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1. 发明申请

WO2007144001A2 EMBRYO QUALITY ASSESSMENT BASED ON BLASTOMERE DIVISION AND MOVEMENT 审中-公开
标题翻译：基于BLASTOMERE分部和运动的EMBRYO质量评估
公开(公告)号：WO2007144001A2
公开(公告)日：2007-12-21
申请号：PCT/DK2007000291
申请日：2007-06-15
申请人： UNISENSE FERTILITECH AS , RAMSING NIELS B , BERNTSEN JOERGEN
发明人： RAMSING NIELS B , BERNTSEN JOERGEN
IPC分类号： G01N33/68
CPC分类号： C12Q1/02 , A61B17/435 , C12M21/06 , C12M41/46 , C12M41/48 , C12N5/0604 , G01N33/689 , G01N2800/385
摘要： The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and/or ii) determining the extent and/or spatial distribution of cellular or organelle movement during the cell division period; and/or iii) determining duration of an inter-division period; and/or iv) determining the extent and/or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.
摘要翻译：本发明涉及一种用于确定胚胎质量的系统和方法，包括在一段时间内监测胚胎，所述时间段具有足以包括至少一个细胞分裂期和至少部分分期间的长度，并且确定至少一个细胞分裂期的长度; 和/或ii）确定细胞分裂期间细胞或细胞器运动的程度和/或空间分布; 和/或iii）确定分期间的持续时间; 和/或iv）在分隔期间确定细胞或细胞器运动的程度和/或空间分布，从而获得胚胎质量测量。因此，基于观察到的细胞分裂的时间，持续时间，空间分布和程度以及相关的细胞和细胞器运动，促进在体外受精（IVF）后植入的最佳胚胎的选择。

2. 发明申请

WO2010003423A3 ONE TO ONE IDENTIFICATION SYSTEM 审中-公开
标题翻译：一对一的身份识别系统
公开(公告)号：WO2010003423A3
公开(公告)日：2010-08-12
申请号：PCT/DK2009050162
申请日：2009-07-03
申请人： UNISENSE FERTILITECH AS , RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
发明人： RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
IPC分类号： C12M1/18
CPC分类号： C12N5/0604 , C12M21/06 , C12M23/12 , C12M41/12 , C12M41/26 , C12M41/36 , C12M41/46
摘要： The present invention relates to a system arranged for assisting secure handling of cells in order to minimize the risk of handling mistakes resulting in mix-up of cell samples. The system allows for one to one identification of cells during a whole culturing period. This is obtained by providing a culturing system with loading/exit control means which ensures that only one device is capable of being loaded/removed at a time.
摘要翻译：本发明涉及一种用于辅助安全处理细胞的系统，以便最小化处理导致细胞样本混淆的错误的风险。该系统允许在整个培养期间一对一鉴别细胞。这是通过提供具有加载/退出控制装置的培养系统来获得的，该加载/退出控制装置确保一次只能装载/移除一个装置。

3. 发明申请

WO2009003487A3 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 审中-公开
标题翻译：用于监测和/或培养微观物体的装置，系统和方法
公开(公告)号：WO2009003487A3
公开(公告)日：2009-05-07
申请号：PCT/DK2008050162
申请日：2008-06-27
申请人： UNISENSE FERTILITECH AS , RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
发明人： RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
IPC分类号： C12M3/00
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.
摘要翻译：本发明涉及一种用于执行微观物体的监测和/或培养的装置，系统和方法。显微镜物体特别是微生物如细菌和细胞培养物，如培养对象，如组织样本和胚胎，为胚胎发育期间的孵育提供最佳和安全的培养条件，并促进选择用于体外受精的最佳胚胎（ IVF）通过促进自动数字成像和延时显微镜的胚胎处理。

4. 发明专利

AU2016201105A1 Adaptive embryo selection criteria optimized through iterative customization and collaboration 未知
公开(公告)号：AU2016201105A1
公开(公告)日：2016-03-10
申请号：AU2016201105
申请日：2016-02-23
申请人： UNISENSE FERTILITECH AS
发明人： RAMSING NIELS B , GUNDERSEN JENS K , HILLIGSOE KAREN MARIE , BERNTSEN JORGEN , AGERHOLM INGE EREBO
IPC分类号： G01N33/50 , G06K9/00
摘要： Adaptive embryo selection criteria optimized through iterative customization and collaboration The present invention relates to a system and a method for determining quality criteria in order to select the most viable embryos after in vitro fertilization. The present invention may further be applied for iteratively adapting embryo quality criteria based on new knowledge, historical selection & fertilization data and cooperation between fertility clinics.

