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1. 发明申请

WO2005045067A1 IMPROVEMENTS RELATING TO SEMEN PRESERVATION 审中-公开
标题翻译：关于SEMEN保存的改进
公开(公告)号：WO2005045067A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004683
申请日：2004-11-08
申请人： UCL BIOMEDICA PLC , MICHAEL, Anthony , THURSTON, Lisa
发明人： MICHAEL, Anthony , THURSTON, Lisa
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32 , G01N33/5005 , G01N33/689 , G01N2800/367
摘要： The present invention provides a method for determining the suitability of a sample of mammalian semen for cooling and/or cryopreservation or storage, which comprises: (a) providing said sample of semen; (b) determining the level of a hydrophobic stimulator of 11β-HSD activity in said sample; and (c) assessing, from the level of 11β-HSD stimulator determined, the suitability of the semen sample for cooling and/or cryopreservation or storage. The present invention also provides a method of obtaining a hydrophobic product that improves the tolerance of mammalian semen to cooling and/or cryopreservation or storage, a method of improving the survival rate of sperm intended for cooling and/or cryopreservation or storage and a method of performing an assisted conception/reproductive procedure comprising contacting an oocyte with sperm obtained by a method according to the present invention.
摘要翻译：本发明提供了一种用于确定用于冷却和/或冷冻保存或储存的哺乳动物精液样品的适合性的方法，其包括：（a）提供所述精液样品; （b）确定所述样品中11beta-HSD活性的疏水刺激剂的水平; 和（c）从确定的11beta-HSD刺激剂的水平评估精液样品用于冷却和/或冷冻保存或储存的适用性。本发明还提供了获得提高哺乳动物精液对冷却和/或冷冻保存或储存的耐受性的疏水产物的方法，提高用于冷却和/或冷冻保存或储存的精子存活率的方法和执行辅助受孕/繁殖程序，包括使卵母细胞与通过根据本发明的方法获得的精子接触。

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