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1. 发明申请

WO2011056545A3 ANTIMICROBIAL IONIC LIQUIDS 审中-公开
标题翻译：抗微生物离子液体
公开(公告)号：WO2011056545A3
公开(公告)日：2011-09-22
申请号：PCT/US2010054048
申请日：2010-10-26
申请人： UNIV BOSTON , GRINSTAFF MARK W , WATHIER MICHEL , O'TOOLE GEORGE A
发明人： GRINSTAFF MARK W , WATHIER MICHEL , O'TOOLE GEORGE A
IPC分类号： A61K31/495 , A61K9/08 , A61K31/4196 , A61K31/42 , A61K31/426 , A61P31/00 , A61P31/04
CPC分类号： A61K31/66 , A61K9/0014 , A61K9/08 , A61K31/4196 , A61K31/42 , A61K31/426 , A61K31/495
摘要： Certain aspects of the present invention relate to compositions, formulations, and use of ionic liquids as antimicrobial agent (e.g. as antibacterial and/or antifungal agents). In certain embodiments, the ionic liquids can be pared with one or more singly charge species or with one or more multi-charged species.
摘要翻译：本发明的某些方面涉及组合物，制剂和离子液体作为抗微生物剂（例如抗菌剂和/或抗真菌剂）的用途。在某些实施方案中，离子液体可以与一种或多种单电荷物质或与一种或多种多电荷物质配对。

2. 发明申请

WO2007124397A3 IONIC VISCOELASTICS AND VISCOELASTIC SALTS 审中-公开
标题翻译：离子粘度和粘弹性
公开(公告)号：WO2007124397A3
公开(公告)日：2008-12-11
申请号：PCT/US2007067047
申请日：2007-04-20
申请人： UNIV BOSTON , GRINSTAFF MARK W , WATHIER MICHEL
发明人： GRINSTAFF MARK W , WATHIER MICHEL
IPC分类号： C07D231/00
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译：本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体以及含有两个或多个阴离子的小分子或大分子形成交联网络。在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。在某些实施方案中，本发明的离子材料可用于各种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体晶体，生物相容性流体，溶剂和电子材料。

3. 发明申请

WO2007136738A2 NOVEL HYDROPHILIC POLYMERS AS MEDICAL LUBRICANTS AND GELS 审中-公开
标题翻译：新型水解聚合物作为医用润滑剂和凝胶
公开(公告)号：WO2007136738A2
公开(公告)日：2007-11-29
申请号：PCT/US2007011888
申请日：2007-05-18
申请人： UNIV BOSTON , GRINSTAFF MARK W , WATHIER MICHEL
发明人： GRINSTAFF MARK W , WATHIER MICHEL
IPC分类号： C08L5/00
CPC分类号： C08B37/006 , A61K9/0024 , A61L27/52 , C08G61/08 , C08G61/125 , C08G2261/1426 , C08G2261/3324 , C08G2261/3342 , C08L65/00
摘要： The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport- injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译：本发明提供了新的生物聚合物，其模拟体内发现的天然多糖的性质。本发明的多糖可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题的治疗，尿失禁的治疗，以及预防腹部或妇科手术后的粘连形成。

4. 发明专利

AU2019271198A1 Amino acid salts of nicotinic acid mononucleotide and nicotinamide mononucleotide as anti-ageing agents 未知
公开(公告)号：AU2019271198A1
公开(公告)日：2021-01-14
申请号：AU2019271198
申请日：2019-05-15
申请人： DOLLE ROLAND , JOYCE ROHAN DAVID , JUMPSTART FERTILITY PTY LTD , LIFE BIOSCIENCES INC , MARCUCCIO SEBASTIAN MARIO , TUCKER SIMON , WATHIER MICHEL
发明人： MARCUCCIO SEBASTIAN MARIO , JOYCE ROHAN DAVID , WATHIER MICHEL , DOLLE ROLAND , TUCKER SIMON
IPC分类号： C07H19/048 , A61K31/706 , A61P15/08
摘要： The present invention relates to amino acid salts of nicotinic acid mononucleotides and nicotinamide mononucleotides and compositions thereof of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD

5. 发明专利

AU2019268352A1 Inorganic salts of nicotinamide mononucleotide as anti-aging agents, especially for infertility treatment 未知
公开(公告)号：AU2019268352A1
公开(公告)日：2021-01-07
申请号：AU2019268352
申请日：2019-05-15
申请人： DOLLE ROLAND , JOYCE ROHAN DAVID , JUMPSTART FERTILITY PTY LTD , LIFE BIOSCIENCES INC , MARCUCCIO SEBASTIAN MARIO , TUCKER SIMON , WATHIER MICHEL
发明人： MARCUCCIO SEBASTIAN MARIO , JOYCE ROHAN DAVID , WATHIER MICHEL , DOLLE ROLAND , TUCKER SIMON
IPC分类号： C07F9/6558 , A61K31/661 , A61P15/08
摘要： The present invention relates to inorganic salts of nicotinamide mononucleotides and compositions of Formula (I), useful in the treatment of disorders and diseases associated with deficiencies in NAD