5. 发明专利

DE602008005746D1 VORRICHTUNG, SYSTEM UND VERFAHREN ZUR BEOBACHTUNG UND/ODER KULTIVIERUNG MIKROSKOPISCHER OBJEKTE 未知
公开(公告)号：DE602008005746D1
公开(公告)日：2011-05-05
申请号：DE602008005746
申请日：2008-06-27
申请人： UNISENSE FERTILITECH AS
发明人： RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
IPC分类号： C12M3/00

6. 发明专利

AU2016201105B2 Adaptive embryo selection criteria optimized through iterative customization and collaboration 未知
公开(公告)号：AU2016201105B2
公开(公告)日：2018-03-01
申请号：AU2016201105
申请日：2016-02-23
申请人： UNISENSE FERTILITECH AS
发明人： RAMSING NIELS B , GUNDERSEN JENS K , HILLIGSOE KAREN MARIE , BERNTSEN JORGEN , AGERHOLM INGE EREBO
IPC分类号： G01N33/50 , G06K9/00
摘要： Adaptive embryo selection criteria optimized through iterative customization and collaboration The present invention relates to a system and a method for determining quality criteria in order to select the most viable embryos after in vitro fertilization. The present invention may further be applied for iteratively adapting embryo quality criteria based on new knowledge, historical selection & fertilization data and cooperation between fertility clinics.

7. 发明专利

ES2549205T3 Determinación de un cambio en una población de células 未知
公开(公告)号：ES2549205T3
公开(公告)日：2015-10-26
申请号：ES06791469
申请日：2006-10-16
申请人： UNISENSE FERTILITECH AS
发明人： RAMSING NIELS B , BERNTSEN JØRGEN
IPC分类号： G06T7/00 , C12M1/34 , C12M1/36 , C12M3/00 , G06T7/20 , G16B45/00 , G16H10/60
摘要： Un método para determinar un cambio en una población de células que comprende al menos una célula, comprendiendo dicho método las etapas de adquirir secuencialmente al menos dos imágenes de la población de células comparar al menos una parte de las al menos dos imágenes para obtener al menos una imagen de diferencia calcular un parámetro de la al menos una imagen de diferencia, y basándose en dicho parámetro calculado, determinar si se ha producido un cambio, caracterizado por que el parámetro calculado es una desviación estándar o varianza de valores para los píxeles en la imagen de diferencia.

8. 发明专利

DE602007008419D1 EMBRYONENQUALITÄTSBEURTEILUNG AUF DER GRUNDLAGE VON BLASTOMERENTEILUNG UND BEWEGUNG 未知
公开(公告)号：DE602007008419D1
公开(公告)日：2010-09-23
申请号：DE602007008419
申请日：2007-06-15
申请人： UNISENSE FERTILITECH AS
发明人： RAMSING NIELS B , BERNTSEN JOERGEN
IPC分类号： C12N5/073

9. 发明专利

IN9921DEN2014A EMBRYO QUALITY ASSESSMENT BASED ON BLASTOCYST DEVELOPMENT 未知
公开(公告)号：IN9921DEN2014A
公开(公告)日：2015-08-14
申请号：IN9921DEN2014
申请日：2014-11-22
申请人： UNISENSE FERTILITECH AS
发明人： RAMSING NIELS B , KRISTENSEN MORTEN , LÆGDSMAND METTE , KUHLMAN REIDUN BERGHOLD , AGERHOLM INGE ERREBO , ISAKSEN MAI FAURSCHOU , GUNDERSEN J ENS K
IPC分类号： C12N5/073 , G06K9/00
摘要： The present invention relates to a method and to a system for selecting embryos for in vitro fertilization based on observed cell kinetics and cell morphology. One embodiment of the invention relates to a method for determining embryo quality comprising monitoring the embryo for a time period , said time period comprising the transformation of the embryo from initial compaction or morula to blastocyst and determining one or more blastocyst quality criteria for said embryo , and based on said one or more blastocyst quality criteria determining the embryo quality.

10. 发明专利

GB2522683A Incubator apparatus and methods 未知
公开(公告)号：GB2522683A
公开(公告)日：2015-08-05
申请号：GB201401773
申请日：2014-02-03
申请人： UNISENSE FERTILITECH AS
发明人： MADSEN KIM BÃ NDERGAARD , MEJER TROELS KOFOED , BERNTSEN JÃ RGEN , RAMSING NIELS B , HANSEN JONAS LERCHE
IPC分类号： C12M3/00
摘要： Apparatus and methods for monitoring embryos in an incubator are described. The apparatus 2 comprises an incubation chamber defined by an incubation chamber housing 12 and a sample platform comprising a plurality of receptacles for holding embryos within the incubation chamber. The sample platform may comprise a slide carrier 14 on which embryo slides containing the receptacles may be placed for incubation. The sample platform is rotatable about a rotation axis 16 relative to the incubation chamber housing 12 so as to allow receptacles to be selectively rotated to a monitoring position that is aligned with a viewing port provided in the incubation chamber housing 12, for example an opening or window. An imaging device (e.g. a microscope) 20 is located outside the incubation chamber and arranged to image embryos within the incubation chamber at the monitoring position through the viewing port. An embryo slide for use in the aforementioned apparatus is also disclosed.

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