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1. 发明申请

WO0213689A3 METHOD AND APPARATUS FOR REDUCING CONTAMINATION OF AN ELECTRICAL SIGNAL 审中-公开
标题翻译：减少电子信号污染的方法和装置
公开(公告)号：WO0213689A3
公开(公告)日：2003-08-21
申请号：PCT/US0125480
申请日：2001-08-15
申请人： UNIV CALIFORNIA , COHEN MARK S
发明人： COHEN MARK S
IPC分类号： G01R33/28 , A61B5/04 , A61B5/0476 , A61B5/055 , G06F17/00
CPC分类号： A61B5/04004 , A61B5/04017 , A61B5/4094
摘要： The method of reducing contamination of electrical signals recorded in the presence of repeated interference contamination comprises obtaining an electrical signal recorded in the presence of a contaminating signal, and detecting a timing signal that occurs at a fixed time point during the electrical signal relative to the onset of the contaminating signal. The electrical signal is digitized, wherein the digitizing begins with the timing signal. A plurality of digitized electrical signals is analyzed, wherein the electrical signals are synchronized with respect to the timing signal, to obtain an estimated contaminating signal that is subtracted from the digitized electrical signal. This method can be used with electrophysiological signals, such as EEG, ECG, EMG and galvanic skin response, and for elimination of noise associated with concurrently used methods such as MRI. The method of noise reduction is applicable to recordings of other electrical signals, including audio recordings.
摘要翻译：在存在重复的干扰污染的情况下减少记录的电信号的污染的方法包括获得在存在污染信号的情况下记录的电信号，以及检测在电信号期间相对于发生的固定时间点发生的定时信号的污染信号。电信号被数字化，其中数字化以定时信号开始。分析多个数字化电信号，其中电信号相对于定时信号同步，以获得从数字化电信号中减去的估计污染信号。该方法可用于电生理信号，如EEG，ECG，EMG和电流皮肤反应，以及消除与同时使用的方法如MRI相关的噪声。噪声降低的方法适用于包括音频记录在内的其他电信号的记录。

2. 发明专利

CA2409348C MESSAGING AND PROMOTION FOR DIGITAL AUDIO MEDIA PLAYERS 未知
公开(公告)号：CA2409348C
公开(公告)日：2010-08-24
申请号：CA2409348
申请日：2001-06-08
申请人： COHEN MARK S
发明人： COHEN MARK S
IPC分类号： G06Q30/02 , G10K15/02 , G11B20/10 , G11B27/10 , G11B27/11 , G11B31/00 , H04H20/40 , H04H20/57
摘要： Messaging, such as promotional messaging, is delivered to users of digital audio media players, such as digital disc (40) and tape players. Portable players are especially suited for practice of the invention. Players include a wireless receiver (38) to receive messages and memory for storage of messages. Alternatively, player memory is pre-loaded with messages. A controller plays messages at reasonable times, e.g., at breaks between tracks of the audio disc or tape being played. Advertising or promotional messages are broadcast to capable digital audio players via wireless transmission and stored in memory. The player reads control information on the disc and stores it in memory. The control information is used to play messages from memory. An effective promotion method is enabled through the invention and use of a player capable of message reception, storage and play in accordance with the invention. A promoter can arrange for the distribution of players, for free or at a reduced cost. An event, e.g., a festival or concert, provides a preferred circumstance to target a particular group of recipients of promotional or advertising messages. Promotional messaging that preferably comprises advertising is then broadcast to the distributed players, which store and play messages between tracks.

3. 发明专利

CA2409348A1 MESSAGING AND PROMOTION FOR DIGITAL AUDIO MEDIA PLAYERS 未知
公开(公告)号：CA2409348A1
公开(公告)日：2001-12-20
申请号：CA2409348
申请日：2001-06-08
申请人： COHEN MARK S
发明人： COHEN MARK S
IPC分类号： G06Q30/02 , G10K15/02 , G11B20/10 , G11B27/10 , G11B27/11 , G11B31/00 , H04H20/40 , G11B17/22 , G11B7/00
摘要： Messaging, such as promotional messaging, is delivered to users of digital audio media players, such as digital disc and tape players. Portable players are especially suited for practice of the invention. Players include a wireless receiver to receive messages and memory for storage of messages. Alternatively, player memory is preloaded with messages. A controller plays messages at reasonable times, e.g., at breaks between tracks of the audio disc or tape being played. Advertising or promotional messages are broadcast to capable digital audio players via wireless transmission and stored in memory. The player reads control information on the disc and stores it in memory. The control information is used to play messages from memory. An effective promotion method is enabled through the invention and use of a player capable of message reception, storage and play in accordance with the invention.