6. 发明专利

CA3108292A1 QUATERNARY AMMONIUM SALTS OF NICOTINIC ACID AND NICOTINAMIDE MONONUCLOETIDES AND RIBOSIDES AS ANTI-AGING AGENTS 未知
公开(公告)号：CA3108292A1
公开(公告)日：2020-02-06
申请号：CA3108292
申请日：2019-08-01
申请人： JUMPSTART FERTILITY PTY LTD , LIFE BIOSCIENCES INC , MARCUCCIO SEBASTIAN MARIO , JOYCE ROHAN DAVID , WATHIER MICHEL , DOLLE ROLAND , TUCKER SIMON
发明人： MARCUCCIO SEBASTIAN MARIO , JOYCE ROHAN DAVID , WATHIER MICHEL , DOLLE ROLAND , TUCKER SIMON
IPC分类号： A61K31/706 , A61P15/08 , C07H19/048
摘要： The present invention relates to amino acid salts of nicotinic acid and nicotinamide and compositions thereof of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD+: (I) wherein A, L, M1, M2, R1, R2, and R3 are as described herein.

7. 发明专利

AU2019314476A1 Quaternary ammonium salts of nicotinic acid and nicotinamide mononucloetides and ribosides as anti-aging agents 未知
公开(公告)号：AU2019314476A1
公开(公告)日：2021-02-25
申请号：AU2019314476
申请日：2019-08-01
申请人： JUMPSTART FERTILITY PTY LTD , LIFE BIOSCIENCES INC , MARCUCCIO SEBASTIAN MARIO , JOYCE ROHAN DAVID , WATHIER MICHEL , DOLLE ROLAND , TUCKER SIMON
发明人： MARCUCCIO SEBASTIAN MARIO , JOYCE ROHAN DAVID , WATHIER MICHEL , DOLLE ROLAND , TUCKER SIMON
IPC分类号： A61P15/08 , A61K31/7064 , C07H19/048
摘要： The present invention relates to amino acid salts of nicotinic acid and nicotinamide and compositions thereof of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD

8. 发明专利

AU2019271858A1 Inorganic salts of nicotinic acid mononucleotide as anti-aging agents 未知
公开(公告)号：AU2019271858A1
公开(公告)日：2021-01-14
申请号：AU2019271858
申请日：2019-03-15
申请人： DOLLE ROLAND , JOYCE ROHAN DAVID , JUMPSTART FERTILITY PTY LTD , LIFE BIOSCIENCES INC , MARCUCCIO SEBASTIAN MARIO , TUCKER SIMON , WATHIER MICHEL
发明人： WATHIER MICHEL , DOLLE ROLAND , MARCUCCIO SEBASTIAN MARIO , JOYCE ROHAN DAVID , TUCKER SIMON
IPC分类号： C07F9/6558 , A61K31/661 , A61P15/08
摘要： The present invention relates to inorganic salts of nicotinic acid mononucleotides and compositions of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD+:wherein A is O"; M

9. 发明专利

AU2019274524A1 Amino acid salts of nicotinic acid ribosides as anti-aging agents 未知
公开(公告)号：AU2019274524A1
公开(公告)日：2021-01-07
申请号：AU2019274524
申请日：2019-05-22
申请人： DOLLE ROLAND , JOYCE ROHAN DAVID , JUMPSTART FERTILITY PTY LTD , LIFE BIOSCIENCES INC , MARCUCCIO SEBASTIAN MARIO , TUCKER SIMON , WATHIER MICHEL
发明人： MARCUCCIO SEBASTIAN MARIO , JOYCE ROHAN DAVID , WATHIER MICHEL , DOLLE ROLAND , TUCKER SIMON
IPC分类号： C07H19/048 , A61K31/706 , A61P15/00
摘要： The present invention relates to amino acid salts of nicotinic acid ribosides and compositions thereof of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD+: wherein M

10. 发明申请

WO2012097078A2 VISCOSUPPLEMENTARY MATERIALS 审中-公开
标题翻译：粘性材料
公开(公告)号：WO2012097078A2
公开(公告)日：2012-07-19
申请号：PCT/US2012020960
申请日：2012-01-11
申请人： FLEX BIOMEDICAL , WATHIER MICHEL , SUZUKI HIDEKI
发明人： WATHIER MICHEL , SUZUKI HIDEKI
IPC分类号： A61K47/34
CPC分类号： A61L27/16 , A61K9/0019 , A61K45/06 , A61K47/34 , A61L27/52 , A61L27/54 , A61L2400/06 , A61L2400/10 , A61L2430/24 , C08G61/08 , C08G61/12 , C08G2261/1422 , C08G2261/1424 , C08G2261/1426 , C08G2261/3342 , C08G2261/418 , C08L37/00
摘要： A polymer includes at least one of the following repeat units: where R1 and R2 are either the same or different and are individually H, COOR3, COCH3, CONHR4, OR4 or SR4; wherein the polymer has a number average molecular weight from 1,500,000 g/mol to 2,500,000 g/mol; and with the proviso that both R1 and R2 are not H. Such polymers have a variety of uses including injection into a synovial joint for chondroprotection and as a viscosupplement.
摘要翻译：聚合物包括以下重复单元中的至少一个：其中R 1和R 2相同或不同，并且分别为H，COOR 3，COCH 3，CONHR 4，OR 4或SR 4; 其中所述聚合物的数均分子量为1,500,000g / mol至2,500,000g / mol; 并且条件是R 1和R 2都不是H.这样的聚合物具有多种用途，包括注射到用于软骨保护的滑膜接头中并作为粘性补体。

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