磁性使颗粒本身受到操纵，例如振动，移动和重新取向。多孔颗粒也可用于控制，移动和/或传送与颗粒相关的小体积的液体和固体。

9. 发明申请

WO2012050966A3 CARBON AND CARBON/SILICON COMPOSITE NANOSTRUCTED MATERIALS AND CASTING FORMATION METHOD 审中-公开
标题翻译：碳与碳/硅复合纳米结构材料与铸造成形方法
公开(公告)号：WO2012050966A3
公开(公告)日：2012-08-16
申请号：PCT/US2011053965
申请日：2011-09-29
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , KELLY TIMOTHY L
发明人： SAILOR MICHAEL J , KELLY TIMOTHY L
IPC分类号： B82B3/00 , B82B1/00 , C01B31/02
CPC分类号： C01B31/022 , B82B1/00 , B82Y30/00 , B82Y40/00 , C01B32/158 , C01B32/16 , C01B32/166 , D01D5/00 , D01F9/14 , G02B1/005 , Y10T428/249994 , Y10T428/2918
摘要： The invention provides nanostructure composite porous silicon and carbon materials, and also provides carbon nanofiber arrays having a photonic response in the form of films or particles. Composite materials or carbon nanofiber arrays of the invention are produced by a templating method of the invention, and the resultant nanomaterials have a predetermined photonic response determined by the pattern in the porous silicon template, which is determined by etching conditions for forming the porous silicon. Example nanostructures include rugate filters, single layer structures and double layer structures. In a preferred method of the invention, a carbon precursor is introduced into the pores of a porous silicon film. Carbon is then formed from the carbon precursor. In a preferred method of the invention, liquid carbon-containing polymer precursor is introduced into the pores of an porous silicon film. The precursor is thermally polymerized to form a carbon-containing polymer in the pores of the porous silicon film, which is then thermally carbonized to produce the nanostructured composite material. A carbon nanofiber array is obtained by dissolving the porous silicon. A carbon nanofiber array can be maintained as a film in liquid, and particles can be formed by drying the material.
摘要翻译：本发明提供纳米结构复合多孔硅和碳材料，并且还提供具有膜或颗粒形式的光子响应的碳纳米纤维阵列。本发明的复合材料或碳纳米纤维阵列通过本发明的模板化方法生产，并且所得到的纳米材料具有由多孔硅模板中的图案确定的预定光子响应，所述图案由用于形成多孔硅的蚀刻条件确定。示例性纳米结构包括皱纹滤波器，单层结构和双层结构。在本发明的优选方法中，碳前体被引入到多孔硅膜的孔中。然后由碳前体形成碳。在本发明的优选方法中，将液体含碳聚合物前体引入到多孔硅膜的孔中。将前体热聚合以在多孔硅膜的孔中形成含碳聚合物，然后将其热碳化以制备纳米结构复合材料。碳纳米纤维阵列通过溶解多孔硅而获得。碳纳米纤维阵列可以作为膜保持在液体中，并且可以通过干燥材料来形成粒子。

10. 发明申请

WO2012012437A2 TEMPERATURE RESPONSE SENSING AND CLASSIFICATION OF ANALYTES WITH POROUS OPTICAL FILMS 审中-公开
标题翻译：具有多孔光学薄膜的分析仪的温度响应感应和分类
公开(公告)号：WO2012012437A2
公开(公告)日：2012-01-26
申请号：PCT/US2011044549
申请日：2011-07-19
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , KING BRIAN , NODA SADAFUMI
发明人： SAILOR MICHAEL J , KING BRIAN , NODA SADAFUMI
IPC分类号： G01N21/25 , G01M11/00 , G01N25/00
CPC分类号： G01N21/25 , G01N21/171 , Y10T436/153333
摘要： Methods and systems of the invention can determine the identity and quantity of analytes in a vapor. In preferred methods, a porous optical film is exposed to vapor which contains analyte. The porous optical film is heated and its optical response is monitored during heating. An optical response observed via heating can determine the identity and/or quantity of the analyte. In preferred embodiments, optical response during a thermal pulse is compared to a database of sensor responses that are characteristic of various analytes. Preferred methods are conducted a relatively low temperatures, for example below about 200°C. In preferred methods, a heating and cooling cycle produces a hysteresis curve in the optical response that is indicative of analytes. In preferred embodiments, a thermal reset pulse resets the porous optical film for later use and also provides an optical response that can be used for sensing.
摘要翻译：本发明的方法和系统可以确定蒸汽中分析物的身份和数量。在优选的方法中，多孔光学膜暴露于含有分析物的蒸汽。加热多孔光学膜并在加热期间监测其光学响应。通过加热观察到的光学响应可以确定分析物的身份和/或数量。在优选实施例中，将热脉冲期间的光学响应与各种分析物的特征的传感器响应的数据库进行比较。优选的方法进行相对较低的温度，例如低于约200℃。在优选的方法中，加热和冷却循环在指示分析物的光学响应中产生滞后曲线。在优选实施例中，热复位脉冲复位多孔光学膜用于稍后使用，并且还提供可用于感测的光学响应。

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