4. 发明专利

AU6677201A Messaging and promotion for digital audio media players 未知
公开(公告)号：AU6677201A
公开(公告)日：2001-12-24
申请号：AU6677201
申请日：2001-06-08
申请人： COHEN MARK S
发明人： COHEN MARK S
IPC分类号： G06Q30/02 , G10K15/02 , G11B20/10 , G11B27/10 , G11B27/11 , G11B31/00 , H04H20/40 , G11B17/22 , G11B7/00
摘要： Messaging, such as promotional messaging, is delivered to users of digital audio media players, such as digital disc and tape players. Portable players are especially suited for practice of the invention. Players include a wireless receiver to receive messages and memory for storage of messages. Alternatively, player memory is preloaded with messages. A controller plays messages at reasonable times, e.g., at breaks between tracks of the audio disc or tape being played. Advertising or promotional messages are broadcast to capable digital audio players via wireless transmission and stored in memory. The player reads control information on the disc and stores it in memory. The control information is used to play messages from memory. An effective promotion method is enabled through the invention and use of a player capable of message reception, storage and play in accordance with the invention.

5. 发明申请

WO2012106393A3 WITHANOLIDE ISOLATED FROM PHYSALIS LONGIFOLIA AND ANALOGS AND METHODS OF USE THEREOF 审中-公开
标题翻译：甾烷醇类化合物及其类似物及其使用方法
公开(公告)号：WO2012106393A3
公开(公告)日：2012-10-04
申请号：PCT/US2012023431
申请日：2012-02-01
申请人： UNIV KANSAS , TIMMERMANN BARBARA N , AUBE JEFFREY , ZHANG HUAPING , GOLLAPUDI RAO , COHEN MARK S , SAMADI ABBAS , MOTIWALA HASHIM FAKRUDDIN
发明人： TIMMERMANN BARBARA N , AUBE JEFFREY , ZHANG HUAPING , GOLLAPUDI RAO , COHEN MARK S , SAMADI ABBAS , MOTIWALA HASHIM FAKRUDDIN
IPC分类号： A61K31/58
CPC分类号： C07J71/001 , C07J17/00 , C07J17/005 , C07J41/0055 , C07J61/00
摘要： The present invention features novel withanolides, as well as analogs and salts thereof, for use in the treatment of proliferative disease, cardiovascular disease, neurodegenerative disease and inflammatory disease.
摘要翻译：本发明的特征是用于治疗增殖性疾病，心血管疾病，神经退行性疾病和炎性疾病的新型去甲万古醇及其类似物和盐。

6. 发明申请

WO2010053655A3 THERAPEUTIC METHODS WITH WITHAFERIN A AND ANALOGS 审中-公开
标题翻译： WATHAFERIN A和ANALOGS的治疗方法
公开(公告)号：WO2010053655A3
公开(公告)日：2010-07-15
申请号：PCT/US2009060056
申请日：2009-10-08
申请人： UNIV KANSAS , COHEN MARK S , SAMADI ABBAS , TIMERMAN BARBARA N
发明人： COHEN MARK S , SAMADI ABBAS , TIMERMAN BARBARA N
IPC分类号： A61K31/56 , A61P25/28 , A61P35/00
CPC分类号： A61K31/56
摘要： Compounds of Formulas 1 (withaferin A, also referred to as D004), 2 (viscosalactone B, also referred to as E002), and 3 (22R-5ß-formyl-6ß,27-dihydroxyl-l -oxo-4-norwith-24- enolide, also referred to as O010), as well as salts, prodrugs, analogs, and derivatives thereof are biologically active for modulating Hsp70, Hsp90, and/or HSFl. Also, these compounds can be included in pharmaceutical compositions for administration to a subject for modulating the expression or activity of Hsp70, Hsp90, and/or HSFl in order to produce a therapeutic effect.
摘要翻译：式1的化合物（含有铁蛋白A，也称为D004），2（粘内酯B，也称为E002）和3（22R-5β-甲酰基-6β，27-二羟基-1-氧代-4-去甲基 - 24-烯醇化物，也称为O010），以及其盐，前药，类似物和衍生物在调节Hsp70，Hsp90和/或HSF1方面具有生物活性。此外，为了产生治疗效果，这些化合物可以包括在用于给受试者施用以调节Hsp70，Hsp90和/或HSF1的表达或活性的药物组合物中。

7. 发明申请

WO2008091712A3 LOW FIELD ELECTRON PARAMAGNETIC RESONANCE IMAGING WITH SQUID DETECTION 审中-公开
标题翻译：低场电子参考谐波成像与检测
公开(公告)号：WO2008091712A3
公开(公告)日：2008-11-06
申请号：PCT/US2008001136
申请日：2008-01-28
申请人： CALIFORNIA INST OF TECHN , HANH INSEOB , DAY PETER , PENANEN KONSTANTIN I , EOM BYEONG H , COHEN MARK S
发明人： HANH INSEOB , DAY PETER , PENANEN KONSTANTIN I , EOM BYEONG H , COHEN MARK S
IPC分类号： G01N24/10 , G01R33/035 , G01R33/36 , G01R33/48
CPC分类号： G01R33/326 , G01N24/10 , G01R33/0354 , G01R33/0358 , G01R33/445
摘要： A flux transformer is magnetically coupled to a SQUID (112), and a plurality of SQUIDs (114B1 115B, 116B, 117B), connected in series, is magnetically coupled to the output of the SQUID. Alternatively, a flux transformer (108, 110) and a modulating coil (330) are magnetically coupled to a SQUID and an oscillator drives the modulating coil (230) at a frequency f. A processing system (306) mixes the output signal of the SQUID with sin(wt) and cos(2wt), where w = 2TT.f.
摘要翻译：磁通变压器磁耦合到SQUID（112），并且串联连接的多个SQUID（114B1 115B，116B，117B）磁耦合到SQUID的输出端。或者，磁通变压器（108,110）和调制线圈（330）磁耦合到SQUID并且振荡器以频率f驱动调制线圈（230）。处理系统（306）将SQUID的输出信号与sin（wt）和cos（2wt）混合，其中w = 2TT.f。

8. 发明专利

AU8337101A Method and apparatus for reducing contamination of an electrical signal 未知
公开(公告)号：AU8337101A
公开(公告)日：2002-02-25
申请号：AU8337101
申请日：2001-08-15
申请人： UNIV CALIFORNIA
发明人： COHEN MARK S
IPC分类号： G01R33/28 , A61B5/04 , A61B5/0476 , A61B5/055 , G06F17/00 , A61B5/00
摘要： The method of reducing contamination of electrical signals recorded in the presence of repeated interference contamination comprises obtaining an electrical signal recorded in the presence of a contaminating signal, and detecting a timing signal that occurs at a fixed time point during the electrical signal relative to the onset of the contaminating signal. The electrical signal is digitized, wherein the digitizing begins with the timing signal. A plurality of digitized electrical signals is analyzed, wherein the electrical signals are synchronized with respect to the timing signal, to obtain an estimated contaminating signal that is subtracted from the digitized electrical signal. This method can be used with electrophysiological signals, such as EEG, ECG, EMG and galvanic skin response, and for elimination of noise associated with concurrently used methods such as MRI. The method of noise reduction is applicable to recordings of other electrical signals, including audio recordings.

9. 发明专利

CA2418478A1 METHOD AND APPARATUS FOR REDUCING CONTAMINATION OF AN ELECTRICAL SIGNAL 未知
公开(公告)号：CA2418478A1
公开(公告)日：2002-02-21
申请号：CA2418478
申请日：2001-08-15
申请人： UNIV CALIFORNIA
发明人： COHEN MARK S
IPC分类号： G01R33/28 , A61B5/04 , A61B5/0476 , A61B5/055 , G06F17/00 , A61B5/00
摘要： The method of reducing contamination of electrical signals recorded in the presence of repeated interference contamination comprises obtaining an electrical signal recorded in the presence of a contaminating signal, and detecting a timing signal that occurs at a fixed time point during the electrical signal relative to the onset of the contaminating signal. The electrical signal is digitized, wherein the digitizing begins with the timin g signal. A plurality of digitized electrical signals is analyzed, wherein the electrical signals are synchronized with respect to the timing signal, to obtain an estimated contaminating signal that is subtracted from the digitiz ed electrical signal. This method can be used with electrophysiological signals , such as EEG, ECG, EMG and galvanic skin response, and for elimination of noi se associated with concurrently used methods such as MRI. The method of noise reduction is applicable to recordings of other electrical signals, including audio recordings.

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